%PDF-1.3 % 12 0 obj <>>>/BBox[0 0 612 792]/Length 53>>stream xs w3T0WI2P0T5TR Ɩf !\!Y\ !p o endstream endobj 15 0 obj <>>>/BBox[0 0 612 792]/Length 53>>stream xs w3T0WI2P0T5TR Ɩf !\!Y\ !p o endstream endobj 7 0 obj <>>>/BBox[0 0 612 792]/Length 53>>stream xs w3T0WI2P0T5TR Ɩf !\!Y\ !p o endstream endobj 10 0 obj <>>>/BBox[0 0 612 792]/Length 53>>stream xs w3T0WI2P0T5TR Ɩf !\!Y\ !p o endstream endobj 1 0 obj <>>>/BBox[0 0 612 792]/Length 53>>stream xs w3T0WI2P0T5TR Ɩf !\!Y\ !p o endstream endobj 3 0 obj <>>>/BBox[0 0 612 792]/Length 53>>stream xs w3T0WI2P0T5TR Ɩf !\!Y\ !p o endstream endobj 9 0 obj <>>>/BBox[0 0 612 792]/Length 53>>stream xs w3T0WI2P0T5TR Ɩf !\!Y\ !p o endstream endobj 11 0 obj <>>>/BBox[0 0 612 792]/Length 53>>stream xs w3T0WI2P0T5TR Ɩf !\!Y\ !p o endstream endobj 13 0 obj <>>>/BBox[0 0 612 792]/Length 53>>stream xs w3T0WI2P0T5TR Ɩf !\!Y\ !p o endstream endobj 5 0 obj <>>>/BBox[0 0 612 792]/Length 53>>stream xs w3T0WI2P0T5TR Ɩf !\!Y\ !p o endstream endobj 4 0 obj <>>>/BBox[0 0 612 792]/Length 53>>stream xs w3T0WI2P0T5TR Ɩf !\!Y\ !p o endstream endobj 14 0 obj <>>>/BBox[0 0 612 792]/Length 53>>stream xs w3T0WI2P0T5TR Ɩf !\!Y\ !p o endstream endobj 8 0 obj <>>>/BBox[0 0 612 792]/Length 53>>stream xs w3T0WI2P0T5TR Ɩf !\!Y\ !p o endstream endobj 6 0 obj <>>>/BBox[0 0 612 792]/Length 53>>stream xs w3T0WI2P0T5TR Ɩf !\!Y\ !p o endstream endobj 17 0 obj <>stream Acrobat Distiller 8.1.0 (Windows); modified using iText 4.2.0 by 1T3XT Arbortext Advanced Print Publisher 9.0.114/W 2021-01-21T03:57:15-08:00 2020-12-29T23:06:20+05:30 application/pdf NEU-2020-7074-ver9-Mikolic_3P 196..209 uuid:bca59dff-a711-414f-8fd9-40a26cf17c24 uuid:b96b738c-18c0-4cc9-95c2-272f700adb64 endstream endobj 18 0 obj <>stream x+| endstream endobj 19 0 obj <>stream xS**T0T0Biy\' endstream endobj 20 0 obj <>stream x+| endstream endobj 21 0 obj <>stream xS**T0T0Biyw* endstream endobj 22 0 obj <>stream x+| endstream endobj 23 0 obj <>stream xS**T0T0Biye( endstream endobj 24 0 obj <>stream x+| endstream endobj 25 0 obj <>stream xS**T0T0BiyJ% endstream endobj 26 0 obj <>stream x+| endstream endobj 27 0 obj <>stream xS**T0T0BiyS& endstream endobj 28 0 obj <>stream x+| endstream endobj 29 0 obj <>stream xS**T0T0Bih~V endstream endobj 30 0 obj <>stream x+| endstream endobj 31 0 obj <>stream xS**T0T0BiyA$ endstream endobj 32 0 obj <>stream x+| endstream endobj 33 0 obj <>stream xS**T0T0Biy+ endstream endobj 34 0 obj <>stream x+| endstream endobj 35 0 obj <>stream xS**T0T0BihW endstream endobj 36 0 obj <>stream x+| endstream endobj 37 0 obj <>stream xS**T0T0Biy, endstream endobj 38 0 obj <>stream x+| endstream endobj 39 0 obj <>stream xS**T0T0BihlT endstream endobj 40 0 obj <>stream x+| endstream endobj 41 0 obj <>stream xS**T0T0BihuU endstream endobj 42 0 obj <>stream x+| endstream endobj 43 0 obj <>stream xS**T0T0Biyn) endstream endobj 44 0 obj <>stream x+| endstream endobj 45 0 obj <>stream xS**T0T0Biy8# endstream endobj 47 0 obj <>stream /GS1 gs BT /F3 1 Tf 8.9663 0 0 8.9663 59.7543 725.7825 Tm 0 0 0 rg 0 Tc 0 Tw (Introduction)Tj /F6 1 Tf 25.24 0 0 25.24 59.7543 693.014 Tm (T)Tj /F7 1 Tf 8.9663 0 0 8.9663 77.1023 703.8423 Tm [(raumatic)-229.4(brain)-233.9(injury)]TJ /F4 1 Tf 10.1989 0 TD [(\(TBI\))-231.2(is)-231.9(a)-229.6(major)-231.4(health)-231.2(concern)-234.1(with)]TJ /F5 1 Tf -10.1989 -1.2203 TD (>)Tj /F4 1 Tf .5501 0 TD [(50,000,000)-368.7(new)-371(cases)-367.6(reported)-370.6(globally)-364.7(every)-371.7(year.)]TJ 6.7246 0 0 5.9768 273.2598 696.8691 Tm (1,2)Tj 8.9663 0 0 8.9663 284.9385 692.9006 Tm (Ap-)Tj -25.1146 -1.2203 TD [(proximately)-276.9(7090%)-271.1(of)-273.5(patients)-273.4(with)-275(TBI)-277.6(present)-274.8(with)-268.6(a)-273.8(Glasgow)]TJ 0 -1.2266 TD [(Coma)-192.1(Score)-193.3(\(GCS\))-186.4(of)-191.3(1315,)-190.2(which)-190.7(falls)-188.8(in)-186.4(the)-194.7(mild)-186.7(TBI)-189(category.)]TJ 6.7246 0 0 5.9768 295.4834 674.9856 Tm (3)Tj 8.9663 0 0 8.9663 59.7543 660.0187 Tm [(Although)-380.5(the)-371.7(majority)-377.1(of)-374.7(these)-374.3(patients)-380.9(recover)-375.8(shortly)-375.1(after)-378.3(the)]TJ 0 -1.2203 TD [(incident,)-426.9(a)-425.6(notable)-420.4(percentage)-431.1(continue)-420(to)-426.7(have)-420.2(persistent)-428(com-)]TJ 0 -1.2266 TD [(plaints.)-362.9(These)-357.5(complaints)-358.2(can)-357.4(interfere)-360.1(with)-363.5(daily)-355.8(life)-358.9(and)-355(social)]TJ 0 -1.2203 TD [(and)-399.3(work)-389.7(activities,)]TJ 6.7246 0 0 5.9768 133.0582 631.1053 Tm (4,5)Tj 8.9663 0 0 8.9663 145.0204 627.1368 Tm (and)Tj /F8 1 Tf 1.84 0 TD (*)Tj /F4 1 Tf .999 0 TD [(50%)-392.7(of)-393.6(persons)-396(with)-395.1(mild)-395.3(TBI)-397.7(do)]TJ -12.3486 -1.2203 TD [(not)-369.3(return)-362.8(to)-369.8(their)-364.7(pre-injury)-367.5(level)-364.5(of)-368.4(functioning)-365.8(6)-359.9(months)-366.2(after)]TJ T* (injury.)Tj 6.7246 0 0 5.9768 83.5086 609.2219 Tm (68)Tj 8.9663 0 0 8.9663 69.7323 594.2549 Tm [(The)-550.9(most)-550.6(prominent)-549.7(post-injury)-550.5(disturbances)-558.2(are)-549.7(cognitive,)]TJ -1.1128 -1.2203 TD [(emotional,)-271.9(somatic,)-263.7(and)-266.5(behavioral)-265.9(symptoms,)-265.4(often)-265.8(referred)-273(to)-262.3(as)]TJ T* [(post-concussive)-235.4(symptoms,)]TJ 6.7246 0 0 5.9768 158.2866 576.34 Tm (9)Tj 8.9663 0 0 8.9663 163.7291 572.3715 Tm [(or)-229.3(if)-233.3(the)-226.3(sequelae)-232.3(of)-235.6(symptoms)-224.5(persist)]TJ -11.5962 -1.2266 TD [(over)-312.9(time,)-312.1(post-concussion)-308.9(syndrome)-309.3(\(PCS\).)-311.1(The)-310.6(concept)-311.4(of)-311.5(PCS)]TJ 0 -1.2203 TD [(has)-236.1(been)-236.8(questioned)-236.8(in)-237(recent)-232.2(years,)]TJ 6.7246 0 0 5.9768 188.3905 554.3998 Tm (10)Tj 8.9663 0 0 8.9663 197.2346 550.4313 Tm [(and,)-237.8(therefore,)-232.6(some)-239.1(authors)]TJ -15.3331 -1.2203 TD [(refer)-256.8(to)-249.6(the)-257.9(multiple)-252.1(concurrent)-251.9(post-concussive)-260.7(symptoms)-249.8(several)]TJ 0 -1.2266 TD [(months)-492.7(after)-498.5(TBI)-492.5(as)-495.8(persistent)-491.2(post-concussive/post-concussion)]TJ 0 -1.2203 TD [(symptoms)-452.2(\(PPCS\).)]TJ 6.7246 0 0 5.9768 129.7133 521.5179 Tm (1114)Tj 8.9663 0 0 8.9663 150.5763 517.5494 Tm [(The)-443.4(prevalence)-450.1(of)-450.6(6-month)-443(PPCS)-447.4(after)]TJ -10.1293 -1.2203 TD [(mild)-458.5(TBI)-454.6(varies)-452.3(substantially)-457.3(among)-458.8(studies,)-454.9(partly)-452.7(because)-456.4(of)]TJ T* [(differences)-219.7(in)-218(diagnostic)-221.9(criteria,)-219.5(and)-215.9(is)-212.9(typically)-218.9(between)-219.8(10%)-215.6(and)]TJ 0 -1.2266 TD [(40%)-285.2(in)-274.9(civilian)-282.6(samples)-283.2(presenting)-283.7(to)-281.2(hospitals.)]TJ 6.7246 0 0 5.9768 232.9511 488.6361 Tm (4,1518)Tj 8.9663 0 0 8.9663 69.7323 473.7259 Tm [(Considering)-348.7(the)-346.4(high)-349.8(percentage)-348.9(of)-343.1(functionally)-352.8(impaired)-350.2(per-)]TJ -1.1128 -1.2203 TD [(sons)-316.6(with)-306.6(mild)-313.1(TBI,)-312.1(the)-308.5(economic)-314.4(burden)-311.9(of)-311.4(prolonged)-314.5(treatment)]TJ 0 -1.2266 TD [(and)-329.7(decreased)-340.3(productivity,)]TJ 6.7246 0 0 5.9768 160.3842 455.8109 Tm (19)Tj 8.9663 0 0 8.9663 170.0787 451.7857 Tm [(it)-329.5(is)-333(important)-326(to)-331.8(promptly)-332.7(identify)]TJ -12.3044 -1.2203 TD [(persons)-212.6(who)-216.8(are)-208.3(at)-214.1(high)-210.7(risk)-214.5(of)-210.3(long-term)-210.8(consequences.)-213.9(Therefore,)]TJ T* [(a)-343.4(well-performing)-343(prognostic)-338.2(model)-336.3(for)-338.9(outcome)-344.1(prediction)-337.1(after)]TJ 0 -1.2266 TD [(mild)-212(TBI)-208(is)-212.9(important)-205.9(to)-211.7(assist)-213.4(patients)-210.2(and)-209.6(health-care)-209.7(providers)-210.8(in)]TJ 0 -1.2203 TD [(making)-222(well-informed)-221.2(treatment)-223.4(decisions.)-222.4(Before)-226.8(implementation)]TJ T* [(of)-286.2(a)-286.5(model)-285.7(for)-282(decision)-288.4(making)-285.3(in)-287.6(clinical)-285(practice)-288.3(can)-287.9(be)-286(consid-)]TJ 0 -1.2266 TD [(ered,)-229.7(it)-228.4(is)-225.5(crucial)-229.5(to)-230.7(assess)-228(its)-229.1(performance)-230.6(in)-224.3(an)-229.1(external)-229(validation)]TJ 0 -1.2203 TD [(study.)-315.5(In)-311.4(recent)-314.4(years,)-312.6(there)-312.5(have)-319(been)-312.7(initiatives)-315.6(toward)-312.9(external)]TJ T* [(validation)-401.7(of)-400(prognostic)-401.4(models)-406.6(for)-395.8(mild)-401.6(TBI,)]TJ 6.7246 0 0 5.9768 232.3842 368.107 Tm (6,20)Tj 8.9663 0 0 8.9663 247.748 364.1385 Tm [(but)-400.9(validation)]TJ -20.9668 -1.2203 TD [(studies)-275(are)-271.5(still)-274.1(scarce.)-272.7(The)-266.3(Collaborative)-277.2(European)-268.9(NeuroTrauma)]TJ 0 -1.2266 TD [(Effectiveness)-252.7(Research)-254.5(in)-249.6(Traumatic)-250.8(Brain)-245.3(Injury)-246.6(\(CENTER-TBI\))]TJ 0 -1.2203 TD [(project)-246(provides)-240.3(an)-235.4(excellent)-245(opportunity)-236.9(for)-244(external)-241.6(validation)-237.3(of)]TJ T* [(existing)-245.7(models)-235.9(in)-243.3(a)-235.9(large)-243(prospective)-241.3(cohort)-240.1(of)-241.9(contemporary)-241.8(TBI)]TJ 0 -1.2266 TD [(patients)-286.1(from)-278.7(18)-283.6(countries)-277.8(across)-285.1(Europe,)-283(and)-279.2(Israel.)]TJ 6.7246 0 0 5.9768 250.5826 313.3416 Tm (21)Tj 8.9663 0 0 8.9663 69.7323 298.3748 Tm [(The)-184.1(aim)-179.2(of)-185(this)-178(study)-179.8(was)-182.5(to)-180.1(examine)-188.4(the)-175.7(performance)-186.4(of)-185(existing)]TJ -1.1128 -1.2203 TD [(models)-197.9(for)-193.4(prediction)-191.7(of)-191.3(outcome)-198.7(following)-190.6(mild)-193(TBI.)-198.3(We)-193.1(searched)]TJ 0 -1.2266 TD [(for)-541.2(published)-544.7(predictors)-545.5(and)-538.4(prognostic)-540.5(models)-545.7(for)-541.2(functional)]TJ 0 -1.2203 TD [(outcome)-331.4(\(Glasgow)-335.4(Outcome)-328.4(Scale)-336.2(Extended)-327.2([GOSE]\))-338.2(and)-329.7(PPCS)]TJ T* [(for)-351.5(mild)-351.1(TBI)-353.4(and)-348.7(validated)-356.4(selected)-350.1(prognostic)-350.8(models)-356(using)-350.5(the)]TJ T* [(CENTER-TBI)-288.9(database.)]TJ /F3 1 Tf 0 -2.7568 TD (Methods)Tj /F9 1 Tf 0 -1.8336 TD [(Study)-338.6(population)]TJ /F4 1 Tf 1.1128 -1.7451 TD [(The)-260(study)-255.7(population)-256.2(consisted)-257.5(of)-254.5(patients)-260.8(from)-259.7(the)-257.9(prospective)]TJ -1.1128 -1.1128 TD [(longitudinal)-212.7(observational)-206.4(CENTER-TBI)-213.1(study)-211.4(\(Core)-205.9(data,)-212.2(version)]TJ T* [(2.0\).)-266.2(Data)-269.4(were)-268(collected)-263.9(from)-266(December)-268.1(2014)-263.6(to)-268.6(December)-268.1(2017)]TJ T* [(in)-534.2(58)-536.5(centers)-536.4(across)-538(Europe)-533(and)-538.4(Israel.)-533.7(Ethical)-538.1(approval)-532.4(was)]TJ 0 -1.1065 TD [(granted)-242(for)-237.7(each)-245.6(recruiting)-238.5(site)-243.6(and)-241.2(informed)-238.9(consent)-240.6(was)-239.4(obtained)]TJ 0 -1.1128 TD [(for)-225(all)-224(patients)-222.8(by)-226.6(the)-220(patients)-229.2(and/or)-221.1(their)-225.6(legal)-225.4(representative/next)]TJ T* [(of)-279.8(kin.)-283.7(Institutions)-278.5(participating)-282.9(in)-281.3(CENTER-TBI)-282.6(were)-280.7(mainly)-282.9(re-)]TJ T* [(ferral)-235(centers)-232.9(for)-231.4(neurotrauma.)-232.5(Patients)-234.1(who)-235.8(were)-230.1(not)-230.2(seen)-231.7(in)-230.7(study)]TJ 0 -1.1065 TD [(hospitals)-372.9(were)-369.2(not)-363(included.)-366(Inclusion)-370.3(criteria)-368.4(for)-370.5(the)-365.4(core)-365.9(study)]TJ 0 -1.1128 TD [(were)-432.4(a)-425.6(clinical)-436.7(diagnosis)-425.8(of)-425.3(TBI,)-432.2(presentation)-428.2(within)-429.8(24)-169.7(h)-423.1(after)]TJ T* [(injury,)-238.3(and)-234.9(an)-235.4(indication)-237.3(for)-237.7(computed)-236.1(tomography)-235.3(\(CT\))-235.4(scanning.)]TJ 0 -1.1065 TD [(The)-361.2(exclusion)-351.1(criterion)-359.1(was)-359.5(any)-355(severe)-355.9(pre-existing)-358.9(neurological)]TJ 0 -1.1128 TD [(disorder)-204.9(that)-204.5(could)-200(confound)-203.5(outcome)-198.7(assessments.)]TJ 6.7246 0 0 5.9768 242.192 71.2063 Tm (21)Tj 8.9663 0 0 8.9663 250.7527 67.2378 Tm [(The)-203.1(core)-201.5(data)]TJ -21.3019 -1.1128 TD [(set)-297(included)-293.5(three)-287.2(strata)-298.3(that)-293(were)-293.3(differentiated)-292.3(according)-294(to)-293.9(care)]TJ 28.0042 74.5598 TD [(path:)-235.6(patients)-241.8(seen)-238(in)-237(the)-238.9(emergency)-239(room)-231.8(\(ER\);)-238.9(patients)-241.8(primarily)]TJ 0 -1.1128 TD [(admitted)-370.6(to)-369.8(the)-371.7(intensive)-367.8(care)-374.6(unit)-372.8(\(ICU\),)-370.4(and)-367.7(patients)-374.6(primarily)]TJ T* [(admitted)-282.1(to)-281.3(the)-276.9(hospital)-283.6(ward)-278.3(\(non-ICU\).)]TJ 1.1128 -1.1065 TD [(For)-227.3(this)-234.9(study,)-233.3(2862)-232(\()]TJ /F5 1 Tf 8.5106 0 TD ()Tj /F4 1 Tf .784 0 TD [(16)-233(years)-233.8(of)-235.6(age\))-233.1(adults)-236.3(with)-230.7(mild)-237.2(TBI,)-236.2(as)]TJ -10.4075 -1.1128 TD [(dened)-335.6(by)-340.5(a)-337(baseline)-341.4(GCS)-340.3(of)-336.7(1315,)-335.6(were)-337.6(included;)-341.3(2374)-339.5(of)-336.7(the)]TJ T* [(records)-349.3(had)-342.4(information)-346.6(on)-346.8(6-month)-348.2(GOSE,)-347.4(and)-342.4(1605)-345.8(had)-348.7(infor-)]TJ 0 -1.1065 TD [(mation)-282.9(on)-289.9(some)-283.4(or)-286.2(all)-287.2(6-month)-285(Rivermead)-289.6(Postconcussion)-292.7(Symp-)]TJ 0 -1.1128 TD [(toms)-278.7(Questionnaire)-285.6(\(RPQ\))]TJ 6.7246 0 0 5.9768 407.1117 660.0187 Tm (22)Tj 8.9663 0 0 8.9663 416.3526 656.0502 Tm [(items,)-281.2(measuring)-283.7(PPCS.)]TJ /F9 1 Tf -11.7669 -2.5481 TD (Measurements)Tj /F1 1 Tf 1.1128 -1.8336 TD (Predictors.)Tj /F4 1 Tf 5.7665 0 TD [(Sociodemographic,)-302.1(pre-injury)-304.2(and)-304.5(injury)-298.6(charac-)]TJ -6.8793 -1.1128 TD [(teristics)-426.2(were)-426.1(based)-420.9(on)-422.7(information)-422.5(in)-426.7(hospital)-422.8(charts.)-423.6(Imaging,)]TJ 0 -1.1065 TD [(blood)-374.6(sampling,)-380.9(and)-374(neurological)-382.8(assessment)-381.4(were)-381.8(performed)-378.5(in)]TJ 0 -1.1128 TD [(the)-460.2(ER.)-455.4(Post-concussive)-468(and)-456.2(psychological)-463.1(symptoms)-458.5(were)-464(as-)]TJ T* [(sessed)-429.1(at)-429.1(23)-428.5(weeks)-430.5(post-injury)-430.4(\(range)-430.8(1027)-427.5(days\))-433.7(in)-426.7(patients)]TJ T* [(admitted)-294.7(to)-287.6(the)-295.8(ER,)-291(and)-291.8(in)-293.9(some)-296(centers)-296.2(\(participating)-291.3(in)-293.9(an)-292.3(addi-)]TJ 0 -1.1065 TD [(tional)-353(imaging)-352(sub-study\),)-351.1(also)-353.4(in)-357.1(patients)-355.6(admitted)-351.6(to)-350.8(a)-356(hospital)]TJ 0 -1.1128 TD [(ward)-385.7(other)-392.3(than)-383.9(the)-390.7(ICU.)-385.1(The)-392.8(following)-386.6(instruments)-390.7(were)-388.2(used:)]TJ T* [(RPQ)-441.4(for)-440(post-concussive)-444.1(symptoms,)-436.1(PTSD)-440.9(Checklist)-442.1(for)]TJ /F10 1 Tf 24.3306 0 TD (Diag-)Tj -24.3306 -1.1128 TD [(nostic)-381.8(and)-377.9(Statistical)-382.8(Manual)-376.3(of)-382.4(Mental)-376.4(Disorders,)]TJ /F4 1 Tf 21.5485 0 TD [(Fifth)-379.8(edition)]TJ -21.5485 -1.1065 TD [(\(DSM-)-391.1(5\))-387.3(\(PCL-5\))]TJ 6.7246 0 0 5.9768 380.466 521.1211 Tm (23)Tj 8.9663 0 0 8.9663 390.7274 517.1526 Tm [(to)-388.7(screen)-393.8(for)-389.4(post-traumatic)-393.2(stress)-389(disorder)]TJ -8.909 -1.1128 TD [(\(PTSD\),)-435.4(Patient)-435.7(Health)-436.9(Questionnaire)-437.4(\(PHQ)-435.8(-9\))]TJ 6.7246 0 0 5.9768 491.0739 511.1432 Tm (24)Tj 8.9663 0 0 8.9663 501.7321 507.1747 Tm [(to)-433(screen)-438.1(for)]TJ -21.2892 -1.1128 TD [(depression,)-195.2(and)-197(Generalized)-197.7(Anxiety)-193.7(Disorder)-195.6(\(GAD-7\))]TJ 6.7246 0 0 5.9768 509.7258 501.2219 Tm (25)Tj 8.9663 0 0 8.9663 518.2298 497.1967 Tm [(to)-192.7(screen)]TJ -23.1292 -1.1065 TD [(for)-281.9(anxiety.)]TJ /F1 1 Tf 1.1128 -2.5481 TD (Outcome.)Tj /F4 1 Tf 5.3302 0 TD [(The)-367.5(GOSE)-363.5(is)-364.6(widely)-364.9(used)-368.4(as)-363(a)-362.3(primary)-365.8(outcome)]TJ -6.443 -1.1128 TD [(measure)-289.4(in)-293.9(TBI)-290.2(studies.)]TJ 6.7246 0 0 5.9768 397.3038 458.4188 Tm (26)Tj 8.9663 0 0 8.9663 406.6014 454.4503 Tm [(The)-297.9(GOSE)-287.6(provides)-297.2(eight)-286.2(categories)-294.8(of)]TJ -10.6794 -1.1128 TD [(outcome:)-246.5(dead)-249.5(\(1\),)-246.9(vegetative)-250.8(state)-251.9(\(2\),)-246.9(lower)-250.2(severe)-248.4(disability)-246.5(\(3\),)]TJ 0 -1.1065 TD [(upper)-400.9(severe)-406.5(disability)-404.5(\(4\),)-398.7(lower)-401.9(moderate)-405.5(disability)-404.5(\(5\),)-405(upper)]TJ 0 -1.1128 TD [(moderate)-317(disability)-316(\(6\),)-316.5(lower)-319.7(good)-314.2(recovery)-318.4(\(7\),)-316.5(and)-310.8(upper)-318.7(good)]TJ T* [(recovery)-198.2(\(8\).)-202.7(The)-196.8(highest)-197.9(score)-202.2(\(8\))-199.8(represents)-203.7(a)-197.9(complete)-198.3(return)-204.7(to)-192.7(a)]TJ T* [(pre-injury)-190.4(level)-187.5(of)-191.3(functioning.)]TJ 6.7246 0 0 5.9768 420.5479 408.6424 Tm (27)Tj 8.9663 0 0 8.9663 428.9952 404.6172 Tm [(The)-190.5(GOSE)-186.4(was)-188.8(assessed)-191.5(6)-189.2(months)]TJ -13.1769 -1.1065 TD [(postinjury,)-633(and)-626.9(when)-636.1(outside)-627.9(the)-630.9(time)-631.7(window)-633.7(\(range)-633.1(58)]TJ 0 -1.1128 TD [(months\),)-364.9(it)-373.8(was)-365.8(imputed)-371(based)-370.3(on)-372.1(GOSE)-369.8(measurements)-374(at)-365.9(other)]TJ T* [(time)-214.4(points)-208.6(\()]TJ /F8 1 Tf 4.9951 0 TD (*)Tj /F4 1 Tf 1.214 0 TD [(30%,)-212.2(described)-213(in)-211.7(Steyerberg)-218.8(and)-209.6(coworkers\).)]TJ 6.7246 0 0 5.9768 530.6455 378.7086 Tm (2)Tj 8.9663 0 0 8.9663 535.918 374.7401 Tm (The)Tj -25.102 -1.1128 TD [(RPQ)-352.9(is)-358.3(the)-352.7(most)-354.5(frequently)-361(employed)-356.2(self-reported)-355.7(symptom)-356.6(in-)]TJ 0 -1.1065 TD [(ventory)-454.5(measuring)-454.4(PPCS.)]TJ 6.7246 0 0 5.9768 406.8849 358.8094 Tm (28)Tj 8.9663 0 0 8.9663 417.7133 354.8409 Tm [(The)-449.7(RPQ)-454.1(consists)-452.7(of)-456.9(16)-448(cognitive,)]TJ -11.9187 -1.1128 TD [(somatic,)-567.2(and)-563.7(emotional)-572.5(symptoms)-566(that)-564.9(can)-566.1(be)-564.2(assessed)-570.8(from)]TJ T* [(not)-297.6(experienced)-304.2(at)-302.6(all)-297.8(\(0\))-300.9(to)-300.2(severe)-303.2(problem)-304.2(\(4\),)-297.5(and)-298.1(it)-304.2(was)]TJ T* [(administered)-280(6)-284(months)-277.7(post-injury.)]TJ 1.1128 -1.1065 TD [(The)-279(self-report)-284.7(instruments)-283.2(were)-280.7(administered)-286.3(in)-281.3(18)-283.6(languages.)]TJ -1.1128 -1.1128 TD [(Prior)-365.8(to)-363.4(the)-365.4(data)-367.3(collection,)-369.1(instruments)-365.4(existing)-365.8(only)-368.8(in)-363.4(English)]TJ T* [(were)-350.2(translated)-353.3(and)-348.7(linguistically)-349.8(validated)-350(in)-350.8(the)-346.4(respective)-351.7(lan-)]TJ 0 -1.1065 TD [(guages)-338.2(according)-344.6(to)-338.2(the)-340.1(guidelines)-342(of)-336.7(Acquadro.)]TJ 6.7246 0 0 5.9768 489.5999 289.0771 Tm (29)Tj 8.9663 0 0 8.9663 499.3511 285.1086 Tm [(The)-342.2(linguistic)]TJ -21.0237 -1.1128 TD [(validation)-218.4(procedure)-216.7(consisted)-219.5(of)-216.6(multiple)-220.5(steps,)-217.9(including)-218.7(forward)]TJ T* [(translation,)-414.3(cognitive)-417.2(debrieng,)-413.2(backward)-420.2(translation,)-414.3(harmoni-)]TJ T* [(zation,)-303.7(and)-304.4(nalization)-307.4(of)-305.1(translated)-309.1(versions.)-301.3(A)-306.3(manuscript)-306.2(dedi-)]TJ 0 -1.1065 TD [(cated)-565.2(to)-559.5(the)-561.4(linguistic)-562.6(validations)-566.8(is)-560.6(currently)-563.8(in)-565.8(preparation.)]TJ 0 -1.1128 TD [(Psychometric)-261.9(properties)-261(of)-260.9(the)-257.9(instruments)-264.2(have)-262.1(been)-262.1(investigated)]TJ T* [(using)-306.3(criteria)-311.5(of)-311.5(the)-308.5(classical)-316.9(test)-306.9(and)-310.8(item)-309.2(response)-309.4(theory)-309.6(\(other)]TJ T* [(publications)-281.8(in)-281.3(preparation\).)]TJ 6.7246 0 0 5.9768 413.0645 219.3448 Tm (3032)Tj /F9 1 Tf 8.9663 0 0 8.9663 310.8472 192.5291 Tm [(Selection)-335.1(of)-330.4(prognostic)-333.6(models)]TJ /F4 1 Tf 1.1128 -1.7514 TD [(Eligible)-349.5(prognostic)-350.8(models)-349.7(were)-356.6(selected)-356.4(based)-351.3(on)-346.8(a)-349.7(rapid)-354.4(re-)]TJ -1.1128 -1.1128 TD [(view)-418.8(with)-426.7(pre-dened)-423.5(search)-425.4(strategy)-423.8(and)-424.6(pre-dened)-423.5(inclusion)]TJ T* [(criteria.)-270.1(Prognostic)-267.2(models)-267.5(and)-260.2(predictors)-273.6(of)-260.9(GOSE)-268.6(or)-267.2(PPCS)-264.1(were)]TJ 0 -1.1065 TD [(identied)-308.3(by)-315.2(a)-311.7(search)-311.6(in)-312.9(MEDLINE)]TJ /F5 1 Tf 6.7246 0 0 5.9768 442.0345 150.9165 Tm ()Tj /F4 1 Tf 8.9663 0 0 8.9663 447.3636 146.948 Tm [(,)-312.7(Embase,)-312.9(and)-310.8(the)-308.5(Cochrane)]TJ -15.2256 -1.1128 TD [(Library,)-738.1(which)-734.4(included)-736.1(studies)-736.6(published)-740.7(until)-736.8(May)-735.1(2019)]TJ T* [(\(Table)-387.7(S1\),)-382(and)-386.7(reference)-388.6(lists)-385(of)-381(systematic)-393.4(reviews.)]TJ 6.7246 0 0 5.9768 509.7826 130.9606 Tm (3335)Tj 8.9663 0 0 8.9663 530.0219 126.9921 Tm (Prog-)Tj -24.4444 -1.1128 TD [(nostic)-445(models)-444.5(were)-445.1(included)-438.9(if)-448.3(they)-440.8(were)-445.1(developed)-443.2(to)-445.6(predict)]TJ 0 -1.1065 TD [(GOSE)-319.2(or)-324.1(PPCS)-321(at)-321.6(312)-320.5(months)-322(post-injury)-322.9(in)-319.2(patients)-324(with)-325.5(GCS)]TJ 0 -1.1128 TD [(1315)-256.8(at)-264.7(baseline.)-262.1(Models)-264.6(that)-261.4(were)-261.7(developed)-266.1(in)-262.3(populations)-256.9(that)]TJ T* [(included)-331.4(other)-329.1(TBI)-334.5(severities)-335.6(were)-331.3(also)-334.5(selected)-337.5(if)-328.1(at)-334.3(least)-334.1(a)-330.7(pro-)]TJ 0 -1.1065 TD [(portion)-475.1(of)-475.8(patients)-475.8(had)-475.2(a)-476.1(GCS)-473(between)-479.1(13)-473.2(and)-475.2(15.)-469.8(Moreover,)]TJ 0 -1.1128 TD [(models)-337(had)-336.1(to)-331.8(fulll)-339.1(at)-334.3(least)-340.4(one)-336.1(of)-336.7(the)-333.8(following)-336.1(quality)-339.9(criteria)]TJ T* [(to)-287.6(be)-292.3(considered)-294.7(eligible:)-292.4(\(1\))-288.3(large)-293.5(sample)-295.2(size)-286.3(\()]TJ /F10 1 Tf 19.6073 0 TD (n)Tj /F5 1 Tf .6702 0 TD (>)Tj /F4 1 Tf .7145 0 TD [(500\),)-294.4(\(2\))]TJ /F5 1 Tf 3.8317 0 TD (>)Tj /F4 1 Tf .8409 0 TD (10)Tj /F3 1 Tf -53.6689 77.228 TD [(EXTERNAL)-342.3(VALIDATION)-334.1(OF)-337.5(PROGNOSTIC)-332.4(MODELS)-337.7(FOR)-334(MTBI)-22548.5(197)]TJ ET endstream endobj 61 0 obj <>stream hbd`ab`ddp qvL) 6v1v44 Kf!#wʯMߋWv/8ys~AeQfzFF4 @1%?)U!$5X3/9 ($5EOA1'G!dBBPjqjQP4$37X!X!Q(1%57([!?M'3/ U]!1/E?H!483%3(3X@`ޏKD'>BM8Vu~ew, M>Mg1yqS\|gq endstream endobj 64 0 obj <>stream /GS1 gs BT /F4 1 Tf 8.9663 0 0 8.9663 62.022 725.7825 Tm 0 0 0 rg 0 Tc 0 Tw [(outcome)-224(events)-222.1(for)-218.7(each)-220.3(candidate)-222(predictor)-222.3(considered)-218.8(and)-222.3(\(3\))-218.7(the)]TJ 0 -1.1128 TD [(use)-406.8(of)-406.3(shrinkage)-412.9(and/or)-404.5(some)-409.9(form)-405.1(of)-406.3(internal)-407.6(validation.)]TJ 6.7246 0 0 5.9768 278.2487 719.7731 Tm (36)Tj 8.9663 0 0 8.9663 288.6235 715.8046 Tm (We)Tj -25.2727 -1.1128 TD [(extracted)-275.2(predictors)-267.3(of)-267.2(outcome)-268.2(from)-272.3(eligible)-269.9(models)-267.5(and)-266.5(from)-272.4(all)]TJ 0 -1.1065 TD [(studies)-211.7(that)-217.2(explored)-216.2(prediction)-210.6(of)-216.6(312-month)-207.6(GOSE)-218(and)-209.6(PPCS)-213.5(in)]TJ 0 -1.1128 TD [(persons)-282.2(with)-281.3(mild)-281.5(TBI.)]TJ /F9 1 Tf 0 -2.9022 TD [(Statistical)-336.1(analyses)]TJ /F4 1 Tf 1.1128 -1.7514 TD [(The)-253.7(external)-254.3(validity)-254.9(of)-254.5(the)-251.6(models)-254.8(was)-258.4(assessed)-254.7(with)-256(measures)]TJ -1.1128 -1.1128 TD [(of)-267.2(calibration)-273.5(and)-272.8(discrimination.)-268.6(Calibration)-275.8(is)-263.5(the)-270.5(agreement)-274.7(be-)]TJ 0 -1.1065 TD [(tween)-332.2(predicted)-323.3(and)-329.7(observed)-327.2(outcome)-331.4(values)-323.3(and)-329.7(was)-327.9(measured)]TJ 0 -1.1128 TD [(by)-346.8(the)-340.1(calibration)-349.4(intercept)-346.3(and)-348.7(the)-346.4(calibration)-343(slope,)-349.5(and)-342.4(visual-)]TJ T* [(ized)-531.7(by)-523.8(a)-526.7(calibration)-532.7(plot.)-527.5(The)-525.6(calibration)-526.4(intercept)-529.7(expresses)]TJ T* [(calibration-in-the-large:)-306.7(if)-296.5(the)-302.1(outcomes)-294.2(are)-303.2(systematically)-300.7(under-)]TJ 0 -1.1065 TD [(estimated)-373.7(\(intercept)]TJ /F5 1 Tf 8.4411 0 TD (<)Tj /F4 1 Tf .5564 0 TD [(0\))-368.4(or)-362(overestimated)-376.8(\(intercept)]TJ /F5 1 Tf 12.6205 0 TD (>)Tj /F4 1 Tf .5564 0 TD [(0\),)-365(and)-367.7(the)]TJ -22.1745 -1.1128 TD [(calibration)-381(slope)-384.6(indicates)-382.8(if)-378.7(the)-384.3(strength)-383.4(of)-374.7(the)-384.3(associations)-383.7(be-)]TJ T* [(tween)-306.9(predictors)-311.6(and)-304.5(outcomes)-306.8(is)-307.7(underestimated)-313.1(\(slope)]TJ /F5 1 Tf 23.085 0 TD (>)Tj /F4 1 Tf .5501 0 TD [(1;)-306.5()54.8(un-)]TJ -23.635 -1.1128 TD [(dert)55.9(\))-295.1(or)-298.8(overestimated)-300.9(\(slope)]TJ /F5 1 Tf 13.1517 0 TD (<)Tj /F4 1 Tf .5564 0 TD [(1;)-293.9()54.8(overt)54.3(\).)-291.7(A)-300(calibration)-298.8(plot)]TJ -13.7081 -1.1065 TD [(graphically)-459.2(compares)-459.6(mean)-461.7(observed)-460(with)-458.3(mean)-461.7(predicted)-456.1(out-)]TJ 0 -1.1128 TD [(comes.)-402.1(In)-393.6(a)-400.3(perfect)-398.8(scenario,)-399.8(the)-403.3(calibration)-399.9(intercept)-396.9(and)-399.3(slope)]TJ T* [(would)-257.8(be)-254.4(0)-252.4(and)-253.9(1,)-255.3(respectively,)-262.9(and)-253.9(combinations)-256(of)-254.5(predicted)-260.1(and)]TJ T* [(observed)-232.3(outcomes)-231(would)-232.5(be)-235.4(on)-226.6(the)-232.6(45)-233(degree)-234.6(line.)-232.7(Discrimination)]TJ 0 -1.1065 TD [(refers)-320.7(to)-312.9(the)-314.8(ability)-318.6(to)-312.9(classify)-317.4(patients)-317.7(with)-312.9(a)-318.1(poor)-310.5(versus)-320.6(a)-311.8(good)]TJ 0 -1.1128 TD [(outcome)-205(based)-199.6(on)-201.4(a)-197.9(prognostic)-205.4(model,)-200.1(and)-203.3(was)-201.5(assessed)-204.1(by)-195(the)-201(area)]TJ T* [(under)-356.7(the)-359.1(operator)-357.9(receiver)-356.4(characteristic)-365.3(curve)-359.1(\(AUC\),)-358.4(which)-355.1(is)]TJ 0 -1.1065 TD [(equal)-316.2(to)-319.2(the)-314.8(concordance)-325.5(\(C\))-312(index)-320.1(in)-319.2(logistic)-313(regression)-321.4(models.)]TJ 0 -1.1128 TD [(The)-190.5(AUC)-186.9(or)-185(C-index)-187.4(ranges)-189.1(between)-188.2(0.50)-184.8(\(no)-184.5(discrimination,)-186.4(equal)]TJ T* [(to)-281.3(chance\))-280.7(and)-285.5(1.0)-280.1(\(perfect)-280.7(discrimination\).)]TJ 1.1128 -1.1128 TD [(The)-487.6(C-index)-484.6(obtained)-489.5(in)-483.6(validation)-483.9(studies)-490(is)-484.8(inuenced)-486(by)]TJ -1.1128 -1.1065 TD [(differences)-535.8(in)-527.8(both)-526.9(the)-529.8(regression)-530(coefcients)-533.2(\(slope\))-527.9(and)-525.8(the)]TJ 0 -1.1128 TD [(case-mix)-305.5(heterogeneity.)-299.1(To)-302.3(disentangle)-299.7(their)-301.5(inuence)-296.8(on)-302.5(the)-295.8(dis-)]TJ T* [(criminative)-441.4(ability)-438.7(of)-437.9(logistical)-444.9(regression)-441.5(models,)-434.8(we)-441(used)-437.9(the)]TJ T* [(model-based)-291.4(concordance)-293.9(\(mbc\),)-289.8(which)-291.8(is)-288.8(only)-286.6(inuenced)-290(by)-289.9(dif-)]TJ 0 -1.1065 TD [(ferences)-284(in)-281.3(case-mix)-280.3(heterogeneity.)]TJ 6.7246 0 0 5.9768 190.3181 399.118 Tm (37)Tj 8.9663 0 0 8.9663 72 385.1715 Tm [(All)-528.4(models)-533(were)-533.6(validated)-527.1(using)-533.9(patients)-532.7(with)-527.9(GCS)-529.9(1315)]TJ -1.1128 -1.1128 TD [(with)-445.7(all)-451.6(information)-447.8(on)-441.6(the)-447.6(relevant)-450.3(predictors)-450.7(available)-447.3(in)-445.6(the)]TJ 0 -1.1065 TD [(CENTER-TBI)-295.3(data)-285.1(set)-290.7(\()52.7(complete)-288.9(case)-291(analysis)56.1(\).)-291.7(When)-286.9(predic-)]TJ 0 -1.1128 TD [(tors)-454.8(were)-457.7(not)-451.5(registered)-459.4(in)-458.3(CENTER-)-454(TBI,)-457.5(and)-456.2(therefore)-457.3(were)]TJ T* [(completely)-214(unavailable,)-221.6(their)-213(predictor)-216(effect)-215.9(was)-214.1(set)-214.8(to)-211.7(0,)-211.1(and)-215.9(only)]TJ T* [(discrimination)-310(and)-310.8(calibration)-311.4(slope)-315(were)-312.3(assessed.)-308.2(As)-313.3(a)-311.7(sensitiv-)]TJ 0 -1.1065 TD [(ity)-335.4(analysis,)-336.7(models)-337(were)-337.6(also)-334.5(validated)-337.4(in)-338.2(all)-331.5(patients)-343(with)-331.9(GCS)]TJ 0 -1.1128 TD [(1315,)-417.8(using)-420.1(imputation)-421.8(to)-414(complete)-425.9(missing)-415.2(data)-424.2(in)-414(predictors)]TJ T* [(\()52.7(imputation)-278.5(analysis)49.8()-280.3(i)0(n)-281.3(one)-279.2(complete)-280.5(data)-285.1(set\).)]TJ 1.1128 -1.1128 TD [(All)-484.1(analyses)-484(were)-483(performed)-479.7(in)-483.6(R)-478.4(\(3.5.3,)-483.6(R)-484.8(Foundation)-478.4(for)]TJ -1.1128 -1.1065 TD [(Statistical)-272.4(Computing,)-267.7(Vienna,)-271.4(Austria,)-270(2019\))-265.7(using)-268.3(the)-270.5(rms)-265.1(pack-)]TJ 0 -1.1128 TD [(age)-376.4(for)-376.8(model)-374.3(validation)]TJ 6.7246 0 0 5.9768 153.6377 279.5527 Tm (38)Tj 8.9663 0 0 8.9663 163.7291 275.5842 Tm [(and)-380.3(the)-371.7(mice)-377.2(package)-379.3(for)-376.8(imputation)]TJ -11.3433 -1.1128 TD [(of)-431.6(missing)-434.2(values.)]TJ 6.7246 0 0 5.9768 130.337 269.6314 Tm (39)Tj 8.9663 0 0 8.9663 140.9385 265.6063 Tm [(The)-437(calibration)-431.6(plot)-429.7(was)-435.4(created)-430.2(using)-432.7(val)]TJ -8.8015 -1.1065 TD [(.prob.ci.2)-387.4(function.)]TJ 6.7246 0 0 5.9768 131.8677 259.6535 Tm (40)Tj 8.9663 0 0 8.9663 142.0724 255.685 Tm [(The)-386.5(study)-388.5(was)-384.8(conducted)-392.6(and)-380.3(reported)-389.5(ac-)]TJ -8.9279 -1.1128 TD [(cording)-404(to)-407.7(the)-403.3(criteria)-406.3(of)-400(the)-409.6(Transparent)-404.1(Reporting)-405.4(of)-406.3(a)-400.3(Multi-)]TJ T* [(variable)-380.7(Prediction)-373.6(Model)-377.7(for)-376.8(Individual)-378.9(Prognosis)-376.2(or)-374.7(Diagnosis)]TJ T* [(\(TRIPOD\))-285.5(statement.)]TJ 6.7246 0 0 5.9768 139.6346 229.7763 Tm (41)Tj /F3 1 Tf 8.9663 0 0 8.9663 62.022 199.729 Tm (Results)Tj /F9 1 Tf 0 -1.8336 TD [(Model)-334.3(selection)]TJ /F4 1 Tf 1.1128 -1.8336 TD [(Based)-286.5(on)-283.6(the)-283.2(literature)-289.2(search)-286.3(criteria)-292.5(\(Table)-286.6(S1\),)-280.8(417)-289.4(abstracts)]TJ -1.1128 -1.2203 TD [(were)-280.7(screened.)-278(Based)-280.2(on)-277.2(the)-276.9(full-text)-272.2(screen,)-282.9(43)-277.2(articles)-278.4(described)]TJ T* [(predictors)-349.5(of)-349.4(312-month)-346.7(PPCS)-352.6(\()]TJ /F10 1 Tf 13.7839 0 TD (n)Tj /F5 1 Tf .6702 0 TD (=)Tj /F4 1 Tf .7208 0 TD [(29\),)-345.5(GOSE)-350.8(\()]TJ /F10 1 Tf 5.2164 0 TD (n)Tj /F5 1 Tf .6639 0 TD (=)Tj /F4 1 Tf .7208 0 TD [(11\),)-345.5(or)-349.4(both)]TJ -21.7761 -1.2266 TD (\()Tj /F10 1 Tf .3351 0 TD (n)Tj /F5 1 Tf .6639 0 TD (=)Tj /F4 1 Tf .7208 0 TD [(3\),)-352.3(and)-348.7(5)-353.6(articles)-354.3(presented)-352.1(prognostic)-350.8(models)-356(for)-351.5(prediction)]TJ -1.7198 -1.2203 TD [(of)-222.9(GOSE)-230.7(\()]TJ /F10 1 Tf 4.2237 0 TD (n)Tj /F5 1 Tf .6639 0 TD (=)Tj /F4 1 Tf .7208 0 TD [(9\))-222.9(and)-228.6(PPCS)-226.1(\()]TJ /F10 1 Tf 5.6084 0 TD (n)Tj /F5 1 Tf .6702 0 TD (=)Tj /F4 1 Tf .7145 0 TD [(3\))-229.2(\(Tables)-224(1,)-230.1(S2,)-221.8(and)-228.6(S3\).)-223.9(The)-228.4(most)]TJ -12.6016 -1.2203 TD [(frequent)-522.3(predictors)-526.5(in)-527.8(prognostic)-521.5(models)-520.4(were)-527.3(age,)-524.8(GCS,)-526.5(and)]TJ 0 -1.2266 TD [(extracranial)-497.7(injuries,)-497.8(and)-494.1(alcohol)-496.3(intoxication)-499.6(\(Table)-495.2(1\).)-497.7(Other)]TJ 0 -1.2203 TD [(frequent)-357.9(predictors)-362.2(of)-355.7(outcome)-363.1(were:)-360.1(sex/gender,)]TJ 6.7246 0 0 5.9768 243.6094 94.1102 Tm [(8,20,42)-9.8(46)]TJ 8.9663 0 0 8.9663 277.1149 90.1417 Tm (educa-)Tj -23.9891 -1.2203 TD (tion,)Tj 6.7246 0 0 5.9768 78.2929 83.1685 Tm (6,8,20,4651)Tj 8.9663 0 0 8.9663 117.0708 79.2 Tm [(pre-injury)-380.1(mental)-386.5(health,)]TJ 6.7246 0 0 5.9768 208.6866 83.1685 Tm [(6,8,42,43,4)-10.4(6,47,50,5254)]TJ 8.9663 0 0 8.9663 281.1401 79.2 Tm (cause)Tj -24.4381 -1.2266 TD [(of)-267.2(injury,)]TJ 6.7246 0 0 5.9768 95.6409 72.2267 Tm (6,42,45,47)Tj 8.9663 0 0 8.9663 126.6519 68.2015 Tm [(neuroimaging)-272.4(markers,)]TJ 6.7246 0 0 5.9768 210.2173 72.2267 Tm [(49,51)-9.4(,5557)]TJ 8.9663 0 0 8.9663 246.3306 68.2015 Tm [(and)-272.8(post-injury)]TJ -20.5558 -1.2203 TD (symptoms.)Tj 6.7246 0 0 5.9768 101.1401 61.2283 Tm [(8,20,54)-9.8(,55,5860)]TJ 8.9663 0 0 8.9663 150.8031 57.2598 Tm [(\(Tables)-287.3(1,)-280.6(S4,)-278.7(and)-279.2(S5\).)]TJ 19.209 74.5598 TD [(We)-439.7(v)13.1(a)0(l)26.1(i)15.4(d)19.5(a)0(t)26.2(e)17(d)-454.8()14.5(v)13.1(e)-457.2(m)15.9(o)13.1(d)19.5(e)0(l)26.2(s)-455.9(p)19.5(r)0(e)27.6(d)13.1(i)15.4(c)17(t)15.4(i)15.4(n)13.1(g)-454.8(G)16.2(OS)24.4(E)-454.6(a)17(n)13.1(d)-454.8(t)15.4(h)19.5(re)27.6(e)-457.2(m)15.9(o)13.1(d)19.5(el)26.2(s)]TJ -1.1128 -1.2203 TD -.0148 Tc [(pr)-14.8(e)12.8(d)-1.7(icting)-292.5(P)-.3(PCS)-297.4(\()2.1(Ta)-14.8(b)15.4(l).6(e)-14.8(s)-283(2)-292.5(a)-14.8(n)9.1(d)-292.5(3\).)-295.9(A)1.4(n)-292.5(a)-14.8(d)15.4(d)-1.7(itional)-296.5(t).6(hre)-14.8(e)-284.2(mod)4.7(e)-14.8(l)11.4(s)-293.7(we)-14.8(r)12.8(e)]TJ 0 -1.2266 TD -.016 Tc [(de)-16(e)11.8(m)-.1(e)-16(d)-175.5(unsuita)-16(b)7.9(l)-.6(e)-182.3(f)-16(o)14(r)-188.8(va)-16(l)10.2(i)-.6(dation)-186.2(b)-2.9(ec)-16(a)11.8(u)-2.9(se)]TJ /F5 1 Tf 15.997 0 TD 0 Tc (>)Tj /F4 1 Tf .5374 0 TD [(7)19.5(0)13.1(%)-172.3(o)19.5(f)-172.8(p)19.5(re)27.6(d)13.1(i)15.4(ct)26.1(o)19.5(r)-172.8(v)19.5(a)0(r)27.6(i)15.4(ab)23.9(l)15.4(e)17(s)]TJ -16.5344 -1.2203 TD -.0149 Tc [(w)-14.9(e)12(r)-14.9(e)-227.6(not)-239.7(ava)-14.9(i)11.2(lable)-244.5(\()2(CT)-241.8(and)-242(C)-.2(ombin)4.6(e)-14.9(d)-231.3(N)1.3(ijme)-14.9(g)8.9(en)-242(mod)4.6(e)-14.9(l)]TJ 6.7246 0 0 5.9768 506.8912 696.8691 Tm 0 Tc (7)Tj 8.9663 0 0 8.9663 510.1227 692.9006 Tm .2297 Tc [(\)o)249.2(rb)242.8(e)246.7(c)246.7(a)229.7(u)253.6(s)248(e)]TJ -21.9784 -1.2203 TD -.0146 Tc [(t)-14.6(h)14(e)-642.5(m)1.3(odel)-644.1(e)2.4(quation)-640.1(w)-14.6(a)12.3(s)-641.3(not)-637.8(a)-14.6(v)15.6(a)-14.6(i)11.6(lable)-642.5(\()-14.6(e)13(m)1.3(e)-14.6(r)13(gency)-640.1(d)-1.5(e)-14.6(p)15.6(a)-14.6(r)13(tme)-14.6(n)15.6(t)]TJ 0 -1.2266 TD -.0156 Tc [([)-15.6(E)8.3(D])-283.3(UPFRONT)-280.5(m)-15.6(o)13.5(del)]TJ 6.7246 0 0 5.9768 397.077 674.9856 Tm 0 Tc (8)Tj 8.9663 0 0 8.9663 400.3652 670.9604 Tm -.0169 Tc (\).)Tj /F9 1 Tf -9.7373 -2.4406 TD 0 Tc [(Eligible)-340.5(models)-333.8(predicting)-337.4(GOSE)]TJ /F4 1 Tf 1.1128 -1.8336 TD [(Models)-359.5(for)-351.5(predicting)-356.1(6-month)-354.5(GOSE)-357.1(were)-356.6(the)-352.7(Basic)-353.8(and)-355(CT)]TJ -1.1128 -1.2266 TD [(models)-393.9(from)-386.2(the)-390.7(Corticosteroid)-391.9(Randomisation)-386.7(After)-391.9(Signicant)]TJ 0 -1.2203 TD [(Head)-398.2(Injury)-392(\(CRASH\))-395.8(trial;)]TJ 6.7246 0 0 5.9768 417.3731 614.6644 Tm (56)Tj 8.9663 0 0 8.9663 427.6345 610.6959 Tm [(clinical)-392.5(models)-393.9(for)-389.4(mild)-395.3(TBI)-391.4(and)]TJ -12.7786 -1.2203 TD [(isolated)-292.4(TBI)-283.9(from)-285(the)-283.2(Nijmegen)-287.7(Radboud)-288.3(University)-282.3(Brain)-289.5(Injury)]TJ 0 -1.2266 TD [(Cohort)-432.1(Study)-423.8(\(RUBICS\))-430.9(study;)]TJ 6.7246 0 0 5.9768 430.6393 592.7809 Tm (57)Tj 8.9663 0 0 8.9663 441.1841 588.7557 Tm [(and)-430.9(the)-422.3(ED)]TJ /F5 1 Tf 4.8623 0 TD (+)Tj /F4 1 Tf .9801 0 TD [(model)-424.8(from)-430.4(the)]TJ -20.1322 -1.2203 TD [(UPFRONT)-362.3(study)]TJ 6.7246 0 0 5.9768 376.4409 581.7825 Tm (8)Tj 8.9663 0 0 8.9663 382.9605 577.814 Tm [(\(Table)-362.4(2\).)-352.3(All)-357.6(models)-362.3(predicted)-354.9(dichotomized)]TJ -7.7962 -1.2203 TD [(GOSE,)-246.2(but)-236.5(with)-243.3(differently)-240.6(dened)-247.1(end-points:)-240.5(severe)-242.1(disability)-240.1(or)]TJ T* [(death)-638.7(\(GOSE)]TJ /F5 1 Tf 6.3861 0 TD (<)Tj /F4 1 Tf .5501 0 TD [(5\),)-630.5(disability)-638.5(or)-633.9(death)-632.4(\(GOSE)]TJ /F5 1 Tf 13.9357 0 TD (<)Tj /F4 1 Tf .5501 0 TD [(7\),)-636.8(or)-633.9(com-)]TJ -21.422 -1.2266 TD [(plete/upper)-535(good)-529.2(recovery)-527(\(GOSE)]TJ /F5 1 Tf 14.7197 0 TD (=)Tj /F4 1 Tf .7208 0 TD [(8\),)-529.4(respectively)-531.8(\(Table)-533.1(2\).)]TJ -15.4406 -1.2203 TD [(They)-493.5(contained)-485.1(different)-490.5(predictors,)-485.2(but)-489.4(all)-489.5(models)-482.4(included)-489.5(a)]TJ T* [(measure)-504.3(of)-494.8(injury)-494.6(severity)-499.6(\(GCS,)-503.4(Injury)-493.2(Severity)-497(Score)-503.1([ISS],)]TJ 0 -1.2266 TD [(or)-336.7(major)-332.6(extracranial)-339.6(injury\),)-335.2(and)-336.1(most)-335.6(models)-337(also)-334.5(included)-331.4(age)]TJ 0 -1.2203 TD [(and)-323.4(alcohol)-325.6(intoxication.)-319.2(In)-324.1(addition)-320.4(to)-319.2(admission)-321.8(characteristics,)]TJ T* [(the)-220(UPFRONT)-216.9(model)-216.2(included)-211.3(2-week)-216.5(symptoms)-218.2(\(Table)-217(2\),)-213.2(which)]TJ 0 -1.2267 TD [(were)-236.4(assessed)-229.4(with)-230.7(different)-237.6(instruments)-232.6(than)-225.8(in)-230.7(the)-232.6(CENTER-TBI)]TJ 0 -1.2203 TD [(study)-369.5(\(and)-369.8(therefore)-375.1(rescaled)-374(in)-369.8(validation\).)-368.8(The)-373.8(predictors)-368.5(neck)]TJ T* [(pain)-282.7(at)-277.3(the)-283.2(ER)-281.8(and)-279.2(coping)-275.4(styles)-281.8(from)-278.7(the)-283.2(UPFRONT)-280.1(model)-279.4(were)]TJ T* [(not)-223.9(assessed)-229.4(in)-224.3(the)-220(CENTER-TBI)-232(study.)-220.7(The)-222.1(CRASH)-227.2(models)-223.2(were)]TJ 0 -1.2266 TD [(developed)-424.2(in)-414(an)-418.8(adult)-419(population)-420.6(with)-414.1(GCS)-422.5(314,)-412(which)-418.3(partly)]TJ 0 -1.2203 TD [(includes)-250.4(mild)-249.9(TBI.)-248.9(In)-241.9(our)-247.7(study,)-246(they)-251.1(were)-249.1(validated)-248.9(in)-243.3(adults)-249(with)]TJ T* [(GCS)-232.8(1315)-225.2(and)-234.9(GCS)-226.4(1314.)-228.1(Other)-231.2(models)-229.5(were)-230.1(developed)-234.5(only)-223.4(in)]TJ 0 -1.2266 TD [(the)-365.4(population)-357.4(with)-363.5(GCS)-359.2(1315.)-354.6(The)-361.2(UPFRONT)-362.3(model)-361.6(was)-359.5(de-)]TJ 0 -1.2203 TD [(veloped)-264.7(in)-262.3(patients)-267.1(with)-262.3(loss)-263.7(of)-260.9(consciousness)-268.9(\(LOC\))]TJ /F5 1 Tf 21.6813 0 TD (<)Tj /F4 1 Tf .5501 0 TD [(30)-169.7(min)-259(and)]TJ -22.2314 -1.2203 TD [(post-traumatic)-488(amnesia)-480.5(\(PTA\))]TJ /F5 1 Tf 13.0884 0 TD (<)Tj /F4 1 Tf .5501 0 TD [(24)-163.4(h,)-483(and)-481.5(no)-479.6(major)-478(psychiatric)]TJ -13.6385 -1.2267 TD [(disorders)-325.8(\(Table)-318.2(2\).)-320.7(These)-319.5(inclusion)-321.1(criteria)-324.1(were)-324.9(not)-318.7(used)-317.8(in)-319.2(our)]TJ 0 -1.2203 TD [(validation,)-398.3(but)-394.6(were)-394.5(applicable)-396.2(to)-395.1(the)-390.7(majority)-396.1(of)-393.6(the)-390.7(validation)]TJ T* [(population)-281.5(and)-285.5(therefore)-280.3(were)-280.7(not)-280.8(expected)-288(to)-274.9(impact)-285.4(the)-276.9(results.)]TJ /F9 1 Tf 0 -2.447 TD [(Eligible)-340.5(models)-333.8(predicting)-337.4(PPCS)]TJ /F4 1 Tf 1.1128 -1.8336 TD [(Mo)19.2(de)17.5(ls)-301.4(p)13.1(r)0(e)14.9(d)13.1(ic)19.8(ti)18.2(ng)-302.5(6)13.1(-)0(m)13.8(o)13.1(nt)22.2(h)-315.7(P)14.5(PC)16.6(S)-307.9(w)0(e)14.2(r)0(e)-301.2(d)13.1(ev)17.5(el)19.8(op)20(ed)-304.9(in)-300.2(th)22.2(e)-311.7(T)0(r)17.5(a)0(n)17.5(s)0(-)]TJ -1.1128 -1.2203 TD [(fo)17.3(rm)20.1(in)15.9(g)-359.9(R)0(e)19.1(s)0(e)16.3(a)0(r)21.2(c)0(h)-355.5(a)0(n)17.5(d)-366.2(C)14.7(l)0(i)18.2(n)0(i)15.9(c)0(a)21.4(l)-363.9(Kn)16.6(o)13.1(w)0(l)18.9(e)0(d)17.5(g)13.1(e)-368.7(i)0(n)-350.8(T)0(B)15.4(I)-362.5(\(T)17.5(RA)18.2(CK)18.2(-T)23.9(BI)18.9(\))]TJ 0 -1.2267 TD [(pi)15.9(lo)22.2(t)-313.4(s)0(t)21.1(u)0(d)19.9(y)0(,)-305.9(U)0(P)24.4(F)0(R)16.6(O)0(N)19.7(T)0(,)-305.7(a)0(n)23.9(d)-315.7(Ni)18.9(jm)18.7(eg)23.9(en)-304.9(st)21.1(ud)19.9(ie)19.8(s)-316.8(\()0(T)23.9(a)0(b)17.5(l)0(e)-302.6(3)0(\))17.3(.)-312.7(T)13.3(h)0(e)-304.9(e)0(n)17.5(d)13.1(-)]TJ 0 -1.2203 TD [(po)19.9(in)15.9(t)-313.4(w)0(a)14.2(s)-316.8(d)13.1(i)0(f)19.6(f)0(e)14.9(r)0(e)21.2(n)0(t)22.2(l)0(y)-312.9(d)13.1(e)18.9(ne)17.5(d)-315.7(o)13.1(r)-318.3(m)0(e)20.3(a)0(s)16.3(u)0(r)17.3(e)0(d)-304.9(b)0(y)-308.8(d)13.1(if)19.6(fe)14.9(re)21.2(nt)-306.5(in)15.9(st)21.1(ru)23.7(me)14(n)13.1(t)0(s)]TJ T* [(\(T)17.5(ab)17.5(le)-144.6(3\))17.3(.)-154.7(I)0(n)-147.1(t)0(h)15.9(e)-153.7(TR)15.4(AC)18.3(K-)20.4(TB)21.7(I)-160.2(p)13.1(il)18.2(ot)-148.5(st)21.1(ud)19.9(y,)]TJ 6.7246 0 0 5.9768 456.7747 269.4614 Tm -.0194 Tc (46)Tj 8.9663 0 0 8.9663 464.8251 265.4929 Tm 0 Tc [(P)14.5(P)0(C)16.6(S)-156.2(we)20.5(re)-149.5(as)16.3(se)22.7(ss)17.6(ed)-146.9(wi)18.9(th)]TJ -16.9264 -1.2203 TD [(th)15.9(e)-248.5(R)0(P)16.6(Q)-249.4(an)17.5(d)-252.4(d)13.1(ic)19.8(ho)20(to)15.9(mi)25(ze)15.1(d)-252.4(a)0(c)21.4(c)0(o)17.5(r)0(d)23.7(i)0(n)15.9(g)-252.4(t)15.4(o)-252.4(In)17.3(te)19.8(rn)23.7(at)13.5(io)22.2(n)13.1(a)0(l)-245.7(C)0(l)17.5(a)0(s)22.7(s)0(i)21.1()0(c)18.9(a)0(t)13.5(i)15.4(on)]TJ 0 -1.2266 TD [(of)-185(Di)18.9(se)16.3(as)22.7(es)-186(\(I)21.1(CD)18.2(\))-191.8(c)0(r)14.9(i)0(t)24.5(e)0(r)14.9(i)0(a)-182.5(f)0(o)17.3(r)-191.8(P)14.6(C)0(S)16.6(;)-193.2(th)22.2(at)-182.5(is)14.7(,)-192.6(a)-191.6(sc)16.3(o)13.1(r)0(e)]TJ /F5 1 Tf 19.3734 0 TD ()Tj /F4 1 Tf .5438 0 TD [(2)-195.5(o)13.1(n)-195.5(a)0(t)-182.5(l)0(e)19.8(a)0(s)16.3(t)-186.9(th)15.9(re)21.3(e)]TJ -19.9172 -1.2203 TD [(of)-216.6(th)15.9(e)-223.2(f)0(o)17.3(l)0(l)24.5(o)0(w)16.6(i)0(n)22.3(g)-227.1(sy)18.8(mp)22.7(to)15.9(ms)21.5(:)-224.8(h)0(e)17.5(a)0(d)17.5(a)0(c)21.4(h)0(e)17.5(,)-224.2(d)13.1(i)0(z)13.5(z)0(i)19.8(n)13.1(es)16.3(s,)-212.3(fa)14.9(ti)24.5(gu)20(e,)-219.8(ir)19.6(ri)19.6(ta)19.8(b)13.1(i)0(l)18.2(i)0(t)18.2(y)13.1(,)]TJ T* [(sl)14.7(ee)21.4(p)-239.8(d)13.1(is)14.7(tu)22.3(rb)17.3(an)23.9(ce)15.1(s,)-231.2(p)13.1(o)13.1(o)0(r)-229.3(c)0(o)17.5(n)0(c)17.5(e)0(n)17.5(t)15.4(ra)14.9(ti)18.2(o)13.1(n)0(,)-230.1(f)0(o)23.7(r)0(g)17.3(e)0(t)19.8(f)0(u)17.3(l)0(n)22.3(e)0(s)16.3(s)0(,)-224.9(p)0(o)20(o)0(r)-229.3(m)0(e)20.3(m)0(o)16.4(r)0(y)23.7(,)]TJ 0 -1.2266 TD [(fr)14.7(u)13.1(s)0(t)21.1(r)0(a)14.9(t)0(i)18.2(o)13.1(n,)-249(or)-254.5(d)13.1(e)0(p)17.5(r)0(e)21.2(s)0(s)17.6(i)0(o)15.9(n)13.1(.)-262.2(I)0(n)-248.2(t)0(h)15.9(e)-261.2(UP)18.1(F)14.6(R)0(O)18.2(N)0(T)-255.1(s)0(t)21.1(u)0(d)19.9(y)0(,)-249(d)0(i)15.9(c)0(h)23.8(o)0(t)15.9(o)13.1(mi)18.7(za)15.1(ti)24.5(on)]TJ 0 -1.2203 TD [(of)-311.4(PP)22.8(CS)-312.1(wa)20.5(s)-316.8(d)0(o)19.9(n)0(e)-311.3(i)0(n)-306.5(a)-318.1(si)21.1(mi)18.7(la)19.8(r)-318.3(w)0(a)20.5(y)0(,)-312.3(b)13.1(ut)-306.5(me)14(as)22.7(ur)17.3(ed)-304.9(us)18.7(in)15.9(g)-315.7(t)0(h)22.3(e)-318.1(He)14.2(ad)]TJ T* [(In)17.3(ju)22.3(ry)-235.6(Se)18.9(ve)17.5(ri)19.6(ty)-237(C)14.7(h)0(e)17.5(c)0(k)17.5(l)0(i)18.2(s)0(t)-231.9(\()0(H)20.4(I)0(S)18.8(C)0(\))18.9(.)-243.2(Th)20.1(e)-248.5(N)0(i)18.9(j)0(m)18.7(e)0(g)23.9(e)0(n)-235.4(s)0(t)14.7(u)13.1(dy)-233(de)17.5(n)21.4(ed)-235.4(hi)22.2(gh)]TJ 0 -1.2266 TD [(PP)16.5(CS)-192(as)-198.6(a)-204.3(s)0(c)22.7(o)0(r)17.3(e)]TJ /F5 1 Tf 6.4557 0 TD ()Tj /F4 1 Tf .5438 0 TD [(2)-201.8(o)0(n)-195(1)13.1(3)-208.2(o)13.1(ut)-192.7(of)-197.6(al)19.8(l)-205.9(1)13.1(6)-208.2(R)14.7(PQ)-196.9(it)18.2(em)20.3(s.)-193.3(Th)20.1(e)-204.3(T)0(R)15.4(A)0(C)18.2(K)0(-)20.4(T)13.3(BI)]TJ -6.9995 -1.2203 TD [(Pi)17.3(lo)22.3(t)-376.6(m)0(o)16.4(d)13.1(el)-365.9(on)19.9(ly)-369.8(in)22.3(cl)19.8(ud)19.9(ed)-368.2(ad)17.5(mi)25(ss)17.6(io)15.9(n)-372.6(c)0(h)17.5(a)0(r)21.2(a)0(c)15.1(t)0(e)19.8(r)0(i)19.6(s)0(t)21.1(i)0(c)19.8(s)-380.1(as)-363(pr)17.3(ed)23.9(ic)13.5(t)15.4(o)0(r)17.3(s)0(,)]TJ T* [(wh)16.6(er)21.2(ea)15.1(s)-386.4(t)0(h)22.2(e)-387.6(ot)15.9(h)13.1(e)0(r)-377.1(m)0(o)16.4(d)13.1(el)19.8(s)-386.4(a)0(l)19.8(s)0(o)-379.6(i)0(n)22.2(c)0(l)19.8(u)0(d)19.9(e)0(d)-380.8(s)0(y)18.8(m)0(p)22.7(t)0(o)15.9(m)15.9(s)-392.7(m)15.9(e)0(a)15.1(s)0(u)18.8(r)0(e)21.3(d)]TJ /F8 1 Tf 25.1778 0 TD (*)Tj /F4 1 Tf .9927 0 TD (2)Tj -26.1705 -1.2203 TD [(we)14.2(ek)17.5(s)-455.9(p)13.1(os)18.8(t-)19.6(in)22.2(ju)15.9(ry)-444.2(\(T)17.5(ab)17.5(le)-448.1(3)13.1(\))0(.)-447.6(T)0(h)20.1(e)0(s)16.3(e)-457.2(sy)18.8(m)15.9(p)0(t)15.9(o)13.1(ms)-446.4(we)14.2(re)-446.6(as)16.3(se)22.7(ss)17.6(ed)-444(by)]TJ 0 -1.2266 TD [(di)15.9(ff)21.1(er)21.2(en)17.5(t)-319.7(i)0(n)22.2(s)0(t)14.7(r)0(u)23.7(m)0(e)20.3(n)0(t)15.9(s)-316.8(\(T)17.5(ab)23.9(le)-309(S6)15(\).)-302.2(In)-311.5(ad)17.5(d)13.1(i)0(t)18.2(i)0(o)22.3(n)0(,)-312.3(t)15.4(he)17.5(re)-307.5(we)14.2(re)-307.5(so)18.8(me)-308.5(d)13.1(i)0(f)19.6(-)]TJ 0 -1.2203 TD [(fe)14.9(re)21.2(nc)17.5(es)-141.7(b)13.1(e)0(t)13.5(w)0(e)20.5(e)0(n)-140.5(d)13.1(ev)17.5(el)19.8(op)19.9(me)20.3(nt)-142.1(an)17.5(d)-151.3(v)13.1(al)19.8(id)15.9(at)19.8(io)22.3(n)-151.3(s)0(t)21.1(u)0(d)20(i)0(e)19.8(s)-152.5(in)-142.2(th)22.3(e)-153.7(d)13.1(e)18.9(ni)15.9(ti)24.5(on)]TJ T* [(an)17.5(d)-163.9(m)0(e)20.3(a)0(s)16.3(u)13.1(re)14.9(me)20.3(n)13.1(t)-161.6(of)-153.4(pr)17.3(e-)21.3(in)15.9(j)15.4(u)0(r)17.3(y)-163.9(me)20.3(n)13.1(t)0(a)13.5(l)-161.6(an)23.9(d)-163.9(p)0(h)19.9(y)0(s)18.8(i)0(c)19.8(a)0(l)-150.9(h)0(e)17.5(a)0(l)19.8(t)0(h)15.9(,)-161(h)13.1(e)0(a)15.1(d)13.1(ac)15.1(h)13.1(e)0(,)]TJ 0 -1.2266 TD [(an)17.5(d)-309.3(n)0(a)17.5(u)13.1(se)16.3(a)-311.8(\()0(T)17.5(a)0(b)23.9(l)0(e)-302.6(S)0(6)21.4(\))0(.)-302.2(T)0(h)20.1(e)-311.8(TR)21.7(AC)18.2(K-)20.4(TB)15.4(I)-311.9(P)14.6(il)18.2(ot)-300.2(st)21.1(ud)19.9(y)-309.3(e)0(x)17.5(c)0(l)19.8(u)0(d)19.9(e)0(d)-304.9(p)13.1(a-)]TJ 0 -1.2203 TD [(ti)18.2(en)17.5(ts)-339.3(wi)18.9(th)-338.2(ma)14(jo)22.2(r)-349.9(p)0(s)18.8(y)13.1(ch)17.5(ia)19.8(tr)19.6(ic)13.5(,)-344.4(n)0(e)17.5(u)0(r)17.3(o)13.1(lo)15.9(g)13.1(i)0(c)19.8(a)0(l)19.8(,)-350.7(or)-343.1(li)18.2(fe)21.3(-t)19.6(h)13.1(r)0(e)14.9(a)0(t)19.8(e)0(n)17.5(i)0(n)22.2(g)-353.6(d)13.1(i)0(s)21.1(-)]TJ T* [(ea)15.1(se)16.3(s;)-181.3(UP)24.4(FR)16.6(ON)19.7(T)-189(i)0(n)15.9(c)0(l)19.8(u)13.1(de)17.5(d)-189.2(p)0(a)17.5(t)0(i)18.2(e)0(n)17.5(t)15.4(s)-196.7(w)0(h)23(o)-189.2(su)18.8(st)21.1(ai)13.5(n)13.1(e)0(d)-184.8(L)13.3(OC)-184.1(o)13.1(r)-191.8(PT)21.5(A,)-182.8(an)17.5(d)]TJ 0 -1.2266 TD [(wi)18.9(th)15.9(o)13.1(u)0(t)-154.8(s)0(u)18.8(b)13.1(st)14.7(an)23.9(ce)-155.6(ad)17.5(di)22.2(ct)13.5(i)15.4(o)0(n)19.9(;)-167.9(an)23.9(d)-163.9(N)0(i)18.9(j)0(m)18.7(e)0(g)17.5(e)0(n)-153.2(i)0(n)22.2(c)0(l)13.5(u)13.1(de)17.5(d)-163.9(p)13.1(at)19.8(ie)19.8(nt)15.9(s)-165.1(a)0(g)23.8(e)-166.3(1)13.1(8)0()]TJ 0 -1.2203 TD [(60)-283.6(an)17.5(d)-296.7(L)13.3(OC)]TJ /F5 1 Tf 5.2796 0 TD (<)Tj /F4 1 Tf .5438 0 TD [(3)13.1(0)-157.6(mi)18.7(n)-296.7(\()0(T)23.9(a)0(b)17.5(l)0(e)-283.7(3)0(\))17.3(.)-293.8(T)13.3(h)0(e)-286(v)13.1(al)13.5(id)22.3(at)19.8(io)15.9(n)-290.4(p)0(o)19.9(p)13.1(ul)15.9(at)19.8(io)22.2(n)-296.7(w)0(a)20.5(s)-297.9(n)13.1(o)13.1(t)]TJ /F3 1 Tf -33.8213 77.2217 TD (198)Tj 46.8781 0 TD (MIKOLIC)Tj 3.7052 .2213 TD ()Tj .8536 -.2213 TD [(ET)-338.7(AL.)]TJ ET endstream endobj 68 0 obj <>stream /GS1 gs BT /F4 1 Tf 8.9663 0 0 8.9663 59.7543 199.729 Tm 0 0 0 rg 0 Tc 0 Tw [(re)14.9(st)21.1(ri)19.6(ct)19.8(ed)-368.2(ba)17.5(se)16.3(d)-378.9(o)13.1(n)-378.9(a)0(g)17.5(e)0(,)-371.6(p)13.1(sy)18.8(ch)17.5(ia)19.8(tr)19.6(ic)-372.2(d)13.1(i)0(s)21.1(o)0(r)17.3(d)0(e)17.5(r)0(,)-365.4(L)0(O)16.8(C)0(,)-367.6(o)0(r)-374.7(P)14.6(TA)16.8(.)-376(S)0(u)15(b)13.1(-)]TJ 0 -1.2203 TD [(st)14.7(an)23.9(ce)-320(ad)23.9(di)15.9(ct)19.8(io)22.2(n)-328.3(a)0(n)23.9(d)-328.3(L)13.3(O)0(C)]TJ /F5 1 Tf 10.8248 0 TD (>)Tj /F4 1 Tf .5438 0 TD [(3)13.1(0)-157.6(mi)18.7(n)-322(w)0(e)20.5(r)0(e)-313.9(r)0(e)14.9(p)13.1(or)17.3(te)19.8(d)-322(f)0(o)17.3(r)-324.6(o)13.1(n)0(l)15.9(y)-322(a)-324.4(s)0(m)21.5(a)0(l)19.8(l)]TJ -11.3686 -1.2203 TD [(nu)19.9(mb)16.4(er)-282.3(o)13.1(f)-293(p)13.1(a)0(t)19.8(i)0(e)19.8(n)0(t)15.9(s)-291.6(i)15.4(n)-290.4(th)15.9(e)-286.5(v)0(a)17.5(l)0(i)18.2(d)13.1(at)13.5(i)15.4(o)0(n)-283.6(p)13.1(op)19.9(ul)15.9(at)19.8(io)22.2(n.)-280.6(As)-281.7(se)22.7(ns)18.8(it)18.2(iv)22.2(it)18.2(y)-290.4(a)0(n)17.5(a)0(-)]TJ 0 -1.2266 TD [(ly)15.9(se)22.7(s,)-345.1(th)15.9(e)-356(v)13.1(al)19.8(id)15.9(at)19.8(io)22.2(n)-353.6(p)0(o)19.9(p)0(u)19.9(l)0(a)13.5(t)15.4(io)15.9(n)-353.6(f)0(o)17.3(r)-349.9(th)15.9(e)-356(U)0(P)18.1(F)14.6(RO)18.2(NT)-349.9(mo)22.7(de)17.5(l)-351.3(w)0(a)14.2(s)-354.8(re)21.2(-)]TJ 0 -1.2203 TD [(st)14.7(ri)19.6(ct)19.8(ed)-210.1(to)-211.7(su)18.8(st)21.1(ai)19.8(ne)17.5(d)-220.8(L)0(O)16.8(C)-219.2(an)17.5(d/)15.9(o)13.1(r)-223.4(PT)21.5(A,)-214.4(an)23.9(d)-227.1(t)0(h)22.2(e)-223.2(v)13.1(a)0(l)19.8(i)0(d)15.9(a)0(t)19.8(i)0(o)22.2(n)-227.1(p)13.1(o)13.1(p)0(u)19.9(l)0(a)13.5(t)15.4(io)15.9(n)]TJ T* [(fo)17.3(r)-153.9(t)0(h)22.3(e)-160(Ni)18.9(j)15.4(m)0(e)14(g)13.1(en)-146.9(mo)22.7(de)17.5(l)-155.3(w)0(a)20.6(s)-152.4(re)14.9(st)21.1(ri)19.6(ct)19.8(ed)-146.9(to)-142.1(ag)17.5(e)-153.7(g)0(r)17.3(o)13.1(up)-144.4(18)19.9(6)19.9(0)-157.6(\()0(T)23.9(a)0(b)17.5(l)0(e)-144.6(S)0(9)21.4(\))0(.)]TJ /F9 1 Tf 0 -3.0603 TD [(CENTER-TBI)-341.6(data)]TJ /F4 1 Tf 1.1128 -1.8336 TD [(In)-267.2(total,)-261.5(2862)-263.6(adults)-261.6(with)-268.6(mild)-262.5(TBI)-264.9(were)-261.7(included)-268.2(in)-262.3(CENTER-)]TJ -1.1128 -1.2203 TD [(TBI.)-299.4(The)-297.9(majority)-301.2(were)-299.6(male)-295(\(64%\))-302.1(and)-291.8(approximately)-303.6(half)-297.9(were)]TJ T* [(admitted)-256.8(to)-249.6(a)-248.5(non-ICU)-256.4(hospital)-252(ward)-246.6(\(47%\).)-254.4(The)-253.7(mean)-246.7(age)-256.3(was)-252(53)]TJ 0 -1.2266 TD [(years)-429.8(\(interquartile)-426.7(range)-422.3([IQR])-424.4(3368\),)-426.2(and)-418.3(the)-428.6(mean)-423.7(years)-423.5(of)]TJ 0 -1.2203 TD [(education)-187.9(was)-188.8(13)-182.4(\(1116\).)-181.8(The)-184.1(majority)-187.4(of)-185(patients)-184.9(had)-184.3(a)-185.3(GCS)-182.2(of)-185(15)]TJ 28.0042 15.8895 TD [(\(71%\).)-286(More)-282(than)-289(a)-286.5(quarter)-282.5(had)-285.5(a)-286.5(major)-288.3(extracranial)-289.1(injury)-285.9(\(27%\))]TJ 0 -1.2203 TD [(and)-279.2(almost)-284.1(half)-279(had)-279.2(CT)-281.8(abnormalities)-283.6(\(45%\))-283.1(\(Table)-280.2(S7\).)]TJ 1.1128 -1.2203 TD [(Subsamples)-293(without)-290.2(available)-301.9(6-month)-291.3(outcomes)-294.2(did)-293.4(not)-293.4(differ)]TJ -1.1128 -1.2266 TD [(from)-285(the)-289.5(overall)-296.6(cohort)-284.3(in)-293.9(the)-289.5(majority)-288.6(of)-286.2(baseline)-297.1(characteristics,)]TJ 0 -1.2203 TD [(but)-363(patients)-361.9(with)-363.5(completed)-362.2(6-month)-360.8(RPQ)-359.2(were)-369.2(somewhat)-360.7(more)]TJ T* [(educated,)-430(and)-430.9(had)-430.9(more)-430.2(CT)-427.2(abnormalities)-435.3(at)-429.1(baseline,)-426.5(a)-431.9(higher)]TJ T* [(proportion)-362.4(of)-368.4(PTA)-367(and)-361.4(LOC,)-369.7(and)-361.4(a)-368.7(slightly)-367.4(lower)-364(percentage)-367.9(of)]TJ 0 -1.2266 TD [(psychiatric)-283.3(disorders)-281.5(\(Table)-280.2(S7\).)]TJ 1.1128 -1.2203 TD [(Sample)-317.9(with)-325.5(both)-318.2(23)-321(week)-322.3(symptoms)-325.7(and)-323.4(6-month)-316.6(outcomes)]TJ -1.1128 -1.2203 TD [(available)-308.2(differed)-303.6(from)-310.3(the)-302.2(total)-309.2(cohort:)-306.8(patients)-305(were)-306(mostly)-307(dis-)]TJ 0 -1.2266 TD [(charged)-322.6(after)-321.4(ER)-326(and)-323.4(had)-317.1(a)-324.4(median)-325.6(age)-319.5(of)-324.1(51)-321.5(years)-322.3(\(3563\),)-320.9(and)]TJ 0 -1.2203 TD [(there)-274.6(was)-277.3(a)-280.1(higher)-271.7(proportion)-280.3(of)-273.5(females,)-277.3(more)-278.5(patients)-279.7(with)-274.9(GCS)]TJ T* [(15,)-387.6(and)-393(a)-387.6(smaller)-389.8(proportion)-394.1(of)-387.3(patients)-393.6(with)-388.8(major)-389.5(extracranial)]TJ 0 -1.2267 TD [(injuries)-279.9(and)-279.2(with)-281.3(CT)-281.8(abnormalities)-283.6(\(Table)-286.6(S7\).)]TJ ET 59.754 710.135 490.167 .22681 re f 59.754 290.324 490.167 .22681 re f 185.896 690.746 205.172 .28351 re f 401.953 690.746 147.968 .28351 re f 185.896 675.383 43.71 .22675 re f 240.491 675.383 98.986 .22675 re f 350.362 675.383 40.706 .22675 re f 59.754 647.603 490.167 .28345 re f BT /F7 1 Tf 8.9663 0 0 8.9663 66.3307 725.7825 Tm (Table)Tj /F4 1 Tf 2.9971 0 TD (1.)Tj /F7 1 Tf 1.2519 0 TD [(Predictors)-331.2(of)-335.1(Glasgow)-335.5(Outcome)-331.8(Scale)-336.2(Extended)-332.9(\(GOSE\))-336.1(and)-330.6(Persistent)-335(Post-Concussive)-336.7(Symptoms)-333.7(\(PPCS\))]TJ 9.9206 -1.1128 TD [(from)-332.6(the)-333.5(Models)-331.2(Validated)-338.7(in)-331.6(the)-333.5(CENTER-TBI)-339.5(Data)]TJ /F10 1 Tf -14.9031 -6.8793 TD (Predictor)Tj 24.2357 4.5462 TD [(GOSE)-18435.8(PPCS)]TJ /F4 1 Tf -9.3895 -1.7135 TD [(CRASH)-3439.2(Nijmegen,)-334.9(RUBICS)-2665(UPFRONT)]TJ 23.3189 -.0506 TD (TRACK-TBI)Tj 1.7198 -1.1128 TD (Pilot)Tj 4.8244 1.1128 TD [(UPFRONT)-1215.9(Nijmegen,)]TJ 6.0573 -1.1128 TD (RUBICS)Tj -36.6982 -1.6693 TD [(Basic)-1289.5(CT)]TJ 6.089 1.1128 TD (Clinical)Tj 1.0875 -1.1128 TD (all)Tj 3.3132 1.1128 TD (Clinical-isolated)Tj 2.5102 -1.1128 TD [(TBI)-5057.7(ED)]TJ /F5 1 Tf 8.0048 0 TD (+)Tj /F10 1 Tf -35.0732 -2.0929 TD [(Pre-injury)-341.6(and)-333.6(sociodemographic)-335.6(characteristics)]TJ /F4 1 Tf 1.0053 -1.1128 TD [(Age)-11790.2(XX)-1611.6(XX)-2085.9(XX)-4690.9(XX)-5373.8(X)-5427.9(X)0(X)-4709.9(X)-4871.5(X)]TJ 0 -1.1065 TD [(Sex)-328.3(or)-336.7(gender)-7731.1(X)-2329.6(X)-2803.9(X)-5408.9(X)-6091.8(X)-5427.9(X)0(X)-4709.9(X)0(X)-4153.5(X)]TJ 0 -1.1128 TD [(Education)-28891.4(XX)-4709.9(XX)-4709.9(X)-4871.5(X)]TJ T* [(Country)-330.4(income)-6888.8(XX)-1611.6(XX)]TJ 0 -1.1065 TD [(Mental)-333.1(health)-27331.2(XX)-4709.9(XX)-10299.3(X)]TJ 0 -1.1128 TD [(Physical)-331.2(health)]TJ 45.2531 0 TD 4.8715 Tc [(XX)4871.5(X)]TJ -45.2531 -1.1128 TD 0 Tc [(Previous)-333.7(TBI)-27516.7(X)-5427.9(X)0(X)-4709.9(X)-4871.5(X)]TJ T* [(Headache/migraine)-31303.2(XX)-4709.9(X)]TJ 0 -1.1065 TD (Seizures)Tj 39.1072 0 TD (X)Tj /F10 1 Tf -40.1125 -1.1128 TD [(Injury)-336.1(and)-333.6(peri-injury)-339(characteristics)]TJ /F4 1 Tf 1.0053 -1.1128 TD [(GCS)-11519.2(XX)-1611.6(XX)-2085.9(X)-5408.9(X)-6091.8(XX)-4709.9(X)-11017.3(X)]TJ T* [(Abnormal)-334.4(pupillary)-335.2(response)-1605.6(XX)-1611.6(XX)-2085.9(X)-5408.9(X)]TJ 0 -1.1065 TD [(Injury)-328.8(severity)-14074.9(XX)-4690.9(XX)]TJ 0 -1.1128 TD [(Hypotension)-14912.7(X)-5408.9(X)]TJ T* [(Hypoxia)-16578.7(X)-5408.9(X)]TJ T* [(CT)-332.3(abnormalities)]TJ 6.7246 0 0 5.9768 132.2645 479.9621 Tm (a)Tj 8.9663 0 0 8.9663 216.7369 475.9369 Tm [(XX)-2085.9(X)-5408.9(X)-6091.8(X)-5427.9(X)-11017.3(X)]TJ -16.5028 -1.1065 TD [(Cause)-330.8(of)-336.7(injury)-7114.7(X)-2329.6(X)]TJ 0 -1.1128 TD [(Extracranial)-337(injury)-5812.1(XX)-1611.6(XX)-2085.9(XX)-17646.6(X)-5427.9(X)-4871.5(X)]TJ T* [(Facial)-333.4(fractures)-19857.2(X)]TJ 0 -1.1065 TD [(PTA)-18140.7(X)-5408.9(X)-6091.8(XX)-4709.9(XX)-4709.9(X)-4871.5(X)]TJ 0 -1.1128 TD [(LOC)-18026.7(X)-5408.9(X)-12237.6(XX)-4709.9(X)-4871.5(X)]TJ T* [(Time)-330.3(from)-335.6(injury)-6324.3(X)-2329.6(X)]TJ T* [(Alcohol)-332.8(intoxication)-11665.9(XX)-4690.9(XX)-5373.8(XX)-4709.9(X)]TJ 0 -1.1065 TD [(Anticoagulants)-13956.7(X)-5408.9(X)]TJ 0 -1.1128 TD [(Neck)-335(pain)-28786.4(XX)-10855.8(XX)]TJ T* [(Early)-328.9(symptoms)]TJ 6.7246 0 0 5.9768 128.1259 380.296 Tm (b)Tj 8.9663 0 0 8.9663 364.3085 376.3275 Tm 11.5737 Tc [(XX)11573.7(X)]TJ /F10 1 Tf -33.9667 -1.1128 TD 0 Tc [(Post-injury)-336.4(symptoms)-340.3(at)-331.8(2)-334.6(weeks)]TJ /F4 1 Tf 1.0053 -1.1065 TD [(Depression)-28465.4(XX)]TJ 0 -1.1128 TD [(Anxiety)-29734.3(XX)]TJ T* [(Post-concussive)-335.2(symptoms)-22070.2(XX)-10855.8(XX)-4153.5(XX)]TJ 0 -1.1065 TD [(Post-traumatic)-334.8(stress)-24561.5(X)-11573.7(X)0(X)-4153.5(X)0(X)]TJ 0 -1.1128 TD [(Coping)-328.3(styles)-27407.1(XX)]TJ T* (Fatigue)Tj 50.8425 0 TD (X)Tj -50.8425 -1.1128 TD (Self-efcacy)Tj 50.8425 0 TD (X)Tj 5.9774 0 0 5.3127 67.748 282.0472 Tm (a)Tj 7.9702 0 0 7.9702 70.4126 278.5322 Tm [(Hemorrhagic)-254.2(contusion,)-251.9(petechial)-259.9(hemorrhage,)-254.2(ventricle)-260.1(and)-260.2(cisterns)-255.7(obliteration,)-253.7(subarachnoid)-251(hemorrhage,)-254.2(mid-line)-259.3(shift,)-260.4(non-ev)13(acuated)-260(hem)]TJ 57.7155 0 TD (atoma)Tj 5.9774 0 0 5.3127 67.748 273.0897 Tm (b)Tj 7.9702 0 0 7.9702 70.7527 269.518 Tm [(Headache)12.3(,)-333.3(nausea,)-331.6(dizziness)]TJ -.377 -1.1239 TD [(XX,)-376.8(nal)-375.3(model;)-368.2(X,)-376.4(candidate)-375.2(predictor;)-372(CENTER-)14(TBI,)-377.7(Collaborat)10.8(ive)-379.6(European)-370(NeuroTrauma)-369.3(Effective)12.6(ness)-381.4(Research)-368.3(in)-378.4(Traumatic)-371.6(Brain)-376.4(Injury;)]TJ -1.003 -1.1239 TD [(CRASH,)-356.5(Corticostero)10.3(id)-364.2(Randomis)12.6(ation)-359.7(After)-356.3(Signicant)-353.7(Head)-356.3(Injury;)-359.1(CT,)-355(computed)-354.6(tomography;)-347(ED,)-359.9(emergency)-356.7(departmen)10.8(t;)-362.7(GCS,)-360.5(Glasgow)-349(Coma)]TJ T* [(Score;)-263.9(LOC,)-262.9(loss)-270(of)-262.4(consciousness;)-259.7(PTA,)-263.1(post-traumat)11.5(ic)-267.8(amnesia;)-265(RUBIC)11.7(S,)-272.1(Radboud)-256.6(University)-262.4(Brain)-262.6(Injury)-263.1(Cohort)-257.3(Study;)-259.7(TBI,)-271(traumat)11.3(ic)-267.8(brain)-265(injury)]TJ 61.2277 0 TD (;)Tj -61.2277 -1.1239 TD [(TRACK-TBI,)-325.9(Transformi)11.5(ng)-330.2(Research)-332.7(and)-324.2(Clinical)-329.9(Knowledge)-325.5(in)-328.6(TBI;)-332.4(UPFRO)12.2(NT.)]TJ /F3 1 Tf 8.9663 0 0 8.9663 59.7543 749.7069 Tm [(EXTERNAL)-342.3(VALIDATION)-334.1(OF)-337.5(PROGNOSTIC)-332.4(MODELS)-337.7(FOR)-334(MTBI)-22548.5(199)]TJ ET endstream endobj 72 0 obj <>stream /GS1 gs BT /F4 1 Tf 8.9663 0 0 8.9663 72 309.3731 Tm 0 0 0 rg 0 Tc 0 Tw [(More)-256.7(than)-251.1(70%)-253.6(of)-254.5(persons)-256.9(achieved)-262.7(good)-251(recovery)-255.1(\(GOSE)]TJ /F5 1 Tf 23.9196 0 TD ()Tj /F4 1 Tf .5501 0 TD (7\),)Tj -25.5825 -1.2203 TD [(with)-268.6(49%)-272.5(of)-273.5(persons)-269.5(completely)-270.9(returning)-276.8(to)-268.6(their)-269.9(pre-injury)-272.6(level)]TJ 0 -1.2266 TD [(of)-273.5(functioning)-271(\(GOSE)]TJ /F5 1 Tf 9.105 0 TD (=)Tj /F4 1 Tf .7208 0 TD [(8\).)-270.1(Nevertheless,)-276(11%)-272.5(experienced)-272.6(severe)]TJ -9.8258 -1.2203 TD [(disability)-360.3(or)-355.7(had)-355(died)-352.2(\(GOSE)]TJ /F5 1 Tf 12.4625 0 TD (<)Tj /F4 1 Tf .5501 0 TD [(5\))-355.7(at)-359.5(6)-353.6(months,)-356.5(43%)-354.7(had)-355(mild)-357.4(to)]TJ -13.0126 -1.2203 TD [(severe)-280(PPCS)-283(\(ICD)-276.8(classication)-285.9(for)-275.6(PCS\),)-277.3(and)-279.2(22%)-278.9(had)-279.2(moderate)]TJ 0 -1.2266 TD [(to)-224.3(severe)-229.4(PPCS)-219.8(\(ICD)-226.3(classication)-229(for)-225(PCS\).)-226.8(Distributions)-224.4(of)-222.9(some)]TJ 0 -1.2203 TD [(predictors)-343.2(and)-342.4(outcomes)-338.5(differed)-341.6(in)-344.5(the)-340.1(CENTER-TBI)-345.8(compared)]TJ T* [(with)-445.7(the)-447.6(development)-449.7(studies,)-448.6(particularly)-446.3(for)-446.3(models)-450.8(from)-443.1(the)]TJ T* [(CRASH)-284.1(trial)-280.2(\(Table)-280.2(S6\).)]TJ /F9 1 Tf 0 -3.0666 TD [(Model)-334.3(performance)-332.6(in)-336.5(CENTER-TBI)-335.3(study)]TJ /F1 1 Tf 1.1128 -1.8336 TD [(Models)-637.3(predicting)-640.9(GOSE.)]TJ /F4 1 Tf 12.9683 0 TD [(The)-588.8(CRASH)-587.6(models)-583.6(showed)]TJ -14.0811 -1.2203 TD [(poor)-354.7(calibration)-355.7(and)-355(good)-352.1(discrimination)-354.2(for)-357.8(the)-352.7(outcome)-356.7(GOSE)]TJ /F5 1 Tf T* (<)Tj /F4 1 Tf .5501 0 TD [(5,)-356.5(which)-361.4(was)-353.2(observed)-358.8(in)-357.1(only)-356.1(11)-353.1(%)-355.7(o)0(f)-355.7(patients.)-358.5(Percentage)-360.2(of)]TJ -.5501 -1.2203 TD [(death/unfavorable)-267.7(outcome)-268.2(was)-264.7(overestimated)-269.3(\(Basic)-267.3(model:)-270.3(20%)]TJ 0 -1.2266 TD [(vs.)-249.7(11%,)-243.8(calibration)-248.2(intercept)]TJ /F5 1 Tf 11.944 0 TD (=)Tj /F4 1 Tf .7208 0 TD [(-0.82;)-247.4(Table)-246.5(4\),)-251.1(particularly)-250.3(for)-244(the)]TJ -12.6648 -1.2203 TD [(CT)-376.6(model)-380.6(\(27%)-375.8(vs.)-376.2(11%;)-377.2(calibration)-381(intercept)]TJ /F5 1 Tf 19.4556 0 TD (=)Tj /F4 1 Tf .7208 0 TD [(-1.38;)-373.8(Table)-379.3(4\).)]TJ -20.1764 -1.2203 TD [(In)-463.2(a)-463.5(population)-464.8(with)-464.6(GCS)-460.4(1314;)-462.7(that)-463.8(is,)-468.7(the)-460.2(patient)-468.7(selection)]TJ 0 -1.2266 TD [(that)-406.8(was)-410.1(used)-406.3(in)-401.4(the)-409.6(development)-405.5(study,)-404(calibration-in-the-large)]TJ 0 -1.2203 TD [(was)-410.1(better)-410.9(\(calibration)-414.7(intercept)]TJ /F5 1 Tf 13.3919 0 TD (=)Tj /F4 1 Tf .7208 0 TD [(-0.26)-408.2(for)-408.4(Basic,)-413.6(-1.13)-408.2(for)-408.4(CT,)]TJ -14.1127 -1.2203 TD [(Table)-341.3(4\).)-333.3(The)-335.9(calibration)-343(slope)-334(was)-340.6(close)-336.4(to)-338.2(1,)-331.2(indicating)-338.5(similar)]TJ 0 -1.2266 TD [(effects)-501.1(of)-501.1(predictors)-501.3(compared)-496.3(with)-502.6(the)-498.2(CRASH)-499.1(trial.)-498.1(Models)]TJ 0 -1.2203 TD [(showed)-573(good)-573.4(discriminative)-577.9(ability,)-568.1(especially)-580.8(the)-574(CT)-572.6(model)]TJ 27.9978 28.118 TD (\(C-index)Tj /F5 1 Tf 3.7305 0 TD (=)Tj /F4 1 Tf .7208 0 TD [(0.79;)-194.7(Table)-195.9(4\).)-187.9(The)-196.8(discriminative)-198.6(ability)-192.1(of)-197.6(the)-194.7(CRASH)]TJ -4.4513 -1.2203 TD [(models)-305.4(was)-296.3(somewhat)-303.8(reduced)-303.6(by)-296.2(the)-302.2(more)-297.5(homogeneous)-301.4(patient)]TJ 0 -1.2266 TD [(population)-597.6(of)-589.7(CENTER-TBI)-592.4(compared)-597.5(with)-591.1(the)-593(development)]TJ 0 -1.2203 TD [(population,)-246.5(as)-242.9(expressed)-241.8(by)-239.3(the)-245.2(expected)-243.7(C-index)-244.3(if)-239.6(the)-238.9(model)-247.8(was)]TJ T* [(correct)-190.1(\(mbc)]TJ /F5 1 Tf 5.2038 0 TD (=)Tj /F4 1 Tf .7208 0 TD [(0.79-80)-179.6(vs.)-180.2(C-index)-187.4(of)-178.7(0.810.83)-179.5(in)-186.4(the)-182(development)]TJ -5.9246 -1.2266 TD [(data,)-281.7(Table)-284.4(4\).)]TJ 1.1128 -1.2203 TD [(The)-323.2(Nijmegen)-325.6(clinical)-322.9(models)-324.4(showed)-320.1(relatively)-324.6(good)-320.5(calibra-)]TJ -1.1128 -1.2203 TD [(tion,)-476.9(with)-471(slight)-471.9(underestimation)-478.6(of)-469.5(proportions)-477(of)-469.5(unfavorable)]TJ T* [(outcome)-356.7(\(GOSE)]TJ /F5 1 Tf 7.0943 0 TD (<)Tj /F4 1 Tf .5501 0 TD [(7;)-350.8(26%)-348.4(vs.)-350.9(28%;)-351.9(22%)-348.4(vs.)-344.6(26%;)-351.9(Table)-347.7(4\).)-352.3(The)]TJ -7.6444 -1.2266 TD [(slopes)-360(suggested)-354.6(smaller)-358.2(effects)-362(of)-355.7(predictors)-355.8(\(slope)]TJ /F5 1 Tf 21.6686 0 TD (=)Tj /F4 1 Tf .7208 0 TD (0.820.83;)Tj -22.3894 -1.2203 TD [(Table)-240.2(4\))-241.9(and)-234.9(slightly)-241(worse)-241(discriminative)-242.8(ability)-236.4(in)-237(the)-238.9(CENTER-)]TJ T* [(TBI)-366.1(than)-358.6(in)-357.1(the)-359.1(Nijmegen)-363.6(study)-356.9(\(C-index)]TJ /F5 1 Tf 17.3627 0 TD (=)Tj /F4 1 Tf .7145 0 TD [(0.660.69\).)-361.5(The)-361.2(mbc)]TJ -18.0772 -1.2266 TD [(indicated)-286.8(a)-280.1(somewhat)-284.9(more)-278.5(heterogeneous)-289.3(patient)-279(case-mix)-286.6(in)-281.3(the)]TJ 0 -1.2203 TD [(CENTER-TBI)-295.3(study)-287.3(than)-289(in)-287.6(the)-289.5(Nijmegen)-294(study)-287.3(\(mbc)]TJ /F5 1 Tf 22.1175 0 TD (=)Tj /F4 1 Tf .7208 0 TD (0.72-0.70)Tj -22.8384 -1.2203 TD [(vs.)-426.8(C-index)-427.7(0.710.69;)-423.3(Table)-429.9(4\),)-428.2(which)-424.6(increased)-430.4(the)-422.3(ability)-426.1(to)]TJ 0 -1.2266 TD [(correctly)-338.6(discriminate)-334.6(between)-340(patients)-330.3(with)-338.2(GOSE)]TJ /F5 1 Tf 21.3904 0 TD (<)Tj /F4 1 Tf .5501 0 TD [(7)-334.6(and)-336.1(those)]TJ -21.9405 -1.2203 TD [(with)-281.3(GOSE)]TJ /F5 1 Tf 4.9445 0 TD ()Tj /F4 1 Tf .5564 0 TD (7.)Tj -4.3881 -1.2203 TD [(For)-398.1(the)-390.7(ED)]TJ /F5 1 Tf 4.7359 0 TD (+)Tj /F4 1 Tf .9484 0 TD [(model,)-389.8(calibration-in-the-large)-404.4(was)-397.5(not)-394.6(assessed)]TJ -6.7971 -1.2203 TD [(because)-374.2(several)-372.1(predictors)-368.5(were)-375.5(not)-363(registered)-377.2(in)-363.4(CENTER-TBI.)]TJ 0 -1.2266 TD [(Discrimination)-325.9(was)-321.6(assessed,)-327.2(but)-318.7(it)-323.2(was)-321.6(expected)-319.6(to)-319.2(be)-323.9(lower)-319.7(be-)]TJ 0 -1.2203 TD [(cause)-410.7(of)-406.3(the)-409.6(absence)-412.1(of)-406.3(several)-410(predictors)-406.4(in)-407.7(the)-409.6(CENTER-TBI)]TJ T* [(data.)-351.3(The)-342.2(ability)-343.9(to)-344.5(discriminate)-353.6(patients)-343(with)-344.5(complete)-350(recovery)]TJ 0 -1.2266 TD (\(GOSE)Tj /F5 1 Tf 3.1046 0 TD (=)Tj /F4 1 Tf .7208 0 TD [(8\))-349.4(was)-353.2(lower)-351.3(than)-352.2(in)-350.8(the)-352.7(development)-354.9(study)-350.5(\(C-index)]TJ /F5 1 Tf 22.2946 0 TD (=)Tj /F4 1 Tf -26.1199 -1.2203 TD [(0.70;)-276.9(Table)-271.8(4\).)-276.4(Analyses)-276.2(of)-267.2(C-indices)-276.2(and)-272.8(slope)-277.1(suggested)-272.4(smaller)]TJ ET 62.022 720.113 490.167 .22681 re f 62.022 380.863 490.167 .28345 re f 62.022 688.365 490.167 .22675 re f BT /F7 1 Tf 8.9663 0 0 8.9663 75.4015 725.7825 Tm (Table)Tj /F4 1 Tf 2.9971 0 TD (2.)Tj /F7 1 Tf 1.2519 0 TD [(Models)-331.2(for)-334.7(Predicting)-333.8(Glasgow)-335.5(Outcome)-331.8(Scale)-336.2(Extended)-332.9(\(GOSE\))-336.1(Validated)-332.4(in)-331.6(the)-333.5(CENTER-TBI)-339.5(Data)]TJ /F10 1 Tf -5.7412 -3.446 TD [(Study)-4493.3(Model)-3249.8(Population;)-331.6(Setting)-4841.8(Outcome)-7903(Predictors)]TJ 48.7749 1.1128 TD (Reported)Tj -2.2193 -1.1128 TD [(performance)-334(\(AUC\))]TJ /F4 1 Tf -46.5556 -2.0929 TD (CRASH,)Tj .999 -1.1128 TD (2008)Tj 4.9445 1.1128 TD (Basic)Tj .999 -1.1128 TD (model)Tj 4.2111 1.1128 TD [(Adult;)-334.9(GCS)-333.9(3-14)-4761.8(GOS)]TJ /F5 1 Tf 14.0811 0 TD (<)Tj /F4 1 Tf .5501 0 TD [(4)-334.6(\(GOSE)]TJ /F5 1 Tf 4.1036 0 TD (<)Tj /F4 1 Tf .5501 0 TD (5\))Tj -6.5252 -1.1128 TD [(at)-334.3(6)-334.6(months)]TJ /F11 1 Tf 8.4474 1.1128 TD ()Tj /F4 1 Tf 1.0053 0 TD [(Age)-333(\(after)-336.2(40)-334.1(years\))]TJ /F11 1 Tf -1.0053 -1.1128 TD ()Tj /F4 1 Tf 1.0053 0 TD (GCS)Tj /F11 1 Tf -1.0053 -1.1128 TD ()Tj /F4 1 Tf 1.0053 0 TD [(Pupillary)-333.7(reactivity)]TJ /F11 1 Tf -1.0053 -1.1065 TD ()Tj /F4 1 Tf 1.0053 0 TD [(Extracranial)-337(injury)]TJ 16.1803 3.3322 TD (0.81)Tj 6.7246 0 0 5.9768 521.9716 680.088 Tm (a)Tj 8.9663 0 0 8.9663 115.3133 636.2644 Tm [(CT)-332.3(model)-22295.8(Basic)-341.1(model)-330(plus)]TJ /F11 1 Tf 26.4171 -1.1128 TD ()Tj /F4 1 Tf 1.0053 0 TD [(Petechial)-332.1(hemorrhage)]TJ /F11 1 Tf -1.0053 -1.1065 TD ()Tj /F4 1 Tf 1.0053 0 TD [(Obliteration)-334.8(of)-330.4(third)-337(ventricle)]TJ 0 -1.1128 TD [(and)-329.7(cisterns)]TJ /F11 1 Tf -1.0053 -1.1128 TD ()Tj /F4 1 Tf 1.0053 0 TD [(Subarachnoid)-335.4(hemorrhage)]TJ /F11 1 Tf -1.0053 -1.1128 TD ()Tj /F4 1 Tf 1.0053 0 TD [(Mid-line)-330(shift)]TJ /F11 1 Tf -1.0053 -1.1065 TD ()Tj /F4 1 Tf 1.0053 0 TD [(Non-evacuated)-338.1(hematoma)]TJ 16.1803 6.6644 TD (0.83)Tj 6.7246 0 0 5.9768 521.9716 640.2329 Tm (a)Tj 8.9663 0 0 8.9663 62.022 566.5321 Tm (Nijmegen-)Tj .999 -1.1128 TD (RUBICS,)Tj T* (2010)Tj 4.9445 2.2257 TD [(Clinical)-2026.1(Adult;)-334.9(GCS)-333.9(13-15)]TJ 5.2101 -1.1128 TD (Neurological/surgical)Tj 1.0053 -1.1128 TD (consultation;)Tj -1.0053 -1.1065 TD [(Level)-290.8(1)-290.4(trauma)-284(center,)-292.1(the)]TJ 1.0053 -1.1128 TD [(Netherlands,)-241.2(1998-2005)]TJ 10.7553 4.445 TD (GOSE)Tj /F5 1 Tf 2.9338 0 TD (<)Tj /F4 1 Tf .5501 0 TD (7)Tj -2.4849 -1.1128 TD [(at)-334.3(6)-334.6(months)]TJ /F11 1 Tf 8.4474 1.1128 TD ()Tj /F4 1 Tf 1.0053 0 TD (Age)Tj /F11 1 Tf -1.0053 -1.1128 TD ()Tj /F4 1 Tf 1.0053 0 TD [(Injury)-328.8(Severity)-339(Score)-332.4(Total)]TJ /F11 1 Tf -1.0053 -1.1128 TD ()Tj /F4 1 Tf 1.0053 0 TD [(Alcohol)-332.8(intoxication)]TJ 16.1803 2.2257 TD (0.71)Tj -38.3927 -5.5578 TD [(GCS;)-337.5(13-15)]TJ 0 -1.1128 TD [(No)-337.4(polytrauma)-336.6(\(isolated)]TJ 1.0053 -1.1065 TD (TBI\))Tj /F11 1 Tf 20.2017 2.2193 TD ()Tj /F4 1 Tf 1.0053 0 TD (Age)Tj /F11 1 Tf -1.0053 -1.1128 TD ()Tj /F4 1 Tf 1.0053 0 TD [(Injury)-328.8(Severity)-339(Score-Head)]TJ /F11 1 Tf -1.0053 -1.1065 TD ()Tj /F4 1 Tf 1.0053 0 TD [(Alcohol)-332.8(intoxication)]TJ 16.1803 2.2193 TD (0.69)Tj -49.5463 -3.3322 TD (UPFRONT,)Tj .999 -1.1128 TD (2017)Tj 4.9445 1.1128 TD (ED)Tj /F5 1 Tf 1.3341 0 TD (+)Tj /F4 1 Tf 3.8759 0 TD (Adult)Tj 0 -1.1128 TD [(GCS)-333.9(13-15)]TJ 0 -1.1065 TD (LOC)Tj /F5 1 Tf 2.3079 0 TD (<)Tj /F4 1 Tf .5501 0 TD [(30)-169.7(min;)-306.8(PTA)]TJ /F5 1 Tf 5.5073 0 TD (<)Tj /F4 1 Tf .5564 0 TD (24h,)Tj -7.9163 -1.1128 TD [(no)-327.8(major)-338.9(psychiatric)]TJ T* (disorder;)Tj -1.0053 -1.1128 TD [(Three)-339.9(level-1)]TJ 0 -1.1065 TD [(trauma)-340.9(centers,)-330.7(the)]TJ 1.0053 -1.1128 TD [(Netherlands,)-241.2(2013-2015)]TJ 10.7553 7.7772 TD (GOSE)Tj /F5 1 Tf 2.7694 0 TD (=)Tj /F4 1 Tf .7145 0 TD (8)Tj -3.4839 -1.1128 TD [(at)-334.3(6)-328.3(months)]TJ /F11 1 Tf 9.4464 1.1128 TD ()Tj /F4 1 Tf 1.0053 0 TD (Education)Tj /F11 1 Tf -1.0053 -1.1128 TD ()Tj /F4 1 Tf 1.0053 0 TD [(Mental)-333.1(health)-332.4(history)]TJ /F11 1 Tf -1.0053 -1.1065 TD ()Tj /F4 1 Tf 1.0053 0 TD [(Alcohol)-332.8(intoxication)]TJ /F11 1 Tf -1.0053 -1.1128 TD ()Tj /F4 1 Tf 1.0053 0 TD [(Neck)-335(pain)]TJ /F11 1 Tf -1.0053 -1.1128 TD ()Tj /F4 1 Tf 1.0053 0 TD (GCS)Tj /F11 1 Tf -1.0053 -1.1128 TD ()Tj /F4 1 Tf 1.0053 0 TD [(PTA)-329(duration)]TJ /F11 1 Tf -1.0053 -1.1065 TD ()Tj /F4 1 Tf 1.0053 0 TD [(Depression)-334.7(\(2)-330.4(weeks\))]TJ /F11 1 Tf -1.0053 -1.1128 TD ()Tj /F4 1 Tf 1.0053 0 TD [(Anxiety)-332.8(\(2)-330.4(weeks\))]TJ /F11 1 Tf -1.0053 -1.1128 TD ()Tj /F4 1 Tf 1.0053 0 TD [(Complaints)-335.2(\(2)-330.4(weeks\))]TJ /F11 1 Tf -1.0053 -1.1128 TD ()Tj /F4 1 Tf 1.0053 0 TD [(Passive)-335.2(coping)-332.3(style)]TJ /F11 1 Tf -1.0053 -1.1065 TD ()Tj /F4 1 Tf 1.0053 0 TD [(Avoidant)-332.3(coping)-332.3(style)]TJ 16.1803 11.1094 TD (0.77)Tj 6.7246 0 0 5.9768 521.9716 490.7904 Tm (b)Tj 5.9774 0 0 5.3127 70.0157 372.5857 Tm (a)Tj 7.9702 0 0 7.9702 72.6803 369.0708 Tm [(For)-329.3(high-incom)13.7(e)-335.4(countries)]TJ 5.9774 0 0 5.3127 70.0157 363.6283 Tm (b)Tj 7.9702 0 0 7.9702 72.9637 360.1133 Tm [(After)-334.9(internal)-323(validation)]TJ -.3699 -1.1239 TD [(AUC,)-265.6(area)-267.9(under)-266.5(the)-272.9(curve;)-266.1(C,)-271.9(concordan)12.8(ce;)-269(CENTER-TBI,)-264.1(Collaborat)10.8(ive)-272.9(Europea)12(n)-275.3(NeuroTraum)16(a)-271.4(Effectiveness)-262.1(Research)-268.7(in)-271.7(Traumatic)-264.9(Brain)-262.6(Injury;)]TJ -1.003 -1.131 TD [(CRASH,)-356.5(Corticostero)10.3(id)-357.1(Randomisati)11.5(on)-365.7(After)-356.3(Signican)12.6(t)-366.3(Head)-356.3(Injury;)-359.1(CT,)-355(computed)-354.6(tomography;)-347(ED,)-359.9(emergency)-356.7(departmen)10.8(t;)-362.7(GCS,)-353.4(Glasgow)-356.1(Coma)]TJ 0 -1.1239 TD [(Score;)-327.9(LOC,)-327(loss)-334(of)-333.6(conscious)11.4(ness;)-328(PTA,)-327.2(post-traumat)11.5(ic)-339(amnesia;)-321.9(RUBICS,)-324.4(Radboud)-327.7(University)-326.4(Brain)-326.6(Injury)-327.1(Cohort)-328.5(Study;)-323.7(UPFRONT.)]TJ /F3 1 Tf 8.9663 0 0 8.9663 62.022 749.6502 Tm (200)Tj 46.8781 0 TD (MIKOLIC)Tj 3.7052 .2213 TD ()Tj .8536 -.2213 TD [(ET)-338.7(AL.)]TJ ET endstream endobj 77 0 obj <>stream 0 0 0 rg /GS1 gs 59.754 720.113 490.167 .22681 re f 59.754 470.551 490.167 .22681 re f 59.754 688.365 490.167 .22675 re f BT /F7 1 Tf 8.9663 0 0 8.9663 67.9181 725.7825 Tm 0 Tc 0 Tw (Table)Tj /F4 1 Tf 2.9971 0 TD (3.)Tj /F7 1 Tf 1.2519 0 TD [(Models)-331.2(for)-334.7(Predicting)-333.8(Persistent)-335(Post-Concussive)-336.7(Symptoms)-333.7(\(PPCS\))-337.9(Validated)-332.4(in)-331.6(the)-333.5(CENTER-TBI)-339.5(Study)]TJ /F10 1 Tf -5.1595 -3.446 TD [(Model)-7625.2(Population;)-337.9(Setting)-5859.8(Outcome)-8807.2(Predictors)]TJ 48.7749 1.1128 TD (Reported)Tj -2.2193 -1.1128 TD [(performance)-340.4(\(AUC\))]TJ /F4 1 Tf -46.5556 -2.0929 TD [(TRACK)-335.9(TBI)]TJ 1.0053 -1.1128 TD [(Pilot,)-333.6(2017)]TJ 7.1386 1.1128 TD [(Adult)-337.7(GCS)-333.9(13-15;)]TJ 0 -1.1128 TD [(3)-334.6(level)-332.9(I)-337.2(trauma)-334.5(centers,)-337(US,)]TJ .999 -1.1128 TD (2010-2012)Tj 11.9629 2.2257 TD (Score)Tj /F5 1 Tf 2.5924 0 TD ()Tj /F4 1 Tf .5501 0 TD [(2)-315.7(o)0(n)-315.2(3)-315.7(out)-312.4(of)-317.8(8)]TJ -2.1435 -1.1128 TD (symptoms)Tj 6.7246 0 0 5.9768 294.8031 670.11 Tm (a)Tj 8.9663 0 0 8.9663 300.8125 666.1416 Tm (\(ICD\))Tj -4.7801 -1.1128 TD [(Measured)-241.8(by)-239.3(RPQ)-239.1(at)]TJ 0 -1.1065 TD [(6)-328.3(months)]TJ /F11 1 Tf 9.2884 3.3322 TD ()Tj /F4 1 Tf .999 0 TD (Age)Tj /F11 1 Tf -.999 -1.1128 TD ()Tj /F4 1 Tf .999 0 TD [(Female)-339.3(sex)]TJ /F11 1 Tf -.999 -1.1128 TD ()Tj /F4 1 Tf .999 0 TD [(Years)-338.3(of)-330.4(education)]TJ /F11 1 Tf -.999 -1.1065 TD ()Tj /F4 1 Tf .999 0 TD [(Pre-injury)-334.4(migraine)-337.6(or)-330.4(headache)]TJ /F11 1 Tf -.999 -1.1128 TD ()Tj /F4 1 Tf .999 0 TD [(Pre-injury)-334.4(psychiatric)-340.2(disorders)]TJ /F11 1 Tf -.999 -1.1128 TD ()Tj /F4 1 Tf .999 0 TD [(Prior)-334.2(TBI)]TJ /F11 1 Tf -.999 -1.1065 TD ()Tj /F4 1 Tf .999 0 TD (PTA)Tj /F11 1 Tf -.999 -1.1128 TD ()Tj /F4 1 Tf .999 0 TD (LOC)Tj 17.1604 7.7772 TD (0.74)Tj -49.5527 -8.89 TD (UPFRONT,)Tj 1.0053 -1.1128 TD (2018)Tj 7.1386 1.1128 TD (Adult)Tj 0 -1.1128 TD [(GCS)-333.9(13-15;)]TJ 0 -1.1065 TD [(sustained)-339.6(LOC)-335.2(or)-330.4(PTA,)-338.3(no)]TJ .999 -1.1128 TD [(substance)-338(addiction,)]TJ T* (dementia;)Tj -.999 -1.1128 TD [(3)-334.6(level)-332.9(I)-337.2(trauma)-334.5(centers,)-337(The)]TJ .999 -1.1065 TD [(Netherlands,)-342.4(2013-2015)]TJ 11.9629 6.6644 TD [(3)-328.3(out)-337.7(of)-330.4(8)-334.6(symptoms)]TJ .999 -1.1128 TD [(\(ICD\))-335.9(measured)]TJ 0 -1.1065 TD [(by)-334.1(HISC)-329.7(at)]TJ 0 -1.1128 TD [(6)-328.3(months)]TJ /F11 1 Tf 9.2884 3.3322 TD ()Tj /F4 1 Tf .999 0 TD [(Female)-339.3(sex)]TJ /F11 1 Tf -.999 -1.1128 TD ()Tj /F4 1 Tf .999 0 TD [(Neck)-335(pain)]TJ /F11 1 Tf -.999 -1.1065 TD ()Tj /F4 1 Tf .999 0 TD (Nausea)Tj /F11 1 Tf -.999 -1.1128 TD ()Tj /F4 1 Tf .999 0 TD (Headache)Tj /F11 1 Tf -.999 -1.1128 TD ()Tj /F4 1 Tf .999 0 TD [(Post-concussive)-335.2(symptoms)]TJ 0 -1.1128 TD [(\(2)-336.7(weeks\))]TJ /F11 1 Tf -.999 -1.1065 TD ()Tj /F4 1 Tf .999 0 TD [(Post-traumatic)-341.2(symptoms)]TJ 0 -1.1128 TD [(\(2)-336.7(weeks\))]TJ 17.1604 7.7772 TD (0.75)Tj 6.7246 0 0 5.9768 519.7038 600.3778 Tm (b)Tj 8.9663 0 0 8.9663 59.7543 516.6991 Tm (Nijmegen,)Tj 1.0053 -1.1128 TD [(RUBICS,)-334.8(2008)]TJ 7.1386 1.1128 TD [(GCS)-333.9(13-15;)]TJ 0 -1.1128 TD (LOC)Tj /F5 1 Tf 2.3015 0 TD (<)Tj /F4 1 Tf .5501 0 TD [(30)-163.4(min,)-299.9(18-60)-297.3(years)-297(of)]TJ -1.8526 -1.1065 TD (age;)Tj -.999 -1.1128 TD [(1)-334.6(level)-332.9(I)-337.2(trauma)-334.5(center,)-336.3(The)]TJ .999 -1.1128 TD [(Netherlands,)-342.4(2004-2006)]TJ 11.9629 4.445 TD (Score)Tj /F5 1 Tf 2.6114 0 TD ()Tj /F4 1 Tf .5501 0 TD .3343 Tc [(2o)334.3(n1)334.3(3o)334.3(u)334.3(t)]TJ -2.1624 -1.1128 TD 0 Tc [(of)-330.4(16)-334.1(RPQ)-333.9(items)-335.2(at)]TJ 0 -1.1065 TD [(6)-328.3(months)]TJ /F11 1 Tf 9.2884 2.2193 TD ()Tj /F4 1 Tf .999 0 TD [(Pre-injury)-334.4(physical)-339(health)]TJ /F11 1 Tf -.999 -1.1128 TD ()Tj /F4 1 Tf .999 0 TD [(Post-concussive)-335.2(symptoms)]TJ 0 -1.1065 TD [(\(0-37)-337.9(days\))]TJ /F11 1 Tf -.999 -1.1128 TD ()Tj /F4 1 Tf .999 0 TD [(Post-traumatic)-341.2(symptoms)]TJ 0 -1.1128 TD [(\(0-37)-337.9(days\))]TJ 17.1604 4.445 TD (0.73)Tj 6.7246 0 0 5.9768 519.7038 520.7243 Tm (b)Tj 5.9774 0 0 5.3127 67.748 462.2739 Tm (a)Tj 7.9702 0 0 7.9702 70.4126 458.7022 Tm [(Headache,)-328.1(dizziness,)-323.6(fatigue,)-325.5(irritability,)-329.1(sleep)-330(disturbanc)12.8(es,)-333.5(poor)-329.4(concentra)11.1(tion,)-329.1(forgetfulness)11(,)-333.3(poor)-329.4(memory,)-327.4(frustration)-321.5(or)-333.6(depression)]TJ -.3343 -1.1239 TD [(*After)-325.7(internal)-330.1(validation)]TJ T* [(AUC,)-301.2(area)-303.5(under)-295(the)-308.4(curve;)-294.6(CENTER-TBI,)-299.6(Collabora)14.3(tive)-304.9(European)-298.9(NeuroTraum)15.9(a)-307(Effectiveness)-297.7(Research)-297.1(in)-300.2(Traumatic)-300.5(Brain)-298.2(Injury;)-302.2(GCS,)-296.5(Glasgow)]TJ -1.003 -1.1239 TD [(Coma)-387.2(Score;)-392(HISC,)-383.2(Head)-391.8(Injury)-384(Severity)-386.3(Checklist)10.9(;)-394.7(ICD,)-387.5(International)-381.7(Classicatio)9.3(n)-389.1(o)0(f)-390.5(Diseases;)-392.3(LOC,)-383.9(loss)-390.9(of)-390.5(conscious)11.4(ness;)-392(PTS,)-386.5(post-traumat)11.5(ic)]TJ T* (symptoms;)Tj 1.003 -1.1239 TD [(RPQ,)-324.9(Rivermead)-321.1(Post-Concu)12(ssion)-331.9(Symptoms)-315.1(Questionnaire;)-323(RUBIC)11.7(S,)-329(Radboud)-327.7(Univer)12(sity)-331.3(Brain)-326.6(Injury)-320(Cohort)-328.5(Study;)-323.7(TRACK-T)11.3(BI,)-330.1(Transformi)11.5(ng)]TJ -1.003 -1.1239 TD [(Research)-332.7(and)-331.3(Clinical)-322.8(Knowledge)-325.5(in)-328.7(TBI;)-332.4(UPFRON)11.8(T,)]TJ ET 59.754 330.066 490.167 .22681 re f 59.754 114.917 490.167 .22675 re f 143.887 310.677 47.395 .22678 re f 199.672 310.677 350.249 .22678 re f 59.754 282.954 490.167 .22675 re f BT /F7 1 Tf 8.9663 0 0 8.9663 65.7637 345.7133 Tm (Table)Tj /F4 1 Tf 2.9654 0 TD (4.)Tj /F7 1 Tf 1.2456 0 TD [(Results)-300.7(of)-297.2(External)-302.7(Validation)-297.8(of)-297.2(Models)-299.6(Predicting)]TJ /F4 1 Tf 25.279 0 TD (6)Tj /F7 1 Tf .4995 0 TD [(-Month)-302.1(Glasgow)-297.5(Outcome)-300.2(Score)-298.2(Extended)-301.3(\(GOSE\))]TJ -28.3583 -1.1128 TD [(in)-338(Patients)-333.4(with)-334.2(Mild)-330.1(Traumatic)-336.3(Injury)-335.6(\(TBI\):)-335.9(Complete)-335.3(Case)-331.3(Analyses)-333.9(in)-338(the)-333.5(CENTER-TBI)-339.5(Study)-328.2(\()]TJ /F12 1 Tf 46.2331 0 TD (n)Tj /F5 1 Tf .784 0 TD (=)Tj /F10 1 Tf .7145 0 TD (2269)Tj /F7 1 Tf 2.0044 0 TD (\))Tj /F10 1 Tf -52.0376 -4.053 TD [(Models)-335.6(for)-332.5(6-)-336.7(month)]TJ 0 -1.1065 TD (GOSE)Tj 9.3832 2.8263 TD [(Development)-18349.1(Validation)]TJ 2.3079 -2.8263 TD (C)Tj 5.4187 1.1065 TD (Sample/)Tj -1.5049 -1.1065 TD [(outcome)-331.2(events)]TJ 8.0617 1.1065 TD (Intercept)Tj -.1012 -1.1065 TD [(\(95%)-331.6(CI\))]TJ 6.5632 1.1065 TD [(Predicted)-334.4(vs.)]TJ -1.0117 -1.1065 TD [(observed)-340.8(outcome)-969.8(mbc)-1977(C)-333(\(95%)-331.6(CI\))-2151.9(Slope)-339.1(\(95%)-331.6(CI\))]TJ /F4 1 Tf -29.117 -2.0992 TD [(CRASH,)-337.6(Basic)-5020.1(0.81)-3928(2269/259)-3825.5(-0.82)]TJ 22.7751 -1.1065 TD [([-0.96,)-331.1(-0.68])]TJ 8.7888 1.1065 TD (20%;)Tj 0 -1.1065 TD (11%)Tj 5.8297 1.1065 TD [(0.79)-930.9(0.78)-330.2([0.74,)-335.3(0.81])-933(0.96)-330.2([0.83,)-335.3(1.09])]TJ -20.0373 -2.2193 TD (558/111)Tj 6.7246 0 0 5.9768 244.7999 254.7212 Tm (a)Tj 8.9663 0 0 8.9663 278.8723 250.7527 Tm (-0.26)Tj -1.4985 -1.1128 TD ([-0.49,-0.03])Tj 8.6245 1.1128 TD (23%;)Tj 0 -1.1128 TD (20%)Tj 5.8297 1.1128 TD [(0.79)-930.9(0.76)-330.2([0.76,)-335.3(0.77])-933(0.95)-330.2([0.73,1.16])]TJ -37.3937 -2.2193 TD [(CRASH,)-337.6(CT)-5966.1(0.83)-3928(2064/233)-3825.5(-1.38)]TJ 22.9395 -1.1128 TD ([-1.53,-1.22])Tj 8.6245 1.1128 TD (27%;)Tj 0 -1.1128 TD (11%)Tj 5.8297 1.1128 TD [(0.80)-930.9(0.79)-330.2([0.75,0.82])-1268.3(0.90)-330.2([0.78,1.02])]TJ -20.1195 -2.2257 TD (492/93)Tj 6.7246 0 0 5.9768 239.5842 214.8661 Tm (a)Tj 8.9663 0 0 8.9663 278.8723 210.8976 Tm (-1.13)Tj -1.4985 -1.1128 TD ([-1.39,-0.87])Tj 8.6245 1.1128 TD (34%;)Tj 0 -1.1128 TD (19%)Tj 5.8297 1.1128 TD [(0.82)-930.9(0.78)-330.2([0.73,0.84])-1268.3(0.82)-330.2([0.63,1.01])]TJ -37.3937 -2.2193 TD (Nijmegen)Tj 0 -1.1128 TD (Clinical)Tj 1.0053 -1.1128 TD [(In)-330.4(all)-337.8(mild)-332.1(TBI)]TJ 10.1483 2.2257 TD [(0.71)-3928(2248/635)-3989.9(0.13)]TJ 12.121 -1.1128 TD ([0.02,0.23])Tj 8.2893 1.1128 TD (26%;)Tj 0 -1.1128 TD (28%)Tj 5.8297 1.1128 TD [(0.72)-930.9(0.69)-330.2([0.66,0.71])-1268.3(0.82)-330.2([0.71,0.94])]TJ -37.3937 -3.3385 TD (Nijmegen)Tj 0 -1.1065 TD (Clinical)Tj 0 -1.1128 TD [(In)-336.7(Isolated)-335.2(TBI)]TJ 11.1536 2.2193 TD [(0.69)-3928(1098/284)-3989.9(0.24)]TJ 12.3676 -1.1065 TD ([0.1,0.38])Tj 8.0427 1.1065 TD [(22%)-335.8(;)]TJ 0 -1.1065 TD (26%)Tj 5.8297 1.1065 TD [(0.70)-930.9(0.66)-330.2([0.59,0.74])-1268.3(0.83)-330.2([0.64,1.02])]TJ -37.3937 -3.3322 TD (UPFRONT)Tj 0 -1.1065 TD (ED)Tj /F5 1 Tf 1.6692 0 TD (+)Tj /F4 1 Tf 9.4844 1.1065 TD [(0.77)-4269.4(548/352)]TJ 6.7246 0 0 5.9768 243.1558 135.2126 Tm (b)Tj 8.9663 0 0 8.9663 286.9794 131.1874 Tm [(/)-7028.3(/)-4461.2(0.80)-930.9(0.70)-330.2([0.66,0.75])-1268.3(0.49)-330.2([0.36-0.62])]TJ 5.9774 0 0 5.3127 67.748 106.6393 Tm (a)Tj 7.9702 0 0 7.9702 70.4126 103.1244 Tm [(Subset)-329.6(with)-325.5(Glasgow)-327.7(Coma)-330.3(Score)-324.4(\(GCS\))-328.6(1314)]TJ 5.9774 0 0 5.3127 67.748 97.6819 Tm (b)Tj 7.9702 0 0 7.9702 70.7527 94.1669 Tm [(Predicting)-323.7(positive)-324.7(outcome)]TJ -.377 -1.131 TD [(C,)-385.7(concordance)10.5(;)-387.6(CENTER-TBI,)-377.9(Collaborative)-383(Europea)12(n)-389.1(NeuroTrauma)-383.5(Effective)12.6(ness)-388.5(Research)-382.5(in)-392.7(Traumati)13.6(c)-392.3(Brain)-383.5(Injury;)-387.6(CI,)-379.9(condence)-383.1(interval;)]TJ -1.003 -1.1239 TD [(CRASH,)-448.9(Corticostero)10.3(id)-449.6(Randomisa)11.5(tion)-451(After)-448.7(Signicant)-446.2(Head)-448.7(Injury;)-444.5(CT,)-447.5(computed)-447(tomography;)-439.5(ED,)-452.4(emergen)12.2(cy)-454.3(departmen)10.8(t;)-455.2(mbc,)-447.6(model)-443(based)]TJ T* [(concordance;)-327.3(UPFRON)11.8(T.)]TJ /F3 1 Tf 8.9663 0 0 8.9663 297.4109 34.9228 Tm (201)Tj ET endstream endobj 82 0 obj <>stream /GS1 gs BT /F4 1 Tf 8.9663 0 0 8.9663 62.022 725.7825 Tm 0 0 0 rg 0 Tc 0 Tw [(effects)-374.7(of)-374.7(predictors)-374.8(in)-376.1(CENTER-TBI)-377.5(and)-374(substantial)-372(overtting)]TJ 0 -1.2203 TD (\(slope)Tj /F5 1 Tf 2.6177 0 TD (=)Tj /F4 1 Tf .7145 0 TD [(0.5;)-296.3(Table)-303.4(4\).)-295.4(If)-295.1(the)-295.8(regression)-302.4(coefcients)-299.2(were)-299.6(valid)-298.9(for)]TJ -3.3322 -1.2266 TD [(the)-289.5(CENTER-TBI)-288.9(sample,)-291.8(the)-283.2(model)-285.7(would)-289.4(have)-287.4(a)-286.5(good)-288.9(discrim-)]TJ 0 -1.2203 TD [(inative)-209.5(ability)-211.1(\(mbc)]TJ /F5 1 Tf 7.9542 0 TD (=)Tj /F4 1 Tf .7208 0 TD [(0.80;)-207.3(Table)-208.6(4\),)-206.9(even)-205.2(slightly)-209.4(better)-208.6(than)-206.8(in)-205.4(the)]TJ -8.675 -1.2203 TD [(development)-386.5(study)-382.1(\(C)]TJ /F5 1 Tf 9.282 0 TD (=)Tj /F4 1 Tf .7208 0 TD [(0.77,)-383.7(Table)-385.6(4\))-381(because)-386.8(of)-381(the)-384.3(more)-379.7(het-)]TJ -10.0028 -1.2266 TD [(erogeneous)-284.4(case-mix)-280.3(in)-281.3(the)-283.2(CENTER-TBI)-282.6(study.)]TJ /F1 1 Tf 1.1128 -2.7505 TD [(Models)-491.9(predicting)-495.4(PPCS.)]TJ /F4 1 Tf 12.5004 0 TD [(The)-443.4(TRACK)-437.1(-TBI)-444.1(Pilot)-438.2(model)]TJ -13.6132 -1.2203 TD [(correctly)-319.6(estimated)-316.8(the)-321.1(proportion)-311.9(of)-317.8(patients)-317.7(with)-319.2(PPCS,)-311.3(dened)]TJ T* [(as)-217.6(having)-212.2(three)-211.3(or)-216.6(more)-215.3(mild)-212(to)-211.7(severe)-216.8(symptoms)-211.9(at)-214.1(6)-214.5(months)-214.5(\(42%)]TJ 0 -1.2266 TD [(vs.)-224.4(42%;)-219.2(Table)-221.2(5\),)-225.8(but)-217.5(showed)-225.3(overtting)-219.4(\(slope)]TJ /F5 1 Tf 19.3481 0 TD (<)Tj /F4 1 Tf .5564 0 TD [(0.5;)-220.5(Table)-221.2(5\))-222.9(and)]TJ -19.9045 -1.2203 TD [(poor)-228.3(discriminative)-230.2(ability)-230.1(\(C-index)]TJ /F5 1 Tf 14.568 0 TD (=)Tj /F4 1 Tf .7145 0 TD [(0.58;)-226.3(Table)-233.9(5\).)-225.8(The)-228.4(mbc)-225.8(was)]TJ -15.2825 -1.2203 TD [(substantially)-488.9(higher)-486.7(than)-485(the)-491.8(observed)-485.3(C-index)-484.6(\(mbc)]TJ /F5 1 Tf 22.5791 0 TD (=)Tj /F4 1 Tf .7208 0 TD [(0.74)-482(vs.)]TJ -23.2999 -1.2266 TD [(0.58,)-194.1(Table)-195.9(5\))-191.3(and)-197(was)-195.1(equivalent)-191.5(to)-192.7(the)-194.7(C)-193.9(i)0(n)-192.7(the)-194.7(development)-196.8(study)]TJ 0 -1.2203 TD (\(C)Tj /F5 1 Tf 1.1697 0 TD (=)Tj /F4 1 Tf .7145 0 TD [(0.74,)-383.7(Table)-391.9(5\).)-383.9(This)-382.4(pattern)-385.1(suggested)-392.5(that)-381.6(predictor)-386.7(effects)]TJ -1.8842 -1.2203 TD [(\(regression)-399.4(coefcients\))-396.2(differed)-398.5(between)-396.9(studies,)-398(whereas)-396.6(case-)]TJ 0 -1.2266 TD [(mix)-278(heterogeneity)-283.6(was)-283.7(comparable.)]TJ 1.1128 -1.2203 TD [(Models)-384.8(for)-383.1(prediction)-381.3(of)-381(PPCS,)-387.1(which)-380.4(included)-388.3(2-week)-380.9(post-)]TJ -1.1128 -1.2203 TD [(injury)-273.3(symptoms)-268.8(were)-274.4(validated)-274.2(in)-268.6(a)-267.5(smaller)-276(sample)-269.9(of)-273.5(CENTER-)]TJ T* [(TBI)-353.4(patients,)-352.2(for)-351.5(whom)-346.3(that)-349.9(information)-353(was)-353.2(available,)-355.4(and)-348.7(they)]TJ 0 -1.2266 TD [(performed)-391.2(well)-384.9(\(C-index)-391.8(0.750.76\).)-380.5(For)-385.4(the)-390.7(UPFRONT)-387.6(model,)]TJ 0 -1.2203 TD [(calibration-in-the-large)-195.7(was)-195.1(not)-185.9(assessed)-197.8(because)-190.8(of)-191.3(an)-191.1(unmeasured)]TJ T* [(predictor)-298.2(\(neck)-295.8(pain\))-291.1(in)-293.9(the)-295.8(CENTER-TBI)-295.3(study.)-296.5(The)-291.6(discrimina-)]TJ 0 -1.2266 TD [(tion)-303.3(ability)-305.9(\(C-index)]TJ /F5 1 Tf 8.4727 0 TD (=)Tj /F4 1 Tf .7145 0 TD [(0.75;)-308.5(Table)-303.4(5\))-305.1(and)-304.5(the)-302.1(effects)-311.4(of)-298.8(predictors)]TJ -9.1872 -1.2203 TD [(were)-185.8(equivalent)-185.2(to)-180.1(UPFRONT)-185.2(\(slope)]TJ /F5 1 Tf 14.7956 0 TD (=)Tj /F4 1 Tf .7208 0 TD [(1.0;)-182.5(Table)-183.3(5\).)-181.6(The)-184.1(Nijmegen)]TJ -15.5164 -1.2203 TD [(model)-367.9(was)-365.8(well)-365.9(calibrated,)-363.8(but)-363(it)-367.5(slightly)-361.1(overestimated)-370.5(the)-365.4(pro-)]TJ 0 -1.2266 TD [(portion)-399.2(of)-406.3(persons)-402.3(with)-401.4(high)-400.4(PPCS)-403.2(at)-397.5(6)-404.2(months)-397.8(\(19%)-401.1(vs.)-401.5(15%;)]TJ 0 -1.2203 TD [(Table)-341.3(5\).)-333.3(The)-335.9(calibration)-343(slope)-334(was)-340.6(close)-336.4(to)-338.2(1,)-331.2(indicating)-338.5(similar)]TJ T* [(effects)-558(of)-551.7(predictors.)-548.4(Discrimination)-559.9(was)-549.2(even)-553(slightly)-550.8(higher)]TJ 0 -1.2266 TD [(than)-352.2(in)-350.8(the)-346.4(development)-354.9(study)-350.5(\(C-index)]TJ /F5 1 Tf 16.566 0 TD (=)Tj /F4 1 Tf .7208 0 TD [(0.76;)-352.7(Table)-347.7(5\))-349.4(because)]TJ -17.2868 -1.2203 TD [(of)-532.8(the)-536.1(somewhat)-537.8(more)-531.4(heterogeneous)-535.9(patient)-538.3(case-mix)-533.2(of)-532.8(the)]TJ T* [(CENTER-TBI)-282.6(study)-281(compared)-281.4(with)-281.3(Nijmegen.)]TJ 1.1128 -1.2203 TD [(Calibration)-427.5(plots)-424.1(are)-429.6(shown)-425.7(in)-426.7(a)-425.6(Figures)-429(S1S7.)-421.3(The)-430.7(perfor-)]TJ -1.1128 -1.2266 TD [(mance)-394(of)-400(models)-393.9(was)-397.5(consistent)-393.8(in)-395.1(analyses)-395.4(after)-397.3(imputation)-396.5(of)]TJ 0 -1.2203 TD [(missing)-352(values,)-357.8(except)-356.1(for)-351.5(models)-356(containing)-353.5(2-week)-355.6(post-injury)]TJ T* [(symptoms,)-518.3(which)-519.5(showed)-522.5(lower)-522.1(performance)-521.5(\(Table)-520.5(S8\).)-521.1(The)]TJ 0 -1.2266 TD [(sensitivity)-373.6(analyses)-376.5(with)-369.8(the)-371.7(additional)-376.4(inclusion)-371.7(criteria)-374.7(used)-374.7(in)]TJ 0 -1.2203 TD [(the)-194.7(development)-196.8(study)-192.5(showed)-193.7(somewhat)-196.3(better)-195.9(performance)-199(of)-191.3(the)]TJ T* [(UPFRONT)-286.4(and)-279.2(Nijmegen)-281.4(models)-280.1(for)-282(PPCS)-276.7(\(Table)-286.5(S9\).)]TJ /F3 1 Tf 0 -2.7568 TD (Discussion)Tj /F4 1 Tf 1.1128 -1.8273 TD [(This)-382.4(study)-382.1(identied)-390.5(predictors)-387.4(and)-380.3(prognostic)-388.7(models)-381.3(for)-383.1(3)]TJ -1.1128 -1.2267 TD [(12)-188.7(month)-188.5(GOSE)-186.4(and)-184.3(PPCS)-188.2(in)-186.4(persons)-193.7(with)-186.4(mild)-186.7(TBI,)-185.6(and)-190.6(examined)]TJ 0 -1.2203 TD [(the)-491.8(performance)-489.9(of)-488.5(ve)-486.4(models)-488.8(for)-490.6(predicting)-488.8(6-month)-487.3(GOSE)]TJ T* [(outcome)-306.1(and)-310.8(three)-306.2(models)-305.4(for)-307.2(predicting)-305.5(6-month)-310.2(PPCS)-302(in)-306.5(an)-304.9(in-)]TJ 0 -1.2266 TD [(dependent)-373.6(data)-367.3(set)-372.9(of)-368.4(mild)-370(TBI)-366.1(patients)-374.6(from)-367.2(the)-371.7(CENTER-TBI)]TJ 27.9978 56.2296 TD [(study.)-473.6(Overall,)-467.2(the)-472.9(denitions)-464.6(of)-469.5(unfavorable)-472.7(outcome)-470.5(differed)]TJ 0 -1.2203 TD [(among)-224.8(studies,)-214.7(and)-222.3(the)-220(ability)-217.4(of)-216.6(the)-220(models)-223.2(to)-218(distinguish)-215.4(between)]TJ 0 -1.2266 TD [(favorable)-347.2(and)-336.1(unfavorable)-346.2(outcome)-337.8(varied)-343.6(substantially)-343.4(\(C-index)]TJ 0 -1.2203 TD [(0.580.79\).)-443.7(The)-443.4(CRASH)-448.5(models)-444.5(predicting)-444.6(severe)-444.4(disability)-442.5(or)]TJ T* [(death)-404.8(discriminated)-403.7(best,)-406.9(but)-400.9(they)-396.5(were)-407.1(poorly)-402(calibrated)-405.2(to)-401.4(the)]TJ 0 -1.2266 TD [(population)-515.4(of)-513.8(mild)-515.5(TBI)-511.5(patients.)-516.6(For)-511.9(prediction)-520.5(of)-513.8(PPCS,)-513.6(the)]TJ 0 -1.2203 TD [(models)-185.3(that)-185.6(included)-179.7(2-week)-184.9(post-injury)-183.8(symptoms)-180.3(showed)-187.3(the)-182(best)]TJ T* [(discriminative)-445.2(ability)-438.7(and)-437.2(were)-438.7(well)-435.4(calibrated.)-439.7(In)-437.9(models)-438.2(with)]TJ 0 -1.2266 TD [(reasonable)-196(discriminative)-192.2(ability,)-195(the)-188.3(most)-190.2(frequent)-193.5(predictors)-191.4(were)]TJ 0 -1.2203 TD [(age,)-189.7(GCS,)-191.4(and)-190.6(extracranial)-194.2(injuries)-185.1(for)-193.4(GOSE,)-189.3(and)-184.3(pre-injury)-190.4(health)]TJ T* [(and)-285.5(post-injury)-278.7(symptoms)-281.4(for)-281.9(PPCS.)]TJ 1.1128 -1.2203 TD [(CRASH)-606.5(models)-608.9(discriminated)-606(well)-606.2(but)-603.2(they)-605.2(largely)-606.4(over-)]TJ -1.1128 -1.2266 TD [(estimated)-310.5(the)-308.5(percentage)-304.7(of)-305.1(persons)-307.5(with)-306.6(poor)-304.1(outcome,)-309.1(and)-304.4(used)]TJ 0 -1.2203 TD [(an)-248(end-point)-242.6(\(GOSE)]TJ /F5 1 Tf 8.4537 0 TD (<)Tj /F4 1 Tf .5564 0 TD [(5\))-241.9(that)-242.5(might)-243.1(not)-242.8(be)-241.7(appropriate)-242.8(for)-244(the)-238.9(mild)]TJ -9.0102 -1.2203 TD [(TBI)-189(population.)-189.6(It)-189(was)-188.8(developed)-190.2(for)-187.1(mostly)-186.9(moderately)-187.3(to)-186.4(severely)]TJ 0 -1.2266 TD [(injured)-439.6(patients,)-440.7(whereas)-447.2(the)-434.9(validation)-439.7(population)-439.6(consisted)-440.8(of)]TJ 0 -1.2203 TD [(mildly)-297.2(injured)-300.5(patients.)-295.3(In)-298.8(the)-295.8(previous)-297.2(external)-298.5(validation)-294.2(in)-300.2(per-)]TJ T* [(sons)-253.3(with)-256(mild)-249.9(TBI,)]TJ 6.7246 0 0 5.9768 384.9448 543.4581 Tm (6)Tj 8.9663 0 0 8.9663 390.5574 539.4896 Tm [(CRASH)-258.8(models)-248.5(showed)-256.9(good)-251(discriminative)]TJ -8.6434 -1.2266 TD [(ability)-520.9(and)-519.4(miscalibration)-514.7(in)-521.5(the)-517.1(population)-515.4(with)-515.2(GCS)-517.3(1314,)]TJ 0 -1.2203 TD [(consistent)-204.1(with)-205.4(this)-197(study,)-201.7(but)-204.9(discriminated)-201.4(poorly)-199.7(in)-199.1(the)-201(total)-201.7(mild)]TJ T* [(TBI)-378.7(population.)-372.9(The)-380.1(Nijmegen)-376.2(model)-374.3(\(2008\))-375.3(for)-370.5(GOSE)-376.1(showed)]TJ T* [(somewhat)-272.2(lower)-275.5(discriminative)-268.1(ability)-274.3(and)-266.5(some)-270.7(overtting)-270(in)-268.6(our)]TJ 0 -1.2266 TD [(study,)-366.1(and)-361.4(low)-359.9(performance)-363.4(in)-363.4(the)-365.4(previous)-360.4(external)-361.8(validation,)]TJ 6.7246 0 0 5.9768 548.844 488.6361 Tm (6)Tj 8.9663 0 0 8.9663 313.0582 473.7259 Tm [(which)-399.3(could)-389.7(be)-393.5(partly)-395.8(because)-399.5(of)-393.6(the)-390.7(high)-394.1(number)-397.6(of)-393.6(candidate)]TJ 0 -1.2203 TD [(predictors)-191.4(and)-184.3(lack)-183.9(of)-185(internal)-186.3(validation)-180.4(in)-186.4(the)-182(model)-184.6(development.)]TJ 0 -1.2266 TD [(The)-373.8(performance)-369.7(of)-368.4(the)-365.4(UPFRONT)-374.9(model)-367.9(could)-370.7(not)-363(completely)]TJ 0 -1.2203 TD [(be)-286(assessed)-280(in)-281.3(the)-283.2(CENTER-TBI)-282.6(data.)]TJ 1.1128 -1.2203 TD [(The)-702.6(model)-703.1(for)-699.3(PPCS)-700.4(based)-705.4(on)-700.9(admission)-701.2(characteristics)]TJ -1.1128 -1.2266 TD [(\(TRACK-TBI,)-411.9(2008\))-404.8(showed)-402.3(poor)-405.3(performance,)-404.3(consistent)-406.4(with)]TJ 0 -1.2203 TD [(the)-333.8(previous)-328.8(external)-330.1(validation.)]TJ 6.7246 0 0 5.9768 431.2062 411.9306 Tm (20)Tj 8.9663 0 0 8.9663 440.844 407.9621 Tm [(A)-331.6(relatively)-330.9(small)-328.9(sample)-333.1(size)]TJ -14.2518 -1.2203 TD [(for)-294.6(the)-289.5(development)-291.7(of)-292.5(the)-289.5(prognostic)-293.9(model,)-288.7(a)-292.8(particularly)-288.2(effec-)]TJ 0 -1.2266 TD [(tive)-375.2(sample)-377.4(size)-374.8(for)-370.5(binary)-372.8(outcome,)-372.3(might)-375.9(have)-375.9(led)-371.7(to)-369.8(unstable)]TJ 0 -1.2203 TD [(regression)-409.9(coefcients,)-409.7(and,)-402.2(consequently,)-405.6(differences)-409.3(in)-401.4(perfor-)]TJ T* [(mance)-273.9(between)-276.7(development)-272.7(and)-266.5(validation)-275.3(studies.)]TJ 6.7246 0 0 5.9768 501.392 368.107 Tm (46)Tj 8.9663 0 0 8.9663 510.5762 364.1385 Tm [(In)-267.2(addition,)]TJ -22.029 -1.2203 TD [(true)-310.6(differences)-308.2(in)-306.5(populations)-307.5(might)-306.3(also)-309.2(have)-306.4(contributed)-311.3(to)-306.5(the)]TJ 0 -1.2266 TD [(differences)-295.5(in)-287.6(the)-283.2(effects)-292.5(of)-286.2(predictors)-286.3(among)-288(studies.)-290.5(The)-285.3(perfor-)]TJ 0 -1.2203 TD [(mance)-457.3(of)-444.2(models)-450.8(containing)-448.3(post-injury)-455.7(symptoms)-445.8(\(UPFRONT)]TJ T* [(2017,)-298.1(Nijmegen,)-290.6(2008\))-297.3(were)-293.3(in)-293.9(line)-293(with)-293.9(their)-295.2(performance)-300.2(in)-293.9(the)]TJ 0 -1.2266 TD [(development)-392.8(studies.)-391.7(Nevertheless,)-389.8(the)-390.7(CENTER-TBI)-390.1(sample)-390(in)]TJ 0 -1.2203 TD [(which)-190.7(these)-184.6(models)-185.3(have)-186.2(been)-186.2(validated)-185.6(\(both)-187.6(23)-181.9(week)-189.5(post-injury)]TJ T* [(symptoms)-420.5(and)-418.3(6-month)-424.1(PCS)-417.7(scores)-417.9(available\))-424.1(had)-418.3(lower)-420.9(injury)]TJ 0 -1.2266 TD [(severity,)-553.1(younger)-551.7(age,)-550.1(lower)-553.7(percentage)-551.3(of)-551.7(CT)-553.6(abnormalities,)]TJ 0 -1.2203 TD [(and)-456.2(higher)-455(GOSE)-458.3(than)-453.4(the)-460.2(overall)-454.7(mild)-452.2(TBI)-460.9(population)-452.2(in)-458.3(the)]TJ T* [(CENTER-TBI)-428(study.)-423(Therefore,)-424.4(the)-416(performance)-426.6(of)-418.9(the)-422.3(models)]TJ T* [(may)-187.9(have)-186.2(been)-186.2(different)-187(in)-186.4(the)-182(total)-189.1(mild)-186.7(CENTER-TBI)-187.8(population.)]TJ 1.1128 -1.2266 TD [(Although)-405.8(post-injury)-398.8(symptoms)-401.6(substantially)-406.7(improve)-401.2(predic-)]TJ -1.1128 -1.2203 TD [(tion)-341.2(of)-336.7(outcomes,)-341.4(they)-333.3(are)-341.1(measured)-339.5(several)-340.4(days)-336.8(or)-336.7(weeks)-342(post-)]TJ ET 62.022 182.608 490.167 .22676 re f 62.022 87.024 490.167 .22675 re f 139.068 163.219 47.452 .22676 re f 193.266 163.219 358.923 .22676 re f 62.022 135.496 490.167 .22681 re f BT /F7 1 Tf 8.9663 0 0 8.9663 82.885 198.2551 Tm (Table)Tj /F4 1 Tf 3.0034 0 TD (5.)Tj /F7 1 Tf 1.2456 0 TD [(Results)-338.6(of)-328.8(External)-334.3(Validation)-335.7(of)-335.1(Models)-331.2(Predicting)-333.8(Persisting)-337.6(Post-Concussive)-336.7(Symptoms)-333.7(\(PPCS\))]TJ -4.2743 -1.1128 TD [(in)-331.6(Patients)-339.7(with)-334.2(Mild)-330.1(Traumatic)-336.3(Injury)-335.6(\(TBI\):)-335.9(Complete)-335.3(Case)-331.3(Analyses)-333.9(in)-331.6(the)-339.8(CENTER-TBI)-333.2(Study)-334.6(\()]TJ /F12 1 Tf 46.2331 0 TD (n)Tj /F5 1 Tf .7777 0 TD (=)Tj /F4 1 Tf .7208 0 TD (1292)Tj /F7 1 Tf 1.998 0 TD (\))Tj /F10 1 Tf -52.0312 -5.1595 TD [(Model)-334.9(for)-332.5(PCS)]TJ 8.5928 2.8263 TD [(Development)-18652.6(Validation)]TJ 2.3142 -2.8263 TD (C)Tj 5.2354 1.1065 TD (Sample/)Tj -1.5049 -1.1065 TD [(outcome)-337.5(events)]TJ 8.928 1.1065 TD (Intercept)Tj -.1012 -1.1065 TD [(\(95%)-331.6(CI\))]TJ 7.6444 1.1065 TD [(Predicted)-340.7(vs.)]TJ -1.2266 -1.1065 TD [(Observed)-337.8(Outcome)-796.1(mbc)-1629.2(C)-333(\(95%)-331.6(CI\))-1639.8(Slope)-339.1(\(95%)-331.6(CI\))]TJ /F4 1 Tf -29.8821 -2.0992 TD [(TRACK)-335.9(TBI)-334.5(Pilot;)]TJ .999 -1.1065 TD (2017)Tj 9.3642 1.1065 TD [(0.74)-3757.3(1292/544)-2143.6(-0.02)-332.4([-0.14,0.10])-922.7(42%;)-333(42%)-4249.6(0.74)-753.9(0.58)-336.6([0.55,0.61])-749.8(0.32)-336.6([0.20,0.43])]TJ -10.3633 -2.2193 TD [(UPFRONT;)-334.2(2018)-3210.1(0.75)-4117.7(408/147)-5729.2(/)-4360(/)-8248.6(0.75)-753.9(0.75)-336.6([0.71,0.80])-749.8(1.02)-336.6([0.78,1.27])]TJ 0 -1.1128 TD [(Nijmegen;)-335.5(2008)]TJ 6.7246 0 0 5.9768 120.9259 97.3417 Tm (a)Tj 8.9663 0 0 8.9663 154.9417 93.3165 Tm [(0.73)-4086.1(403/61)-2650.4(-0.32)-332.4([-0.62,-0.01])-754.1(19%;)-333(15%)-4249.6(0.74)-753.9(0.76)-336.6([0.69,0.82])-749.8(1.03)-336.6([0.77,1.28])]TJ 5.9774 0 0 5.3127 70.0157 78.7464 Tm (a)Tj 7.9702 0 0 7.9702 72.6803 75.1748 Tm [(To)-330(be)-333.4(compara)12.2(ble)-336.9(with)-325.5(other)-329(models,)-327.2(high)-331.6(PCS)-328.4(were)-331.2(set)-331(as)-327.4(end-point)-326.3(instead)-324.4(of)-333.6(low)-329.1(PCS.)]TJ -.3343 -1.1239 TD [(C,)-250.6(concordance;)-249.1(CENTER-TBI)12.3(,)-262.1(Collaborat)10.8(ive)-258.6(Europea)12(n)-261.1(NeuroTrauma)-248.4(Effective)12.6(ness)-260.5(Research)-247.4(in)-257.5(Traumatic)-250.7(Brain)-255.5(Injury;)-252.4(CI,)-251.9(condence)-255.1(interval)11.3(;)-259.6(ED,)]TJ -1.003 -1.1239 TD [(emergency)-328.3(departmen)10.8(t;)-334.3(mbmc,)-321(model)-329.2(based)-331.5(concordan)12.8(ce;)-333(TRACK-TBI,)-325.9(Transformi)11.5(ng)-330.2(Research)-325.6(and)-331.3(Clinical)-329.9(Knowledge)-325.5(in)-328.7(TBI;)-332.4(UPFRO)12.2(NT.)]TJ /F3 1 Tf 8.9663 0 0 8.9663 62.022 749.6502 Tm (202)Tj 46.8781 0 TD (MIKOLIC)Tj 3.7052 .2213 TD ()Tj .8536 -.2213 TD [(ET)-338.7(AL.)]TJ ET endstream endobj 86 0 obj <>stream /GS1 gs BT /F4 1 Tf 8.9663 0 0 8.9663 59.7543 725.7825 Tm 0 0 0 rg 0 Tc 0 Tw [(injury,)-219.3(which)-222.3(does)-223(not)-217.5(routinely)-221.3(happen)-223.2(across)-221.9(hospital)-220.4(centers)-220.3(and)]TJ 0 -1.2203 TD [(for)-269.3(all)-261.9(persons)-269.5(with)-262.3(mild)-268.9(TBI.)-261.5(The)-266.3(majority)-269.6(of)-260.9(centers)-270.9(only)-261.3(follow)]TJ 0 -1.2266 TD [(persons)-421.3(that)-419.5(were)-419.8(admitted)-421.2(to)-420.4(hospital,)-419.3(and)-418.3(frequently)-424.2(schedule)]TJ 0 -1.2203 TD [(appointments)-262.4(a)-254.8(month)-258(or)-260.9(later)-259.6(following)-253.8(injury,)]TJ 6.7246 0 0 5.9768 231.2503 696.8691 Tm (61)Tj 8.9663 0 0 8.9663 240.2645 692.9006 Tm [(when)-256.7(symptoms)]TJ -20.1322 -1.2203 TD [(are)-360.1(already)-358.2(persisting.)-358.9(The)-354.8(clinical)-360.9(applicability)-360.1(of)-355.7(a)-356(model)-355.3(con-)]TJ 0 -1.2266 TD [(taining)-314.6(predictors)-317.9(measured)-314.2(after)-315.1(discharge)-320.5(is)-314.1(therefore)-311.9(debatable)]TJ 0 -1.2203 TD [(for)-300.9(some)-296(hospital)-296.3(settings,)-294.1(and)-298.1(when)-294.6(the)-295.8(intention)-292.3(is)-301.4(to)-293.9(make)-297.3(pre-)]TJ T* [(dictions)-188.8(at)-182.5(the)-188.3(time)-182.8(of)-185(presentation/admission.)-187.4(Symptoms)-184(measured)]TJ 0 -1.2266 TD [(weeks)-405.2(after)-397.3(injury)-399.7(may)-402.8(be)-399.8(particularly)-402.1(helpful)-395.3(for)-402.1(making)-399.1(deci-)]TJ 0 -1.2203 TD [(sions)-301.1(about)-294.9(rehabilitation)-299(and)-298.1(specialized)-304.5(care.)-301.7(A)-293.7(model)-298.4(based)-300.8(on)]TJ T* [(measures)-580.9(of)-577(medical)-578.1(history,)-580.4(injury)-576.8(characteristics,)-583.9(and)-576.3(early)]TJ T* [(symptoms,)-366.6(which)-367.7(are)-366.4(easily)-371.5(obtainable)-368.5(and)-361.4(have)-369.6(shown)-362.5(associa-)]TJ 0 -1.2266 TD [(tions)-411.5(with)-401.4(outcomes)-408(following)-405.6(TBI)-410.3(in)-407.7(previous)-404.7(studies,)-404.4(may)-409.2(be)]TJ 0 -1.2203 TD [(more)-367(universally)-369.4(useful)-367.7(for)-370.5(the)-365.4(early)-369.4(prediction)-368.7(of)-362(outcome.)-372.3(For)]TJ T* [(example,)-545.4(protein)-540.8(biomarkers)-545(are)-543.4(currently)-544.8(considered)-541.3(to)-540.5(have)]TJ 0 -1.2266 TD [(potential)-313.7(for)-307.2(diagnosis)-305.6(and)-304.5(prediction)-311.8(in)-306.5(the)-308.5(context)-306.6(of)-311.4(TBI.)]TJ 6.7246 0 0 5.9768 278.6456 565.3983 Tm (1,62,63)Tj 8.9663 0 0 8.9663 59.7543 550.4313 Tm [(However,)-475.1(their)-478.5(prognostic)-470.9(value)-474.3(for)-471.6(longer-term)-474.1(outcomes)-477.6(fol-)]TJ 0 -1.2203 TD [(lowing)-280.3(mild)-281.5(TBI)-283.9(is)-282.4(yet)-276.9(to)-281.3(be)-279.6(established.)]TJ 1.1128 -1.2266 TD [(In)-279.8(addition)-282.5(to)-281.3(difculties)-283.5(in)-281.3(the)-283.2(selection)-281.7(of)-286.2(appropriate)-280.7(predic-)]TJ -1.1128 -1.2203 TD [(tors,)-192.1(problematic)-197.1(practices)-194.1(and)-197(lack)-190.3(of)-191.3(agreement)-198.8(in)-186.4(assessment)-198(and)]TJ T* [(denition)-350.1(of)-349.4(outcomes)-351.1(hinder)-353.9(development)-348.6(of)-349.4(prognostic)-350.8(models)]TJ T* [(for)-212.4(both)-210.7(GOSE)-211.7(and)-215.9(PPCS.)-210.1(The)-209.4(models)-216.9(for)-206.1(functional)-217(outcome)-211.3(used)]TJ 0 -1.2266 TD [(different)-421(cutoffs)-420.4(of)-418.9(GOSE)-420.4(to)-420.4(dene)-418.3(the)-422.3(end-point,)-416.3(which)-418.3(could)]TJ 0 -1.2203 TD [(partly)-313.6(explain)-319.3(the)-314.8(variability)-313(in)-312.9(performance)-319.1(among)-313.3(them.)-314.4(It)-309.2(may)]TJ T* [(be)-349.2(more)-341.7(difcult)-346.9(to)-344.5(discriminate)-347.3(between)-346.3(persons)-345.4(with)-350.8(mild)-344.7(TBI)]TJ 0 -1.2266 TD [(who)-299(have)-293.7(incomplete)-296.2(and)-291.8(those)-296(who)-292.7(have)-293.7(complete)-293.1(return)-299.6(to)-293.9(pre-)]TJ 0 -1.2203 TD [(injury)-254.3(functioning)-258.3(\(e.g.,)-252.6(GOSE)]TJ /F5 1 Tf 12.6648 0 TD (<)Tj /F4 1 Tf .5564 0 TD [(8\))-254.5(than)-251.1(between)-257.8(persons)-250.6(with)-256(and)]TJ -13.2212 -1.2203 TD [(without)-404(disability)-410.8(\(GOSE)]TJ /F5 1 Tf 10.9513 0 TD (<)Tj /F4 1 Tf .5501 0 TD [(7)-404.2(o)0(r)-400(even)-407.5(GOSE)]TJ /F5 1 Tf 7.4484 0 TD (<)Tj /F4 1 Tf .5501 0 TD (5\),)Tj 6.7246 0 0 5.9768 244.2897 433.8707 Tm (6)Tj 8.9663 0 0 8.9663 251.2629 429.9023 Tm [(and)-405.6(different)]TJ -21.3588 -1.2266 TD [(predictors)-374.8(may)-371.2(be)-368.2(relevant)-368.1(for)-370.5(predicting)-368.7(upper)-369.3(good)-371.1(overall)-372.5(re-)]TJ 0 -1.2203 TD [(covery)-232.1(\(GOSE)]TJ /F5 1 Tf 6.0637 0 TD (=)Tj /F4 1 Tf .7145 0 TD [(8\))-229.3(versus)-225.8(disability/death)-231.1(\(GOSE)]TJ /F5 1 Tf 13.4299 0 TD (<)Tj /F4 1 Tf .5501 0 TD [(5\).)-225.8(In)-229.3(addition,)]TJ -20.7581 -1.2203 TD [(using)-217.7(GOSE)-211.7(as)-211.3(an)-216.4(ordinal)-212(outcome)-217.6(seems)-210.6(to)-218(have)-211.5(added)-211.1(value)-215.1(over)]TJ 0 -1.2266 TD (dichotomization.)Tj 6.7246 0 0 5.9768 120.5858 390.0471 Tm (64)Tj 8.9663 0 0 8.9663 131.1874 386.0219 Tm [(It)-441.9(is)-434.2(of)-437.9(note)-434.4(that)-438.5(the)-434.9(overall)-435.7(utility)-440.3(of)-431.6(using)]TJ -7.9669 -1.2203 TD [(GOSE)-293.9(as)-287.2(an)-292.3(outcome)-293.5(measure)-289.4(in)-287.6(persons)-294.8(with)-287.6(mild)-287.8(TBI)-296.5(has)-286.7(been)]TJ T* [(disputed,)-238.3(because)-241.4(the)-232.6(measure)-238.8(may)-238.4(not)-230.2(be)-235.4(sensitive)-242.5(enough)-233.4(to)-237(cap-)]TJ T* [(ture)-241(different)-243.9(health)-237.6(disturbances)-242(despite)-244.6(good)-238.3(overall)-239.7(functioning.)]TJ 0 -1.2266 TD [(Usage)-354.6(of)-355.7(a)-349.7(broad)-356.7(battery)-353.5(of)-355.7(different)-351.4(measures)-359.6(in)-350.8(CENTER-TBI)]TJ 0 -1.2203 TD [(and)-323.4(TRACK-TBI)-324.7(studies,)-322.2(which)-323.4(cover)-321.1(health-related)-323.7(generic)-326.6(and)]TJ T* [(disease-specic)-298.2(quality)-289.3(of)-286.2(life,)-285.9(return)-293.2(to)-287.6(work)-288.5(and)-285.5(daily)-292.5(activities,)]TJ 0 -1.2266 TD [(and)-506.8(cognitive)-505.7(and)-506.8(psychological)-501(functioning,)-507.8(provide)-505.1(new)-503.8(op-)]TJ 0 -1.2203 TD [(portunities)-453.2(for)-452.7(prognostic)-452(modeling)-452.7(of)-456.9(outcome)-451.6(following)-449.9(mild)]TJ T* (TBI.)Tj 6.7246 0 0 5.9768 76.4787 291.4015 Tm (1,65,66)Tj 8.9663 0 0 8.9663 100.8567 287.433 Tm [(Moreover,)-471.3(composite)-468.5(measures)-467.1(based)-471.5(on)-460.6(several)-473.2(in-)]TJ -4.5841 -1.2266 TD [(struments,)-466.4(and)-456.2(encompassing)-460.3(different)-465.2(symptoms)-458.5(together)-460.5(with)]TJ 0 -1.2203 TD [(global)-627.2(functioning,)-628(have)-628.8(been)-628.8(proposed)-628.3(as)-628.6(an)-627.4(alternative)-630(to)]TJ T* (GOSE.)Tj 6.7246 0 0 5.9768 85.3795 258.5196 Tm (55)Tj 8.9663 0 0 8.9663 95.3575 254.5511 Tm [(Nevertheless,)-364.5(our)-361.5(study)-363.2(conrms)-359(that)-362.6(a)-362.3(signicant)-365.9(per-)]TJ -3.9708 -1.2203 TD [(centage)-294.8(of)-292.5(persons)-294.8(with)-293.9(mild)-294.2(TBI)-290.2(do)-296.2(not)-287.1(return)-293.2(to)-293.9(baseline)-297.1(global)]TJ 0 -1.2266 TD [(functioning)-283.6(6)-277.7(months)-284(post-injury.)]TJ 6.7246 0 0 5.9768 181.3039 236.5795 Tm [(6,)-8.8(8)]TJ 8.9663 0 0 8.9663 69.7323 221.6693 Tm [(Similarly,)-356.9(there)-350.5(is)-352(no)-353.1(agreement)-350.5(regarding)-357.4(the)-352.7(clinical)-354.5(criteria)]TJ -1.1128 -1.2203 TD [(or)-393.6(operational)-395.9(denition)-394.4(of)-387.3(PCS)-392.4(or)-393.6(PPCS.)]TJ 6.7246 0 0 5.9768 217.1905 214.696 Tm (17)Tj 8.9663 0 0 8.9663 227.4519 210.7275 Tm [(The)-392.8(Common)-388.2(Data)]TJ -18.7032 -1.2267 TD [(Elements)-392.9(\(CDEs\))-390.7(initiative,)-393.7(which)-386.7(aims)-394.9(to)-388.7(standardize)-389.2(data)-392.6(col-)]TJ 0 -1.2203 TD [(lection)-215.8(in)-218(TBI,)-217.2(recommends)-215.6(the)-213.6(RPQ)-213.8(for)-218.7(assessing)-217.9(post-concussive)]TJ T* [(symptoms,)-455.1(but)-445.2(does)-450.6(not)-451.5(provide)-448.2(further)-453.4(guidance.)]TJ 6.7246 0 0 5.9768 249.1653 181.8141 Tm (67)Tj 8.9663 0 0 8.9663 259.9369 177.8456 Tm [(For)-448.7(exam-)]TJ -22.3262 -1.2266 TD [(ple,)-602.2(PCS)-601.1(can)-604(be)-602.1(mapped)-599.8(to)-603.7(ICD-10)-598.3(based)-604.3(on)-599.7(several)-606(RPQ)]TJ 0 -1.2203 TD (items,)Tj 6.7246 0 0 5.9768 81.5244 159.874 Tm [(17,20)-9.4(,46,68)]TJ 8.9663 0 0 8.9663 117.6944 155.9055 Tm [(thereby)-457(using)-464.3(different)-465.2(scoring)-462.1(criteria)-463.2(\(mild)-460.7(or)]TJ -6.462 -1.2203 TD [(worse)-519.2(and)-519.4(moderate)-519.3(or)-513.8(worse)-519.2(symptoms\);)-514.7(composed)-517.8(from)-518.9(all)]TJ 0 -1.2266 TD [(RPQ)-523.6(items,)]TJ 6.7246 0 0 5.9768 103.5212 137.9905 Tm (58)Tj 8.9663 0 0 8.9663 114.9165 133.9653 Tm [(or)-520.1(based)-515.7(on)-517.5(a)-520.4(cutoff)-514.5(of)-520.1(the)-517.1(total)-517.9(RPQ)-517.3(score.)]TJ 6.7246 0 0 5.9768 292.1385 137.9905 Tm (69)Tj 8.9663 0 0 8.9663 59.7543 123.0236 Tm [(According)-345.5(to)-344.5(the)-340.1(classication)-349.2(methods)-342.9(and)-342.4(criteria)-343.1(in)-344.5(use,)-340.2(asso-)]TJ 0 -1.2203 TD [(ciations)-513.7(with)-508.9(predictors)-507.6(and)-506.8(other)-506.1(outcome)-508.5(measures)-511.4(\(such)-509.6(as)]TJ T* [(GOSE\))-346.6(vary)-344.5(substantially.)]TJ 6.7246 0 0 5.9768 155.9055 105.1086 Tm (17)Tj 8.9663 0 0 8.9663 165.7133 101.1401 Tm [(In)-343.1(our)-342.6(study,)-340.8(models)-343.3(for)-345.2(PPCS)-340(used)]TJ -11.8175 -1.2266 TD [(different)-408.3(denitions)-407.7(of)-400(outcome)-407.3(and/or)-404.5(different)-408.3(instruments)-403.3(for)]TJ 0 -1.2203 TD [(measuring)-403.8(post-concussive)-406.2(symptoms.)-398.2(Therefore,)-405.4(a)-400.3(sensible)-403.4(and)]TJ T* [(uniform)-293.9(denition)-293.2(of)-292.5(the)-289.5(PCS)-291.3(or)-292.5(PPCS)-289.4(end-point)-293.2(is)-295.1(a)-286.5(prerequisite)]TJ 0 -1.2267 TD [(of)-279.8(a)-286.5(good)-276.3(model.)]TJ 29.117 74.5598 TD [(A)-375.9(limitation)-379.3(of)-381(this)-380.3(study)-375.8(is)-377.3(that)-381.6(some)-378.2(of)-381(the)-378(predictors)-381.1(from)]TJ -1.1128 -1.2203 TD [(validated)-432.2(models)-431.9(were)-438.7(not)-426.2(assessed)-438(in)-433(the)-428.6(CENTER-TBI)-440.7(study)]TJ 0 -1.2266 TD [(\(e.g.,)-309.5(early)-312.5(neck)-306.4(pain)-314.3(and)-310.8(coping)-307(styles\),)-312.1(which)-310.8(prevented)-313(assess-)]TJ 0 -1.2203 TD [(ment)-475.9(of)-475.8(calibration)-475.8(intercepts)-479.8(and)-481.5(could)-471.9(have)-477.1(inuenced)-479.7(other)]TJ T* [(performance)-483.5(indices.)-481.5(Moreover,)-484(some)-485.7(predictors)-482.3(and)-481.5(outcomes)]TJ 0 -1.2266 TD [(were)-394.5(measured)-390(by)-391(different)-395.7(tools)-392.5(and)-393(instruments)-390.7(\(e.g.,)-391.7(medical)]TJ 0 -1.2203 TD [(history,)-314.8(psychological)-311.3(symptoms\).)-318.1(The)-310.6(differences)-320.8(emphasize)-317.5(the)]TJ T* [(importance)-332.7(of)-330.4(incorporating)-331.9(newly)-336.1(discovered)-332.6(predictors)-330.5(into)-334.9(the)]TJ 0 -1.2266 TD [(CDEs)-184.1(and)-178(using)-186.1(uniform)-180.1(instruments)-182(in)-186.4(TBI)-182.7(research.)-185.8(Additionally,)]TJ 0 -1.2203 TD [(the)-403.3(prognostic)-414(models)-406.6(we)-409.4(validated)-406.9(were)-407.1(selected)-413.3(based)-408.2(on)-403.7(our)]TJ T* [(search)-532.9(strategy)-537.6(and)-538.4(eligibility)-537.3(criteria,)-535.7(and)-538.4(do)-530.1(not)-533.7(necessarily)]TJ T* [(represent)-278.8(all)-287.2(existing)-277.3(prognostic)-281.3(models)-280.1(for)-282(mild)-281.5(TBI.)]TJ 1.1128 -1.2266 TD [(Further,)-313.2(a)-311.8(substantial)-315.1(percentage)-317.3(of)-311.4(CENTER-TBI)-314.2(patients)-317.7(did)]TJ -1.1128 -1.2203 TD [(not)-407.2(have)-413.9(an)-412.4(assessment)-413(of)-412.6(23)-409.5(week)-410.9(post-injury)-411.4(symptoms)-407.9(and)]TJ T* [(6-month)-316.6(outcomes;)-329.3(therefore,)-321.1(the)-321.1(models)-324.4(that)-318.3(included)-325.1(23)-321(week)]TJ 0 -1.2266 TD [(symptoms)-414.2(were)-413.5(validated)-413.3(in)-414(a)-412.9(smaller)-415.1(and)-411.9(more)-417.6(favorable)-410.4(sub-)]TJ 0 -1.2203 TD [(sample.)-298.1(The)-297.9(response)-296.8(rate)-294(at)-302.6(6)-290.4(months)-296.7(was,)-299.2(however,)-301.1(in)-293.9(line)-299.4(with)]TJ T* [(that)-438.5(in)-439.3(other)-442.9(observational)-440.4(studies)-439.4(in)-439.3(the)-441.3(eld,)-442.3(and)-437.2(comparable)]TJ 0 -1.2266 TD [(with)-382.4(the)-384.3(response)-391.6(rate)-382.6(in)-388.7(the)-384.4(development)-386.5(studies.)-385.4(Patients)-392.1(with)]TJ 0 -1.2203 TD [(and)-184.3(without)-182.7(6-month)-183.8(RPQ)-182.2(differed)-183.5(in)-186.4(some)-182.2(baseline)-189.6(characteristics,)]TJ T* [(but)-375.6(without)-378.7(a)-381.3(clear)-378.2(pattern)-378.8(that)-381.6(would)-377.9(suggest)-378.4(a)-375(substantial)-384.7(sys-)]TJ T* [(tematic)-234.4(inuence)-239.9(on)-233(the)-232.6(validation)-237.3(results.)-236.2(Further,)-231(CENTER-)-239(TBI)]TJ 0 -1.2266 TD [(core)-524(study)-527.6(included)-527.5(neurotrauma)-533.1(centers,)-526.7(recruitment)-528.5(was)-530.2(not)]TJ 0 -1.2203 TD [(consecutive,)-383.2(and)-374(patients)-380.9(without)-378.7(an)-380.8(indication)-376.4(for)-383.1(CT)-376.6(were)-381.8(not)]TJ T* [(considered)-345.3(eligible.)-342.4(Therefore,)-348.5(the)-346.4(participants)-343.7(might)-344.2(not)-344(be)-342.9(rep-)]TJ 0 -1.2266 TD [(resentative)-273.1(of)-267.2(mild)-268.9(TBI)-271.2(patients)-273.4(in)-268.6(other)-272.2(hospital)-264.7(and)-272.8(non-hospital)]TJ 0 -1.2203 TD [(settings.)-313(The)-310.6(self-report)-316.3(instruments)-314.8(were)-312.3(administered)-318(in)-312.9(several)]TJ T* [(languages)-444.3(and)-449.9(in)-445.6(several)-447.9(European)-445.9(countries,)-451.5(but)-445.2(the)-447.6(linguistic)]TJ 0 -1.2266 TD [(and)-304.5(cultural)-312.8(comparability)-314(was)-308.9(good)-307.9(\(unpublished)-305.6(data\).)-309.1(A)-312.6(major)]TJ 0 -1.2203 TD [(strength)-269.6(of)-267.2(this)-272.8(study)-268.3(is)-269.8(the)-264.2(use)-274(of)-267.2(a)-267.5(large)-274.6(sample)-269.9(of)-267.2(contemporary)]TJ T* [(patients)-248.1(from)-240.7(different)-250.2(countries)-246.2(and)-241.2(numerous)-246.1(medical)-249.4(centers.)-248.5(In)]TJ 0 -1.2266 TD [(addition,)-525.7(all)-533.8(important)-528.4(indices)-535.5(relevant)-526.2(for)-534.9(external)-526.1(validation)]TJ 0 -1.2203 TD [(studies)-281.3(are)-277.9(reported.)]TJ 6.7246 0 0 5.9768 384.0377 379.0487 Tm (70)Tj /F3 1 Tf 8.9663 0 0 8.9663 310.8472 347.6975 Tm (Conclusion)Tj /F4 1 Tf 1.1128 -1.8336 TD [(We)-313.2(assessed)-317.9(the)-314.8(performance)-312.8(of)-317.8(several)-315.2(prognostic)-312.9(models)-318.1(for)]TJ -1.1128 -1.2203 TD [(GOSE)-256(and)-260.2(PPCS.)-254.4(None)-256.7(of)-260.9(the)-257.9(models)-254.8(predicting)-261.2(GOSE)-256(have)-262.1(both)]TJ 0 -1.2266 TD [(good)-371.1(discriminative)-375.6(ability)-375.5(and)-374(good)-371.1(calibration)-374.7(in)-376.1(persons)-377(with)]TJ 0 -1.2203 TD [(mild)-420.6(TBI.)-425.9(Models)-422.7(for)-421.1(PPCS)-422.2(based)-427.2(on)-422.7(admission)-423(characteristics)]TJ T* [(perform)-364.4(poorly,)-360.7(whereas)-365(models)-362.3(that)-362.6(included)-369.4(post-injury)-360.9(symp-)]TJ 0 -1.2266 TD [(toms)-443.1(perform)-446.6(better)-448.8(in)-445.6(terms)-441.3(of)-444.2(discrimination)-449.1(and)-443.6(calibration.)]TJ 0 -1.2203 TD [(TBI-related)-502.8(and)-494.1(psychological)-501(symptoms)-502.7(collected)-497.9(at)-498.6(2)-499(weeks)]TJ T* [(improve)-300(prediction)-305.5(and)-298.1(should)-305.8(be)-298.6(collected)-308.2(when)-300.9(possible.)-302.7(Novel)]TJ 0 -1.2266 TD [(predictors)-355.8(obtainable)-355.9(at)-353.2(admission,)-356.3(such)-355.7(as)-350.4(biomarkers,)-358.3(could)-351.8(be)]TJ 0 -1.2203 TD [(incorporated)-292.9(in)-287.6(future)-293.3(model)-285.7(developments.)-295.3(Future)-289.2(studies)-293.9(should)]TJ T* [(improve)-255.8(prediction)-254.9(following)-253.8(mild)-256.2(TBI)-258.6(by)-251.9(developing)-254.6(models)-254.8(that)]TJ 0 -1.2266 TD [(\(1\))-383.1(distinguish)-386.1(well)-384.9(between)-384.2(persons)-383.4(who)-387.5(will)-380.1(have)-388.6(longer-term)]TJ 0 -1.2203 TD [(negative)-245.3(outcomes)-243.6(and)-241.2(those)-245.5(who)-242.1(will)-247.4(not,)-239.4(\(2\))-244(are)-246.2(calibrated)-247.1(to)-243.3(the)]TJ T* [(population)-249.9(of)-241.9(mild)-249.9(TBI,)-248.9(\(3\))-250.3(use)-248.7(relevant)-247.9(cutoffs)-249.7(and)-247.5(end-points)-249.6(for)]TJ T* [(persons)-282.2(with)-281.3(mild)-281.5(TBI,)-280.5(such)-279.9(as)-280.8(return)-286.9(to)-281.3(normal)-281.5(life)-283(without)-277.5(TBI-)]TJ 0 -1.2266 TD [(related)-261.1(symptoms,)-265.4(and)-260.2(\(4\))-263(use)-261.4(predictors)-261(available)-263.9(at)-264.7(admission)-264.9(or)]TJ 0 -1.2203 TD [(before)-310.6(discharge,)-317.1(which)-310.8(are)-315.8(feasible)-312.4(to)-312.9(collect)-319.4(in)-306.5(clinical)-316.6(practice)]TJ T* [(for)-515.9(early)-527.5(detection)-520.8(of)-520.1(persons)-522.5(with)-521.5(longer-term)-518.4(consequences.)]TJ 0 -1.2266 TD [(These)-313.2(models)-318.1(could)-313.8(be)-311.3(extended)-317.2(with)-312.9(symptoms)-313.1(collected)-314.5(at)-315.3(23)]TJ 0 -1.2203 TD [(weeks)-278.8(for)-282(later)-284.9(stage)-279.5(outcome)-280.9(prediction.)]TJ /F3 1 Tf 0 -3.054 TD (Acknowledgments)Tj /F4 1 Tf 1.1128 -1.8336 TD [(The)-272.7(authors)-278.7(thank)-275.9(the)-276.9(Medical)-284.5(Library)-273.6(of)-279.8(the)-276.9(Erasmus)-279.2(Medical)]TJ -1.1128 -1.2266 TD [(Centre)-531.7(for)-528.5(creating)-526.1(the)-529.8(literature)-529.5(search)-532.9(strategy,)-534.2(and)-525.8(Simone)]TJ 0 -1.2203 TD [(Dijkland)-475.4(and)-468.8(Kelly)-479.2(Foks)-472(for)-471.6(their)-472.2(support)-472.3(in)-477.3(data)-474.8(preparation.)]TJ /F3 1 Tf -28.0042 77.228 TD [(EXTERNAL)-342.3(VALIDATION)-334.1(OF)-337.5(PROGNOSTIC)-332.4(MODELS)-337.7(FOR)-334(MTBI)-22548.5(203)]TJ ET endstream endobj 90 0 obj <>stream /GS1 gs BT /F4 1 Tf 8.9663 0 0 8.9663 62.022 725.7825 Tm 0 0 0 rg 0 Tc 0 Tw [(We)-243.6(are)-239.9(grateful)-241.8(to)-237(all)-242.9(patients)-241.8(and)-234.9(investigators)-247.2(that)-236.1(participated)-243.8(in)]TJ 0 -1.2203 TD [(the)-283.2(CENTER-TBI)-282.6(study.)]TJ /F3 1 Tf 0 -3.0603 TD [(The)-331.9(CENTER-TBI)-340.2(Participants)-336.1(and)-338.2(Investigators)]TJ /F4 1 Tf 1.1128 -1.8336 TD [(Cecilia)-482.2(A)]TJ 3.5345 .2403 TD ()Tj .5185 -.2403 TD [(kerlund,)-482.8(Karolinska)-489.3(Institutet,)-485.9(Stockholm,)-479(Sweden;)]TJ -5.1658 -1.2203 TD [(Krisztina)-386.3(Amrein,)-376.3(University)-383.4(of)-381(Pe)]TJ 14.1823 .0379 TD ()Tj .3857 -.0379 TD [(cs,)-378.6(Pe)]TJ 2.0802 .0379 TD ()Tj .3794 -.0379 TD [(cs,)-384.9(Hungary,)-380.9(Nada)-379.2(An-)]TJ -17.0276 -1.2203 TD [(delic,)-525.5(Oslo)-518.7(University)-528.9(Hospital)-520.9(and)-519.4(University)-528.8(of)-520.1(Oslo,)-521.6(Oslo,)]TJ 0 -1.2266 TD [(Norway;)-214.6(Lasse)-213.2(Andreassen,)-215.9(University)-212.7(Hospital)-211.1(Northern)-213.4(Norway,)]TJ 0 -1.2203 TD [(Tromso,)-576.2(Norway;)-568.6(Audny)-576.3(Anke,)-569.4(University)-579.4(Hospital)-571.5(Northern)]TJ T* [(Norway,)-606(Tromso,)-601.5(Norway;)-606.6(Anna)-604.4(Antoni,)-605.7(Medical)-606.9(University)]TJ 0 -1.2267 TD [(Vienna,)-492.7(Vienna,)-492.7(Austria;)-485.6(Ge)]TJ 11.7669 .0443 TD ()Tj .3857 -.0443 TD [(rard)-486.2(Audibert,)-495.9(University)-490.9(Hospital)]TJ -12.1526 -1.2203 TD [(Nancy,)-229.9(Nancy,)-229.9(France,)-229.7(University)-231.7(Hospital)-230(Nancy,)-236.2(Nancy,)-229.9(France;)]TJ T* [(Philippe)-205.2(Azouvi,)-212.1(Raymond)-203.3(Poincare)-210.9(Hospital,)-207.7(Assistance)-207(Publique)]TJ 0 -1.2266 TD [()-309.3(Hopitaux)-307(de)-304.9(Paris,)-312.8(Paris,)-306.5(France;)-306.2(Maria)-313.2(Luisa)-308.5(Azzolini,)-310.1(S.)-304.5(Raf-)]TJ 0 -1.2203 TD [(faele)-352.9(University)-358.1(Hospital,)-353.1(Milan,)-353.1(Italy;)-355.6(Ronald)-349.7(Bartels,)-356(Radboud)]TJ T* [(University)-200.1(Medical)-208.6(Center,)-199.5(Nijmegen,)-202.1(The)-203.1(Netherlands;)-203.9(Pa)]TJ 23.1545 .0379 TD ()Tj .3857 -.0379 TD [(l)-199.5(Barzo)]TJ 2.4596 .0379 TD ()Tj .4173 -.0379 TD (,)Tj -26.4171 -1.2203 TD [(University)-655.3(of)-659.2(Szeged,)-657.1(Szeged,)-657.1(Hungary;)-659.7(Romuald)-656.2(Beauvais,)]TJ 0 -1.2266 TD [(ARTTIC,)-229.9(Munchen,)-232.7(Germany;)-229.4(Ronny)-229.9(Beer,)-228.1(Medical)-233.9(University)-231.7(of)]TJ 0 -1.2203 TD [(Innsbruck,)-323.5(Innsbruck,)-317.2(Austria;)-321.2(Bo-Michael)-328.3(Bellander,)-318.3(Karolinska)]TJ T* [(University)-471.9(Hospital,)-473.2(Stockholm,)-472.7(Sweden;)-475.2(Antonio)-469.5(Belli,)-474.9(NIHR)]TJ 0 -1.2266 TD [(Surgical)-743.6(Reconstruction)-741.8(and)-734.4(Microbiology)-745.4(Research)-741.4(Centre,)]TJ 0 -1.2203 TD [(Birmingham,)-320.1(UK;)-325.3(Habib)-317.1(Benali,)-321.1(Assistance)-327.1(Publique)-315()-322(Hopitaux)]TJ T* [(de)-191.1(Paris,)-186.3(Paris,)-192.7(France;)-192.4(Maurizio)-189.3(Berardino,)-188(AOU)-191.8(Citta)]TJ 21.441 .0379 TD (`)Tj .5691 -.0379 TD [(della)-193.8(Salute)]TJ -22.0101 -1.2266 TD [(e)-229.6(della)-238.1(Scienza)-230.2(di)-230.7(Torino)-231.1(-)-229.7(Orthopedic)-235.2(and)-234.9(Trauma)-229.2(Center,)-237.5(Torino,)]TJ 0 -1.2203 TD [(Italy;)-298.7(Luigi)-296.3(Beretta,)-294(S.)-298.2(Raffaele)-297.9(University)-294.9(Hospital,)-302.5(Milan,)-296.2(Italy;)]TJ T* [(Morten)-240.8(Blaabjerg,)-242.4(Odense)-240.3(University)-244.3(Hospital,)-239.3(Odense,)-236.9(Denmark;)]TJ 0 -1.2266 TD [(Peter)-349(Bragge,)-353.6(Monash)-349.1(University,)-348.4(Victoria,)-350.6(Australia;)-351.9(Alexandra)]TJ 0 -1.2203 TD [(Brazinova,)-371.2(Trnava)-371.1(University,)-373.7(Trnava,)-367.6(Slovakia;)-371.5(Vibeke)-369.6(Brinck,)]TJ T* [(Quesgen)-619.2(Systems)-614.5(Inc.,)-616.4(Burlingame,)-622.4(California,)-612.9(USA;)-620.6(Joanne)]TJ T* [(Brooker,)-732.7(Monash)-728.5(University,)-734.1(Melbourne,)-731.5(Australia;)-737.6(Camilla)]TJ 0 -1.2266 TD [(Brorsson,)-422.3(Umea)]TJ 6.285 .0316 TD ()Tj .803 -.0316 TD [(University,)-418(Umea)]TJ 6.9046 .0316 TD ()Tj .3857 -.0316 TD [(,)-420.2(Sweden;)-418.3(Andras)-423.9(Buki,)-420.7(Uni-)]TJ -14.3783 -1.2203 TD [(versity)-270.1(of)-273.5(Pe)]TJ 4.7169 .0443 TD ()Tj .3857 -.0443 TD [(cs,)-271.1(Hungary;)-274(Monika)-269.8(Bullinger,)-266.9(Universita)]TJ 16.8885 .019 TD ()Tj .3857 -.019 TD (tsklinikum)Tj -22.3768 -1.2203 TD [(Hamburg-Eppendorf,)-718.4(Hamburg,)-719.5(Germany;)-722.6(Manuel)-721.1(Cabeleira,)]TJ 0 -1.2266 TD [(University)-478.3(of)-475.8(Cambridge,)-479.8(Addenbrookes)-476.1(Hospital,)-479.6(Cambridge,)]TJ 0 -1.2203 TD [(UK;)-192.5(Alessio)-189.8(Caccioppola,)-197(Fondazione)-188.3(IRCCS)-196.3(Ca)]TJ 19.228 .0443 TD (`)Tj .5754 -.0443 TD [(Granda)-191.2(Ospedale)]TJ -19.8034 -1.2203 TD [(Maggiore)-286.5(Policlinico,)-286.6(Milan,)-289.8(Italy;)-286(Emiliana)-288.2(Calappi,)-289(Fondazione)]TJ 0 -1.2266 TD [(IRCCS)-392.3(Ca)]TJ 4.0024 .0443 TD (`)Tj .7777 -.0443 TD [(Granda)-387.2(Ospedale)-397.6(Maggiore)-387.6(Policlinico,)-394.1(Milan,)-391(Italy;)]TJ -4.7801 -1.2203 TD [(Maria)-376.4(Rosa)-379.4(Calvi,)-376.1(S.)-374.1(Raffaele)-373.8(University)-377.1(Hospital,)-378.4(Milan,)-378.4(Italy;)]TJ T* [(Peter)-481.8(Cameron,)-476.8(Monash)-475.6(University,)-481.2(Melbourne,)-478.6(Victoria,)-477.1(Aus-)]TJ 0 -1.2267 TD [(tralia;)-481.7(Guillermo)-481.1(Carbayo)-483(Lozano,)-478.9(Hospital)-476.6(of)-482.2(Cruces,)-481.2(Bilbao,)]TJ 0 -1.2203 TD [(Spain;)-246.4(Marco)-246(Carbonara,)-249.7(Fondazione)-245.2(IRCCS)-246.9(Ca)]TJ 19.1205 .0443 TD (`)Tj .626 -.0443 TD [(Granda)-248.1(Ospedale)]TJ -19.7465 -1.2203 TD [(Maggiore)-191.6(Policlinico,)-191.8(Milan,)-195(Italy;)-191.2(Ana)-187.6(M.)-192.8(Castan)]TJ 19.5188 .0126 TD ()Tj .4173 -.0126 TD (o-Leo)Tj 1.9791 .0379 TD ()Tj .4173 -.0379 TD [(n,)-192.1(Hospital)]TJ -22.3325 -1.2203 TD [(Universitario)-201.3(12)-201.4(de)-203.8(Octubre,)-197.6(Madrid,)-205.7(Spain;)-202.1(Simona)-195.3(Cavallo,)-206.8(AOU)]TJ 0 -1.2266 TD (Citta)Tj 1.5744 .0443 TD (`)Tj .8726 -.0443 TD [(della)-497.3(Salute)-489.1(e)-495.1(della)-491(Scienza)-495.7(di)-489.9(Torino)-490.4(-)-495.3(Orthopedic)-494.4(and)]TJ -2.447 -1.2203 TD [(Trauma)-298.7(Center,)-300.7(Torino,)-297.3(Italy;)-298.7(Giorgio)-295.1(Chevallard,)-305.2(Niguarda)-295.4(Hos-)]TJ T* [(pital,)-362.7(Milan,)-359.4(Italy;)-361.9(Arturo)-357.4(Chieregato,)-362.1(Niguarda)-364.9(Hospital,)-359.4(Milan,)]TJ 0 -1.2266 TD [(Italy;)-311.3(Giuseppe)-312.9(Citerio,)-312.2(Universita)]TJ 13.6701 .0443 TD (`)Tj .6955 -.0443 TD [(Milano)-311.7(Bicocca,)-315.1(Milano,)-308.3(Italy)]TJ -14.3657 -1.2203 TD [(and)-291.8(ASST)-289.2(di)-293.9(Monza,)-290.5(Monza,)-290.5(Italy;)-292.4(Iris)-286.7(Ceyisakar,)-296.5(Erasmus)-291.9(Med-)]TJ T* [(ical)-440.9(Center-University)-449.4(Medical)-442.5(Center,)-439.8(Rotterdam,)-445.9(The)-437(Nether-)]TJ 0 -1.2266 TD [(lands;)-508.2(Hans)-510.8(Clusmann,)-508.1(Aachen)-513.5(University,)-506.5(Aachen,)-510.1(Germany;)]TJ 0 -1.2203 TD [(Mark)-313.6(Coburn,)-304.5(University)-313.9(Hospital)-312.2(of)-305.1(Aachen,)-314(Aachen,)-307.7(Germany;)]TJ T* [(Jonathan)-328.6(Coles,)-322.6(Cambridge)-325.1(University)-326.5(Hospital)-324.9(NHS)-326.2(Foundation)]TJ T* [(Trust,)-311.6(Cambridge,)-309.1(UK;)-312.7(Jamie)-308.3(D.)-315.6(Cooper,)-306.9(Monash)-311.2(University)-313.9(and)]TJ 0 -1.2266 TD [(The)-354.8(Alfred)-353.5(Hospital,)-359.4(Melbourne,)-352.1(Victoria,)-356.9(Australia;)-358.2(Marta)-357.5(Cor-)]TJ 0 -1.2203 TD [(reia,)-379.2(MRC)-381.7(Cognition)-385.4(and)-374(Brain)-384.4(Sciences)-382.6(Unit,)-379(Cambridge,)-385(UK;)]TJ T* [(Amra)-231.2(C)]TJ 2.6746 .2466 TD ()Tj .4995 -.2466 TD (ovic)Tj 1.3468 .0379 TD ()Tj .3794 -.0379 TD [(,)-230.5(Universita)]TJ 4.268 .019 TD ()Tj .3857 -.019 TD [(tsmedizin)-232.2(Go)]TJ 4.9382 .019 TD ()Tj .411 -.019 TD [(ttingen,)-229(Go)]TJ 4.072 .019 TD ()Tj .4173 -.019 TD [(ttingen,)-222.6(Germany;)]TJ -19.3924 -1.2266 TD [(Nicola)-436.9(Curry,)-434(Oxford)-429.2(University)-434(Hospitals)-439.4(NHS)-433.7(Trust,)-431.7(Oxford,)]TJ 0 -1.2203 TD [(UK;)-211.5(Endre)-204.7(Czeiter,)-211.8(University)-212.7(of)-210.3(Pe)]TJ 13.9863 .0443 TD ()Tj .3857 -.0443 TD [(cs,)-207.9(Hungary;)-210.8(Marek)-208(Czosnyka,)]TJ -14.372 -1.2203 TD [(University)-478.3(of)-475.8(Cambridge,)-479.8(Addenbrookes)-476.1(Hospital,)-479.6(Cambridge,)]TJ 0 -1.2266 TD [(UK;)-382.2(Claire)-377.7(Dahyot-Fizelier,)-388.8(CHU)-376.6(Poitiers,)-382.6(Potiers,)-379.1(France;)-382.1(Paul)]TJ 0 -1.2203 TD [(Dark,)-508.8(Salford)-512.6(Royal)-514.6(Hospital)-508.3(NHS)-509.6(Foundation)-510(Trust,)-513.9(Salford,)]TJ 27.9978 74.5598 TD [(UK;)-578.2(Helen)-578.8(Dawes,)-582.2(Oxford)-581(Brookes)-576.6(University,)-576(Oxford,)-577.6(UK;)]TJ 0 -1.2203 TD (Ve)Tj .784 .0379 TD ()Tj .3857 -.0379 TD [(ronique)-201.6(De)-200.7(Keyser,)-195.3(Antwerp)-201.9(University)-206.4(Hospital)-198.4(and)-197(University)]TJ -1.1697 -1.2266 TD [(of)-381(Antwerp,)-381.9(Edegem,)-387.5(Belgium;)-379.2(Vincent)-385.8(Degos,)-380.4(Assistance)-384(Pub-)]TJ 0 -1.2203 TD [(lique)-368.4()-359.9(Hopitaux)-363.9(de)-361.8(Paris,)-363.4(Paris,)-363.4(France;)-363.1(Francesco)-368.1(Della)-361.5(Corte,)]TJ T* [(Maggiore)-261.2(Della)-254(Carita)]TJ 8.6561 .0379 TD (`)Tj 8.9663 0 0 8.9663 396.3967 681.9589 Tm [(Hospital,)-251.9(Novara,)-257.3(Italy;)-254.4(Hugo)-254.3(den)-253.9(Boogert,)]TJ -9.2947 -1.2266 TD [(Radboud)-288.3(University)-288.6(Medical)-290.8(Center,)-288.1(Nijmegen,)-284.3(The)-291.6(Netherlands;)]TJ 0 -1.2203 TD [(Bart)-365.9(Depreitere,)-372(University)-364.5(Hospitals)-369.9(Leuven,)-365(Leuven,)-365(Belgium;)]TJ T* [(ula)-267(ilvesi,)-258.7(University)-263.3(of)-260.9(Novi)-258.3(Sad,)-261.7(Novi)-258.3(Sad,)-261.7(Serbia;)-263.6(Abhishek)]TJ 0 -1.2266 TD [(Dixit,)-426.8(University)-427.7(of)-425.3(Cambridge,)-429.2(Addenbrookes)-425.5(Hospital,)-429(Cam-)]TJ 0 -1.2203 TD [(bridge,)-464.3(UK;)-458.1(Emma)-462.6(Donoghue,)-460(Monash)-456.6(University,)-462.2(Melbourne,)]TJ T* [(Australia;)-307.7(Jens)-300(Dreier,)-301.9(Charite)]TJ 11.963 .0379 TD ()Tj .6829 -.0379 TD [()-303(Universita)]TJ 4.5904 .019 TD ()Tj .3857 -.019 TD [(tsmedizin)-301.7(Berlin,)-302.3(Ber-)]TJ -17.622 -1.2203 TD [(lin,)-249.8(Germany;)-242(Guy-Loup)-242.1(Dulie)]TJ 12.0641 .0379 TD (`)Tj .3857 -.0379 TD [(re,)-240.9(CHR)-245.2(Citadelle,)-247.9(Lie)]TJ 8.6561 .0379 TD (`)Tj .3857 -.0379 TD [(ge,)-244.6(Belgium;)]TJ -21.4916 -1.2266 TD [(Ari)-482.7(Ercole,)-485.5(University)-478.3(of)-482.2(Cambridge,)-479.8(Addenbrookes)-482.4(Hospital,)]TJ 0 -1.2203 TD [(Cambridge,)-720.1(UK;)-717.3(Patrick)-712.5(Esser,)-715.9(Oxford)-720.1(Brookes)-715.7(University,)]TJ T* [(Oxford,)-413.2(UK;)-407.5(Erzse)]TJ 7.5116 .0379 TD ()Tj .3857 -.0379 TD [(bet)-409.6(Ezer,)-406.6(University)-408.7(of)-412.6(Pe)]TJ 10.6288 .0379 TD ()Tj .3857 -.0379 TD [(cs,)-403.9(Pe)]TJ 2.1055 .0379 TD ()Tj .3794 -.0379 TD [(cs,)-410.2(Hungary;)]TJ -21.3967 -1.2266 TD [(Martin)-396.5(Fabricius,)-393.2(Region)-387.6(Hovedstaden)-396.1(Rigshospitalet,)-394.8(Copenha-)]TJ 0 -1.2203 TD [(gen,)-800.6(Denmark;)-804.8(Valery)-802.2(L.)-798.9(Feigin,)-799.4(Auckland)-804.9(University)-800.7(of)]TJ T* [(Technology,)-348.1(Auckland,)-346.3(New)-349(Zealand;)-346.3(Kelly)-346.4(Foks,)-342.2(Erasmus)-348.8(MC,)]TJ 0 -1.2266 TD [(Rotterdam,)-370(the)-359.1(Netherlands;)-368.3(Shirin)-360.4(Frisvold,)-363.5(University)-364.5(Hospital)]TJ 0 -1.2203 TD [(Northern)-377.8(Norway,)-378.3(Tromso,)-373.9(Norway;)-379(Alex)-374.5(Furmanov,)-372.9(Hadassah-)]TJ T* [(Hebrew)-675(University)-668(Medical)-670.2(Center,)-667.4(Jerusalem,)-675.9(Israel;)-667.1(Pablo)]TJ T* [(Gagliardo,)-194.4(Fundacio)]TJ 7.7645 .0379 TD ()Tj .4173 -.0379 TD [(n)-189.2(Instituto)-192.5(Valenciano)-193.2(de)-191.1(Neurorrehabilitacio)]TJ 17.5714 .0379 TD ()Tj .4173 -.0379 TD (n)Tj -26.1705 -1.2266 TD [(\(FIVAN\),)-205.5(Valencia,)-209.7(Spain;)-202.1(Damien)-202.4(Galanaud,)-209.6(Assistance)-207(Publique)]TJ 0 -1.2203 TD [()-492.7(Hopitaux)-496.7(de)-494.6(Paris,)-496.2(Paris,)-489.8(France;)-495.9(Dashiell)-498(Gantner,)-494.8(Monash)]TJ T* [(University,)-323.1(Melbourne,)-320.5(Victoria,)-319(Australia;)-320.3(Guoyi)-314.7(Gao,)-317(Shanghai)]TJ 0 -1.2266 TD [(Renji)-265.7(Hospital,)-258.3(Shanghai)-262.8(Jiaotong)-260.7(University/School)-262.6(of)-260.9(Medicine,)]TJ 0 -1.2203 TD [(Shanghai,)-461.7(China;)-461.2(Pradeep)-460.3(George,)-466(Karolinska)-457.7(Institutet,)-466.9(Stock-)]TJ T* [(holm,)-286.7(Sweden;)-291.9(Alexandre)-291(Ghuysen,)-284.6(CHU,)-291(Lie)]TJ 18.4819 .0379 TD (`)Tj .3857 -.0379 TD [(ge,)-288.9(Belgium;)-290.7(Lelde)]TJ -18.8676 -1.2266 TD [(Giga,)-428(Pauls)-427.4(Stradins)-419.9(Clinical)-426.4(University)-427.7(Hospital,)-422.6(Riga,)-429.4(Latvia;)]TJ 0 -1.2203 TD [(Ben)-631.6(Glocker,)-627.6(Imperial)-624.7(College)-627.5(London,)-625.8(London,)-625.8(UK;)-628.8(Jagos)]TJ 26.316 .0443 TD ()Tj -26.316 -1.2646 TD [(Golubovic,)-391.7(University)-389.7(of)-387.3(Novi)-384.8(Sad,)-388.2(Novi)-391.1(Sad,)-388.2(Serbia;)-390(Pedro)-386.9(A.)]TJ 0 -1.2266 TD [(Gomez,)-524.3(Hospital)-527.2(Universitario)-523.8(12)-523.8(de)-519.9(Octubre,)-526.4(Madrid,)-521.9(Spain;)]TJ 0 -1.2203 TD [(Johannes)-275.2(Gratz,)-274.5(Medical)-271.8(University)-269.6(of)-273.5(Vienna,)-271.4(Austria;)-270.6(Benjamin)]TJ T* [(Gravesteijn,)-327.5(Erasmus)-323.5(Medical)-322.4(Center-University)-322.9(Medical)-322.4(Center,)]TJ T* [(Rotterdam,)-433.3(The)-424.4(Netherlands;)-431.5(Francesca)-433.7(Grossi,)-423.3(Maggiore)-431.9(Della)]TJ 0 -1.2266 TD (Carita)Tj 2.0739 .0443 TD (`)Tj .8346 -.0443 TD [(Hospital,)-441.6(Novara,)-447(Italy;)-450.4(Russell)-444.1(L.)-444.8(Gruen,)-445.1(Medical)-448.9(Uni-)]TJ -2.9085 -1.2203 TD [(versity)-396.5(of)-387.3(Vienna,)-391.5(Austria;)-390.7(Deepak)-393.3(Gupta,)-389.6(All)-389.3(India)-392.3(Institute)-390.9(of)]TJ T* [(Medical)-214.9(Sciences,)-214.8(New)-209.9(Delhi,)-210.2(India;)-212.5(Juanita)-206.7(A.)-214.4(Haagsma,)-210.8(Erasmus)]TJ 0 -1.2266 TD [(Medical)-777.6(Center-University)-784.5(Medical)-771.3(Center,)-781.2(Rotterdam,)-774.7(The)]TJ 0 -1.2203 TD [(Netherlands;)-298.8(Iain)-285.3(Haitsma,)-298.6(Erasmus)-285.5(MC,)-291.9(Rotterdam,)-294.1(The)-291.6(Nether-)]TJ T* [(lands;)-805.4(Raimund)-801.6(Helbok,)-800.1(Medical)-802.9(University)-800.7(of)-798.3(Innsbruck,)]TJ 0 -1.2266 TD [(Innsbruck,)-285.5(Austria;)-283.2(Eirik)-286.2(Helseth,)-282.4(Oslo)-284.8(University)-282.3(Hospital,)-283.5(Oslo,)]TJ 0 -1.2203 TD [(Norway;)-511.7(Lindsay)-509.9(Horton,)-509.4(University)-509.9(of)-507.5(鶹ýAV,)-509.5(鶹ýAV,)-509.5(UK;)]TJ T* [(Jilske)-730.7(Huijben,)-734.1(Erasmus)-728.1(Medical)-733.4(Center-University)-727.6(Medical)]TJ T* [(Center,)-294.4(Rotterdam,)-287.8(The)-285.3(Netherlands;)-292.4(Peter)-285.8(J.)-288.1(Hutchinson,)-291.2(Adden-)]TJ 0 -1.2266 TD [(brookes)-308.4(Hospital)-305.9(and)-304.4(University)-307.5(of)-305.1(Cambridge,)-309.1(Cambridge,)-302.8(UK;)]TJ 0 -1.2203 TD [(Bram)-251.6(Jacobs,)-253.8(University)-244.3(of)-248.2(Groningen,)-251.1(University)-250.6(Medical)-252.8(Center)]TJ T* [(Groningen,)-289.1(Groningen,)-289.1(The)-291.6(Netherlands;)-292.4(Stefan)-285.3(Jankowski,)-288.9(Shef-)]TJ 0 -1.2267 TD [(eld)-414.1(Teaching)-411.8(Hospitals)-414.1(NHS)-408.4(Foundation)-415.2(Trust,)-406.4(Shefeld,)-412.3(UK;)]TJ 0 -1.2203 TD [(Mike)-232.8(Jarrett,)-233.7(Quesgen)-227.2(Systems)-228.8(Inc.,)-230.7(Burlingame,)-230.4(California,)-233.5(USA;)]TJ T* [(Ji-yao)-481.5(Jiang,)-482.3(Shanghai)-477.8(Renji)-480.6(Hospital,)-479.6(Shanghai)-477.8(Jiaotong)-482(Uni-)]TJ 0 -1.2266 TD [(versity/School)-326.3(of)-324.1(Medicine,)-331.2(Shanghai,)-322.6(China;)-328.4(Faye)-323.9(Johnson,)-324.3(Sal-)]TJ 0 -1.2203 TD [(ford)-395.3(Royal)-394.4(Hospital)-400.8(NHS)-395.7(Foundation)-389.9(Trust,)-393.8(Salford,)-395.4(UK;)-394.9(Kelly)]TJ T* [(Jones,)-296.1(Auckland)-292.8(University)-294.9(of)-292.5(Technology,)-297.6(Auckland,)-295.7(New)-292.1(Zeal-)]TJ 0 -1.2266 TD [(and;)-421.8(Mladen)-423.9(Karan,)-422.2(University)-421.4(of)-418.9(Novi)-422.7(Sad,)-419.8(Novi)-416.4(Sad,)-419.8(Serbia;)]TJ 0 -1.2203 TD [(Angelos)-494.4(G.)-492.6(Kolias,)-489.2(Addenbrookes)-495.1(Hospital)-489.3(and)-494.1(University)-490.9(of)]TJ T* [(Cambridge,)-328.1(Cambridge,)-321.7(UK;)-319(Erwin)-323.4(Kompanje,)-324.5(Erasmus)-317.1(Medical)]TJ T* [(Center,)-395.5(Rotterdam,)-395.3(The)-386.5(Netherlands;)-393.6(Daniel)-392.6(Kondziella,)-393.7(Region)]TJ 0 -1.2266 TD [(Hovedstaden)-617.4(Rigshospitalet,)-616.1(Copenhagen,)-617(Denmark;)-615.1(Evgenios)]TJ 0 -1.2203 TD [(Koraropoulos,)-272.4(University)-269.6(of)-267.2(Cambridge,)-271.2(Addenbrookes)-267.4(Hospital,)]TJ T* [(Cambridge,)-448.2(UK;)-439.1(Lars-Owe)-443.7(Koskinen,)-439.9(Umea)]TJ 18.2795 .0316 TD ()Tj .8283 -.0316 TD [(University,)-443.3(Umea)]TJ 6.9299 .0316 TD ()Tj .3794 -.0316 TD (,)Tj -26.4171 -1.2267 TD [(Sweden;)-323.5(Noe)]TJ 5.052 .0443 TD ()Tj .3857 -.0443 TD [(mi)-322.7(Kova)]TJ 3.1615 .0443 TD ()Tj .3857 -.0443 TD [(cs,)-321.7(University)-326.5(of)-317.8(Pe)]TJ 7.7266 .0443 TD ()Tj .3857 -.0443 TD [(cs,)-321.7(Pe)]TJ 2.017 .0443 TD ()Tj .3857 -.0443 TD [(cs,)-321.7(Hungary;)-318.3(Ana)]TJ /F3 1 Tf -47.4977 77.2217 TD (204)Tj 46.8781 0 TD (MIKOLIC)Tj 3.7052 .2213 TD ()Tj .8536 -.2213 TD [(ET)-338.7(AL.)]TJ ET endstream endobj 94 0 obj <>stream /GS1 gs BT /F4 1 Tf 8.9663 0 0 8.9663 59.7543 725.7825 Tm 0 0 0 rg 0 Tc 0 Tw [(Kowark,)-688.2(University)-686.9(Hospital)-691.6(of)-684.5(Aachen,)-687.1(Aachen,)-687.1(Germany;)]TJ 0 -1.2203 TD [(Alfonso)-393.4(Lagares,)-389.7(Hospital)-388.1(Universitario)-391(12)-391(de)-387.1(Octubre,)-387.3(Madrid,)]TJ 0 -1.2266 TD [(Spain;)-366.5(Linda)-370.5(Lanyon,)-362.6(Karolinska)-369.2(Institutet,)-372.1(Stockholm,)-365.2(Sweden;)]TJ 0 -1.2203 TD [(Steven)-194.2(Laureys,)-197.6(University)-193.7(of)-191.3(Lie)]TJ 12.9999 .0443 TD (`)Tj .3857 -.0443 TD [(ge,)-187.7(Lie)]TJ 2.3458 .0443 TD (`)Tj .3857 -.0443 TD [(ge,)-194(Belgium;)-189.5(Fiona)-192.3(Lecky,)]TJ -16.1171 -1.2203 TD [(University)-225.4(of)-216.6(Shefeld,)-222.6(Shefeld,)-222.6(UK,)-217.2(and)-222.3(Salford)-221.8(Royal)-217.4(Hospital,)]TJ 0 -1.2266 TD [(Salford)-285(UK;)-281(Didier)-285.3(Ledoux,)-280.4(University)-282.3(of)-279.8(Lie)]TJ 18.2479 .0443 TD (`)Tj .3794 -.0443 TD [(ge,)-282.6(Lie)]TJ 2.4406 .0443 TD (`)Tj .3857 -.0443 TD [(ge,)-282.6(Belgium;)]TJ -21.4536 -1.2203 TD [(Rolf)-439.3(Lefering,)-436.5(Witten/Herdecke)-446(University,)-436.9(Cologne,)-440.6(Germany;)]TJ T* [(Valerie)-542.6(Legrand,)-544.2(ICON,)-539.7(Paris,)-534.1(France;)-546.5(Aurelie)-540.2(Lejeune,)-535.4(Lille)]TJ 0 -1.2266 TD [(University)-370.8(Hospital,)-365.7(Lille,)-368.9(France;)-369.4(Leon)-367(Levi,)-361.3(Rambam)-367.8(Medical)]TJ 0 -1.2203 TD [(Center,)-711.7(Haifa,)-717.1(Israel;)-711.4(Roger)-709.1(Lightfoot,)-708.5(University)-712.2(Hospitals)]TJ T* [(Southhampton)-386.1(NHS)-383.1(Trust,)-381.2(Southhampton,)-382.7(UK;)-382.2(Hester)-379.8(Lingsma,)]TJ T* [(Erasmus)-399.3(Medical)-404.6(Center-University)-398.8(Medical)-398.3(Center,)-401.9(Rotterdam,)]TJ 0 -1.2266 TD [(The)-247.4(Netherlands;)-254.5(Andrew)-249(I.R.)-246.1(Maas,)-248(Antwerp)-246.2(University)-250.6(Hospital)]TJ 0 -1.2203 TD [(and)-475.2(University)-478.3(of)-469.5(Antwerp,)-476.7(Edegem,)-469.7(Belgium;)-474.1(Marc)-480.4(Maegele,)]TJ T* [(Cologne-Merheim)-610.2(Medical)-606.9(Center)-601.3(\(CMMC\),)-604.1(Witten/Herdecke)]TJ 0 -1.2266 TD [(University,)-221.9(Cologne,)-213(Germany;)-216.7(Marek)-214.4(Majdan,)-218.2(Trnava)-219.3(University,)]TJ 0 -1.2203 TD [(Trnava,)-570(Slovakia;)-567.5(Alex)-564.2(Manara,)-567(Southmead)-569.3(Hospital,)-568.1(Bristol,)]TJ T* [(Bristol,)-595.5(UK;)-597.2(Geoffrey)-600.1(Manley,)-597.6(University)-592.1(of)-596(California,)-600.2(San)]TJ 0 -1.2266 TD [(Francisco,)-347.3(California,)-347.3(USA;)-348.7(Costanza)-348.4(Martino,)-348.4(M.)-344.6(Bufalini)-346.7(Hos-)]TJ 0 -1.2203 TD [(pital,)-546.1(Cesena,)-544.3(Italy;)-539(Hugues)-541.4(Mare)]TJ 14.2582 .0443 TD ()Tj .3857 -.0443 TD [(chal,)-540.9(CHR)-542.4(Citadelle,)-545.1(Lie)]TJ 10.4454 .0443 TD (`)Tj .3794 -.0443 TD (ge,)Tj -25.4687 -1.2203 TD [(Belgium;)-379.2(Julia)-382.3(Mattern,)-382.4(University)-377.1(Hospital)-381.8(Heidelberg,)-379.6(Heidel-)]TJ T* [(berg,)-448.6(Germany;)-450.7(Catherine)-448.2(McMahon,)-448.3(The)-443.4(Walton)-452.1(Centre)-443.2(NHS)]TJ 0 -1.2266 TD [(Foundation)-193.8(Trust,)-191.5(Liverpool,)-188.4(UK;)-192.5(Be)]TJ 14.3404 .0443 TD ()Tj .3857 -.0443 TD [(la)-188.8(Melegh,)-192.9(University)-193.7(of)-185(Pe)]TJ 10.4771 .0443 TD ()Tj .3857 -.0443 TD (cs,)Tj -25.5888 -1.2203 TD (Pe)Tj .6196 .0379 TD ()Tj .3857 -.0379 TD [(cs,)-353.3(Hungary;)-362.5(David)-361.4(Menon,)-357.7(University)-358.1(of)-355.7(Cambridge,)-359.7(Adden-)]TJ -1.0053 -1.2203 TD [(brookes)-403.3(Hospital,)-403.7(Cambridge,)-403.9(UK;)-401.2(Tomas)-402.9(Menovsky,)-395.3(Antwerp)]TJ 0 -1.2266 TD [(University)-219(Hospital)-217.4(and)-215.9(University)-219(of)-216.6(Antwerp,)-217.5(Edegem,)-216.8(Belgium;)]TJ 0 -1.2203 TD [(Ana)-231.9(Mikolic,)-236(Erasmus)-228.6(Medical)-233.9(Center-University)-234.4(Medical)-233.9(Center,)]TJ T* [(Rotterdam,)-332.1(The)-329.6(Netherlands;)-330.4(Benoit)-334.7(Misset,)-329.7(University)-326.5(of)-330.4(Lie)]TJ 25.0893 .0379 TD (`)Tj .3794 -.0379 TD (ge,)Tj -25.4687 -1.2266 TD (Lie)Tj .9611 .0443 TD (`)Tj .3857 -.0443 TD [(ge,)-605(Belgium;)-600.5(Visakh)-608.7(Muraleedharan,)-606.6(Karolinska)-603.1(Institutet,)]TJ -1.3468 -1.2203 TD [(Stockholm,)-365.2(Sweden;)-361.4(Lynnette)-362.9(Murray,)-362.4(Monash)-361.8(University,)-361.1(Mel-)]TJ T* [(bourne,)-498.2(Victoria,)-496(Australia;)-503.7(Ancuta)-496.1(Negru,)-495.7(Emergency)-502(County)]TJ 0 -1.2266 TD [(Hospital)-565.2(Timisoara,)-562.3(Timisoara,)-562.3(Romania;)-561(David)-563.7(Nelson,)-561(Kar-)]TJ 0 -1.2203 TD [(olinska)-324.4(Institutet,)-321.5(Stockholm,)-320.9(Sweden;)-323.5(Virginia)-320(Newcombe,)-326.2(Uni-)]TJ T* [(versity)-364.9(of)-362(Cambridge,)-359.7(Addenbrookes)-362.3(Hospital,)-365.7(Cambridge,)-359.7(UK;)]TJ T* [(Daan)-316(Nieboer,)-311.4(Erasmus)-310.8(Medical)-316.1(Center-University)-310.3(Medical)-316.1(Cen-)]TJ 0 -1.2266 TD [(ter,)-478.4(Rotterdam,)-471.2(The)-475(Netherlands;)-475.8(Jo)]TJ 14.8462 .0443 TD ()Tj .4173 -.0443 TD [(zsef)-474.6(Nyira)]TJ 3.9834 .0443 TD ()Tj .3857 -.0443 TD [(di,)-473.9(University)-471.9(of)]TJ -19.6326 -1.2203 TD (Pe)Tj .6196 .0443 TD ()Tj .3857 -.0443 TD [(cs,)-353.3(Pe)]TJ 2.0486 .0443 TD ()Tj .3857 -.0443 TD [(cs,)-353.3(Hungary;)-356.2(Otesile)-353.1(Olubukola,)-360(University)-351.8(of)-355.7(Shefeld,)]TJ -3.4397 -1.2203 TD [(Shefeld,)-292.2(UK;)-293.7(Matej)-295.7(Oresic,)-294.1(O)]TJ 12.1526 .2276 TD ()Tj .5185 -.2276 TD [(rebro)-296(University,)-291.5(O)]TJ 7.3788 .2276 TD ()Tj .5185 -.2276 TD [(rebro,)-292.6(Sweden;)]TJ -20.5684 -1.2266 TD [(Fabrizio)-288.4(Ortolano,)-287.3(Fondazione)-289.5(IRCCS)-284.8(Ca)]TJ 16.585 .0443 TD (`)Tj .6702 -.0443 TD [(Granda)-292.3(Ospedale)-283.7(Mag-)]TJ -17.2552 -1.2203 TD [(giore)-360.7(Policlinico,)-356.2(Milan,)-359.4(Italy;)-355.6(Aarno)-360(Palotie,)-356.4(University)-358.1(of)-355.7(Hel-)]TJ T* [(sinki,)-306.9(Helsinki,)-308.8(Finland,)-305.7(Massachusetts)-307.7(General)-310.9(Hospital,)-302.5(Boston,)]TJ 0 -1.2266 TD [(MA,)-398(USA,)-398.7(and)-393(The)-399.1(Broad)-393(Institute)-397.3(of)-400(MIT)-393.7(and)-393(Harvard,)-398.5(Cam-)]TJ 0 -1.2203 TD [(bridge,)-388.4(MA,)-391.6(USA;)-386.6(Paul)-388.8(M.)-388.8(Parizel,)-389(University)-389.7(Hospital)-388.1(of)-387.3(Gre-)]TJ T* [(noble,)-221.9(Grenoble,)-222.4(France;)-224(Jean-Franc)]TJ 14.138 0 TD [()-52.7(ois)-218.7(Payen,)-218.9(University)-225.4(Hospital)]TJ -14.138 -1.2203 TD [(of)-754.1(Grenoble,)-753.6(Grenoble,)-759.9(France;)-755.1(Natascha)-754.1(Perera,)-757.1(ARTTIC,)]TJ 0 -1.2266 TD [(Munchen,)-580.4(Germany;)-583.5(Vincent)-575.5(Perlbarg,)-580.7(Assistance)-580(Publique)-580.5()]TJ 0 -1.2203 TD [(Hopitaux)-382.9(de)-387.1(Paris,)-382.3(Paris,)-382.3(France;)-388.4(Paolo)-382(Persona,)-386.1(Azienda)-384.2(Ospe-)]TJ T* [(daliera)-400.2(Universita)]TJ 6.9299 .0379 TD (`)Tj .7777 -.0379 TD [(di)-401.4(Padova,)-395.4(Padova,)-395.4(Italy;)-399.9(Wilco)-402(Peul,)-391.7(Leiden)]TJ -7.7076 -1.2267 TD [(University)-294.9(Medical)-297.1(Center,)-288.1(Leiden,)-293.2(The)-297.9(Netherlands)-288.9(and)-291.8(Medical)]TJ 0 -1.2203 TD [(Center)-398.9(Haaglanden,)-394.4(The)-399.1(Hague,)-394.3(The)-392.8(Netherlands.)-399.3(Anna)-395.8(Piippo-)]TJ T* [(Karjalainen,)-366.6(Helsinki)-356.5(University)-364.5(Central)-358.2(Hospital;)-360(Matti)-360.5(Pirinen,)]TJ 0 -1.2266 TD [(University)-320.2(of)-311.4(Helsinki,)-321.5(Helsinki,)-315.2(Finland;)-312.7(Horia)-319.7(Ples,)-317(Emergency)]TJ 0 -1.2203 TD [(County)-499(Hospital)-501.9(Timisoara,)-505.4(Timisoara,)-499.1(Romania;)-504.1(Suzanne)-501.9(Po-)]TJ T* [(linder,)-354.5(Erasmus)-348.8(Medical)-354(Center-University)-354.5(Medical)-354(Center,)-351.3(Rot-)]TJ 0 -1.2266 TD [(terdam,)-520.8(The)-512.9(Netherlands;)-520.1(Inigo)-510(Pomposo,)-515(Hospital)-520.9(of)-513.8(Cruces,)]TJ 0 -1.2203 TD [(Bilbao,)-590.6(Spain;)-581.5(Jussi)-586.8(P.)-582.7(Posti,)-583.7(Turku)-588(University)-585.8(Hospital)-584.1(and)]TJ T* [(University)-522.5(of)-520.1(Turku,)-521.4(Turku,)-521.4(Finland;)-521.3(Louis)-521.1(Puybasset,)-520.5(Pitie)]TJ 25.4307 .0379 TD ()Tj .9042 -.0379 TD (-)Tj -26.3349 -1.2203 TD (Salpe)Tj 1.8463 .0379 TD ()Tj .3857 -.0379 TD (trie)Tj .9548 .0379 TD (`)Tj .3857 -.0379 TD [(re)-364.5(Teaching)-361.3(Hospital,)-365.7(Assistance)-365(Publique,)-355.8(Ho)]TJ 18.8612 .0379 TD ()Tj .4173 -.0379 TD [(pitaux)-361.6(de)]TJ -22.851 -1.2266 TD [(Paris)-265.6(and)-260.2(University)-263.3(Pierre)-262.6(et)-258.4(Marie)-262.6(Curie,)-260.8(Paris,)-262.2(France;)-262(Andreea)]TJ 0 -1.2203 TD [(Radoi,)-428.9(Vall)-429.1(dHebron)-424.3(Research)-425.3(Institute,)-431.8(Barcelona,)-424.2(Spain;)-429.8(Ar-)]TJ T* [(minas)-362.8(Ragauskas,)-354.3(Kaunas)-360.5(University)-358.1(of)-355.7(Technology)-357.9(and)-361.4(Vilnius)]TJ 0 -1.2267 TD [(University,)-538.1(Vilnius,)-534.5(Lithuania;)-534.3(Rahul)-533.5(Raj,)-531.1(Helsinki)-533.5(University)]TJ 28.0042 74.5598 TD [(Central)-320.3(Hospital;)-322.1(Malinka)-320(Rambadagalla,)-322.6(Rezekne)-320.8(Hospital,)-321.5(Lat-)]TJ 0 -1.2203 TD [(via;)-343.6(Jonathan)-341.3(Rhodes,)-349.7(NHS)-338.8(Lothian)-348.3(and)-342.4(University)-345.5(of)-343.1(Edinburg,)]TJ 0 -1.2266 TD [(Edinburgh,)-276.9(UK;)-281(Sylvia)-278(Richardson,)-281(Cambridge)-287.2(Institute)-277.1(of)-279.8(Public)]TJ 0 -1.2203 TD [(Health,)-224.8(Cambridge,)-220.6(UK;)-224.1(Sophie)-223.4(Richter,)-228.4(University)-225.3(of)-222.9(Cambridge,)]TJ T* [(Addenbrookes)-463.4(Hospital,)-460.6(Cambridge,)-467.2(UK;)-458.1(Samuli)-464.9(Ripatti,)-459(Uni-)]TJ 0 -1.2266 TD [(versity)-529.3(of)-532.7(Helsinki,)-530.1(Helsinki,)-536.5(Finland;)-527.6(Saulius)-531.6(Rocka,)-534.8(Kaunas)]TJ 0 -1.2203 TD [(University)-503.6(of)-501.1(Technology)-503.3(and)-506.8(Vilnius)-500(University,)-506.5(Vilnius,)-502.9(Li-)]TJ T* [(thuania;)-246.9(Cecilie)-248.2(Roe,)-248.9(Oslo)-246.8(University)-250.6(Hospital/University)-250.3(of)-248.2(Oslo,)]TJ 0 -1.2266 TD [(Oslo,)-344.6(Norway;)-353.7(Olav)-342.9(Roise,)-354.3(Oslo)-348(University)-345.5(Hospital,)-353.1(Oslo,)-344.6(Nor-)]TJ 0 -1.2203 TD [(way;)-305(Jonathan)-309.6(Rosand,)-311.8(The)-310.6(Broad)-310.8(Institute,)-305.3(Cambridge)-312.5(MA)-306.5(Har-)]TJ T* [(vard)-275(Medical)-278.1(School)-280.3(and)-272.8(Massachusetts)-282.4(General)-279.3(Hospital,)-277.2(Boston)]TJ T* [(MA,)-429.6(USA;)-430.9(Jeffrey)-434.1(V.)-429.4(Rosenfeld,)-433.2(The)-430.7(Alfred)-435.7(Hospital,)-429(Monash)]TJ 0 -1.2266 TD [(University,)-367.4(Melbourne,)-371.1(Victoria,)-369.6(Australia;)-370.9(Christina)-372.7(Rosenlund,)]TJ 8.9663 0 0 8.9663 310.8472 583.3132 Tm [(Odense)-430(University)-427.7(Hospital,)-429(Odense,)-426.6(Denmark;)-425.4(Guy)-431.8(Rosenthal,)]TJ 0 -1.2203 TD [(Hadassah-Hebrew)-426.9(University)-427.7(Medical)-429.9(Center,)-427.2(Jerusalem,)-423(Israel;)]TJ 0 -1.2266 TD [(Rolf)-300.2(Rossaint,)-301.1(University)-301.2(Hospital)-305.9(of)-298.8(Aachen,)-301.4(Aachen,)-301.4(Germany;)]TJ 0 -1.2203 TD [(Sandra)-275(Rossi,)-277.2(Azienda)-283(Ospedaliera)-278.7(Universita)]TJ 18.2795 .0443 TD (`)Tj .6576 -.0443 TD [(di)-274.9(Padova,)-281.6(Padova,)]TJ -18.9371 -1.2203 TD [(Italy;)-431.5(Daniel)-430.6(Rueckert,)-434.9(Imperial)-435(College)-431.5(London,)-429.8(London,)-429.8(UK;)]TJ 0 -1.2266 TD [(Martin)-232.1(Rusna)]TJ 5.0773 .0443 TD ()Tj .3794 -.0443 TD [(k,)-236.4(International)-230.9(Neurotrauma)-239.3(Research)-235.6(Organisation,)]TJ -5.4567 -1.2203 TD [(Vienna,)-492.7(Austria;)-498.2(Juan)-494.8(Sahuquillo,)-498(Vall)-498.7(dHebron)-493.9(Research)-501.1(In-)]TJ T* [(stitute,)-487.1(Barcelona,)-487.4(Spain;)-486.7(Oliver)-487.7(Sakowitz,)-488(University)-484.6(Hospital)]TJ T* [(Heidelberg,)-329.1(Heidelberg,)-335.4(Germany)-333.3(and)-323.4(Klinik)-334.9(fu)]TJ 19.2153 .0063 TD ()Tj .411 -.0063 TD [(r)-330.9(Neurochirurgie,)]TJ -19.6263 -1.2266 TD [(Klinikum)-280.6(Ludwigsburg,)-286.7(Ludwigsburg,)-280.4(Germany;)-286.3(Renan)-285.3(Sanchez-)]TJ 0 -1.2203 TD [(Porras,)-867.3(Klinik)-866(fu)]TJ 7.5116 .0126 TD ()Tj .4173 -.0126 TD [(r)-868.4(Neurochirurgie,)-869.8(Klinikum)-868.6(Ludwigsburg,)]TJ -7.9289 -1.2203 TD [(Ludwigsburg,)-438.4(Germany;)-438(Janos)-438.6(Sandor,)-433.6(University)-440.3(of)-437.9(Debrecen,)]TJ 0 -1.2266 TD [(Debrecen,)-248.5(Hungary;)-255(Nadine)-249.5(Scha)]TJ 13.0758 .0253 TD ()Tj .3857 -.0253 TD [(fer,)-249.3(Witten/Herdecke)-256.3(University,)]TJ -13.4615 -1.2203 TD [(Cologne,)-883.2(Germany;)-893.3(Silke)-885.5(Schmidt,)-884.6(University)-889.3(Greifswald,)]TJ T* [(Greifswald,)-226.2(Germany;)-223(Herbert)-222.6(Schoechl,)-223.9(AUVA)-226.2(Trauma)-222.8(Hospital,)]TJ 0 -1.2266 TD [(Salzburg,)-306.2(Austria;)-308.5(Guus)-306(Schoonman,)-309(Elisabeth-Twee)-312.5(Steden)-308(Zie-)]TJ 0 -1.2203 TD [(kenhuis,)-329.6(Tilburg,)-332.4(The)-329.6(Netherlands;)-336.7(Rico)-331.7(Frederik)-337.5(Schou,)-330.3(Odense)]TJ T* [(University)-200.1(Hospital,)-195(Odense,)-199(Denmark;)-204.1(Elisabeth)-196.9(Schwendenwein,)]TJ 0 -1.2266 TD [(Medical)-619.6(University)-617.4(Vienna,)-612.8(Vienna,)-619.1(Austria;)-618.3(Charlie)-617.5(Sewalt,)]TJ 0 -1.2203 TD [(Erasmus)-399.3(Medical)-398.3(Center-University)-405.1(Medical)-398.3(Center,)-395.5(Rotterdam,)]TJ T* [(The)-392.8(Netherlands;)-399.9(Toril)-400(Skandsen,)-395.6(Norwegian)-399.4(University)-396.1(of)-393.7(Sci-)]TJ T* [(ence)-327.8(and)-323.4(Technology,)-329.2(NTNU)-323.9(and)-323.4(St.)-327(Olavs)-324.6(Hospital,)-327.8(Trondheim)]TJ 0 -1.2266 TD [(University)-294.9(Hospital,)-296.2(Trondheim,)-295.4(Norway;)-296.8(Peter)-298.5(Smielewski,)-293.4(Uni-)]TJ 0 -1.2203 TD [(versity)-358.6(of)-362(Cambridge,)-359.7(Addenbrookes)-368.6(Hospital,)-359.4(Cambridge,)-366(UK;)]TJ T* [(Abayomi)-275.4(Sorinola,)-276.2(University)-282.3(of)-273.5(Pe)]TJ 14.1507 .0379 TD ()Tj .3857 -.0379 TD [(cs,)-277.4(Pe)]TJ 1.9727 .0379 TD ()Tj .3857 -.0379 TD [(cs,)-277.4(Hungary;)-280.3(Emmanuel)]TJ -16.8948 -1.2266 TD [(Stamatakis,)-488.5(University)-490.9(of)-482.2(Cambridge,)-492.5(Addenbrookes)-488.7(Hospital,)]TJ 0 -1.2203 TD [(Cambridge,)-397.6(UK;)-394.9(Simon)-395.7(Stanworth,)-392.9(Oxford)-397.6(University)-396.1(Hospitals)]TJ T* [(NHS)-187.1(Trust,)-185.1(Oxford,)-185.5(UK;)-186.2(Robert)-187.9(Stevens,)-185.2(Johns)-189.6(Hopkins)-188.5(University)]TJ 0 -1.2266 TD [(School)-242.4(of)-248.2(Medicine,)-249(Baltimore,)-247.6(Maryland,)-245.1(USA;)-247.5(William)-248.2(Stewart,)]TJ 0 -1.2203 TD [(Queen)-334.5(Elizabeth)-330.9(University)-332.8(Hospital)-337.5(and)-329.7(University)-332.8(of)-330.4(Glasgow,)]TJ T* [(Glasgow,)-431(UK;)-426.5(Ewout)-428.3(W.)-428(Steyerberg,)-430.4(Erasmus)-431(Medical)-429.9(Center-)]TJ T* [(University)-313.9(Medical)-322.4(Center,)-313.3(Rotterdam,)-319.4(The)-316.9(Netherlands)-314.2(and)-317.1(Lei-)]TJ 0 -1.2266 TD [(den)-437.2(University)-434(Medical)-436.2(Center,)-439.8(Leiden,)-438.6(The)-437(Netherlands;)-437.9(Nino)]TJ 0 -1.2203 TD [(Stocchetti,)-355.1(Milan)-350.2(University,)-348.4(and)-355(Fondazione)-352.7(IRCCS)-348(Ca)]TJ 22.9838 .0379 TD (`)Tj .7335 -.0379 TD (Granda)Tj -23.7172 -1.2203 TD [(Ospedale)-441.8(Maggiore)-444.5(Policlinico,)-438.4(Milano,)-441.1(Italy;)-444.1(Nina)-444.1(Sundstro)]TJ 25.2158 .019 TD ()Tj .4173 -.019 TD (m,)Tj -25.6331 -1.2267 TD (Umea)Tj 2.0107 .0316 TD ()Tj .9484 -.0316 TD [(University,)-569.7(Umea)]TJ 7.0564 .0316 TD ()Tj .3794 -.0316 TD [(,)-565.7(Sweden;)-570.1(Anneliese)-565.5(Synnot,)-565.3(Monash)]TJ -10.3949 -1.2203 TD [(University,)-361(Melbourne,)-364.8(Australia)-367.4(and)-361.4(La)-368(Trobe)-362.8(University,)-361.1(Mel-)]TJ T* [(bourne,)-352.8(Australia;)-364.6(Riikka)-353.7(Takala,)-358.8(Turku)-360.4(University)-358.1(Hospital)-356.5(and)]TJ 0 -1.2266 TD [(University)-193.7(of)-191.3(Turku,)-192.6(Turku,)-192.6(Finland;)-192.5(Vikto)]TJ 16.6229 .0443 TD ()Tj .4173 -.0443 TD [(ria)-190.9(Tama)]TJ 3.1615 .0443 TD ()Tj .3857 -.0443 TD [(s,)-187(University)-200.1(of)]TJ -20.5874 -1.2203 TD (Pe)Tj .6133 .0443 TD ()Tj .3857 -.0443 TD [(cs,)-460.8(Pe)]TJ 2.1561 .0443 TD ()Tj .3857 -.0443 TD [(cs,)-460.8(Hungary;)-463.7(Tomas)-459.8(Tamosuitis,)-467.2(Kaunas)-461.6(University)-465.6(of)]TJ -3.5408 -1.2203 TD [(Health)-310.4(Sciences,)-316(Kaunas,)-312.8(Lithuania;)-319.4(Mark)-313.6(Steven)-308(Taylor,)-318.7(Trnava)]TJ 0 -1.2266 TD [(University,)-253.6(Trnava,)-253.8(Slovakia;)-251.4(Braden)-249.5(Te)-254.2(Ao,)-251.8(Auckland)-254.8(University)]TJ 0 -1.2203 TD [(of)-488.5(Technology,)-487.3(Auckland,)-491.7(New)-494.4(Zealand;)-491.7(Olli)-487.6(Tenovuo,)-488.6(Turku)]TJ T* [(University)-206.4(Hospital)-204.8(and)-197(University)-206.4(of)-204(Turku,)-205.2(Turku,)-198.9(Finland;)-205.2(Alice)]TJ T* [(Theadom,)-431.3(Auckland)-438.2(University)-434(of)-431.6(Technology,)-436.7(Auckland,)-434.8(New)]TJ 0 -1.2266 TD [(Zealand;)-276.8(Matt)-281.1(Thomas,)-278.8(Southmead)-278.5(Hospital,)-283.5(Bristol,)-279.3(Bristol,)-279.3(UK;)]TJ 0 -1.2203 TD [(Dick)-393.5(Tibboel,)-389.1(Erasmus)-393(Medical)-392(Center,)-395.5(Sophia)-387.8(Childrens)-396.1(Hos-)]TJ T* [(pital,)-362.7(Rotterdam,)-363.7(The)-361.2(Netherlands;)-368.3(Marjolein)-363.6(Timmers,)-364.4(Erasmus)]TJ 0 -1.2267 TD [(Medical)-531.1(Center,)-534.6(Rotterdam,)-534.4(The)-531.9(Netherlands;)-532.7(Christos)-532.3(Tolias,)]TJ /F3 1 Tf -28.0042 77.228 TD [(EXTERNAL)-342.3(VALIDATION)-334.1(OF)-337.5(PROGNOSTIC)-332.4(MODELS)-337.7(FOR)-334(MTBI)-22548.5(205)]TJ ET endstream endobj 98 0 obj <>stream /GS1 gs BT /F4 1 Tf 8.9663 0 0 8.9663 62.022 725.7825 Tm 0 0 0 rg 0 Tc 0 Tw [(Kings)-575.1(College)-570.6(London,)-575.2(London,)-568.9(UK;)-578.2(Tony)-566.9(Trapani,)-579.8(Monash)]TJ 0 -1.2203 TD [(University,)-221.9(Melbourne,)-225.7(Victoria,)-224.1(Australia;)-225.5(Cristina)-221.4(Maria)-224.7(Tudora,)]TJ 0 -1.2266 TD [(Emergency)-539.9(County)-530.6(Hospital)-539.9(Timisoara)-534.1(,)-534(Timisoara,)-537(Romania;)]TJ 0 -1.2203 TD [(Peter)-576.7(Vajkoczy,)-582.7(Charite)]TJ 9.8764 .0443 TD ()Tj .9611 -.0443 TD [()-574.9(Universita)]TJ 4.8686 .019 TD ()Tj .3857 -.019 TD [(tsmedizin)-580(Berlin,)-574.2(Berlin,)]TJ -16.0918 -1.2203 TD [(Germany;)-305.2(Shirley)-305.4(Vallance,)-304.6(Monash)-304.9(University,)-304.1(Melbourne,)-307.9(Vic-)]TJ 0 -1.2266 TD [(toria,)-304.4(Australia;)-301.3(Egils)-297.5(Valeinis,)-304.9(Pauls)-300.9(Stradins)-299.8(Clinical)-306.3(University)]TJ 0 -1.2203 TD [(Hospital,)-391(Riga,)-385.2(Latvia;)-386.3(Zolta)]TJ 11.5456 .0443 TD ()Tj .3794 -.0443 TD .3852 Tc [(nV)385.2(a)]TJ 1.6692 .0443 TD 0 Tc ()Tj .3857 -.0443 TD [(mos,)-385.5(University)-389.7(of)-387.3(Pe)]TJ 8.7509 .0443 TD ()Tj .3857 -.0443 TD [(cs,)-384.9(Pe)]TJ 2.0802 .0443 TD ()Tj .3857 -.0443 TD (cs,)Tj -25.5825 -1.2203 TD [(Hungary;)-217.1(Mathieu)-218.8(van)-215.9(der)-212.2(Jagt,)-217.2(Erasmus)-216(MC)-213.1()-214.5(University)-219(Medical)]TJ 0 -1.2266 TD [(Center)-297.8(Rotterdam,)-294.1(Rotterdam,)-294.1(The)-291.6(Netherlands;)-298.8(Gregory)-292(Van)-295.1(der)]TJ 0 -1.2203 TD [(Steen,)-406.3(Antwerp)-397.9(University)-408.7(Hospital)-400.8(and)-399.3(University)-402.4(of)-406.3(Antwerp,)]TJ T* [(Edegem,)-254.8(Belgium;)-259.1(Joukje)-251.3(van)-253.9(der)-256.5(Naalt,)-250.6(University)-257(of)-254.5(Groningen,)]TJ T* [(University)-465.6(Medical)-467.8(Center)-468.5(Groningen,)-466.1(Groningen,)-466.1(The)-462.3(Nether-)]TJ 0 -1.2266 TD [(lands;)-236.3(Jeroen)-233.3(T.J.M.)-230.3(van)-234.9(Dijck,)-235.5(Leiden)-233.4(University)-238(Medical)-233.9(Center,)]TJ 0 -1.2203 TD [(Leiden,)-457.6(The)-462.3(Netherlands)-459.6(and)-456.2(Medical)-461.5(Center)-462.2(Haaglanden,)-464(The)]TJ T* [(Hague,)-236.2(The)-234.7(Netherlands;)-235.5(Thomas)-238(A.)-233.4(van)-234.9(Essen,)-232.7(Leiden)-239.7(University)]TJ 0 -1.2266 TD [(Medical)-518.4(Center,)-515.7(Leiden,)-514.5(The)-512.9(Netherlands)-516.5(and)-513.1(Medical)-512.1(Center)]TJ 0 -1.2203 TD [(Haaglanden,)-312.2(The)-310.6(Hague,)-305.8(The)-310.6(Netherlands;)-311.4(Wim)-311.5(Van)-307.8(Hecke,)-314.5(ico-)]TJ T* [(Metrix)-548.3(NV,)-546(Leuven,)-548.4(Belgium;)-543.6(Caroline)-547.4(van)-551(Heugten,)-542.8(Oxford)]TJ 0 -1.2266 TD [(Brookes)-260.4(University,)-259.9(Oxford,)-255.1(UK;)-255.8(Dominique)-259.5(Van)-257.2(Praag,)-259.4(Antwerp)]TJ 0 -1.2203 TD [(University)-611(Hospital,)-606(Edegem,)-608.8(Belgium;)-606.9(Thijs)-613.6(Vande)-606.4(Vyvere,)]TJ T* [(icoMetrix)-528(NV,)-527(Leuven,)-523.1(Belgium;)-524.7(Roel)-527.7(P.J.)-523.1(van)-525.8(Wijk,)-523.1(Leiden)]TJ T* [(University)-294.9(Medical)-290.8(Center,)-294.4(Leiden,)-293.2(The)-291.6(Netherlands)-295.2(and)-291.8(Medical)]TJ 0 -1.2266 TD [(Center)-436.9(Haaglanden,)-445(The)-437(Hague,)-438.6(The)-437(Netherlands;)-437.9(Alessia)-445.1(Var-)]TJ 0 -1.2203 TD [(giolu,)-539.6(ASST)-542.1(di)-540.5(Monza,)-543.5(Monza,)-543.5(Italy;)-545.3(Emmanuel)-543(Vega,)-540.2(Lille)]TJ T* [(University)-655.3(Hospital,)-656.6(Lille,)-653.4(France;)-654(Kimberley)-650.2(Velt,)-653.3(Erasmus)]TJ 0 -1.2266 TD [(Medical)-777.6(Center-University)-778.2(Medical)-777.6(Center,)-774.9(Rotterdam,)-781(The)]TJ 0 -1.2203 TD [(Netherlands;)-488.4(Jan)-489(Verheyden,)-492.2(icoMetrix)-490(NV,)-489.1(Leuven,)-485.2(Belgium;)]TJ T* [(Paul)-635.4(M.)-635.4(Vespa,)-642.1(University)-636.3(of)-640.2(California,)-638.2(Los)-631.8(Angeles,)-638.8(Los)]TJ 0 -1.2266 TD [(Angeles,)-449.1(California,)-448.5(USA;)-449.9(Anne)-446.4(Vik,)-445.1(Norwegian)-450(University)-446.7(of)]TJ 0 -1.2203 TD [(Science)-514.7(and)-513.1(Technology,)-512.5(NTNU,)-510.2(Trondheim,)-516.7(Norway)-514.5(and)-506.8(St.)]TJ T* [(Olavs)-299.3(Hospital,)-296.2(Trondheim)-292.5(University)-294.9(Hospital,)-296.2(Trondheim,)-295.4(Nor-)]TJ 0 -1.2266 TD [(way;)-431.4(Rimantas)-429.4(Vilcinis,)-433(Kaunas)-430(University)-434(of)-431.6(Health)-430.6(Sciences,)]TJ 0 -1.2203 TD [(Kaunas,)-243.3(Lithuania;)-237.2(Victor)-241.1(Volovici,)-238.1(Erasmus)-241.3(MC,)-235(Rotterdam,)-243.6(The)]TJ T* [(Netherlands;)-286.1(Nicole)-278.8(von)-283.1(Steinbu)]TJ 12.7849 .0126 TD ()Tj .4173 -.0126 TD [(chel,)-281.7(Universita)]TJ 6.0004 .019 TD ()Tj .3857 -.019 TD [(tsmedizin)-282.8(Go)]TJ 4.9888 .019 TD ()Tj .411 -.019 TD (ttin-)Tj -24.9881 -1.2203 TD [(gen,)-339(Go)]TJ 2.839 .019 TD ()Tj .4173 -.019 TD [(ttingen,)-342.8(Germany;)-336.9(Daphne)-346.6(Voormolen,)-336.9(Erasmus)-342.4(Medical)]TJ -3.2563 -1.2266 TD [(Center-University)-411.4(Medical)-410.9(Center,)-408.2(Rotterdam,)-414.3(The)-405.4(Netherlands;)]TJ 0 -1.2203 TD [(Petar)-260.5(Vulekovic,)-261.3(University)-263.3(of)-254.5(Novi)-264.6(Sad,)-255.4(Novi)-258.3(Sad,)-261.7(Serbia;)-263.6(Kevin)]TJ T* [(K.W.)-490.6(Wang,)-485.9(University)-490.9(of)-488.5(Florida,)-485.4(Gainesville,)-493.3(Florida,)-491.7(USA;)]TJ 0 -1.2266 TD [(Eveline)-546.7(Wiegers,)-551.5(Erasmus)-551.1(Medical)-550(Center-University)-550.5(Medical)]TJ 0 -1.2203 TD [(Center,)-269.1(Rotterdam,)-262.5(The)-266.3(Netherlands;)-267.1(Guy)-267.4(Williams,)-264.4(University)-269.6(of)]TJ T* [(Cambridge,)-498.8(Addenbrookes)-507.7(Hospital,)-498.5(Cambridge,)-498.8(UK;)-502.3(Lindsay)]TJ 0 -1.2266 TD [(Wilson,)-548.6(University)-554.1(of)-545.4(鶹ýAV,)-547.4(鶹ýAV,)-553.7(UK;)-546.6(Stefan)-550.9(Winzeck,)]TJ 0 -1.2203 TD [(University)-478.3(of)-475.8(Cambridge,)-479.8(Addenbrookes)-476.1(Hospital,)-479.6(Cambridge,)]TJ T* [(UK;)-432.8(Stefan)-430.7(Wolf,)-433.2(Charite)]TJ 10.4581 .0379 TD ()Tj .8157 -.0379 TD [()-429.5(Universita)]TJ 4.7232 .019 TD ()Tj .3857 -.019 TD [(tsmedizin)-428.2(Berlin,)-435.1(Berlin,)]TJ -16.3827 -1.2203 TD [(Germany;)-204.1(Zhihui)-194.6(Yang,)-202.7(University)-200.1(of)-197.6(Florida,)-200.8(Gainesville,)-202.4(Florida,)]TJ 0 -1.2266 TD [(USA;)-544.7(Peter)-545(Yle)]TJ 6.481 .0443 TD ()Tj .3857 -.0443 TD [(n,)-539.9(VTT)-545.2(Technical)-544.3(Research)-545.4(Centre,)-547.3(Tampere,)]TJ -6.8667 -1.2203 TD [(Finland;)-736.3(Alexander)-739.9(Younsi,)-735.6(University)-743.8(Hospital)-735.9(Heidelberg,)]TJ T* [(Heidelberg,)-461.8(Germany;)-457(Frederick)-459.6(A.)-454.7(Zeiler,)-457.9(University)-459.3(of)-456.9(Cam-)]TJ 0 -1.2267 TD [(bridge,)-198.7(Addenbrookes)-204.2(Hospital,)-201.3(Cambridge,)-201.6(UK)-195.3(and)-203.3(University)-200.1(of)]TJ 0 -1.2203 TD [(Manitoba,)-398.3(Winnipeg,)-397.1(MB,)-399.4(Canada;)-398.3(Veronika)-402.9(Zelinkova,)-396.9(Trnava)]TJ T* [(University,)-323.1(Trnava,)-323.4(Slovakia;)-320.9(Agate)-325.9(Ziverte,)-324.6(Pauls)-319.9(Stradins)-318.8(Clin-)]TJ 0 -1.2266 TD [(ical)-573.7(University)-573.1(Hospital,)-574.4(Riga,)-574.9(Latvia;)-576(and)-570(Tommaso)-576.1(Zoerle,)]TJ 0 -1.2203 TD [(Fondazione)-472.9(IRCCS)-468.2(Ca)]TJ 9.2314 .0443 TD (`)Tj .8536 -.0443 TD [(Granda)-469.4(Ospedale)-473.4(Maggiore)-476.2(Policlinico,)]TJ -10.085 -1.2203 TD [(Milan,)-283.5(Italy.)]TJ /F3 1 Tf 0 -3.0603 TD [(Ethical)-337.7(Approval)]TJ /F4 1 Tf 1.1128 -1.8336 TD [(The)-203.1(CENTER-TBI)-206.7(study)-205.1(\(EC)-201.7(grant)-202.6(602150\))-207.8(has)-198.1(been)-205.2(conducted)]TJ -1.1128 -1.2203 TD [(in)-306.5(accordance)-309.4(with)-306.6(all)-312.5(relevant)-304.8(laws)-312.5(of)-305.1(the)-308.5(European)-306.8(Union)-308.4(if)-302.8(di-)]TJ T* [(rectly)-404.6(applicable)-402.5(or)-400(of)-400(direct)-404.6(effect)-399.2(and)-399.3(all)-401(relevant)-406(laws)-401(of)-400(the)]TJ 0 -1.2266 TD [(country)-309.1(where)-311.8(the)-314.8(recruiting)-308.1(sites)-313.9(were)-312.3(located,)-312(including)-307.3(but)-312.4(not)]TJ 0 -1.2203 TD [(limited)-322.1(to,)-322.1(the)-321.1(relevant)-323.8(privacy)-324.2(and)-323.4(data)-323(protection)-324.4(laws)-325.1(and)-317.1(reg-)]TJ 27.9978 74.5598 TD [(ulations)-233.1(\(the)-234.7()54.8(Privacy)-230(Law)50.7(\),)-228.5(the)-232.6(relevant)-235.3(laws)-230.3(and)-228.6(regulations)-236.6(on)]TJ 0 -1.2203 TD [(the)-346.4(use)-343.6(of)-343.1(human)-344.9(materials,)-347.6(and)-342.4(all)-344.1(relevant)-349.1(guidance)-342.5(relating)-344.4(to)]TJ 0 -1.2266 TD [(clinical)-215.4(studies)-211.8(from)-209.1(time)-214.4(to)-205.4(time)-214.4(in)-211.7(force)-209.9(including,)-209(but)-211.2(not)-211.2(limited)]TJ 0 -1.2203 TD [(to,)-435.9(the)-434.9(ICH)-432.8(Harmonised)-438.2(Tripartite)-432(Guideline)-439.4(for)-433.7(Good)-431.3(Clinical)]TJ T* [(Practice)-305.8(\(CPMP/ICH/135/95\))-300.4(\()52.7(ICH)-302.1(GCP)56(\))-301.4(and)-298.1(the)-302.2(World)-297(Med-)]TJ 0 -1.2266 TD [(ical)-339.7(Association)-339.7(Declaration)-344.7(of)-330.4(Helsinki)-343.9(entitled)-333.2()54.8(Ethical)-337.9(Princi-)]TJ 0 -1.2203 TD [(ples)-302.9(for)-300.9(Medical)-303.4(Research)-298.8(Involving)-303.4(Human)-297.7(Subjects)52.4(.)-295.9(Informed)]TJ T* [(consent)-310.1(by)-302.5(the)-308.5(patients)-305(and/or)-309.6(the)-302.2(legal)-307.6(representative/next)-309.9(of)-305.1(kin)]TJ 0 -1.2266 TD [(was)-378.5(obtained,)-372.3(according)-376.2(to)-376.1(the)-371.7(local)-377.2(legislations,)-378.5(for)-370.5(all)-375.7(patients)]TJ 0 -1.2203 TD [(recruited)-401.8(in)-388.7(the)-397(core)-391.2(data)-398.9(set)-391.9(of)-393.6(CENTER-TBI)-396.4(and)-393(documented)]TJ T* [(in)-350.8(the)-346.4(electronic)-348.2(case)-354.2(report)-343.8(form)-348.2(\(e-CRF\).)-352.9(Ethical)-348.4(approval)-349(was)]TJ T* [(obtained)-293.5(for)-294.6(each)-289.8(recruiting)-295.4(site.)-290.8(The)-291.6(list)-289.5(of)-286.2(sites,)-297.8(ethical)-287.8(commit-)]TJ 0 -1.2266 TD [(tees,)-377.7(approval)-374.3(numbers,)-376(and)-367.7(approval)-374.3(dates)-374.3(can)-376.4(be)-374.5(found)-373.2(on)-372.1(the)]TJ 0 -1.2203 TD [(Web)-287.4(site)-281.6(https://www.centertbi.eu/project/ethical-approval)]TJ /F3 1 Tf 0 -2.4596 TD [(Funding)-340.9(Information)]TJ /F4 1 Tf 1.1128 -1.8336 TD [(The)-538.2(authors)-537.9(Mikolic)]TJ 8.3715 .0443 TD ()Tj .3857 -.0443 TD [(,)-540.4(Polinder,)-535.5(Steyerberg,)-537.9(Retel)-540(Helmrich,)]TJ -9.8701 -1.2203 TD [(Maas,)-323.8(Voormolen,)-324.2(Steinbuechel,)-320.9(Wilson,)-321(and)-317.1(Lingsma)-323.7(were)-318.6(sup-)]TJ T* [(ported)-720.6(by)-713.5(the)-719.5(European)-717.8(Union)-719.4(7th)-717(Framework)-719.2(programme)]TJ 0 -1.2266 TD [(\(EC)-498.9(grant)-487.1(602150\).)-495.3(Additional)-491.1(support)-491.3(was)-492.3(obtained)-495.8(from)-493.7(the)]TJ 0 -1.2203 TD [(Hannelore)-512.3(Kohl)-504.9(Stiftung)-508.9(\(Germany\),)-511.2(OneMind)-506.5(\(USA\),)-504.1(Integra)]TJ T* [(LifeSciences)-705.7(Corporation)-697.9(\(USA\),)-700.1(and)-696.5(Neurotrauma)-700.8(Sciences)]TJ 0 -1.2266 TD (\(USA\).)Tj /F3 1 Tf 0 -2.4596 TD [(Author)-338.7(Disclosure)-336.7(Statement)]TJ /F4 1 Tf 1.1128 -1.8336 TD [(No)-280.5(competing)-283.9(nancial)-281.9(interests)-283.1(exist.)]TJ /F3 1 Tf -1.1128 -2.4533 TD [(Supplementary)-341.9(Material)]TJ /F4 1 Tf 1.1128 -1.8336 TD [(Supplementary)-285.6(Figure)-282.9(S1)]TJ 0 -1.2267 TD [(Supplementary)-285.6(Figure)-282.9(S2)]TJ 0 -1.2203 TD [(Supplementary)-285.6(Figure)-282.9(S3)]TJ T* [(Supplementary)-285.6(Figure)-282.9(S4)]TJ 0 -1.2266 TD [(Supplementary)-285.6(Figure)-282.9(S5)]TJ 0 -1.2203 TD [(Supplementary)-285.6(Figure)-282.9(S6)]TJ T* [(Supplementary)-285.6(Figure)-282.9(S7)]TJ 0 -1.2266 TD [(Supplementary)-285.6(Table)-278.1(S1)]TJ 0 -1.2203 TD [(Supplementary)-285.6(Table)-278.1(S2)]TJ T* [(Supplementary)-285.6(Table)-278.1(S3)]TJ T* [(Supplementary)-285.6(Table)-278.1(S4)]TJ 0 -1.2266 TD [(Supplementary)-285.6(Table)-278.1(S5)]TJ 8.9663 0 0 8.9663 323.0361 270.5952 Tm [(Supplementary)-285.6(Table)-278.1(S6)]TJ 0 -1.2203 TD [(Supplementary)-285.6(Table)-278.1(S7)]TJ 0 -1.2266 TD [(Supplementary)-285.6(Table)-278.1(S8)]TJ 0 -1.2203 TD [(Supplementary)-285.6(Table)-278.1(S9)]TJ /F3 1 Tf -1.1128 -2.4596 TD (References)Tj /F4 1 Tf 7.9702 0 0 7.9702 317.0834 200.7496 Tm [(1.)-494.8(Maas,)-409.9(A.I.R.,)-405.7(Menon,)-403.5(D.K.,)-410.3(Adelson,)-402.4(P.D.,)-412.7(Andelic,)-402.9(N.,)-410.9(Bell,)-415.2(M.J.,)]TJ 1.2448 -1.131 TD [(Belli,)-276.5(A.,)-275.8(Bragge,)-278.4(P.,)-278.2(Brazinova,)-273.9(A.,)-275.8(Bu)]TJ 15.6204 .0142 TD ()Tj .4126 -.0142 TD [(ki,)-277.8(A.,)-282.9(Chesnut,)-269.4(R.M.,)-281.1(Citerio,)]TJ -16.033 -1.1239 TD [(G.,)-339.8(Coburn,)-343.1(M.,)-343.5(Cooper,)-339.2(D.J.,)-337.9(Crowder,)-343.1(A.T.,)-336.5(Czeiter,)-347.7(E.,)-344.2(Czosnyk)12.5(a,)]TJ T* [(M.,)-400.4(Diaz-Arr)10.7(astia,)-405.7(R.,)-398.9(Dreier,)-399(J.P.,)-397.2(Duhaime,)-393.7(A.-C.,)-399.6(Ercole,)-400(A.,)-396.7(van)]TJ T* [(Essen,)-342.5(T.A.,)-336.5(Feigin,)-340.1(V.L.,)-343.6(Gao,)-347(G.,)-339.8(Giacino,)-338.9(J.,)-345.6(Gonzalez-L)10.9(ara,)-351.1(L.E.,)]TJ T* [(Gruen,)-374.7(R.L.,)-374.2(Gupta,)-376.9(D.,)-382.5(Hartings,)-373.7(J.A.,)-373.4(Hill,)-379.9(S.,)-377.7(Jiang,)-375.6(J.-y.,)-379.3(Kethar-)]TJ T* [(anathan,)-412.2(N.,)-425.1(Kompanje)12.8(,)-425.7(E.J.O.,)-419.9(Lanyon,)-416.3(L.,)-422.4(Laureys,)-414.9(S.,)-420.4(Lecky,)-414.5(F.,)]TJ 0 -1.131 TD [(Levin,)-480.9(H.,)-489.2(Lingsma,)-481.4(H.F.,)-483.8(Maegele,)-485.7(M.,)-485.8(Majdan,)-481.3(M.,)-485.8(Manley,)-481.3(G.,)]TJ 0 -1.1239 TD [(Marstelle)9.9(r,)-391.5(J.,)-381.1(Mascia,)-386.1(L.,)-379.8(McFadyen,)-380.1(C.,)-384.7(Mondello,)-372.9(S.,)-384.9(Newcombe,)]TJ T* [(V.,)-346.9(Palotie,)-346.9(A.,)-346.9(Parizel,)-340.8(P.M.,)-345.3(Peul,)-345.8(W.,)-352.6(Piercy,)-341.1(J.,)-352.7(Polinder,)-339.4(S.,)-349.3(Puy-)]TJ T* [(basset,)-313.9(L.,)-322.9(Rasmussen,)-311.5(T.E.,)-319.6(Rossaint,)-316.8(R.,)-313.5(Smielewski,)-312.3(P.,)-320.8(So)]TJ 24.5332 .0213 TD ()Tj .4197 -.0213 TD (derberg,)Tj -24.9529 -1.1239 TD [(J.,)-473.6(Stanworth,)-467.8(S.J.,)-475.4(Stein,)-470.2(M.B.,)-473.1(von)-477.5(Steinbu)]TJ 18.5226 .0071 TD ()Tj .4126 -.0071 TD [(chel,)-472.1(N.,)-474.9(Stewart,)-475.2(W.,)]TJ -18.9352 -1.1239 TD [(Steyerberg,)-282.5(E.W.,)-278.2(Stocchetti,)-285.4(N.,)-290(Synnot,)-281.5(A.,)-282.9(Te)-290.5(Ao,)-289(B.,)-285.1(Tenovuo,)-279.1(O.,)]TJ T* [(Theadom)11.9(,)-482.7(A.,)-474.9(Tibboel,)-475.2(D.,)-474.9(Videtta,)-479.6(W.,)-473.6(Wang,)-478.7(K.K.W.,)-472.3(Williams,)]TJ 0 -1.131 TD [(W.H.,)-352(Wilson,)-348.6(L.,)-358.4(Yaffe,)-352.8(K.,)-361.1(Adams,)-347.5(H.,)-354(Agnoletti,)-349.8(V.,)-361.1(Allanson)12.7(,)-361.7(J.,)]TJ 0 -1.1239 TD [(Amrein,)-331.9(K.,)-339.8(Andaluz,)-340.4(N.,)-339.8(Anke,)-337.8(A.,)-339.8(Antoni,)-334.5(A.,)-339.8(van)-338.4(As,)-339.9(A.B.,)-341.4(Audi-)]TJ T* [(bert,)-230.5(G.,)-233.1(Azas)]TJ 5.1357 .0427 TD ()Tj .3557 -.0427 TD [(evac,)-235(A.,)-233.1(Azouvi,)-225.4(P.,)-235.5(Azzolini,)-228.6(M.L.,)-233.5(Baciu,)-232.9(C.,)-235.3(Badenes,)]TJ /F3 1 Tf 8.9663 0 0 8.9663 62.022 749.6502 Tm (206)Tj 46.8781 0 TD (MIKOLIC)Tj 3.7052 .2213 TD ()Tj .8536 -.2213 TD [(ET)-338.7(AL.)]TJ ET endstream endobj 104 0 obj <>stream /GS1 gs BT /F4 1 Tf 7.9702 0 0 7.9702 73.7008 726.1793 Tm 0 0 0 rg 0 Tc 0 Tw [(R.,)-320.6(Barlow,)-311.8(K.M.,)-314.4(Bartels,)-317.2(R.,)-320.7(Bauerfeind,)-317.9(U.,)-318.4(Beaucham)9.8(p,)-324.1(M.,)-315(Beer,)]TJ 0 -1.1239 TD [(D.,)-439.4(Beer,)-446.2(R.,)-441.6(Belda,)-446.3(F.J.,)-439.8(Bellander,)-443.1(B.-M.,)-438.9(Bellier,)-442.5(R.,)-441.6(Benali,)-442.7(H.,)]TJ T* [(Benard,)-314(T.,)-322.9(Beqiri,)-322(V.,)-325.6(Beretta,)-319.2(L.,)-322.9(Bernard,)-315.3(F.,)-328(Bertolini)13.4(,)-326.2(G.,)-325.6(Bilotta,)]TJ 0 -1.131 TD [(F.,)-271(Blaabjerg,)-272.4(M.,)-272.4(den)-274.4(Boogert,)-271.6(H.,)-275.8(Boutis,)-273.9(K.,)-275.8(Bouzat,)-266.4(P.,)-278.2(Brooks,)-266.1(B.,)]TJ 0 -1.1239 TD [(Brorsson,)-508.4(C.,)-512.7(Bullinger)11.9(,)-518.2(M.,)-514.2(Burns,)-510(E.,)-514.9(Calappi,)-511.8(E.,)-514.9(Cameron,)-507.5(P.,)]TJ T* [(Carise,)-448.8(E.,)-450.9(Castan)]TJ 7.1345 .0142 TD ()Tj .4126 -.0142 TD (o-Leo)Tj 1.9703 .0427 TD ()Tj .4197 -.0427 TD [(n,)-452.1(A.M.,)-449.6(Causin,)-449.3(F.,)-456(Chevallar)11.1(d,)-459.2(G.,)-453.6(Chier-)]TJ -9.937 -1.1239 TD [(egato,)-278(A.,)-282.9(Christie,)-274.8(B.,)-278(Cnossen,)-279.2(M.,)-279.5(Coles,)-273.6(J.,)-281.6(Collett,)-277.9(J.,)-281.6(Della)-280(Corte,)]TJ T* [(F.,)-328(Craig,)-332.7(W.,)-324.2(Csato,)-330.5(G.,)-332.7(Csomos,)-324.3(A.,)-332.7(Curry,)-327.3(N.,)-332.7(Dahyot-Fi)14.8(zelier,)-330.8(C.,)]TJ T* [(Dawes,)-385.3(H.,)-389.6(DeMatteo,)-388.9(C.,)-391.8(Depreitere)8.8(,)-397.3(B.,)-391.8(Dewey,)-384.1(D.,)-389.6(van)-395.3(Dijck,)-389.6(J.,)]TJ T* [(ilvesi,)-513.2(.,)-524.7(Dippel,)-515.6(D.,)-524.7(Dizdarevic)12.2(,)-525.3(K.,)-524.7(Donoghue,)-514.4(E.,)-522(Duek,)-515.6(O.,)]TJ 0 -1.131 TD (Dulie)Tj 1.8352 .0427 TD (`)Tj .3841 -.0427 TD [(re,)-271.7(G.-L.,)-273.8(Dzeko,)-267.8(A.,)-268.7(Eapen,)-272.2(G.,)-268.6(Emery,)-268.8(C.A.,)-270.3(English,)-266.9(S.,)-271(Esser,)]TJ -2.2193 -1.1239 TD [(P.,)-228.4(Ezer,)-235(E.,)-230.4(Fabricius,)-227.9(M.,)-229.7(Feng,)-233.5(J.,)-231.8(Fergusson,)-228.9(D.,)-233.1(Figaji,)-224.8(A.,)-233.1(Fleming,)]TJ T* [(J.,)-452.3(Foks,)-452(K.,)-453.6(Francony,)-445.2(G.,)-453.6(Freedman,)-444.8(S.,)-456(Freo,)-450.3(U.,)-453.6(Frisvold,)-451.2(S.K.,)]TJ T* [(Gagnon,)-568.4(I.,)-575.4(Galanaud,)-576.2(D.,)-574.5(Gantner,)-571.4(D.,)-581.6(Giraud,)-570.3(B.,)-576.7(Glocker,)-571.4(B.,)]TJ T* [(Golubov)13.5(ic,)-579.8(J.,)-580.3(Go)]TJ 7.3052 .0427 TD ()Tj .4197 -.0427 TD [(mez)-579.9(Lo)]TJ 2.9448 .0427 TD ()Tj .4197 -.0427 TD [(pez,)-575.3(P.A.,)-576.3(Gordon,)-575.7(W.A.,)-572.5(Gradisek,)-570.5(P.,)]TJ -11.0894 -1.1239 TD [(Gravel,)-438.3(J.,)-445.2(Griesdale,)-442.1(D.,)-439.4(Grossi,)-441.4(F.,)-448.9(Haagsma)11.9(,)-447.1(J.A.,)-444.6(Ha)]TJ 23.2173 .0285 TD ()Tj .3841 -.0285 TD [(berg,)-438.3(A.K.,)]TJ -23.6014 -1.131 TD [(Haitsma)11(,)-269.3(I.,)-262.4(Van)-262.7(Hecke,)-263.9(W.,)-260.2(Helbok,)-253.9(R.,)-263.7(Helseth,)-261.8(E.,)-266(van)-260.2(Heugten,)-255(C.,)]TJ 0 -1.1239 TD [(Hoedemae)12(kers,)-567.5(C.,)-569.6(Ho)]TJ 9.2969 .0213 TD ()Tj .4126 -.0213 TD [(fer,)-571.8(S.,)-569.8(Horton,)-559.9(L.,)-571.8(Hui,)-562.8(J.,)-573.2(Huijben,)-563.3(J.A.,)]TJ -9.7094 -1.1239 TD [(Hutchins)12.7(on,)-250.9(P.J.,)-247.8(Jacobs,)-244.2(B.,)-249.5(van)-245.9(der)-249.3(Jagt,)-242.5(M.,)-251(Jankow)12.7(ski,)-248.5(S.,)-249.7(Janssens,)]TJ T* [(K.,)-510.5(Jelaca,)-511.2(B.,)-512.7(Jones,)-513.4(K.M.,)-506.5(Kamnitsas,)-511.3(K.,)-510.5(Kaps,)-509.7(R.,)-512.7(Karan,)-513(M.,)]TJ T* [(Katila,)-431.9(A.,)-432.3(Kaukone)12.7(n,)-437.9(K.-M.,)-429.6(De)-428.3(Keyser,)-433.9(V.,)-432.3(Kivisaari,)-430.3(R.,)-427.3(Kolias,)]TJ T* [(A.G.,)-268(Kolumba)]TJ 5.7901 .0427 TD ()Tj .3841 -.0427 TD [(n,)-267.2(B.,)-270.9(Kolundz)]TJ 5.5127 .0285 TD ()Tj .3841 -.0285 TD [(ija,)-270.3(K.,)-268.7(Kondziella,)-270.3(D.,)-268.7(Koskinen,)-265.1(L.-O.,)]TJ -12.071 -1.1239 TD (Kova)Tj 1.7712 .0356 TD ()Tj .3841 -.0356 TD [(cs,)-255.3(N.,)-254.4(Kramer,)-247.6(A.,)-247.3(Kutsogiannis,)-240.8(D.,)-254.4(Kyprianou,)-243.9(T.,)-251.7(Lagares,)-247.4(A.,)]TJ -2.1553 -1.131 TD [(Lamontagne,)-281.3(F.,)-292.4(Latini,)-290.9(R.,)-299.3(Lauzier)10.3(,)-297.7(F.,)-292.4(Lazar,)-293(I.,)-298(Ledig,)-288.8(C.,)-292.2(Lefering,)]TJ 0 -1.1239 TD [(R.,)-334.9(Legrand,)-335.5(V.,)-339.8(Levi,)-340.7(L.,)-337.1(Lightfoot,)-334.6(R.,)-334.9(Lozano,)-334.2(A.,)-339.8(MacDonald,)-331.4(S.,)]TJ T* [(Major,)-241.7(S.,)-249.7(Manara,)-247.6(A.,)-254.4(Manhes,)-242.2(P.,)-249.7(Mare)]TJ 15.9548 .0427 TD ()Tj .3841 -.0427 TD [(chal,)-244.5(H.,)-254.4(Martino,)-243.2(C.,)-249.5(Masala,)]TJ -16.3389 -1.1239 TD [(A.,)-268.7(Masson,)-268.6(S.,)-271(Mattern,)-267.7(J.,)-274.4(McFadyen,)-259.2(B.,)-278(McMahon,)-259.4(C.,)-270.9(Meade,)-274.7(M.,)]TJ T* [(Melegh,)-730.3(B.,)-733.2(Menovsky,)-732.7(T.,)-735.4(Moore,)-734.1(L.,)-735.4(Morgado)-730.9(Correia,)-733.5(M.,)]TJ T* [(Morganti)13.9(-Kossmann,)-343.8(M.C.,)-345.1(Muehlan,)-344.1(H.,)-346.9(Mukherjee,)-339.4(P.,)-349.3(Murray,)-344.2(L.,)]TJ 0 -1.131 TD [(van)-267.3(der)-270.7(Naalt,)-271.9(J.,)-267.3(Negru,)-268(A.,)-268.7(Nelson,)-269.3(D.,)-268.7(Nieboer,)-265.5(D.,)-275.8(Noirhom)13.7(me,)-271.8(Q.,)]TJ 0 -1.1239 TD (Nyira)Tj 1.885 .0427 TD ()Tj .3841 -.0427 TD [(di,)-427.2(J.,)-416.7(Oddo,)-419.9(M.,)-421.7(Okonkwo,)-409.1(D.O.,)-417.4(Oldenbeuving)11.9(,)-425.8(A.W.,)-416(Orto-)]TJ -2.2691 -1.1239 TD [(lano,)-312.4(F.,)-313.7(Osmond,)-313.8(M.,)-315(Payen,)-312.9(J.-F.,)-313.1(Perlbarg,)-311.9(V.,)-318.4(Persona,)-313.3(P.,)-313.7(Pichon,)]TJ T* [(N.,)-311.3(Piippo-Kar)13.5(jalainen,)-307.5(A.,)-311.3(Pili-Floury,)-306.8(S.,)-306.6(Pirinen,)-313(M.,)-307.9(Ple,)-312.3(H.,)-311.3(Poca,)]TJ T* [(M.A.,)-392.7(Posti,)-404.2(J.,)-395.4(Van)-404.9(Praag,)-394.5(D.,)-403.8(Ptito,)-394.4(A.,)-403.8(Radoi,)-400.4(A.,)-396.7(Ragauskas,)-395.3(A.,)]TJ T* [(Raj,)-297.9(R.,)-306.4(Real,)-299(R.G.L.,)-302.5(Reed,)-300.5(N.,)-304.2(Rhodes,)-294.4(J.,)-302.9(Robertson,)-297.1(C.,)-299.3(Rocka,)-298.5(S.,)]TJ T* [(Re,)-313.6(C.,)-313.5(Rise,)-316.3(O.,)-318.4(Roks,)-309.5(G.,)-318.4(Rosand,)-315.7(J.,)-317.1(Rosenfe)13.1(ld,)-320.5(J.V.,)-316.5(Rosenlund,)]TJ 0 -1.131 TD [(C.,)-306.4(Rosenthal,)-302.5(G.,)-304.2(Rossi,)-307.1(S.,)-306.6(Ruecker)11(t,)-308.4(D.,)-311.3(de)-304.9(Ruiter,)-307.8(G.C.W.,)-303.8(Sacchi,)]TJ 0 -1.1239 TD [(M.,)-258.1(Sahakian,)-258.5(B.J.,)-261.8(Sahuquill)15.1(o,)-267.2(J.,)-260.2(Sakowitz,)-256.3(O.,)-261.5(Salvato,)-255.9(G.,)-261.5(Sa)]TJ 25.2018 .0427 TD ()Tj .3841 -.0427 TD (nchez-)Tj -25.5859 -1.1239 TD [(Porras,)-244.4(R.,)-249.5(Sa)]TJ 5.0788 .0427 TD ()Tj .3841 -.0427 TD [(ndor,)-243(J.,)-253.1(Sangha,)-246.8(G.,)-254.4(Scha)]TJ 9.937 .0213 TD ()Tj .3841 -.0213 TD [(fer,)-251.7(N.,)-247.3(Schmidt,)-249.1(S.,)-249.7(Schneider,)]TJ -15.784 -1.1239 TD [(K.J.,)-288.1(Schnyer,)-290.8(D.,)-290(Scho)]TJ 9.0479 .0213 TD ()Tj .4126 -.0213 TD [(hl,)-292(H.,)-297.1(Schoonman,)-279.6(G.G.,)-289.4(Schou,)-288.3(R.F.,)-294(Sir,)-291.2(O)]TJ 17.7757 .2276 TD ()Tj .5193 -.2276 TD (.,)Tj -27.7555 -1.1239 TD [(Skandsen,)-236.7(T.,)-237.5(Smeets,)-242.9(D.,)-240.2(Sorinola,)-232.7(A.,)-247.3(Stamataki)12.3(s,)-247(E.,)-244.6(Stevanov)13.9(ic,)-245.5(A.,)]TJ T* [(Stevens,)-336.8(R.D.,)-341.4(Sundstro)]TJ 9.2969 .0213 TD ()Tj .4197 -.0213 TD [(m,)-341.8(N.,)-339.8(Taccone,)-345.6(F.S.,)-336.9(Takala,)-343(R.,)-342(Tanskanen,)]TJ -9.7165 -1.131 TD [(P.,)-328(Taylor,)-325.7(M.S.,)-331.1(Telgmann,)-324.9(R.,)-327.8(Temkin,)-325.8(N.,)-332.7(Teodorani,)-322.7(G.,)-332.7(Thomas,)]TJ 0 -1.1239 TD [(M.,)-414.6(Tolias,)-414.5(C.M.,)-416.2(Trapani,)-412.2(T.,)-415.3(Turgeon,)-417.6(A.,)-418(Vajkocz)11(y,)-423.7(P.,)-413.3(Valadka,)]TJ T* [(A.B.,)-384.1(Valeinis,)-379.1(E.,)-386.9(Vallance,)-385.9(S.,)-384.9(Va)]TJ 14.4112 .0427 TD ()Tj .3841 -.0427 TD [(mos,)-381.6(Z.,)-394(Vargio)12(lu,)-391.6(A.,)-382.5(Vega,)-390.8(E.,)]TJ -14.7953 -1.1239 TD [(Verheyden,)-251.9(J.,)-260.2(Vik,)-264(A.,)-254.4(Vilcinis,)-260.6(R.,)-256.6(Vleggeert-Lan)8.1(kamp,)-260.6(C.,)-256.6(Vogt,)-262(L.,)]TJ T* [(Volovici,)-246.7(V.,)-254.4(Voormolen,)-247.5(D.C.,)-256(Vulekovic,)-249.4(P.,)-256.8(Vande)-254.6(Vyvere,)-254.9(T.,)-251.7(Van)]TJ T* [(Waesbergh)10.5(e,)-426.9(J.,)-416.7(Wessels,)-420.8(L.,)-422.4(Wildschut,)-415.2(E.,)-422.4(Williams,)-419.3(G.,)-418(Winkler,)]TJ T* [(M.K.L.,)-261.3(Wolf,)-264(S.,)-263.9(Wood,)-262.1(G.,)-261.5(Xirouchaki)11.5(,)-269.3(N.,)-268.7(Younsi,)-259(A.,)-268.7(Zaaroor,)-260.6(M.,)]TJ 0 -1.131 TD [(Zelinkova,)-438.7(V.,)-446.5(Zemek,)-446.5(R.,)-448.7(and)-452.2(Zumbo,)-440(F.)-449.9(\(2017\).)-448.5(Traumati)13.6(c)-456.4(brain)]TJ 0 -1.1239 TD [(injury:)-254.6(integrated)-258(approaches)-252.7(to)-264.6(improve)-257.3(preventio)11.9(n,)-260.1(clinical)-264.4(care,)-259.7(and)]TJ T* [(research)10(.)-333.3(Lancet)-329.8(Neurol.)-328.4(16,)-329.1(9871048.)]TJ -1.2519 -1.1239 TD [(2.)-501.9(Steyerberg,)-360.8(E.W.,)-363.6(Wiegers,)-372(E.,)-365.5(Sewalt,)-367.2(C.,)-370.4(Buki,)-363.7(A.,)-368.2(Citerio,)-368.2(G.,)-368.2(De)]TJ 1.2519 -1.1239 TD [(Keyser,)-455.2(V.,)-460.7(Ercole,)-457(A.,)-460.7(Kunzmann,)-450(K.,)-460.7(Lanyon,)-451.9(L.,)-458(and)-459.3(Lecky,)-457.2(F.)]TJ T* [(\(2019\).)-569.5(Case-mix,)-569.1(care)-573.8(pathways,)-574.2(and)-573.1(outcomes)-569.2(in)-577.6(patients)-569.7(with)]TJ 0 -1.131 TD [(traumat)11.3(ic)-772.9(brain)-770(injury)-770.4(in)-769.7(CENTER-TBI)12.3(:)-771.7(a)-776.5(European)-768.3(prospec-)]TJ 0 -1.1239 TD [(tive,)-325.2(multicentr)13.5(e,)-327.3(longitudinal,)-318.2(cohort)-326.9(study.)-322.6(Lancet)-322.7(Neurol.)-321.3(18,)-329.1(923)]TJ T* (934.)Tj -1.2519 -1.1239 TD [(3.)-501.9(Cassidy,)-476.9(J.D.,)-473(Carroll,)-479.8(L.J.,)-477.4(Peloso,)-478(P.M.,)-480.4(Borg,)-475.3(J.,)-480.7(von)-477.5(Holst,)-480.1(H.,)]TJ 1.2519 -1.1239 TD [(Holm,)-293.9(L.,)-308.6(Kraus,)-297.6(J.,)-302.9(Coronado)12.4(,)-304.8(V.G.,)-303.6(and)-302.8(WHO)-298.7(Collaborat)10.8(ing)-305.2(Centre)]TJ T* [(Task)-415.6(Force)-409.8(on)-415.5(Mild)-414.6(Traumatic)-407.2(Brain)-419.1(Injury)-412.5(\(2004\).)-405.9(Incidence,)-414.6(risk)]TJ 0 -1.131 TD [(factors)-389.6(and)-395.3(preventio)11.9(n)-396.3(o)0(f)-390.5(mild)-390.5(traumatic)-391.7(brain)-393(injury:)-389.8(results)-389.8(of)-397.6(the)]TJ 0 -1.1239 TD [(WHO)-334.2(Collabora)14.3(ting)-337.2(Centre)-334.9(Task)-330.2(Force)-331.5(on)-337.3(Mild)-329.2(Traumatic)-329(Brain)-333.7(In-)]TJ T* [(jury.)-326.9(J.)-332.4(Rehabil.)-326.8(Med.)-329.4(43)-330.2(Suppl.,)-325.2(2860.)]TJ -1.2519 -1.1239 TD [(4.)-501.9(McMahon,)-593.7(P.J.,)-596.3(Hricik,)-597.2(A.,)-603(Yue,)-603.1(J.K.,)-593.9(Puccio,)-600.9(A.M.,)-599(Inoue,)-599.8(T.,)]TJ 1.2519 -1.1239 TD [(Lingsma,)-630.8(H.F.,)-640.3(Beers,)-637.4(S.R.,)-642.5(Gordon)13.7(,)-646.3(W.A.,)-636.5(Valadka,)-635.2(A.B.,)-640.1(and)]TJ T* [(Manley,)-502.7(G.T.)-515.3(\(2014\).)-505.4(Symptomat)13.7(ology)-507.4(and)-509.1(functional)-503.8(outcome)-506(in)]TJ T* [(mild)-269.6(traumat)11.3(ic)-275(brain)-272.1(injury:)-268.9(results)-268.8(from)-272.3(the)-265.8(prospective)-265.7(TRACK-TBI)]TJ 0 -1.131 TD [(study.)-322.6(J.)-332.4(Neurotrauma)-325.3(31,)-329.1(2633.)]TJ -1.2519 -1.1239 TD [(5.)-501.9(Langlois,)-538.4(J.A.,)-551.2(Rutland-B)12.8(rown,)-544.3(W.)-552.8(and)-544.7(Wald,)-548.3(M.M.)-546.8(\(2006\).)-541(The)]TJ 1.2519 -1.1239 TD [(epidemiol)13.3(ogy)-321(and)-324.2(impact)-321.7(of)-319.3(traumatic)-320.5(brain)-314.8(injury:)-318.6(a)-328.3(brief)-318.2(overview.)]TJ T* [(J.)-332.4(Head)-327.8(Trauma)-327.9(Rehabil.)-326.8(21,)-329.1(375378)14.5(.)]TJ -1.2519 -1.1239 TD [(6.)-501.9(Lingsma,)-417.4(H.F.,)-419.8(Yue,)-425.2(J.K.,)-423.2(Maas,)-424.2(A.I.R.,)-419.9(Steyerberg,)-417.7(E.W.,)-427.6(Manley,)]TJ 1.2519 -1.1239 TD [(G.T.,)-229.8(Cooper,)-232.6(S.R.,)-230(Dams-OCon)10.6(nor,)-238(K.,)-233.1(Gordon,)-227.1(W.A.,)-238.2(Menon,)-225.6(D.K.,)]TJ 0 -1.131 TD [(Mukherjee,)-716.4(P.,)-719.2(Okonkwo,)-715(D.O.,)-723.3(Puccio,)-721.8(A.M.,)-719.9(Schnyer,)-717.6(D.M.,)]TJ 31.497 83.2521 TD [(Valadka,)-329.4(A.B.,)-334.3(Vassar,)-328.4(M.J.,)-334.5(and)-331.3(Yuh,)-329.6(E.L.)-334.8(\(2015\).)-327.6(Outcome)-330.7(predic-)]TJ 0 -1.1239 TD [(tion)-337.2(after)-342.7(mild)-340.7(and)-338.4(complicated)-330.4(mild)-340.7(traumatic)-334.8(brain)-343.2(injury:)-332.9(external)]TJ T* [(validation)-506(of)-518.5(existing)-509.6(models)-513.2(and)-509.1(identicatio)10.8(n)-517.2(o)0(f)-518.5(new)-511.6(predictors)]TJ 0 -1.131 TD [(using)-330.7(the)-329.8(TRACK-T)11.3(BI)-331.2(pilot)-333.6(study.)-322.6(J.)-332.4(Neurotrauma)-325.3(32,)-329.1(8394.)]TJ -1.2448 -1.1239 TD [(7.)-494.8(Jacobs,)-457.6(B.,)-462.9(Beems,)-459.7(T.,)-465.1(Stulemeijer,)-453.9(M.,)-464.4(Van)-461.8(Vugt,)-461.1(A.B.,)-462.3(Van)-461.8(Der)]TJ 1.2448 -1.1239 TD [(Vliet,)-281.4(T.M.,)-276.2(Borm,)-279.7(G.F.,)-284.7(and)-281.5(Vos,)-280.9(P.E.)-275.9(\(2010\).)-277.8(Outcome)-280.9(prediction)-276.1(in)]TJ T* [(mild)-440.3(traumatic)-434.3(brain)-442.8(injury:)-432.5(age)-441.2(and)-445.1(clinical)-435.1(variables)-440.6(are)-437.5(stronger)]TJ T* [(predictors)-324.9(than)-327.7(CT)-334.7(abnormal)11.9(ities.)-329.9(J.)-332.4(Neurotrauma)-325.3(27,)-329.1(655668.)]TJ -1.2448 -1.1239 TD [(8.)-494.8(van)-302.8(der)-299.1(Naalt,)-300.3(J.,)-302.9(Timmerm)13.3(an,)-303.9(M.E.,)-297.5(de)-297.8(Koning,)-300.5(M.E.,)-297.5(van)-295.7(der)-306.2(Horn,)]TJ 1.2448 -1.1239 TD [(H.J.,)-288.1(Scheene)11(n,)-288.5(M.E.,)-283.3(Jacobs,)-286.9(B.,)-285.1(Hageman,)-277.5(G.,)-290(Yilmaz,)-280.5(T.,)-287.3(Roks,)-281.1(G.,)]TJ 0 -1.131 TD [(and)-466.4(Spikman,)-456.9(J.M.)-463.5(\(2017\).)-462.8(Early)-464(predictors)-453(of)-468.7(outcome)-463.4(after)-463.7(mild)]TJ 0 -1.1239 TD [(traumatic)-455.7(brain)-457.1(injury)-457.4(\(UPFRONT\):)-454.5(an)-461.4(observational)-452.1(cohort)-462.1(study.)]TJ T* [(Lancet)-329.8(Neurol.)-328.4(16,)-329.1(532540)14.5(.)]TJ -1.2448 -1.1239 TD [(9.)-494.8(Andelic,)-395.8(N.,)-403.8(Sigurdard)12.4(ottir,)-400(S.,)-399.1(Arango-L)11.4(asprilla,)-394.3(J.C.,)-404.1(and)-395.3(Godbolt,)]TJ 1.2448 -1.1239 TD [(A.K.)-489.6(\(2016\).)-491.2(Long-term)-483.9(functional)-489.5(and)-487.8(psychosocial)-489.1(consequenc)13.9(es)]TJ T* [(and)-302.8(health)-303.9(care)-303.5(provision)-303(after)-300.1(traumatic)-306.3(brain)-300.6(injury.)-299.9(Behav.)-298.5(Neurol.)]TJ 0 -1.131 TD [(2016,)-325(3.)]TJ -1.7427 -1.1239 TD [(10.)-492.7(Evans,)-348.4(R.W.)-355.3(\(2010\).)-341.8(Persistent)-354.6(post-traum)16.2(atic)-357.9(headache,)-346.9(postconcus-)]TJ 1.7427 -1.1239 TD [(sion)-645.8(syndrome,)-640.9(and)-644.3(whiplash)-641.7(injuries:)-644.6(the)-649.9(evidence)-642(for)-647.9(a)-648.4(non-)]TJ T* [(traumatic)-327.6(basis)-328(with)-332.6(an)-326.3(historical)-325.6(review.)-331.6(Headache)-329.1(50,)-329.1(716724)14.5(.)]TJ -1.7427 -1.1239 TD [(11.)-492.7(Polinder,)-296.7(S.,)-306.6(Cnossen,)-300.6(M.C.,)-302.4(Real,)-299(R.G.L.,)-302.5(Covic,)-300.9(A.,)-304.2(Gorbunova,)-295.2(A.,)]TJ 1.7427 -1.1239 TD [(Voormolen,)-261.7(D.C.,)-263.1(Master,)-265.4(C.L.,)-267.6(Haagsma,)-264.4(J.A.,)-266.7(Diaz-Arr)10.7(astia,)-270.6(R.,)-263.8(and)]TJ T* [(von)-406.3(Steinbuechel)11.7(,)-411.5(N)0(.)-412(\(2018\).)-405.8(A)-413(multidim)15.6(ensional)-407.6(approach)-401.8(to)-414(post-)]TJ 0 -1.131 TD [(concussion)-263.9(symptom)14.9(s)-269.4(i)0(n)-271.7(mild)-262.5(traumatic)-263.6(brain)-272.1(injury.)-257.2(Front.)-265.7(Neurol.)-264.4(9,)]TJ 0 -1.1239 TD (1113.)Tj -1.7427 -1.1239 TD [(12.)-492.7(Ponsford,)-372.2(J.,)-381.1(Nguyen,)-376.3(S.,)-384.9(Downing,)-372(M.,)-379.1(Bosch,)-374.7(M.,)-379.1(McKenzie,)-379.4(J.E.,)]TJ 7.9702 0 0 7.9702 324.7369 493.0581 Tm [(Turner,)-259.5(S.,)-256.8(Chau,)-254.6(M.,)-265.3(Mortimer)14.1(,)-262.1(D.,)-261.5(Gruen,)-260.9(R.L.,)-253.3(Knott,)-258.4(J.,)-260.2(and)-260.2(Green,)]TJ T* [(S.)-421.5(\(2019\).)-413(Factors)-419.5(associated)-418.2(with)-418(persistent)-413.7(post-concussio)11.6(n)-424.7(symp-)]TJ T* [(toms)-279.4(following)-281.4(mild)-276.7(traumatic)-277.9(brain)-286.3(injury)-279.5(in)-286(adults.)-279.5(J.)-282.6(Rehabil.)-277.1(Med.)]TJ 0 -1.131 TD [(51,)-329.1(3239.)]TJ -1.7427 -1.1239 TD .0133 Tc [(1)13.3(3)13.3(.)-479.4(Pott)-4.5(er,)-355.5(S)-3.7(.,)-355.5(and)-361.6(B)3.6(rown,)-362.7(R)3.5(.G.)-362.7(\()-2.2(2012\).)-362.7(C)3.6(og)-6(nit)-4.5(i)2.7(v)-6(e)-357.7(behavi)-4.4(oural)-360.1(t)2.7(herapy)]TJ 1.7427 -1.1239 TD [(and)-375.8(p)1.2(ersi)-4.5(stent)-381.4(post)-4.5(-)4.9(con)-6(c)-2.1(ussi)-4.5(onal)-374.3(s)0(ympt)-4.5(oms:)-374.3(in)-6(tegrati)-4.5(n)1.2(g)-375.8(c)-2.1(oncept)-4.5(u)1.2(al)]TJ T* .0148 Tc [(issues)-240.4(and)-232.1(p)-4.5(ra)6.6(ctical)-237.7(aspects)-233.3(i)-3(n)-239.2(t)4.2(r)]TJ 13.1878 0 TD .0141 Tc [(eatment.)-233.8(N)-.6(europsychol.)-233.8(R)-2.8(ehabil.)-240.9(2)2(2,)]TJ -13.1878 -1.1239 TD .0121 Tc [(12)-7.2(5.)]TJ -1.7427 -1.1239 TD 0 Tc [(14.)-492.7(Stein,)-377.8(M.B.,)-380.7(Ursano,)-373.8(R.J.,)-382.7(Campbe)12(ll-Sills,)-382.6(L.,)-379.8(Colpe,)-379.1(L.J.,)-377.8(Fullerton,)]TJ 1.7427 -1.1239 TD [(C.S.,)-336.7(Heeringa,)-330.7(S.G.,)-334.5(Nock,)-337.8(M.K.,)-335.8(Sampson,)-331.6(N.A.,)-332.1(Schoenbaum,)-330.6(M.,)]TJ 0 -1.131 TD [(and)-231.7(Sun,)-232.4(X.)-234.1(\(2016\).)-228(Prognostic)-223.6(indicators)-227.5(of)-234(persistent)-228.7(post-concus)12.2(sive)]TJ 0 -1.1239 TD [(symptoms)-524.8(after)-527.7(deployment)13.8(-related)-530.3(mild)-525.7(traumatic)-526.8(brain)-521.1(injury:)-524.9(a)]TJ T* [(prospective)-365.3(longitudinal)-362(study)-373.4(in)-371.3(US)-373.1(Army)-371(soldiers.)-372.4(J.)-368(Neurotrauma)]TJ T* [(33,)-329.1(21252132.)]TJ -1.7427 -1.1239 TD [(15.)-492.7(Iverson,)-251.7(G.L.,)-258.2(Zasler,)-251.9(N.D.,)-260.9(Lange,)-250.9(R.T.,)-253.3(Katz,)-261.2(D.I.,)-254.7(and)-253(Zafonte,)-255.7(R.D.)]TJ 1.7427 -1.1239 TD (\(2007\).)Tj /F10 1 Tf 3.5495 0 TD [(Brain)-636.4(Injury)-634(Medicine:)-639.9(Principles)-630.6(and)-633.9(Practice.)]TJ /F4 1 Tf 21.88 0 TD (Demos)Tj -25.4295 -1.131 TD [(Medical)-325.5(Publishing)-322.2(Inc.:)-330.1(New)-329.2(York.)]TJ -1.7427 -1.1239 TD [(16.)-492.7(Andelic,)-410(N.,)-418(Roe,)-413.2(C.,)-413.1(Jerstad,)-407.7(T.,)-415.3(and)-416.6(Schanke,)-404.4(A.-K.)-412.7(\(2009\).)-413(Post-)]TJ 1.7427 -1.1239 TD [(concussion)-292.4(symptoms)-297.2(after)-300.1(traumatic)-299.2(brain)-293.5(injury)-300.9(at)-303.4(3)-303.8(and)-295.7(12)-301.7(months)]TJ T* [(post-injury:)-325.6(A)-327.6(prospective)-322.7(study.)-329.7(Brain)-326.6(Inj.)-328.9(23,)-336.2(489497)14.5(.)]TJ -1.7427 -1.1239 TD [(17.)-492.7(Voormolen,)-311.5(D.C.,)-320(Cnossen,)-314.8(M.C.,)-316.6(Polinder,)-318(S.,)-320.8(von)-321(Steinbueche)15.2(l,)-322.6(N.,)]TJ 1.7427 -1.1239 TD [(Vos,)-245.4(P.E.,)-239.3(and)-238.8(Haagsma,)-243.1(J.A.)-239.3(\(2018\).)-235.1(Divergent)-239.6(classication)-236(methods)]TJ T* [(of)-340.7(post-concussio)11.6(n)-346.5(syndrom)13.5(e)-342.6(after)-342.7(mild)-340.7(traumatic)-341.9(brain)-336.1(injury:)-340(prev-)]TJ 0 -1.131 TD [(alence)-297.6(rates,)-303.9(risk)-300.6(factors,)-296.1(and)-295.7(functional)-297.5(outcome.)-291.6(J.)-303.9(Neurotrau)11.6(ma)-301.3(35,)]TJ 0 -1.1239 TD (12331241.)Tj -1.7427 -1.1239 TD [(18.)-492.7(Broshek,)-331.2(D.K.,)-332.1(De)-335.9(Marco,)-331.8(A.P.,)-334.5(and)-331.3(Freeman,)-333.1(J.R.)-334(\(2015\).)-327.6(A)-341.9(review)]TJ 1.7427 -1.1239 TD [(of)-532.7(post-concussio)11.6(n)-538.5(syndrom)13.5(e)-541.7(and)-530.5(psychological)-527(factors)-531.8(associated)]TJ T* [(with)-332.6(concussio)11.4(n.)-331.2(Brain)-326.6(Inj.)-336(29,)-329.1(228237)14.5(.)]TJ -1.7427 -1.1239 TD [(19.)-492.7(Silverberg,)-519.7(N.D.,)-531.2(Panenka,)-525.3(W.J.,)-521.4(and)-530.5(Iverson,)-522(G.L.)-529.6(\(2018\).)-519.7(Work)]TJ 1.7427 -1.131 TD [(productivity)-338.4(loss)-348.2(after)-342.7(mild)-347.9(traumatic)-341.9(brain)-350.4(injury.)-342.5(Arch.)-341.2(Phys.)-345.3(Med.)]TJ 0 -1.1239 TD [(Rehabil.)-326.9(99,)-329.1(250256.)]TJ -1.7427 -1.1239 TD [(20.)-492.7(Cnossen,)-414.4(M.C.,)-416.2(Naalt,)-421.3(J.V.,)-416.1(Spikman,)-414.2(J.M.,)-419.8(Nieboer,)-414.9(D.,)-418(Yue,)-418.1(J.K.,)]TJ 1.7427 -1.1239 TD [(Winkler,)-707.6(E.A.,)-706.4(Manley,)-701.8(G.T.,)-706.4(Steinbuechel)11.7(,)-710.3(N.V.,)-709.1(Polinder,)-702.1(S.,)]TJ T* [(Steyerberg,)-481.7(E.W.,)-477.4(and)-487.8(Lingsma,)-474.3(H.F.)-484.9(\(2018\).)-477(Prediction)-480.2(of)-482.9(persis-)]TJ T* [(tent)-575.2(post-concus)12.2(sion)-581.8(symptom)14.9(s)-582.4(after)-577.5(mild)-568.4(traumatic)-576.6(brain)-570.9(injury.)]TJ 0 -1.131 TD [(J.)-332.4(Neurotrau)11.6(ma)-336.9(35,)-329.1(269126)14.5(98.)]TJ -1.7427 -1.1239 TD [(21.)-492.7(Maas,)-424.2(A.I.,)-425.4(Menon,)-417.7(D.K.,)-424.5(Steyerberg,)-417.7(E.W.,)-427.6(Citerio,)-425.1(G.,)-425.1(Lecky,)-421.6(F.,)]TJ 1.7427 -1.1239 TD [(Manley,)-360.4(G.T.,)-364.9(Hill,)-365.6(S.,)-370.6(Legrand,)-363.9(V.,)-361.1(Sorgner,)-362.1(A.,)-368.2(and)-366.9(CENTER-TBI)]TJ T* [(Participant)11(s)-945.2(and)-943(Investigators)-937.2(\(2015\).)-939.3(Collaborat)10.8(ive)-941.5(European)]TJ T* [(NeuroTrauma)-660.9(Effectiveness)-660.4(Research)-667(in)-663(Traumatic)-663.3(Brain)-668.1(Injury)]TJ T* [(\(CENTER-TB)12.3(I\):)-760.2(a)-755.1(prospectiv)12.8(e)-755.1(longitudinal)-746.1(observational)-750.9(study.)]TJ T* [(Neurosurg)12.1(ery)-334.7(76,)-329.1(6780.)]TJ -1.7427 -1.131 TD [(22.)-492.7(King,)-326(N.S.,)-320.2(Crawford,)-315.9(S.,)-327.9(Wenden,)-321.2(F.J.,)-318.9(Moss,)-326.5(N.E.,)-322.3(and)-324.2(Wade,)-318.3(D.T.)]TJ 1.7427 -1.1239 TD [(\(1995\).)-341.8(The)-338.2(Rivermead)-342.5(Post)-337.7(Concussion)-336.6(Symptoms)-336.4(Questionna)13.7(ire:)-343.8(a)]TJ T* [(measure)-259.3(of)-255.3(symptoms)-254.5(commonly)-255.3(experien)12.2(ced)-263.4(after)-257.4(head)-261.3(injury)-258.2(and)-253.1(its)]TJ T* [(reliability.)-325.4(J.)-332.4(Neurol.)-328.4(242,)-327(587592.)]TJ -1.7427 -1.1239 TD [(23.)-492.7(Bovin,)-866.7(M.J.,)-875.1(Marx,)-871.3(B.P.,)-870.2(Weathers)9.9(,)-881(F.W.,)-866.6(Gallagher,)-867.7(M.W.,)]TJ 1.7427 -1.1239 TD [(Rodriguez,)-356.1(P.,)-370.6(Schnurr)13.9(,)-368.8(P.P.,)-365.3(and)-366.9(Keane,)-356.4(T.M.)-369.7(\(2016\).)-356.1(Psychometri)13.6(c)]TJ 0 -1.131 TD [(properties)-630.8(of)-632.3(the)-635.7(PTSD)-629.8(Checklist)-629.3(for)-633.6(Diagnostic)-625(and)-637.1(Statistical)]TJ /F3 1 Tf 8.9663 0 0 8.9663 59.7543 749.7069 Tm [(EXTERNAL)-342.3(VALIDATION)-334.1(OF)-337.5(PROGNOSTIC)-332.4(MODELS)-337.7(FOR)-334(MTBI)-22548.5(207)]TJ ET endstream endobj 108 0 obj <>stream /GS1 gs BT /F4 1 Tf 7.9702 0 0 7.9702 75.9118 726.1793 Tm 0 0 0 rg 0 Tc 0 Tw [(Manual)-653.1(of)-653.6(Mental)-644.5(DisordersF)11.7(ifth)-653.6(Edition)-649.4(\(PCL-5\))-645.3(in)-655.9(veterans.)]TJ 0 -1.1239 TD [(Psychol.)-326.5(Assess.)-331.3(28,)-329.1(137913)14.5(91.)]TJ -1.7427 -1.1239 TD [(24.)-492.7(Kroenke,)-416.4(K.,)-410.9(Spitzer,)-415.8(R.L.,)-409.8(and)-416.6(Williams,)-412.1(J.B.)-412.2(\(2001\).)-413(The)-409.3(PHQ-9:)]TJ 1.7427 -1.131 TD [(validity)-371.8(of)-369.1(a)-378.1(brief)-368(depression)-366.9(severity)-368.4(measure)11(.)-376(J)0(.)-375.1(Gen.)-368.3(Intern.)-372(Med.)]TJ 0 -1.1239 TD [(16,)-329.1(606613.)]TJ -1.7427 -1.1239 TD [(25.)-492.7(Spitzer,)-522.5(R.L.,)-523.6(Kroenke,)-516(K.,)-524.7(William)12.7(s,)-524.4(J.B.,)-525(and)-523.3(Lowe,)-515.4(B.)-528(\(2006\).)]TJ 1.7427 -1.1239 TD [(A)-292.1(brief)-282.6(measure)-287.7(for)-285.1(assessing)-282.6(generalized)-285.2(anxiety)-280.5(disorder:)-288.2(the)-287.1(GAD-)]TJ T* [(7.)-331.2(Arch.)-334.1(Intern.)-322.2(Med.)-329.4(166,)-327(10921097.)]TJ -1.7427 -1.1239 TD [(26.)-492.7(Wilde,)-416.7(E.A.,)-407.6(Whiteneck)11(,)-418.6(G.G.,)-410.3(Bogner,)-410.4(J.,)-409.6(Bushnik,)-408.5(T.,)-415.3(Cifu,)-409.8(D.X.,)]TJ 1.7427 -1.1239 TD [(Dikmen,)-421(S.,)-420.4(French)12(,)-425.7(L.,)-422.4(Giacino,)-417.1(J.T.,)-413.4(Hart,)-425(T.,)-415.3(Malec,)-422.6(J.F.,)-418.5(Millis,)]TJ 0 -1.131 TD [(S.R.,)-286.9(Novack,)-279.9(T.A.,)-286.7(Sherer,)-282(M.,)-286.6(Tulsky,)-277.6(D.S.,)-284.7(Vanderploeg,)-281.8(R.D.,)-284.5(and)]TJ 0 -1.1239 TD [(von)-377.9(Steinbuechel)11.7(,)-376(N)0(.)-376.4(\(2010\).)-377.4(Recommend)11.5(ations)-373(for)-377.6(the)-372.5(use)-375.2(of)-376.2(com-)]TJ T* [(mon)-253.4(outcome)-242.8(measures)-251.3(in)-250.4(traumatic)-249.4(brain)-250.8(injury)-244(research.)-252.1(Arch.)-248.7(Phys.)]TJ T* [(Med.)-329.4(Rehabil.)-326.8(91,)-329.1(16501660)-322.7(e1617.)]TJ -1.7427 -1.1239 TD [(27.)-492.7(Wilson,)-355.7(J.T.,)-356.5(Pettigrew,)-355.7(L.E.,)-355.1(and)-359.7(Teasdale,)-357.4(G.M.)-351(\(1998\).)-356.1(Structured)]TJ 1.7427 -1.1239 TD [(interviews)-728(for)-733.2(the)-728.1(Glasgow)-726(Outcome)-729(Scale)-728.2(and)-736.7(the)-728.1(Extended)]TJ 0 -1.131 TD [(Glasgow)-299.2(Outcome)-302.3(Scale:)-297.8(guidelines)-295.3(for)-306.4(their)-299.1(use.)-303(J.)-303.9(Neurotrau)11.6(ma)-301.3(15,)]TJ 0 -1.1239 TD (573585.)Tj -1.7427 -1.1239 TD [(28.)-492.7(Marshall,)-274(S.,)-285.3(Bayley,)-273.5(M.,)-279.5(McCullagh)11.5(,)-283.5(S.,)-278.2(Velikonja,)-269.2(D.,)-282.9(and)-274.4(Berrigan,)]TJ 1.7427 -1.1239 TD [(L.)-309.7(\(2012\).)-299.2(Clinical)-301.5(practice)-309.6(guidelines)-295.3(for)-306.4(mild)-305.2(traumatic)-299.2(brain)-307.7(injury)]TJ T* [(and)-430.9(persistent)-420.8(symptoms.)-417(Can.)-427.4(Fam.)-424(Physician)-417.6(58,)-421.6(257267,)-418.3(e128)]TJ T* (240.)Tj -1.7427 -1.1239 TD [(29.)-492.7(Acquadro,)-279.2(C.,)-278(Conway,)-274.3(K.,)-282.9(Hareendra)10.8(n,)-281.4(A.,)-282.9(and)-281.5(Aaronson)13.4(,)-283.5(N)0(.)-283.9(\(2008\).)]TJ 1.7427 -1.131 TD [(Literature)-296.8(review)-297.1(of)-298(methods)-297.7(to)-300.2(translate)-296.8(health-re)12.4(lated)-298.9(quality)-297.1(of)-298(life)]TJ 0 -1.1239 TD [(questionnair)11.3(es)-263.4(for)-256.6(use)-254.2(in)-257.5(multinational)-251.3(clinical)-257.3(trials.)-253(Value)-260.2(Health)-249.5(11,)]TJ T* (509521.)Tj -1.7427 -1.1239 TD [(30.)-492.7(Teymoori,)-382(A.,)-389.6(Real,)-391.5(R.,)-384.7(Gorbunova,)-380.6(A.,)-389.6(Haghish,)-388.1(E.F.,)-381.5(Andelic,)-388.7(N.,)]TJ 1.7427 -1.1239 TD [(Wilson,)-305.9(L.,)-308.6(Asendorf,)-301.9(T.,)-308.6(Menon,)-303.9(D,)-305.3(and)-309.9(von)-306.7(Steinbu)]TJ 21.4248 .0071 TD ()Tj .4126 -.0071 TD [(chel,)-308.5(N.)-312.4(\(2020\).)]TJ -21.8373 -1.1239 TD [(Measurement)-415.4(invariance)-419.2(of)-418.9(assessment)11.5(s)-425.9(o)0(f)-418.9(depression)-416.7(\(PHQ-9\))-418.1(and)]TJ 0 -1.131 TD [(anxiety)-543.7(\(GAD-7\))-536.7(across)-540.3(sex,)-544.8(strata)-543.2(and)-537.6(linguistic)-538(backgrounds)-535.9(in)]TJ 0 -1.1239 TD [(a)-598.6(european-wi)12.6(de)-596.6(sample)-587.5(of)-589.6(patients)-591.1(after)-591.7(traumatic)-590.8(brain)-592.2(injury.)]TJ T* [(J.)-332.4(Affect.)-327.9(Disord.)-326.4(262,)-334.2(278285)14.5(.)]TJ -1.7427 -1.1239 TD [(31.)-492.7(Plass,)-331.9(A.M.,)-328.7(Van)-326.7(Praag,)-330.5(D.,)-325.6(Covic,)-329.3(A.,)-332.7(Gorbun)13.7(ova,)-330.3(A.,)-332.7(Real,)-327.5(R.,)-327.8(von)]TJ 1.7427 -1.1239 TD [(Steinbuechel,)-286(N.,)-297.1(and)-295.7(Dutch)-292.6(and)-288.6(Flemish)-294(CENTER-TB)13.6(I)-300.1(Investigators)]TJ T* [(\(2019\).)-541(The)-537.4(psychometri)11.3(c)-548.8(validation)-534.4(of)-539.8(the)-543.2(Dutch)-534.4(version)-539.4(of)-539.8(the)]TJ T* [(Rivermead)-563(Post-Concu)12(ssion)-566.6(Symptoms)-557(Questionnaire)-561.3(\(RPQ\))-563.4(after)]TJ 0 -1.131 TD [(traumatic)-327.6(brain)-329(injury)-329.3(\(TBI\).)-330.5(PLoS)-321.4(One)-333.8(14,)-329.1(e0210138)13.4(.)]TJ -1.7427 -1.1239 TD [(32.)-492.7(Van)-262.7(Praag,)-259.4(D.L.G.,)-250.5(Fardzadeh,)-257.5(H.E.,)-258.2(Covic,)-251.1(A.,)-261.5(Maas,)-260.5(A.I.R.,)-256.3(and)-253(von)]TJ 1.7427 -1.1239 TD (Steinbu)Tj 2.639 .0142 TD ()Tj .4197 -.0142 TD [(chel,)-258.7(N.)-269.7(\(2020\).)-256.5(Preliminar)10.8(y)-268.2(validation)-257(of)-269.5(the)-258.6(Dutch)-264.1(version)-262(of)]TJ -3.0586 -1.1239 TD [(the)-393.8(Posttraumatic)-387.9(stress)-394.5(disorder)-391.4(checkl)11.5(ist)-397.4(for)-391.8(DSM-5)-390.8(\(PCL-5\))-389.2(after)]TJ T* [(traumatic)-676.2(brain)-677.6(injury)-677.9(in)-677.2(a)-684(civilian)-673.7(populatio)12.9(n.)-679.7(PLoS)-677.1(One)-675.2(15,)]TJ T* (e0231857.)Tj -1.7427 -1.131 TD [(33.)-492.7(Carroll,)-479.8(L.J.,)-477.4(Cassidy,)-476.9(J.D.,)-480.1(Peloso,)-478(P.M.,)-473.3(Borg,)-482.5(J.,)-480.7(von)-477.5(Holst,)-480.1(H.,)]TJ 1.7427 -1.1239 TD [(Holm,)-550(L.,)-557.6(Paniak,)-544(C.,)-555.4(and)-551.8(Pe)]TJ 12.6045 .0427 TD ()Tj .3841 -.0427 TD [(pin,)-553.2(M.)-550.8(\(2004\).)-548.1(Prognosis)-545.3(for)-548.3(mild)]TJ -12.9886 -1.1239 TD [(traumatic)-285(brain)-279.2(injury:)-283.1(results)-275.9(of)-290.9(the)-280(WHO)-284.4(Collaborat)10.8(ing)-283.9(Centre)-285.1(Task)]TJ T* [(Force)-239.1(on)-230.6(Mild)-236.7(Traumati)13.6(c)-243(Brain)-227(Injury.)-233.6(J.)-232.8(Rehabil.)-234.4(Med.)-229.8(Suppl.)-233.8(43,)-229.5(84)]TJ T* (105.)Tj -1.7427 -1.1239 TD [(34.)-492.7(Iverson,)-358.4(G.L.,)-364.9(Gardner,)-355.8(A.J.,)-359.2(Terry,)-361.2(D.P.,)-362.9(Ponsford,)-350.9(J.L.,)-363.6(Sills,)-360(A.K.,)]TJ 1.7427 -1.1239 TD [(Broshek,)-395.3(D.K.,)-389(and)-395.3(Solomon,)-389.7(G.S.)-392.4(\(2017\).)-384.5(Predictors)-393.8(of)-390.5(clinical)-392.4(re-)]TJ 0 -1.131 TD [(covery)-345.9(from)-343.4(concussio)11.4(n:)-350(a)-349.7(system)12(atic)-350.7(review.)-338.7(Br.)-351.5(J.)-346.6(Sports)-336.9(Med.)-343.6(51,)]TJ 0 -1.1239 TD (941948.)Tj -1.7427 -1.1239 TD [(35.)-492.7(Silverberg,)-398.7(N.D.,)-396.1(Gardner,)-398.5(A.J.,)-394.8(Brubacher,)-392.6(J.R.,)-404.1(Panenka,)-390.2(W.J.,)-400.5(Li,)]TJ 1.7427 -1.1239 TD [(J.J.,)-500.1(and)-502(Iverson,)-493.5(G.L.)-501.1(\(2015\).)-491.2(Systematic)-499(review)-496.3(of)-504.3(multiva)12.3(riable)]TJ T* [(prognostic)-268.5(models)-271.4(for)-278(mild)-276.7(traumatic)-270.7(brain)-272.1(injury.)-271.4(J.)-275.5(Neurotrauma)-268.4(32,)]TJ T* (517526.)Tj -1.7427 -1.131 TD [(36.)-492.7(Mushkudiani,)-766.2(N.A.,)-766(Hukkelhoven,)-766(C.W.P.M.,)-764.6(Herna)]TJ 24.519 .0427 TD ()Tj .3841 -.0427 TD [(ndez,)-772.4(A.V.,)]TJ -23.1604 -1.1239 TD [(Murray,)-280.1(G.D.,)-282.3(Choi,)-278.4(S.C.,)-279.8(Maas,)-281.9(A.I.R.,)-277.6(and)-281.5(Steyerberg,)-282.5(E.W.)-279.2(\(2008\).)]TJ T* [(A)-469.9(systematic)-466.8(review)-460.7(nds)-467.2(methodol)12.9(ogical)-467.5(improvemen)12.5(ts)-465(necessary)]TJ T* [(for)-256.6(prognostic)-247.2(models)-250(in)-250.4(determining)-249.1(traumatic)-249.4(brain)-250.8(injury)-251.1(outcomes.)]TJ T* [(J.)-332.4(Clin.)-333.8(Epidemio)13.1(l.)-336.8(61,)-329.1(331343)14.5(.)]TJ -1.7427 -1.1239 TD [(37.)-492.7(van)-409.5(Klaveren,)-401.8(D.,)-410.9(Gonen,)-399.7(M.,)-407.5(Steyerberg,)-403.4(E.W.,)-399.1(and)-409.5(Vergouwe,)-402.6(Y.)]TJ 1.7427 -1.131 TD [(\(2016\).)-462.8(A)-462.8(new)-461.8(concordan)12.8(ce)-464.6(measure)-465.5(for)-462.9(risk)-457.1(prediction)-461.1(models)-456.3(in)]TJ 0 -1.1239 TD [(external)-327.7(validation)-328.1(settings.)-324.8(Stat.)-330.1(Med.)-329.4(35,)-329.1(41364152.)]TJ -1.7427 -1.1239 TD [(38.)-492.7(Harrell)-794.8(Jr,)-796.1(F.E.)-795.2(\(2016\).)-790(rms:)]TJ /F10 1 Tf 15.8836 0 TD [(Regression)-791.3(Modeling)-788.7(Strategies.)]TJ -14.1409 -1.1239 TD [(R)-381.8(Package)-379(Version)]TJ /F4 1 Tf 8.3224 0 TD [(5.)-381(https://gi)14.4(thub.com/harr)12.3(elfe/rms)-382.4(\(Last)-379.8(accessed)]TJ -8.3224 -1.1239 TD [(February)-328.7(10,)-329.1(2020\).)]TJ -1.7427 -1.1239 TD [(39.)-492.7(Buuren,)-282.3(S.,)-292.4(and)-281.5(Groothuis-Ouds)10.8(hoorn,)-283.6(C.)-286.1(\(2011\).)-277.8(MICE:)-286.8(Multivaria)10.8(te)]TJ 1.7427 -1.1239 TD [(imputation)-328.5(by)-337.3(chained)-327.9(equations)-327.3(in)-335.8(r.)-334.6(J.)-332.4(Statist.)-336.2(Soft.)-324.6([Epub)-334.2(ahead)-333.6(of)]TJ 0 -1.131 TD [(print;)-327.8(DOI:)-332.9(10.18637/j)15.6(ss.v045.i03.])]TJ -1.7427 -1.1239 TD [(40.)-492.7(Van)-390.7(Calster,)-388.3(B.,)-391.8(Nieboer,)-393.6(D.,)-389.6(Vergouwe,)-381.3(Y.,)-389.6(De)-392.8(Cock,)-389.8(B.,)-391.8(Pencina,)]TJ 1.7427 -1.1239 TD [(M.J.,)-419.8(and)-423.8(Steyerber)13.1(g,)-423.7(E.W.)-414.4(\(2016\).)-420.1(A)-420.1(calibration)-410.9(hierarchy)-415.9(for)-420.2(risk)]TJ T* [(models)-257.1(was)-263.9(dened:)-258.5(from)-258.1(utopia)-258(to)-257.5(empirical)-256.5(data.)-258.7(J.)-261.3(Clin.)-262.6(Epidemio)13.1(l.)]TJ T* [(74,)-329.1(167176.)]TJ -1.7427 -1.1239 TD [(41.)-492.7(Clayton,)-302.3(J.A.,)-295.2(and)-302.8(Collins,)-298.8(F.S.)-295.2(\(2014\).)-299.2(Policy:)-302(NIH)-300.9(to)-300.2(balance)-295.5(sex)-304(in)]TJ 1.7427 -1.131 TD [(cell)-336.5(and)-331.3(animal)-321.7(studies.)-328.4(Nature)-332.7(509,)-327(282283)14.5(.)]TJ 29.7542 83.2521 TD [(42.)-499.8(Lagarde,)-473.8(E.,)-472.2(Salmi,)-473.8(L.-R.,)-475.2(Holm,)-471.8(L.W.,)-477.4(Contrand,)-468.7(B.,)-477.1(Masson,)-474.9(F.,)]TJ 1.7498 -1.1239 TD (Ribe)Tj 1.508 .0427 TD ()Tj .3841 -.0427 TD [(reauGayon)12.4(,)-333.3(R.,)-334.9(Laborey,)-335.5(M.,)-329.3(and)-338.4(Cassidy,)-327.5(J.D.)-338.9(\(2014\).)-327.6(Associ-)]TJ -1.8921 -1.1239 TD [(ation)-395.2(of)-390.5(symptoms)-389.6(following)-388.1(mild)-397.6(traumatic)-391.7(brain)-393(injury)-393.4(with)-396.6(post-)]TJ 0 -1.131 TD [(traumatic)-846.9(stress)-842.7(disorder)-846.6(vs)-850.6(postconcussi)10.8(on)-849.4(syndrome)12.4(.)-852.5(JAMA)]TJ 0 -1.1239 TD [(Psychiatry)-319.3(71,)-336.2(103210)14.5(40.)]TJ -1.7498 -1.1239 TD [(43.)-499.8(Theadom)11.9(,)-496.9(A.,)-489.2(Parag,)-487(V.,)-496.3(Dowell,)-489.6(T.,)-486.5(McPherson,)-486.1(K.,)-489.2(Starkey,)-488.4(N.,)]TJ 1.7498 -1.1239 TD [(Barker-Col)10.5(lo,)-306.3(S.,)-306.6(Jones,)-300(K.,)-311.3(Ameratung)11.5(a,)-306(S.,)-306.6(and)-302.8(Feigin,)-304.6(V.L.)-302(\(2016\).)]TJ T* [(Persisten)11.7(t)-345(problem)13(s)-340.5(1)-339.3(year)-335.8(after)-342.7(mild)-333.6(traumatic)-334.8(brain)-329(injury:)-340(a)-335.4(longi-)]TJ T* [(tudinal)-318.5(population)-319.3(study)-323.6(in)-321.5(New)-329.2(Zealand.)-319.5(Br.)-323(J.)-332.4(Gen.)-318.5(Pract.)-329(66,)-322(e16)]TJ T* (e23.)Tj -1.7498 -1.131 TD [(44.)-499.8(Rabinow)12.7(itz,)-391.3(A.R.,)-384.1(Li,)-391.4(X.,)-389.6(McCauley)11.8(,)-390.2(S.R.,)-386.5(Wilde,)-381.1(E.A.,)-386.3(Barnes,)-386.3(A.,)]TJ 1.7498 -1.1239 TD [(Hanten,)-513.2(G.,)-517.6(Mendez,)-514.5(D.,)-524.7(McCarthy)11.6(,)-525.3(J.J.,)-514.4(and)-523.3(Levin,)-516.5(H.S.)-513.3(\(2015\).)]TJ T* [(Prevalence)-286.6(and)-288.6(predictors)-282.2(of)-290.9(poor)-286.7(recovery)-284.3(from)-286.5(mild)-290.9(traumatic)-285(brain)]TJ T* [(injury.)-328.3(J.)-325.3(Neurotrauma)-325.3(32,)-329.1(14881496.)]TJ -1.7498 -1.1239 TD [(45.)-499.8(Booker,)-239.7(J.,)-238.9(Sinha,)-237(S.,)-242.6(Choudhari,)-239(K.,)-240.2(Dawson,)-237.8(J.,)-238.9(and)-245.9(Singh,)-233.8(R.)-243.5(\(2019\).)]TJ 1.7498 -1.1239 TD [(Descriptio)11.8(n)-332.2(o)0(f)-333.6(the)-336.9(predictors)-324.9(of)-333.6(persistent)-321.2(post-concussio)11.6(n)-332.2(symptoms)]TJ 0 -1.131 TD [(and)-310(disability)-303.3(after)-307.2(mild)-312.3(traumatic)-306.3(brain)-307.7(injury:)-304.4(the)-315.6(SHEFBIT)-304.3(cohort.)]TJ 0 -1.1239 TD [(Br.)-330.1(J.)-332.4(Neurosurg)12.1(.)-333.3(33,)-329.1(367375.)]TJ -1.7498 -1.1239 TD [(46.)-499.8(Cnossen,)-371.7(M.C.,)-366.4(Winkler,)-373.2(E.A.,)-372(Yue,)-375.4(J.K.,)-373.4(Okonkwo,)-366.4(D.O.,)-374.7(Valadka,)]TJ 1.7498 -1.1239 TD [(A.B.,)-768.2(Steyerberg,)-766.2(E.W.,)-776.1(Lingsma,)-766(H.F.,)-768.4(Manley,)-773(G.T.,)-770.4(Dams-)]TJ T* [(OConnor,)-515.6(K.,)-517.6(Gordon,)-518.8(W.A.,)-522.7(Hricik,)-519(A.J.,)-515.7(Maas,)-523.7(A.I.R.,)-519.5(Menon,)]TJ T* [(D.K.,)-310.7(Mukherjee,)-303.9(P.,)-313.7(Puccio,)-309.3(A.M.,)-307.3(Schnyer,)-312.1(D.M.,)-307.3(Vassar,)-307.1(M.J.,)-313.1(and)]TJ T* [(Yuh,)-578.5(E.L.)-583.8(\(2017\).)-576.6(Developm)12.8(ent)-585.9(of)-582.5(a)-584.4(prediction)-582(model)-578.1(for)-583.8(post-)]TJ 0 -1.131 TD [(concussiv)11.4(e)-691.1(symptom)14.9(s)-689.1(following)-679.8(mild)-682.2(traumatic)-683.3(brain)-677.6(injury:)-681.4(A)]TJ 0 -1.1239 TD [(TRACK-T)11.3(BI)-331.2(pilot)-333.6(study.)-322.6(J.)-332.4(Neurotrauma)-325.3(34,)-329.1(239624)14.5(08.)]TJ -1.7498 -1.1239 TD [(47.)-499.8(Booker,)-239.7(J.,)-238.9(Sinha,)-237(S.,)-242.6(Choudhari,)-239(K.,)-240.2(Dawson,)-237.8(J.,)-238.9(and)-245.9(Singh,)-233.8(R.)-243.5(\(2019\).)]TJ 1.7498 -1.1239 TD [(Predicting)-387.8(function)13(al)-395.9(recovery)-391(after)-392.5(mild)-390.5(traumat)11.3(ic)-395.9(brain)-393(injury:)-389.8(the)]TJ T* [(SHEFBIT)-325.6(cohort.)-325.9(Brain)-326.6(Inj.)-328.9(33,)-329.1(11581164.)]TJ -1.7498 -1.1239 TD [(48.)-499.8(Yue,)-517.7(J.K.,)-522.8(Winkler,)-515.5(E.A.,)-521.4(Sharma,)-524(S.,)-520(Vassar,)-520.5(M.J.,)-519.4(Ratcliff,)-522.1(J.J.,)]TJ 1.7498 -1.131 TD [(Korley,)-264.4(F.K.,)-270.4(Seabury,)-269.4(S.A.,)-270.4(Ferguson,)-265.3(A.R.,)-270.3(Lingsma,)-268.1(H.F.,)-270.4(Meeuws,)]TJ 0 -1.1239 TD [(S.,)-434.7(Adeoye,)-436.4(O.M.,)-435.4(Rick,)-438.1(J.W.,)-436.1(Robinson,)-427.7(C.K.,)-441(Duarte,)-431.2(S.M.,)-437.8(Yuh,)]TJ T* [(E.L.,)-390.7(Mukher)13.9(jee,)-396(P.,)-392(Dikmen,)-385.5(S.S.,)-386.7(McAllister,)-383.1(T.W.,)-392(Diaz-Arr)10.7(astia,)]TJ T* [(R.,)-299.3(Valadka,)-300.9(A.B.,)-298.7(Gordon,)-298.3(W.A.,)-302.2(Okonkw)14.6(o,)-302.7(D.O.,)-303.6(and)-302.8(Manley,)-296.4(G.T.)]TJ T* [(\(2017\).)-220.9(Temporal)-229.8(prole)-225.2(of)-234(care)-232.3(following)-224.5(mild)-226.9(traumatic)-228.1(brain)-229.4(injury:)]TJ T* [(predictors)-502.8(of)-504.3(hospital)-509.6(admiss)12(ion,)-510.5(follow-up)-499.7(referral)-510.1(and)-509.1(six-mo)13(nth)]TJ T* [(outcome.)-320.1(Brain)-333.7(Inj.)-328.9(31,)-329.1(18201829.)]TJ -1.7498 -1.131 TD [(49.)-499.8(Yuh,)-436.3(E.L.,)-447.6(Cooper,)-438.8(S.R.,)-436.2(Mukherjee,)-439(P.,)-441.8(Yue,)-439.5(J.K.,)-444.6(Lingsma,)-438.8(H.F.,)]TJ 1.7498 -1.1239 TD [(Gordon,)-646.8(W.A.,)-657.9(Valadka,)-649.4(A.B.,)-654.4(Okonkwo,)-651(D.O.,)-652.2(Schnyer,)-653.5(D.M.,)]TJ T* [(Vassar,)-484.9(M.J.,)-483.8(Maas,)-488.2(A.I.,)-489.4(Manley,)-481.3(G.T.,)-485.8(Casey,)-484.6(S.S.,)-486.2(Cheong,)-485.2(M.,)]TJ T* [(Dams-OCon)10.6(nor,)-316.2(K.,)-318.4(Hricik,)-319.8(A.J.,)-316.5(Inoue,)-315.3(T.,)-322.9(Menon,)-311(D.K.,)-317.8(Morabito,)]TJ T* [(D.J.,)-352.1(Pacheco,)-357.8(J.L.,)-349.4(Puccio,)-352(A.M.,)-357.1(and)-352.6(Sinha,)-357.9(T.K.)-351.7(\(2014\).)-356.1(Diffusion)]TJ T* [(tensor)-299.7(imaging)-287.9(for)-306.4(outcome)-292.6(prediction)-290.4(in)-307.3(mild)-298.1(traumat)11.3(ic)-303.4(brain)-300.6(injury:)]TJ 0 -1.131 TD [(a)-328.3(TRACK-TBI)-327(study.)-329.7(J.)-325.3(Neurotrauma)-325.3(31,)-329.1(14571477.)]TJ -1.7498 -1.1239 TD [(50.)-499.8(Yue,)-233.2(J.,)-238.9(Cnossen,)-229.5(M.,)-236.8(Winkler,)-231(E.A.,)-236.9(Deng,)-231.1(H.S.,)-234.9(Phelps,)-236.1(R.R.L.,)-226.5(Coss,)]TJ 1.7498 -1.1239 TD [(N.A.,)-360.5(Sharma,)-353.3(S.,)-363.5(Robinson,)-356.6(C.K.,)-362.7(Suen,)-354.4(C.G.,)-362.7(Vassar,)-356.8(M.,)-364.8(Schnyer,)]TJ T* [(D.,)-282.9(Puccio,)-273.7(A.,)-282.9(Gardner,)-277.5(R.C.,)-279.6(Yuh,)-279.8(E.,)-280.2(Mukherjee,)-275.4(P.,)-278.2(Valadka,)-279.6(A.B.,)]TJ T* [(Okonkwo,)-288.2(D.,)-297.1(Lingsma,)-296.5(H.,)-297.1(Manley,)-296.4(G.,)-297.1(Cooper,)-296.6(S.,)-299.5(Dams-Oco)10(nnor,)]TJ T* [(K.,)-304.2(Gordon)13.7(,)-304.8(W.,)-302.8(Hricik,)-298.5(A.,)-304.2(Maas,)-303.2(A.,)-304.2(Menon,)-296.8(D.,)-304.2(and)-295.7(Morabito,)-298(D.J.)]TJ T* [(\(2019\).)-448.5(Pre-injury)-456.9(comorbi)13(dities)-456.9(are)-458.8(associated)-453.8(with)-460.6(function)13(al)-459.9(im-)]TJ 0 -1.131 TD [(pairment)-278.2(and)-288.6(post-concus)12.2(sive)-286.2(symptoms)-282.9(at)-289.2(3-and)-287.8(6-mont)14.2(hs)-288.7(after)-292.9(mild)]TJ 0 -1.1239 TD [(traumatic)-313.4(brain)-314.8(injury:)-311.5(A)-313.4(TRACK-TBI)-312.7(study.)-308.3(Front.)-315.5(Neurol.)-314.2(10,)-314.9(343.)]TJ -1.7498 -1.1239 TD [(51.)-499.8(Yuh,)-336.7(E.L.,)-333.8(Mukherjee,)-332.3(P.,)-342.2(Lingsma,)-332.1(H.F.,)-334.5(Yue,)-339.9(J.K.,)-337.9(Ferguson,)-336.5(A.R.,)]TJ 1.7498 -1.1239 TD [(Gordon,)-262.7(W.A.,)-273.8(Valadka,)-265.3(A.B.,)-277.4(Schnyer,)-262.3(D.M.,)-271.8(Okonkwo,)-266.8(D.O.,)-268(Maas,)]TJ T* [(A.I.R.,)-441.2(and)-452.2(Manley,)-438.6(G.T.)-451.3(\(2013\).)-441.4(Magnetic)-444.3(resonance)-446.8(imaging)-437.3(im-)]TJ T* [(proves)-443.5(3-month)-439(outcome)-442(prediction)-439.7(in)-449.6(mild)-447.4(traumat)11.3(ic)-452.8(brain)-442.8(injury.)]TJ 0 -1.131 TD [(Ann.)-329.6(Neurol.)-321.3(73,)-329.1(224235.)]TJ -1.7498 -1.1239 TD [(52.)-499.8(Yue,)-503.5(J.K.,)-508.6(Winkler,)-501.3(E.A.,)-507.2(Puffer,)-502.7(R.C.,)-507.2(Deng,)-508.5(H.,)-503.4(Phelps,)-506.4(R.R.L.,)]TJ 1.7498 -1.1239 TD [(Wagle,)-328.9(S.,)-335.1(Morrissey,)-324.6(M.R.,)-330.9(Rivera,)-333.8(E.J.,)-328(Runyon,)-325.5(S.J.,)-333.1(Vassar,)-335.5(M.J.,)]TJ 7.9702 0 0 7.9702 327.0046 206.1354 Tm [(Taylor,)-226.1(S.R.,)-230(Cnossen,)-229.5(M.C.,)-231.3(Lingsma,)-225.4(H.F.,)-234.9(Yuh,)-230(E.L.,)-227.1(Mukherjee,)-232.7(P.,)]TJ T* [(Schnyer,)-433(D.M.,)-442.5(Puccio,)-437.3(A.M.,)-435.4(Valadka,)-443.2(A.B.,)-433.9(Okonkwo,)-437.6(D.O.,)-438.8(and)]TJ T* [(Manley,)-524(G.T.)-529.6(\(2018\).)-526.8(Temporal)-528.5(lobe)-526.9(contusions)-529.5(on)-529.3(computed)-525.3(to-)]TJ 0 -1.131 TD [(mography)-356.3(are)-366.3(associated)-361.3(with)-368.2(impaire)11.3(d)-367.8(6-month)-360.8(functional)-361.5(recovery)]TJ 0 -1.1239 TD [(after)-342.7(mild)-340.7(traumatic)-341.9(brain)-343.2(injury:)-340(a)-342.6(TRACK-TBI)-341.2(study.)-336.8(Neurol.)-342.6(Res.)]TJ T* [(40,)-329.1(972981.)]TJ -1.7498 -1.1239 TD [(53.)-499.8(Wa)]TJ 2.7528 .0213 TD ()Tj .3841 -.0213 TD [(ljas,)-653.5(M.,)-649.4(Iverson)-651.1(Grant,)-643.5(L.,)-650.1(Lange)-650.2(Rael,)-654.7(T.,)-650.1(Hakulinen)12.8(,)-653.4(U.,)]TJ -1.3871 -1.1239 TD [(Dastidar,)-633(P.,)-648(Huhtala,)-637.6(H.,)-638.5(Liimatainen,)-630.3(S.,)-648(Hartikain)10.9(en,)-645.3(K.,)-638.5(and)]TJ T* (O)Tj .1992 .2276 TD ()Tj .5193 -.2276 TD [(hman,)-680.2(J.)-695.2(\(2015\).)-683.3(A)-690.4(prospective)-685.4(biopsych)13.7(osocial)-687.1(study)-693.5(of)-689.2(the)]TJ -.7184 -1.1239 TD [(persistent)-378.1(post-concus)12.2(sion)-382.6(symptoms)-375.4(following)-381(mild)-383.4(traumat)11.3(ic)-388.8(brain)]TJ 0 -1.131 TD [(injury.)-328.3(J.)-325.3(Neurotrauma)-325.3(32,)-329.1(534547.)]TJ -1.7498 -1.1239 TD [(54.)-499.8(Ponsford,)-272.6(J.,)-281.6(Cameron,)-279.9(P.,)-278.2(Fitzgerald,)-276.1(M.,)-286.6(Grant,)-273.6(M.,)-286.6(Mikocka-Wa)16.1(lus,)]TJ 1.7498 -1.1239 TD [(A.,)-354(and)-345.5(Scho)]TJ 4.9436 .0213 TD ()Tj .4197 -.0213 TD [(nberger,)-346.2(M.)-351.7(\(2012\).)-348.9(Predicto)12(rs)-356.1(of)-354.9(postconcu)12.6(ssive)-356.5(symp-)]TJ -5.3633 -1.1239 TD [(toms)-258.1(3)-261.1(months)-253.9(after)-264.5(mild)-255.4(traumatic)-256.5(brain)-265(injury.)-250.1(Neuropsychol)12.9(ogy)-264.1(26,)]TJ T* [(304313)14.5(.)]TJ -1.7498 -1.1239 TD [(55.)-499.8(Hellstrom,)-1063.6(T.,)-1076.8(Kaufmann,)-1065.2(T.,)-1076.8(Andelic,)-1064.4(N.,)-1072.4(Soberg,)-1072.1(H.L.,)]TJ 1.7498 -1.131 TD [(Sigurdard)12.4(ottir,)-392.9(S.,)-392(Helseth,)-382.7(E.,)-394(Andreassen)10(,)-390.2(O.A.,)-389(and)-395.3(Westlye,)-388.5(L.T.)]TJ /F3 1 Tf 8.9663 0 0 8.9663 62.022 749.6502 Tm (208)Tj 46.8781 0 TD (MIKOLIC)Tj 3.7052 .2213 TD ()Tj .8536 -.2213 TD [(ET)-338.7(AL.)]TJ ET endstream endobj 113 0 obj <>stream /GS1 gs BT /F4 1 Tf 7.9702 0 0 7.9702 73.7008 726.1793 Tm 0 0 0 rg 0 Tc 0 Tw [(\(2017\).)-348.9(Predicting)-345.1(outcome)-349.5(12)-351.5(months)-353.5(after)-357(mild)-347.9(traumatic)-349(brain)-357.5(in-)]TJ 0 -1.1239 TD [(jury)-342.1(in)-342.9(patients)-342.1(admitted)-344.5(to)-342.9(a)-349.7(neurosurger)12.2(y)-353.6(service.)-338.5(Front.)-343.9(Neurol.)-342.6(8,)]TJ T* (125.)Tj -1.7498 -1.131 TD [(56.)-499.8(MRC)-279.7(CRASH)-279.3(Trial)-284.6(Collaborat)10.8(ors,)-281.8(Perel,)-286.3(P.,)-285.3(Arango,)-273(M.,)-286.6(Clayton,)-281(T.,)]TJ 1.7498 -1.1239 TD [(Edwards)11.5(,)-553.8(P.,)-541.3(Komolafe,)-544.4(E.,)-543.4(Poccock,)-546.7(S.,)-548.5(Roberts,)-536(I.,)-554.1(Shakur,)-538.6(H.,)]TJ T* [(Steyerberg,)-367.9(E.,)-379.8(and)-374(Yutthakasems)9.9(unt,)-375.3(S.)-378.8(\(2008\).)-370.3(Predicting)-373.5(outcome)]TJ T* [(after)-506.3(traumat)11.3(ic)-509.7(brain)-506.9(injury:)-496.5(practical)-505.1(prognost)13.5(ic)-509.7(models)-499(based)-509.4(on)]TJ T* [(large)-325.1(cohort)-326.9(of)-333.6(internation)12(al)-339(patients.)-326.8(BMJ)-326(336,)-327(425429.)]TJ -1.7498 -1.1239 TD [(57.)-499.8(Jacobs,)-457.6(B.,)-462.9(Beems,)-459.7(T.,)-465.1(Stulemeijer,)-453.9(M.,)-464.4(Van)-461.8(Vugt,)-461.1(A.B.,)-455.2(Van)-468.9(Der)]TJ 1.7498 -1.1239 TD [(Vliet,)-281.4(T.M.,)-276.2(Borm,)-279.7(G.F.,)-277.6(and)-281.5(Vos,)-281(P.E.)-283(\(2010\).)-277.8(Outcome)-273.8(prediction)-276.1(in)]TJ 0 -1.131 TD [(mild)-440.3(traumat)11.3(ic)-445.7(brain)-435.7(injury:)-439.6(age)-441.2(and)-438(clinical)-442.2(variables)-433.5(are)-444.6(stronger)]TJ 0 -1.1239 TD [(predictors)-324.9(than)-327.7(CT)-327.6(abnormalities.)-325.1(J.)-332.4(Neurotrau)11.6(ma)-336.9(27,)-329.1(655668)14.5(.)]TJ -1.7498 -1.1239 TD [(58.)-499.8(Stulemeijer)14.6(,)-283.5(M.,)-279.5(Van)-276.9(Der)-280.3(Werf,)-272.1(S.,)-278.2(Borm,)-272.6(G.F.,)-277.6(and)-281.5(Vos,)-273.8(P.E.)-275.9(\(2008\).)]TJ 1.7498 -1.1239 TD [(Early)-271.9(prediction)-269(of)-276.7(favourable)-271.5(recovery)-270.1(6)-275.3(months)-275.3(after)-271.6(mild)-276.7(traumatic)]TJ T* [(brain)-329(injury.)-321.2(J.)-332.4(Neurol.)-328.4(Neurosurg.)-321.2(Psychiatry)-326.4(79,)-329.1(936942.)]TJ -1.7498 -1.1239 TD [(59.)-499.8(Waljas,)-376.3(M.,)-372(Iverson,)-379.7(G.L.,)-372(Lange,)-378.9(R.T.,)-374.3(Hakulinen,)-370.3(U.,)-382.5(Dastidar,)-369.8(P.,)]TJ 1.7498 -1.131 TD [(Huhtala,)-338.9(H.,)-339.8(Liimatainen,)-338.7(S.,)-342.2(Hartikain)10.9(en,)-346.6(K.,)-339.8(and)-345.5(Ohman,)-332.1(J.)-346.6(\(2015\).)]TJ 0 -1.1239 TD [(A)-285(prospectiv)12.8(e)-285.7(biopsychosocia)13(l)-288.1(study)-280.9(of)-283.8(the)-287.1(persistent)-278.5(post-concus)12.2(sion)]TJ T* [(symptom)14.9(s)-347.7(following)-345.5(mild)-340.7(traumatic)-341.9(brain)-343.2(injury.)-342.5(J.)-346.6(Neurotrau)11.6(ma)-351.1(32,)]TJ T* [(534547)14.5(.)]TJ -1.7498 -1.1239 TD [(60.)-499.8(King,)-418.4(N.S.,)-412.7(Crawford,)-415.5(S.,)-420.4(Wenden,)-413.7(F.J.,)-418.5(Caldwell,)-418.2(F.E.,)-417.1(and)-416.6(Wade,)]TJ 1.7498 -1.1239 TD [(D.T.)-287.7(\(1999\).)-277.8(Early)-293.3(predicti)11.3(on)-287.5(of)-290.9(persisting)-282.4(post-concussio)11.6(n)-289.6(symptoms)]TJ T* [(following)-359.7(mild)-369.2(and)-366.9(moderate)-361.2(head)-368(injuries.)-362.6(Br.)-372.8(J.)-368(Clin.)-369.3(Psychol)13.9(.)-376(38,)]TJ 0 -1.131 TD (1525.)Tj -1.7498 -1.1239 TD [(61.)-499.8(Foks,)-274.2(K.A.,)-282.3(Cnossen,)-272.1(M.C.,)-274(Dippel,)-280.8(D.W.J.,)-279(Maas,)-274.8(A.I.R.,)-277.6(Menon,)-275.4(D.,)]TJ 1.7498 -1.1239 TD [(van)-366.9(der)-363.1(Naalt,)-371.5(J.,)-366.9(Steyerberg,)-360.8(E.W.,)-363.6(Lingsma,)-360.5(H.F.,)-362.9(and)-366.9(Polinder,)-360.7(S.)]TJ T* [(\(2017\).)-306.3(Managemen)10.3(t)-323.6(o)0(f)-312.2(mild)-319.4(traumat)11.3(ic)-317.6(brain)-314.8(injury)-315.1(at)-317.6(the)-315.6(emergency)]TJ T* [(departmen)10.8(t)-359.2(and)-359.7(hospita)13.2(l)-359.2(admission)-357.3(in)-357.1(Europe:)-353.1(a)-356.8(survey)-351(of)-362(71)-351.5(neuro-)]TJ T* [(trauma)-454.6(centers)-460.5(particip)11.3(ating)-459.3(in)-463.8(the)-457.8(CENTER-TBI)-450(Study.)-461.4(J.)-460.4(Neuro-)]TJ 0 -1.131 TD [(trauma)-326.6(34,)-329.1(25292535.)]TJ -1.7498 -1.1239 TD [(62.)-499.8(Wang,)-265.3(K.K.,)-275.2(Yang,)-266.7(Z.,)-273.1(Zhu,)-270(T.,)-273.1(Shi,)-273.5(Y.,)-268.7(Rubenstein)11.5(,)-276.4(R.,)-270.9(Tyndall,)-268.9(J.A.,)]TJ 1.7498 -1.1239 TD [(and)-452.2(Manley,)-452.9(G.T.)-451.3(\(2018\).)-448.5(An)-453.6(update)-454.8(on)-451.1(diagnostic)-451.8(and)-452.2(prognostic)]TJ T* [(biomark)13(ers)-414.1(for)-413.1(traumatic)-405.9(brain)-414.4(injury.)-406.6(Expert)-412.1(Rev.)-406.1(Mol.)-410(Diagn.)-412.5(18,)]TJ T* [(165180)14.5(.)]TJ -1.7498 -1.1239 TD [(63.)-499.8(Di)-245.8(Pietro,)-243.9(V.,)-240.2(Ragusa,)-247.8(M.,)-243.9(Davies,)-244.1(D.,)-247.3(Su,)-241.6(Z.,)-244.6(Hazeldine,)-241.5(J.,)-246(Lazzarino,)]TJ 1.7498 -1.1239 TD [(G.,)-368.2(Hill,)-365.6(L.J.,)-370.7(Cromb)13(ie,)-373.5(N.,)-368.2(Foster,)-367.6(M.,)-364.8(Purrello,)-364.1(M.,)-364.8(Logan,)-368.6(A.,)-368.2(and)]TJ 0 -1.131 TD [(Belli,)-390.3(A.)-390.6(\(2017\).)-384.5(MicroRNAs)-387.6(as)-391.5(novel)-389.6(biomark)13(ers)-392.8(for)-391.8(the)-393.8(diagnosis)]TJ 0 -1.1239 TD [(and)-423.8(prognosis)-426.6(of)-426(mild)-433.2(and)-423.8(severe)-428.5(traumatic)-427.2(brain)-428.6(injury.)-427.9(J.)-432(Neuro-)]TJ T* [(trauma)-326.6(34,)-329.1(19481956.)]TJ -1.7498 -1.1239 TD [(64.)-499.8(Roozenbeek)10.3(,)-511.1(B.,)-505.6(Lingsma,)-502.8(H.,)-510.5(Perel,)-506.8(P.,)-505.8(Edwards,)-506.7(P.,)-505.8(Roberts,)-507.6(I.,)]TJ 1.7498 -1.1239 TD [(Murray,)-322.8(G.,)-332.7(Maas,)-331.7(A.)-333.7(and)-331.3(Steyerberg,)-325.2(E.)-331(\(2011\).)-327.6(The)-331.1(added)-330.3(value)-328.8(of)]TJ 31.497 44.9977 TD [(ordinal)-373.2(analysis)-380.4(in)-378.4(clinical)-378.2(trials:)-378.4(An)-382.5(example)-374.1(in)-378.4(traumatic)-377.4(brain)-378.8(in-)]TJ 0 -1.1239 TD [(jury.)-326.9(Critical)-333.3(care)-331.9(\(London,)-321.9(England\))-322.6(15,)-329.1(R127.)]TJ -1.7427 -1.1239 TD [(65.)-492.7(Bodien,)-554.9(Y.G.,)-559.7(McCrea,)-565.3(M.,)-556.9(Dikmen,)-556.2(S.,)-562.7(Temkin,)-560.6(N.,)-560.3(Boase,)-555.7(K.,)]TJ 1.7427 -1.131 TD [(Machamer,)-520.5(J.,)-530.5(Taylor,)-524.9(S.R.,)-521.6(Sherer,)-523.9(M.,)-528.4(Levin,)-523.6(H.,)-524.7(Kramer,)-525(J.H.,)]TJ 0 -1.1239 TD [(Corrigan,)-379.7(J.D.,)-387.6(McAllister,)-383.1(T.W.,)-384.9(Whyte,)-382.6(J.,)-388.3(Manley,)-381.7(G.T.,)-386.3(Giacino,)]TJ T* [(J.T.)-393.1(and)-388.2(TRACK-T)11.3(BI)-395.2(Investigators)-382.4(\(2018\).)-384.5(Optimizing)-387.9(outcome)-385.1(as-)]TJ T* [(sessment)-258.6(in)-257.5(multicenter)-250.8(tbi)-261.1(trials:)-257.5(perspect)11(ives)-264.9(From)-252.5(TRACK-T)11.3(BI)-260(and)]TJ T* [(the)-358.2(TBI)-357.3(Endpoints)-349.2(Developme)11.7(nt)-357.1(Initiative.)-357.4(J.)-353.7(Head)-356.3(Trauma)-356.3(Rehabil.)]TJ T* [(33,)-329.1(147157.)]TJ -1.7427 -1.1239 TD [(66.)-492.7(Peeters,)-684.9(W.,)-694.1(van)-686.9(den)-686.9(Brande,)-683.9(R.,)-690.5(Polinder,)-680.8(S.,)-690.7(Brazinova,)-679.4(A.,)]TJ 1.7427 -1.131 TD [(Steyerberg,)-339.4(E.W.,)-342.2(Lingsma,)-339.2(H.F.,)-341.6(and)-345.5(Maas,)-345.9(A.I.)-348.2(\(2015\).)-341.8(Epidemio)13.1(l-)]TJ 0 -1.1239 TD [(ogy)-299.6(of)-298(traumat)11.3(ic)-303.4(brain)-293.5(injury)-293.8(in)-300.2(Europe.)-291.7(Acta)-297.9(Neurochir.)-293.2(\(Wien\))-295.9(157,)]TJ T* (16831696.)Tj -1.7427 -1.1239 TD [(67.)-492.7(Hicks,)-399.4(R.,)-391.8(Giacino,)-395.8(J.,)-402.5(Harrison)11.6(-Felix,)-400.4(C.,)-391.8(Manley,)-396(G.,)-396.7(Valadka,)-393.4(A.,)]TJ 1.7427 -1.1239 TD [(and)-445.1(Wilde,)-445.1(E.A.)-444.2(\(2013\).)-441.4(Progress)-441.7(in)-449.6(developing)-437.9(common)-438.8(data)-451.8(ele-)]TJ T* [(ments)-316.1(for)-313.5(traumatic)-313.4(brain)-314.8(injury)-315.1(research:)-313.6(version)-311.8(twothe)-308.3(end)-317.1(of)-319.3(the)]TJ 0 -1.131 TD [(beginning.)-321.9(J.)-332.4(Neurotrauma)-325.3(30,)-329.1(185218)14.5(61.)]TJ -1.7427 -1.1239 TD [(68.)-492.7(Hou,)-336.7(R.,)-342(Moss-Morri)11.5(s,)-346.6(R.,)-342(Peveler,)-335.2(R.,)-342(Mogg,)-338.3(K.,)-339.8(Bradley,)-338.9(B.P.,)-336.7(and)]TJ 1.7427 -1.1239 TD [(Belli,)-568.1(A.)-575.6(\(2012\).)-562.3(When)-572.2(a)-570.2(minor)-571.2(head)-567.2(injury)-571.2(results)-567.6(in)-570.5(enduring)]TJ T* [(symptoms:)-670.6(a)-676.9(prospective)-671.2(investigation)-670.1(of)-675(risk)-677.6(factors)-674.1(for)-676.3(post-)]TJ T* [(concussiona)12.4(l)-416.1(syndrome)-414.4(after)-413.9(mild)-411.9(traumat)11.3(ic)-417.2(brain)-414.4(injury.)-413.7(J.)-410.6(Neurol.)]TJ T* [(Neurosurg)12.1(.)-333.3(Psychiatry)-326.4(83,)-329.1(217223.)]TJ -1.7427 -1.1239 TD [(69.)-492.7(Potter,)-592.5(S.,)-598.3(Leigh,)-594.7(E.,)-593.2(Wade,)-595.7(D.,)-595.9(and)-601.6(Fleming)13(er,)-598.9(S.)-599.3(\(2006\).)-590.8(The)]TJ 1.7427 -1.131 TD [(Rivermead)-363.8(post)-375.5(concussio)11.4(n)-374.9(symptoms)-361.2(questionnair)11.3(e.)-377.1(J.)-368(Neurol.)-371.1(253,)]TJ 0 -1.1239 TD (16031614.)Tj -1.7427 -1.1239 TD [(70.)-492.7(Collins,)-398.4(G.S.,)-405.6(de)-404.5(Groot,)-398.4(J.A.,)-409(Dutton,)-398.5(S.,)-406.2(Omar,)-401.6(O.,)-403.8(Shanyinde,)-395.5(M.,)]TJ 1.7427 -1.1239 TD [(Tajar,)-473.3(A.,)-467.8(Voysey,)-470(M.,)-464.4(Wharton,)-467.2(R.,)-470(Yu,)-473.9(L.M.,)-468.2(Moons,)-465.5(K.G.,)-467.2(and)]TJ T* [(Altman,)-355.5(D.G.)-354.4(\(2014\).)-348.9(External)-352.8(validation)-349.5(of)-362(multivaria)13.5(ble)-358.2(prediction)]TJ T* [(models:)-253.6(a)-264.3(systematic)-253.4(review)-261.5(of)-262.4(methodol)12.9(ogical)-261.2(conduct)-253.6(and)-260.1(reporting.)]TJ 0 -1.131 TD [(BMC)-329.5(Med.)-329.4(Res.)-329(Methodol.)-323.1(14,)-329.1(40.)]TJ 8.9663 0 0 8.9663 448.7243 454.2235 Tm [(Address)-336.1(correspondence)-334.1(to:)]TJ /F10 1 Tf 3.9012 -1.2266 TD [(Ana)-333.5(Mikolic)]TJ 4.7422 .0316 TD ()Tj .2782 -.0316 TD [(,)-338(MSc)]TJ -18.7158 -1.2203 TD [(Erasmus)-338.4(MC-University)-337.9(Medical)-334(Center)-340.6(Rotterdam)]TJ 9.1682 -1.2203 TD [(Department)-338.3(of)-331.8(Public)-336.1(Health)]TJ 6.3545 -1.2266 TD [(PO)-330.9(Box)-335.9(2040)]TJ -2.6177 -1.2203 TD [(3000)-333.2(CA)-338.7(Rotterdam)]TJ 1.4479 -1.2203 TD [(The)-334.7(Netherlands)]TJ -6.892 -2.3332 TD (E-mail:)Tj /F4 1 Tf 3.3954 0 TD (a.mikolic@erasmusmc.nl)Tj /F3 1 Tf -44.4437 42.6227 TD [(EXTERNAL)-342.3(VALIDATION)-334.1(OF)-337.5(PROGNOSTIC)-332.4(MODELS)-337.7(FOR)-334(MTBI)-22548.5(209)]TJ ET endstream endobj 117 0 obj <>stream 8;X]O>EqN@%''O_@%e@?J;%+8(9e>X=MR6S?i^YgA3=].HDXF.R$lIL@"pJ+EP(%0 b]6ajmNZn*!='OQZeQ^Y*,=]?C.B+\Ulg9dhD*"iC[;*=3`oP1[!S^)?1)IZ4dup` E1r!/,*0[*9.aFIR2&b-C#soRZ7Dl%MLY\.?d>Mn 6%Q2oYfNRF$$+ON<+]RUJmC0InDZ4OTs0S!saG>GGKUlQ*Q?45:CI&4J'_2j$XKrcYp0n+Xl_nU*O( l[$6Nn+Z_Nq0]s7hs]`XX1nZ8&94a\~> endstream endobj 119 0 obj <>stream hlV{TSW{ZMmKޛJWqJQà 0 r D (jR]Zkg;U3:vf:0;߬9iWu8ggVxyym̫KĤ&&͎1+.̳<ѥrM0[G1{ڟi8g^^;yEM:uІszp:&=o}:HѪs7i4iiju̖-Z m&gdhYZuZIKIlVmT/gcrӧiY`6+=+M^t(Fy) JR(i>Y pb"(Bi ؤ):뤷wytT0Fv?&^?~~kTԨQ0:ԬLjcGJQ>1(Ǿ'J-rFW>aw?;+0TX}uU!t}&)Ы^)$2&c64sKr(L9}[h43$uftʑ.e5> bۤOݲPP7%8Hu[lwam`T;[7f[6 zI%?agGnL1;ę afjvC#fE+9Na:f nuـxJz/;Gǖ//j<(lmV[lwOV@&SUeWWl^?Y#hM|u|rop&:rehGav8`c+qAp =*b7h$õ,nu[QrY\g?qVD`Bct5UA6vwZ XG ;\u6I~YҨFWr$ޤT 񮙸ǻ ֳիE_ĵ}iwu0jp4KaTsC?4`LFK_A>ˇg1#*ek-8޽ª~e5]UbrXTGvuQ8(L6c "_p[U/PMOqpZ{>\M' xaso˕m15<:HDcSVV(s ak]w7wx 'fɮ$ژ Rs.Ok/'!4zSY+7@*W/^d:ٶv^Tx?w; d߉3ۅn~ k09.)BoVA>VałW>x>pײ1=5?F5S4={|v=_hH3W 8!5;Y4wXO{4Гwv`q hcA:ma2nC0g]O ސFAL) Ԣm5* dY}U=vpW`M\(KʗS3ݟ#6m'>忎@"`~Q+PnxʒM|d]|Ʀ} RT]UVL[Fp B0hccaOv:4/͖l!~%U|{xN.يUwDM?z?ɆR5Q|f7 Ѯedos0Mh_\ j;y# #2I!nɭghq@/(J#D6;mFgA~.$u" !B8V'0'0w }fC蹲>}zEDe YMfP`u>6+")]ݸw[J2I.~I@$-YEAm_#\gkomKqZbYcYuuiiVJլui D5V V&p 0lohhw.^?G>}GĮvP' c;,sVӖV-ь{>[vlkS-9ڧI|͸G A0`x{fZ$rIUdIT8u]ߨܤT]~Y o?P'I Z*׉ [LU[u (a!g8W-;XfDT4ڲ @ "g,WLkO}p,^{ETxoCn-xw8LI.NXl #.Kgu1_\n* /=fm-v^nm"Qwe71W&yEmrKKxFB%Zdh-e_X/@ƥ;x6]l~.0=QE2c61B(S⬰x{{c#{TkqZ0 KX6-rd\ 0Z݅ endstream endobj 121 0 obj <>stream h,=N0F (p&Э D&vk&M8Nc'g`bFBL,LPZ}Fc0 vN{gݣmxS߇;cu^v_YhFZ9ˇgI@dNC>>nQj/XiE)gEQ䥐,Oih=VT{w_,F $Hc+ 2]dƋL )+UYJT5؜?(brQL |?v6:S;٠'O7 NJa ! endstream endobj 123 0 obj <>stream hބU TGfbm" .Aēˀg3#3*Ɒ]xL<^uQtU jO׃I!ݗ}wWwWW_U$7IR;.rBB) C"kR{h1 3xj `o\Tʺ(cŔ:7[7nqh89 Egts!ìl4eMlCJN3SXgH5d%uif^mҧ2:]LZ1ےeE3SM4q֜3ۜ7Ao|T4J򓤾/IAR4J$)MJtfHAr%)K:*=Tū>V5.uѻ|:5ɵ-4I9K;MOq?RNe8 4颁F2 5-!bA (:~' !/#>{ On /R ~9<-z+acH1|,3bZä}b{6zrή#;QXEq (#:&u_&J#լS #R&?䐰<]o_^!VzL>5F{S/.A,VBPClG2-gI9)#;5绖6S-ѥr s:"|4I7S.LF)e h@}S=1aXo. /TޮMi`zE3A=`;tzdfBpA 'SK oiA%vex IeXFA]<&!fj,5MWW-.׵5톚9]5ٻvj?vbx狀9/@W3͉f#jo#c9Qnf.ti>fn^wcfm#IRgn=]&ŷt2dN=쓼!ncT_V7"kbWNۺ=:)wj K}vv)#LZ[,>o}ݟߗ|kWWqk ).((^,+o*-p@m_g(@tptal|NUr֍ׂu |s `]F}v$EJ>0MORӓ`%!?%HTnԟ%F߮9=3(KhWcdžq?]Sy*ֶ]]5vHUdR7R+` ;zz%QK¶Y?TΠb1‘gIdVQ>P9 fb(3xS;<ݞڪF~u[|ƕeaܙ?(Sdkj kIINJKIy\T(dL;{2h ZF9.p;xieaF ܰOnr7 ;àp?$U AR'EWG0~7 rxm=zm#ܚ)VZ/err]G}z ^>Y>uFtT g4bZFBFiE~;_H~Td,^qsl2Cp/@lLpk/َnKxɢpy3.!H?ɍc (sl{_D a|ypJZu[DUlq]5w3W6+䆵UYoߩnK͹hyli]԰t^=)?$ۻeiS߆dZ3n 3ڴas&[?rt(~"GF;J# _]~kyY]$2hZpUġ8OF.]mwjx8) v5ݱGxiD E# } GAi̜|9 'E7md@**!g0qǫsUUm- endstream endobj 125 0 obj <>stream htWwTTESs1[Ċ]TP02)t)T,1QDcInM$77&oG{$wܷ[g)}9;89;;g}De8rU&pPΎS=л(꿵cܡ򪓋sI4 >6N_pb!UoOv{/DFFId!WʉTAZ BIJO hA&p|r/GEA"?57>%U$IGD-MA|pɟ]prf/'i4W\H7]8-i!i='Wz98swq~%$I\ BO%X |cB"<:q㛣䀠5^Æ Ș1Y$@b/i8yQm;՞ޔ,$Fw&[BOuvw6a<ˈo;Xan2ں }õPO# F^aUg_OX3 ic0DTBa ơ;C/f :,ScU>ݿ/AwB & 'cavI^DN ` eطOcD.%8NI2Cd,mG䓭> h@qf=̌=$ac*މF۱O )^Cl9+I P*+3'%->,ׁ\41>D#j/}lAۖw\JI(MG5a5*PO`w~1#8!X&䤈RH|Q: @`v¼9xVaB|!Bn0G1]T# +xB\5iI*Ig2p}>X jal^ K@DŽEΉf>GN a|e%؂m(J7Wkn5Z!eFڻ 2YJWFFV参^d,OS[*.=_ǎE͘"O!J׵B EIx+Jꏿ\շ͗^6T+h),mIѢAQ mL>QPº 2|@۬#%ZFLGk1ԋ@`yKmqulD"o*z(W'Fw\þkq,&utdxVߴ/ryBVf:n:NcYk|dXcNP^/?P`h RP+$I'Y, 'e# Z8ulɺ1މUc3HEHiAxkBCXs:k^)Ug,Pah ?U U1#7/@E1GkhpudY@xVGALTݮ8uGTe6 DpTpoGZ<M2[0al.ylk[LUP:e|dOvQտLf" A2`ړU(8v x`ZWƠB$*E6 \"|72l1Ŀ[6"(^0yOI6biTV MC~# %{s&$ceQ0%s}ok=`*FQSl.} Z9f*4 &#2!%9Jg1EaQ(dηv[rFθSI{Ƞ8}UI㑀 vb܇x}ף`V~ps L3_Ȇ0plDʷhIМFɮp]cl!֒?|STEWߩ #%kU=/5m54gsW#_ʳLhO9 TACHäa񽿁i ts m25G)Q(;UW;̗t8W&1nնSޢOh Ie1ڏ様V|r+𞰃&fHA?=VJ<{i0%+dB4+-2;x b(˲2UZ6##. ""vRǴ1X]gI GYAs[9ktKKJRC5٘^(c zxљv W&8cu` XSe:g s:kvlh+z5yN 1$2˚S$d/g_0.'*]%vM-3DPpr9r274馍"Xe S쑆͎=ڠEBCw|oMb5 haR+Ϡ}8c\$(7V79Gl4b%9\A#OVyNxze.W)[eF}dZctK=lA8q02EC)%}*)<ke,m&#%sWG;M:IigPW/m촵YYA24ԑub8F w>VX:\9Uu-j)ifdc8A)y *=,l ޶ Fq[ YIE6Dn+Dt2?#GvIC<(K]Q!:VN ؂*䆪fc)/`&;^I?8}EzPw,:=1ћϠ5zwLJU?"3AKgWx$H^@~RFݲ]C}7}͏~J+ iYQA[VoĽ~T%gPG0_rc92Lɰ@ztA=`sW(ܖ#?ʛNFvn~u`=# ZvΜ;IGtJvAm谷 ;۵+~{xozh~uF=f`qzs%7`R{Iue83_ W7 'o76 UZM4Y\JRKb6ۢ]d,лꉴL[~2䗪FRM MJjR5h 5VԂdY~r2%~b,QwLLjKJMc/%/BX\j\[PnVٙOG3p.2u&9ds֐¤mB02Vcwi.rcpSl92rnJz+)3dZkjҝ춶yJؔ )t@y0Sy2xzi (m"wnec!FbWU Cb>mV!&/4(ʩʚ}X #[e1)JNƒZD@`QSNgؽ ;.LHި~2?Vy0HNdRbuMhaF i Z!"+w {{*2]Becc%UR٬H*e ]KI7K% *3G"$eLשmhJkv+UjC* ԵeLu@?MG RJ$%KpNbs3HzDbf?<; $dvwx8%ʋd:3WhhĺY_1C endstream endobj 127 0 obj <>stream HAJPNJ+AdvP4C4E74 wR`C15AdvP4C4E74 s3!%0; 5|#p3Lp|~zx~M~c~kqqt endstream endobj 130 0 obj <>stream hbd`ab`ddp vL) 01t1rJf!#wʯ'?Y/~Mq\ʢdMCK Si&-AcJ~RBpeqIjng^r~QA~QbIjcNBȄbԢ2hHfnjBfBBIQbJjnbQB~Of^~IeABb^~~B&P_qiRqfJfbQfj5{ߏ_?f}g3cG{%gbk>9.Z߹ߟ-4FrVuU]լCg4̙[}|"t9 endstream endobj 131 0 obj <>stream 8;Z\7$aPC-%*\Z'\C]sZP7T!n#_#tC^,K*?0"YPs'B$\4W.eZ_STW3+4h)5)+ugDg +Nkka8Z1OoUp$qRYD;iaQ\LTb)4@*>eqSArej]mf=V>;\7JVG.YYkY%A5.YrYa/)d a9"nu6Ca3.d,T/PUn?tlLqN/sEn^V(1$)oi\s5=X)LKAl\*LIEEdG7pZEXdk]K.'5 elf^P3I"-@^)?"'g3qo7XBB@JX&EChhP7)2*9\a(C6cHJg2b)@oj^i@K1&R):%![H ktfn$+HCAGT97'a&NFDY=+PiamI:UC1V0U<^AH,mH`Vnn*d1?Jj`([Yi>t4>XbZYP f?#((FZgeLE48'/l?0u4j)7q='BVnoKbZ#*""_bhJ%Keig(7tJ92>B#>j2O3@Yo5Z SkIW<+eiFhJoJTP[uF#u$r9ZgH3@$%>T`AQTejYM6>8t[eJu*Zl]t7G=+l*EBg`Mt X^k'@/(8N)M]X)j\9-hp$`k5O!ON/tdN4+p@RnQ2hBJ+G@q$>`_Z;IQe9GX^MWdZM 4r0`I endstream endobj 48 0 obj <>stream 8;Z]";%A7%$q.Z+"acg=&rk7PV_,!,2L]HFhb6ND=6-DI27pZ3)iZ2emN^51hNp+F phFdEC_5eSQ=Z$!!;^6si.NZt5+-$eD6#5%`u'l#Arl>b+1L8Rl*&[Dm%Z$#frDc$ HPD'S*Nt9Q0&0qSWNX_'Ee2$-(7;/;/j.=GSBS$1lETYi*K/+YQ'ZPf/++!ui+(h/ ?W;3?Cn8;AFi)2Ir\BR`@B"4,j4,-MV?`/!,t1")ZW,5l$k(C0bBG*J=dRa?*r.YE q$O>o@p/SkO[SS9jO0XWTSQg"cPs8-cL"k4^hoY5AIPJoGSY.'i!j:#I;=pn&?Pn[ qc6ao0B6NX[!fYD/2bG&Aaa,_QFF'S<5/G6:.IFP~> endstream endobj 65 0 obj <>stream 8;Z]!5o.<[$q.Z+"hBX$I4@'I1E>9i*Y(C.h4.^?aC%HsZpf+B (XGA\+ZhtBO[h6^$_ODka62.Qd$#Lu;.+BpZ'6)3lFCP:8":U-Ek(VCo)$LJPldq( Q!/%NCNWG/"<,QL@-mkc=cN^obF-"7bF$Fdeae?p3c$+]7T6_`0.rkCe)r.E77gc] 2L&KLa12&h@P1D=?_0bR?:(k[rPlXC\QBFUZ>ips2P?K)Ql_T\-kkdpOAi[>/c3C% f5O.s!EHKsQ'Rm)VAM$(p#+`Ghuf0p8cKQhtH9AL)5's[J]Beh\1aa\c"[3 T$#7EGgrKdlV!>ba-=+W#-e\f4T>$.ob[\IqeVA~> endstream endobj 69 0 obj <>stream 8;Z\7>ET(3#itt$oK$35K7Y;?U=n?05E:c29e/D*qV$OPD2RdNU-%KCEZt@m4?$Li @iTT6@ji>JJnC\NN@hO"iAKOY^&<735aTO7WQD0!;0&cQ[o6(.5,L2>V#W%h/I0du 5?`'?&m(.A&>Gt&IK*n+<%O6GO&r+`0lC[n#a3L:D:<`T7Q7P`G[8kV'BOII&M3CT No+EXNE"+5E^"Lj;K0+Pcbdf:k-2Et>0LDtXinA1eg7Cgl^.SHRZR:-4^R2;)XW;& 'acVAgWrLnOjB_tEG!J7MfgoM,12(g@mbh)!M!8/.kG>(Z:.4bX8i-3o;mY'(e`*.fZcfZkni8GR8rB"*'bO9bL.7sN7d=dU%A1!)5K_+1CN):Yn8rREC1misB@q)k=(j2-aqM`I; nCf0DTtT endstream endobj 73 0 obj <>stream 8;Z\7=gGsg#itt$j>sL0\Y0'3_8MD.C*nkcF;(AQnRimFnAJjqVfTknA&q5`+VDrA %+kd*[ih6;6ZMGIJQtM[*T09MQ0tI&SI5moK?r/_d9oH)_'f&qqT4DeHSSEAoXrgR c`eJ.Kg!A:D!^Us'=*J@u"7pEr72%3.8fPLSY0"9K16>E&,:+h iKa_c`uqVkko*8uP-YHFZsGkWeH3Z%e"qcJCQI*;H:_>*CY+T=?#G,o!4/5[1]~> endstream endobj 78 0 obj <>stream 8;Z\7$#[[(%.sQakjMJVN"=3A9X8En9%uU=11MX6,JN\;4('YapcYPgq:bt"("Jl' Q`dk.#b?P27\qgp?_-TDQOQ$?EAOhN]!O.JEmFNGA:sZLm3,r Uf]T1rPnStf,_RQKA,D0YK%<"=QS'J9f#QrXlIV=$bZ08[\?6dXHShZP^+DMW?ra2 e^EfGmmH*-pHN\!@L=k7%0Gs6SE9MU!#f2kZ7H?I4QqW]>APLQ3E,KFEFiQd/_JKR bdu\uDuAQ"h/dsWXcM0OXa=@bhQpC0gd`$U7\EIZoAP9Vn"pJ*EfHfBAFgN.]SN," HIt:,A+Hm]iTUF*5L8e-%Fm8WeN%:&)`6\'VFKtlnC#h3nN%[kgG9`WI$K''F3\Pd [DKR8(=P61P(r4I11.(WEJ+_SYYnK#6'O4Oo&ZQ!i8oq&>-7t#d-P1q=F=u!:l)t9 ,o04/PTQ]:+YFg. endstream endobj 83 0 obj <>stream 8;Z\7$PJ+8#ke05j>oAdpdmb:Z.e$$AnsgWn"FCq]Ja7Cb`"jZVmF@Zd%IqYm^maa D?JJ:h(O=*?5jQ$k.J],kVGQ4f$&",WX?/4J\'*cQ:^+ZJK8N^^p5]^@fZlgfAjDM 3F>VJBlC_5Bb,GcgV]VuA%1Vb+`q<^QQlV&`((S2O=4[5\h7@-cI7>YI:p#H?Z*MN =H7CE_*as.o(&S>ToijDZrX_#HC6_!B*nshF0_"fECN:Z:i*lf=9^S0?Jr44=IW(? a23#R;m_#?gh'9pSgTUlN30+t=NW7C*EWnHC67Djfs[=p`&d=\&k>%Rc4YHUtl EGam%:DJt8!%(+T*\>!FroB1YV)k(-P5 endstream endobj 87 0 obj <>stream 8;Z\7;&4d,%-.='lui$Y4qn/=;CKN/Hu)"2dNh1FOV\3I%-=r+Kan+ZZe9QS`V_]R@kPntL&am2$ke3rC52npEs;-I6#/Ol)Xb87`BDCn7]W0J/8n38M.@_>q`Har/1 4m\:7C<#MdCDebLS;gG)0Q/QHn1L(1J`4S\CiomXS(R)lH +HNk=c?C?X,>_J=E#O1kX.G^=k)>5=7P2l=hEHgKA(b(TQW,V"4Y"DZQa]Jc/u4s- W4!enb8Mf@A'_3\Z'i+$M3r'jB"B+.S]E.3UibAf=c\5WkV;[44pINI]iZZKi0*Cr YHF9YI2Ob#f>'DEniY2#6gNn)1jX&:6n>&`];cpu]RX0b'J@f+io0Y@!0u%\g]~> endstream endobj 91 0 obj <>stream 8;Z\7>8"js#j_FBaE@2h+4EQ.Yb60:I+;8-P#7kr:LrHE12G`D:T#KK)X-eUr=iQE g<$HJfJ"*"2Cp&\knpUS?cWaD-=JT@D@!;o&0]fKr/,3Qo5gNl[P?5Z9V\PC"4.rZ D%CYeeI V+$q3+dRZu4'rXYH5:=MjgCp(puUTD\I:`H7Te8'NQ78a\R5.$_lI/X6hDN;dE!-m SYLPtOIbiQCF%fH^s]!$^Au%(^Oi6'r"!K.U[.jsi?e=TMT)Gdf''L65K[]T>`F., QG)(_d#Q[I7mffl#B?p4AA>;G">1i5Q6R,5T>Wha^.+\\'A!$1gRBmuS";:c endstream endobj 95 0 obj <>stream 8;Z]"h%mp?%#"BR?SJ[i=5?;W&i;o#WLNlAndRlRhD.qlIPKP/%.m"<:`;+]Z5Z"^ 0&5tf>c2=RorECKB]57HIo)'R(]"-=ZMY?kFjQWi,%#J`b%Q;GRR>)`"LOp%b%((@ qM82&5i5O`T&Wo*!:E=I>3V":]3+Bfb&'K)Xc\\W8BCgWQsZ;IN4#SFjH.41)].aR P@&?iARWtl7[@Vt(urY6n.XC4MFZ`hQNUW"]#DN+1:4@b!cc`#US>tBN7:Jl9D(B_ fQFn56aMs'3*p\]d`QQ5hO9\tQ[.4O-Z^/:*;.MQIG12Y`MM7S`u%[=q@7>uM\u+> HB#HI1M.>%HdXRG-aX\cQ/EI4Qst0EaQ+5c1;Bl>R)OMW^P$=X-Sm[P?EJ.rpFO^B+"):?8R@#]'`id9j3^VUh?[?tN endstream endobj 99 0 obj <>stream 8;Z\7Mitt##iu#8OPdU:ScVAL(JQPA/Mh88^iak;e1c@s'1A6C--juM,tN[c,CA1% p[I`#L3UZ;.4jmWo'6sarEI#XJT\G/c2td=G!dWZT?n6n+0W0M'kVPi6$[Ed'nkIRZ[,!e]G0 B.OS2!iNn\ai`>)fV*lGY!M".kHnSmN:f1I=0Z"d,VKt=]q6)/ba%-ulaVkLg\nbh #P1fA*UO/codGekn#[]C/$!*F(GaTWm\$44>"\XKA0hIu,SkaON8h66seRWb^9G J*@TuYA.-KQ.H]X]VHiU)5`_H2a/U<"ou]q<2'~> endstream endobj 105 0 obj <>stream 8;Z]!CK;H1%"l7n%=1*!5l=2K*%oT5J!'HoaCGufQ?C=I>sDH]H@>APIjFkl/)IeM s*sq:rbK16Q##87/0/)d3S^KJ5o' H"dCqKkZTnc..MTJ?6Th6=U*3i9>UKEVVZ X_>&L%Tk\a[30I*5EiHu:T.dUC6R/%n=iu;bfk.ArME8`NLX1OGe>f,"bVi?Q'I]"kSb6oN;t1?o K9sn#R5/B7ca#=42\pQ$iLJJ6%H2j:p]YAY$_CU'\><:j+HP\gSZjA8SE2M6i<&(7 1)s90\b"qa1PE6acqLF-_k.97Bc@pqs7-I Bk#;sU#.KNdmPbTq/2\ES%fd"72nEc?QCLeD]o Xm,CO.Ik!>aOHk>0r=BU!>m7+&%Z5=mnea.(">L>BEp@b=L9#Daq-YBCQI&-5/`fj X(W`&=c9+>dr*aJUO45WO@6QKA,.m1LUAUX3&nCMCBj(VbqTCQAn9]7OYL_=bUm,h c;GXQ`F!.i+#Qc5?j>hkQr3uk$pg;jfjpoQ\cRL%8Zm.FjpFV/]i;TOJ>a4/>;K k+5Sbj5R-%.6&WnMU"-&(\4f3$@P8cjS%'-6VaSnUKord35AOAY^t`%k;ma.HVV4iaJ\c.)*P34iAbX^ZlfkRkS, [[1/VD$SJu"`las9>8aiM@U>`@5@5kY?Gn^jEMhAS_RO=AhT(D1E;_\0tZ$`]'2ej"&q9lmX$dVO(b,SlRT@iCuE,I7/D_c`[ZL.m<#UD"[r= ;P5Yl%C#faBS`q endstream endobj 114 0 obj <>stream 8;Z\5D6edZ#i#5`OR'QYKd6q-m2Pq\9W,:IYh9S^g#*7>cT$4DLID/rD&Y.>nQ?h. mjdpO FAiT!F%;b?=d!o#/]1;KCn&70cl6IKV9t$7 <*&3]8>=Z(&h*-l3hf=NOH?-p(lF3q5dJ8C>%o$Q=\8+:,Ld]MBi;-9Yq/h7Y.OkN Kg[uk4aa&Bj:tn^f)am9X+](@Zi5bZg-t2T1bY;>&'&WCB][_dot(]Wcob4/pc!T9 F?D!q0\]YkI0IflD3lc9/[q_t``FNqFcu-hs#4d9$jM@#?n`E+#(s`tr!`Xfb9>@~> endstream endobj 136 0 obj <> endobj 137 0 obj <>stream HN8t%bx),#"f/fM\(]fPqs~=8-4YYP gEFB`u4Œi'{XUzY|E7jl|9 I+.Zmx@Sϥc+u˿ :) pan0gah[̻C c"!ѻ)EWM[7)*{;mT)@mtRq_Ka&T}7t _l6$\7|!nP{G%kC@~uOF,UjqUѹa C)~mI7t.Wyyzmv nט%8ݒ+YLr &+:l|_t-pP[b" eCQXh`{p5@B!;p_`Spw?:oRh^ˤƼG2%pA<Ȼz==$K TFhlt~&15o%22hP̏LgHxM']ݻd.qQ@ѕÜ3B}9`)Α=c\+m9[ jA 30|ApuKZ3x߇9fh[pHdA9XY$tJuSA$@af!"$  B Č߿[=v]@F YE endstream endobj 138 0 obj <>stream HtTMoFW8 -K=Վ- &CÚZ4$RR ۙҶ\>x;3{O2mjQ[eRUI[! fw/L\hۆ?O5”3F&DaL2EiJGA"f(`~JXp.^#ԯ߻c"PG"_[wF6e_#oc>ߩ8CLIL+tM.mϭF7uGz2]:CX5|x݌$w9^ڷ)!=_}n{j(D τft|COe .FIce~pyJ3O׬My7a7Nl'˗\G ^Aq0d-!Kkޑ޿}ЉLYX]VI*1ѣ?4:*nKTTFsrNi20XRإR6*8n7ZjQ^RdEK4.a ,ѐp8E aTdB~)/H-Gp6xO"v ?Yjv԰]1s.{KM-$J4sūuxw,SaͽqsYl}k5~w _."7ܸ%!4{C@5)iCXSTHV꟩_tG_F50lbjivC@9NYG7-}ZܞK<v?^Q!$ D~IsUt%$.[X"= J:UIiEe~/fX9vNAܾgCGD L =*p"ȑ?ж% endstream endobj 139 0 obj <>stream HtUR@ Sۻ0) Tqp031e) 02;z-9Y.IZ˓$o_ξȋPQ7 4BHKc-r*Ʀ^L}OԱ8Fc| )kNiSXB@RwX}.EH4؄a"~YVc)TTxiJdOɗ5|q_A:8s@bWG)h`zq_:csFW*%nN0O3|b=otc \m/yY4"..{LأL9L"-QѲ8QV ![,ل0LFgL"( 9V%| pltЏ8הH(*E>2'h,=JuQ5?ee>S =D(\h-]FɐtD &cO˗L\] ͊gqvJXAR&o(cЭ-'KNRP\Zգ*i{1 ^ bݽN=ix,SyעnAYq9nh|'ԭS ̂v)S> :`J4d2OqNA纾 _%^jT`.>쀥&,sgF%&$:ǔ!5U $vt)A`PJI&֑eˀ}av.s=L(k8P؝FpfqxFZ(dAk*vzZ'2|B.{+YUv.o}귒 endstream endobj 159 0 obj <>stream htkRaƿftz]ƚXW`P  b&]D9Z9rtUM #060* ע4<<rDA8>5r&p? (JRɂ>n-˼Ԕ}4<6xipwp b"A..ÑNg;\}L!%A2Amn" HTRi@R LA l@BiL>LZVMlC̣ ]NCB7P5¦4uݞK 6ilAtI @ 76nA/:Ў Y<6f^pgͼ}%zrqeNFǥEkerm%c1:SD_bꍨazP{\X'x,26Oޚ']śpqz܏]CeTp̗}|9WM.FU |V҈n秌|z73\b(Rk5׎eK}Ӳϲ2 endstream endobj 158 0 obj <>stream hTP=o _Ձ!j^pR BB>ӺylK@dZL;o# B8Xgґmu:'O %S\tw[}.3%o'@)Z?GZdcdq`~@S PLj]ot$;Yys+r\Ĺ =60$pc`X\q`dxjBY<#Iz endstream endobj 140 0 obj <>stream H|Un0#W,%J(PhAZ,z8qr'rf9\~Y~IcTP* 5&Ì.Ps5,aL+ =P 彜_*@@BQT@% ㍂O.K&NsKTE-VS<y~āvAS)ز8*=n90q[〷vHj_D5%~dkIgtl$L3zFK6$}BrauE_t藓vHN։S09N%R@.W).V9Se8Tפ|O% K)wG-ښ\9/v>{>B_ z@k!gYS&A}<g|9v/# nфl;Z@kvHMKB{e6Nq)A8V2[7+ wA(2zKvD ڽHrVZE{{4U#Jײpr9]~{,aFcpZ^^)Lslċ\1f"-"7=)Z.Lz6MX'D$LcAjQWgN!ZOfiHd{5 !?y71M>d=՘?!@Lnf2ՠ11̖u.1׹ `n5U endstream endobj 141 0 obj <>stream HUMs@ #:םzL/iR&-`3i'i@j{Orq=*>ԶtӑMM(< wg?Qni?W%7Sv oT{:c5 V]KySUSѹQMzaۚgBR~k9KO'~ĕHb:s[ Â%jHKEp\,.(+s>stream HUMs6Wu, A֧:vua.?߷LLс ݇U}%wl !X-D P`Y,(bI^KXm+6Ā8Chr˸dxaK&kc "B A ,#BcK fl"v] GRw G:z֌/>?TCR(Tw 3)S)ZƩ?,'[A &Ww=# ѧv g۵[(sN *mg#Da;,Ay5vE@e(Bq9Y%蟆TH͓"%p?vi}HB#办LV[Ct,<(Kر~l\ܮs"6MċE>sq:tp]?!{|x kei|=EUDW/%] z,r4pUW\i]^#LۃhJX⥬ncwT|]Kfxl7ϢR7pp) {OkRgtַRIRۿ`d}Q7ˏ^yLb{R!ߗ_08574r{M5Vk7uvh|hJGQFoKӫ$H+EqbP(զ|il4uyZҰ_]۸!%u=zQJ \PHqH0R\˪ W)0y)_gzcb9XB Ƴov&Tێ62c `A:;x7 ݁.N `@zoWwqϳ?A[ endstream endobj 143 0 obj <>stream Hn!y qkaRV=U=T%6ߨ6Vv/? H'fʉԈ 5rtLFEﰔ 7S𥸩*|k}ܛ.NgR,1\JiGb>]nJ(2G`tNK7;`[uf g~J|;|h9N C%$ Av}0qpb8/y4O/߄%B I@CbzB﷩d? Ktş?3 }C; 9d1pwC`~?ʄ),1z ?nQמֻv[ӽ}  Mタ-˝) dwƷ;  VT ЅhcMVt^2P~Uޒ­lj7ogOkPgzc#ܺ\.K6l d{}~0'^PG[;Ct4"qE84el+~2N[ZD[Hz 'Yj 6nWR0d>=cl3*%h!UC~sHCkg^f1|gB> ɧť{8$_AEGTUjj 3iC*4w]܋د & KJ@Y/2MשG.BVa)TB4ᬮ0&eMQ޿}l/~ܻAW7_7<Γ>[thsfT[,i |DnmDб䆘`4 =AZL~ 05 endstream endobj 144 0 obj <>stream H\Sn0zWH1%H'# Fr{e&f#S%%Kmٝ.,#ϳ43Qy9#7䲐cBE)U\0M rg_r9˨\G4͸{T9>C5Đ<N3s4ۙ-ɨ"#F9/l0SAn\Mnj;a ^׵0n Ğlm{ 2R nk|/H3Syo Ei/T}3'~ߺnp.dRS0.t0uPj]]Γ14']И/IP]P9&M1XĹ;[g]8 T]( AItύu ʛoC y'qq:2T fk{nG^Px&V j_`ߩ}a>=+) 9NY{`r(fӯPEC~q;V!ê &ǻN`PL1l/-Pp& m@gH$eZ/֟_q^~|lM`Xt3t⿃/*ld+\kRȨ\E~F@r`:Fy endstream endobj 150 0 obj <>stream htV TTW~H+I{ D&-*aSPZEbd`@j4JMtQ(N<ьA #zə̜?}νݪUWUO.Sr9J*N&H\0FZ#0]d6ryMCT^~){BKS5Aud]8A֟y=L[^7VClpZ!D 5_=ٌVV؆;;W<.`& H&=>)b U0D)?8NsswOh>1 7T0ӳp\ ~VIflzOv @\3&M*Gjdfmfơ2Wm'o6sƥJosm#VS`/>Jr\ԑ-AP^ ׺ ,ė5J%Ψ~ܥۏcBP|8MRb0 #w06w?30C ̧}p"x!|d,d9y"FO|C@ ==6k;M'?Eɠe<Iƽ7C/v1VtichDոM v}DyN<@a]RNRQe,L[` ^b,."&l,1^rB4 Ai>/&Y0H&8($3ŧV,1i x;$?_ PSQc`Tx5I 0ߝw2=$qy^Qf4- M Re/cZ?ǰO65$Ҧ*ՈZ0fz 3ÀJU-th6瘵jK(t k"À|c}d< a>8^ci C* l ,@?&h`?J8+qRor*<0C`҇/{]a.\mv5Q^!S_}ѿꅊ!Gz{V7:4[G*ںR-bhM܍ xF##,;ɿOB )ۓ=9Q! 7 ptC^C AULjTTma KuUd:ޙ9ſByj}yefB4ߵBvk)Ir !ujٵ}oկ7㸷ۛthgpȮ|̮𸺭g^I^Yi%؇VwGG^Kndcgْ7mo6+}} ,cXtiyϝ/_lC8aTZi&3@jxYa1ƣ3] Pa QMEjуB//M J6m,C؊+jy`^[!Γ9KkJO?׹`)6t endstream endobj 154 0 obj <>stream hdV TGwGAT@B?># "Qg0#!A?"AcE0Qh/}Vc={:_n[02&,xjTa)|&N#9=cֿlf6TV8ҏ*NgSCݴ^cxHoEe[8m䗠%Ao(F(CY ZV=:`mVlWwhօGO6mUj :v*Xj@w /1)cqa]o4*o`Y!@ Nlɐ&i s&ǏPsb>y1N w _iU⎞霹 Hd8Ng!R?h-c2P܏{3u;NS?w]=N{Z#3UގQm Zlx$%=Eh|fKgW{^6h$NFpx .i䫼~F3( tV0`' @8 _8.la卩BBAqcCyOIΖYS{DWj k2?-P Y5mKX5HM7ޓDPu 9~xCGrJbE{oF+C*Q`Č(SEW #XV܂+lJ ɨ\W53jvloVOAR8HŽϢuq* p4[Pհ8& @o2[^^+<,Z=>pi(:\k*UZVA&%-{Rb>H.bq R8(i8_ъ=<-\F齌 .3[0(G,evȁ Lb1V%4"Bus(hi"K& ξC+|RS?صk P TχhTYčcBr=7;%fXs2/ B|iJ $$.ļvnirmgr-a!`,tCP  Ź8GzS/-AKSȟIMgʌB:ivڈ<(w|h_N+Ȍ%_G/$1C':Q1Q 1}\ 2:;>oղ2oڰ<쑣bz.l߬Yϔxԑv㪵< VYYB鏨^+?@NOp'{p`iڄQ uD F?Lݴڵ ^bOb+xL }jRSc4*V(+(#@磥4gǴ9;nK:^=gySH0$S7J7$$;m-l&b?ޅp#.:/w<@Zҹeo?Ǚ!i/6/\Qu{ wB\Go_='¾ 0Np2 endstream endobj 155 0 obj <>stream h|xiT6UE4XUIy1*"4 ЌMC7̣̂5ys51}^crwqY;ywu~֪v=g}}՘QVﻻn65Xc'[?Xkwm3 |8X6FY[ŧ&Ffi-eoN"!;R!1I! \[$$JΈ$$ qbPpHLPbC\gDl85>uCPl¸D_R򁤈Ĉ5~H++V'XMeVYY2V1䣭rFYJLVV{q`Vzu?5qԶQQFۏvmј1Ǽ&7yd5wjUM;2vh=.mWﺼvD2EDD'|4|‹WI$IO}g]&'O~LBfl{iʦ)gfm~}¾ C0p&yɺaH'P45 M}0 ̅ѿ-+a~K#~fso||K1QB>ƴǔh\ᬙÏGb:%qw,mZf% xy D1߳۷E=$эDz3!GBWK6q<4R"gfg&(D(UXʇ{\wlv_f #_d?{h#2BP B_} caC8fé;$ȝD? ZmO>k:"|<׸߇Ʀ.V$K,pLgM5bH7FBTBpi0ƕY79ڣNj"L s'>sCr1?qڞdnOg|8kWq%Sa}wdGhH"cFtIBCqogehuAV8ٚޣ^SMl@SU,.MNMw~`E>^7vx1Y-k IjghП>!?0F3獗'+A<ؠ'tvdG| &6!S?4y_I2+hPbdUqSѪ/?^^c'34Yw>+t<rA3P4bDfKx>Lˣ!p.D# i`Zq}4M-HLIj J8CGWFʘHM('j$PЊCjR=<*ߨpeF(7E25{NAb-p}XRc ,DK8IzAtHştbg{xrqIoʌ:k)gyq|ea+ΆdBBFDjɛ:qVנh<#=·OxOSkunh&q1 ^=„.5YTe $\z`b X\5HGyYo"[`p՚`҅'[[1(h7+8 ?J:'Mdn 4 I̬$H$*u$n9&RӈV)1oeUT#$aԚ'M|B5:͔!qP?4f/pdF%Mef9Rai@/~3׵p dd\^2'*s&‘- 47Q`Nhf[0+ 8&?yű3v\TT>,̨C38jt'=@tMѬidZ3p::{gǡjѝ0SцJRtz`#P}ooqj!}bg'qC; ` [YygSq}~KZb-6L'$Pdw la`rsPkgKV͔KA{ zF)9/|C)*d^,7w2S%.^ìO"3nwA/I91َˆzTV]ǵ|´? 2WNwbjȟ^fPo2B9 FQu|#vBޖn?o6-xS.vX܈}\En&)&A!Ȯ13M0;Ա|Vs,wL-eTelǂ^&7zmt¢2Rp~#L# T ZM47*+49ՈO wfx"݄~aMR~'Q~ W.dK'BE uR{P ه?B 1YNn M#r4j67\u /:Fsd64c7:]`)7:̌, mko4u;(h6qJl\mвK"f1gΝ?˹jjت <'nП\9~3} /:V/ѡ&-`z8SyROKϰQ2m{T+"7"t:vنlajL _\\ЬoW:*q) E<zE ;7zBL\uʄO8s_ER%t0$]= ;f1q͊ 7| շ|{=؝G~*O-)j#g jܻoJ}唾Rod/ɩiy[TwZjiokMn G"i'=\X V*CK=wJiIIa_?+ #"% xCDEZiv.r5b߫cmB$`[gYڟN dfd^;âz;a ߝ;-SKull?"v3qui" i%?w /ܜ + >L4QHInP IgDE2PHuway(,Sq&*AOqMO=mmIn03zp@>/H+ߛaFKғ=gLn| U tQ}쥚< V'(C- Lpk  xAA-ㄬv06p?Ì)|V+ϟilˋ`uޟ/Priq_DEuff<(_9 j=qK喼iKnCAkWtQ!Z*FkK#w= +`q/&A=X|!BIQa2ԾԂ=_"֢g&J+䦦c/a{_skzL3 ,D# n1L:zk, fΔf=~o^Z?Tǧp·L2_N dz>J818Zl+#ʳ´~9_;⳾L$3-ೢ%°.ٷ<9$&999O*;ΑN:t('22SX_NS6cu[] 9 %ǤǰW N1X9#n,&M} sC"q3P*zC3!_9U3[llqi}K9~.GnbH9ըObybS+aښ 2PN (s{d/xim(hL.%"YlQay m ~2p>-)(⁃Meu{tB!g$і`t񺐋h2=wK*ۏMQNUk4&3/{'5L]pPNu*[@*{9xm/7rO`!,d!]UΈʊVDDA*έdZu : | T7++D;crFv}eDijꐼS^4y&\*rX:X)ˋ"zaaBMXRW7dmuY㚻]Xjt1E)rocл}v۹c.to[LXXll>@Sc1_sb%QPfҖ&8"!3*'8O&LY'ٿ jQj|U": h: A%+xF63oCX|Us 傂&#k"6(,Y{9_x""#}[w^ǣHRw5g-Ce>{y3tk>)RyH tF3!]B `m endstream endobj 160 0 obj <>stream hތViTWn UG [6YeQƎ" *"1FQIиLQT\F@(&Founqμ6sf̜3~ԫ[}*JmCT*qIqfȬ`,qfRF7:M:PHCim(HQ*lev&$E}JQ1JMT5**jꚊW-T}jI9h`gn[iRmTOTQT_Ww:6ѹZ(0iL69c٣Jc4kvv6_{.ʮخw{~t 챏NyÇ:<y%R:bS.ؠXàp=D.E5p@k=6#3pE p=F$pn_Xgsir߷W-Hv+`/?L& LԲ03-[)bںFO #\<|^.,`IMg!fjM&#A|k;MiiJ+șgALiCGiӎAQрR?Jއ8mz6{2u݄!cο ޜ!4KnUMg`pmWϜ.N>^t\xʬ`BCbO=g9 VG;Ae/3` n^9{tVp Τ(ӫ " qF]K:rah+I8X*Ð{`a9!u6oZ2zCѕSfWgEPgh2A4XURI+{:wtKtzu㑔e9#7%Tw1wFTExxg%NqO)OC5R"ڮ ҇Z4Cԝٲi`#PAG2R Spн/Bl&Q9Pr ܳ c} J ?9Jovȣ6ӆyU+,Y,Y8h.׺9ebǾQKKHF~  G1s04xuM]*ak69AeL3qko[N@!gtB}ЀT)aY` A'ӓ` S+q קN[|דm-_u.+≘Q[MPBںK/RA?t$Ο6AFW 75JAonPjP!B%0b\QE4~SsF  [)Vʀ_.ڷKc(M0808{滑5/&H1,8L@]#x >R#3ݥdʑ;Q9IӺ߶jW y8BӶN= >"#1r8 lM7?T*>υ哓 ڧtmqxpxUrx(f1VV,"85J5rR^ggq&K,Y {t[t4 RDW+b0N8TꯞӹA<Ժr Ceiz;;[*Νgo>FSicf %clz'e>?6 uċò? '.XJZjg 5$ qTTc@~|(tS+I]D9F_p39ߕ@boV-Q}GG{CIOuEf0 MH )SU jpuz\"%`xoG5_$p@uF5 467I%j-Y$*8l9J\ԐABq 4N荾P пgü0pM| bP[Z9IXIu]‚-Ytٲ|80)̔qz3X~=񺸵t7.d# h!ݚ[Юt10Tů$CGdHXٟJbW[IY EJz0zJvd ~HrYyy{sby;t-ILc n-*f-9)$8ƀ=c#fEgK%T hP ^b'#vQ ]:tI0ۃ`U[7v( >cK8_>oSy͐p[ÂeBF7@I/pMDWsFȚ,PmN6 0O߬DxOXyDU8 720UNc0BI9,-߅ (>J:@e;}V6ZNr68Z҄_ m;!AѪ:\Ip9!Ɣ/iV>tsg'BDV bD˿;H-J4ʷKc ['p_r`I} endstream endobj 161 0 obj <> endobj 16 0 obj <>stream x[isH+8S[Շ);lv)>(!ɐ̯纫ْ,6!.ճ㾱8'wx;rp/9#<~*P9" =GD БG8~$XJ2t"ߑ!]x GTG)Wb 1Ī9B0xpfp#qR`;^ 81k =<$0P ؖ`L`i  @XD>8iX!B( @;A(iSA)1@VxH>r# "RDB!INNh6gx6٘κ<-?}JK0=/S}pȮnk藾]$| +geR8yaWm)sϞO?e |vIXXSM?dmNfUQD`nHHZ<i{1xS2׼O#U\e؇>3ȅ̂юΒa7'QZAh9h1Zv Q$O`kwg7/w֋ϓt|S|vY$w`;I' "_krY(;ܑ+(9ižw_:WwRe{ Es?"l;v& aC6g9gl̾7cv$fn7ɌW`7쌽c;b|ƺ5-%p r e?hC.0rm.T?I 9mwDBW}7 <Uԕ3}֣͏y{|Lk7 4u4xHiT }رRIƼh:p*MAW%ޭ;kyTBLI柫ّ8jsMv_m1$6 Zp`qk:oȑGM翄/wp9\>Fu8}0ozp+8uvUVM]+MxB64qr`F(ڡoSE*ܷ)֌\U'v\\3J׎v[ºVNgZ5[%|8nlWaT1L5M`mKX%";VFv [D4H@YLSL.*iVSQ޲Y:Kޱ|7l~M"ɈJ:!&x,`oHm'ٜP&K`0u-iy+ Τmg6Y=߾݆* ۲;l_,v> :2 Tpܫ^e5e[j}l{_nО@ ~ !m/nűjK{U>tPѹ&{w5{f] Fo4Nv(A]ϘkMLkVZ]ټ8w5c(y[*ȠyE :7T&h3 ,v49Ao^UR#!gdC]/Root 136 0 R/Length 494/Size 163>>stream x5IhQમ6:k61q\C "K zEDrEH$C F<"" x>|G~""a DDT =XrA:`)(NBMtE]nP&Lp.w(}SzNt `6:@†tq5~64_'viʓ6 i=m:nt9 T4(v>"y-V}լKh fΣ{w3Pto]n9Pv畴JVw<5qnvt#{yt߰fKi#|S|4vpГڡ!jknP;q&3 z1]v|ejWlC7MZڡ@7Mj39LvE0{#' hg endstream endobj startxref 283901 %%EOF